LOCUS       NM_013261               6288 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens PPARG coactivator 1 alpha (PPARGC1A), transcript
            variant 2, mRNA.
ACCESSION   NM_013261
VERSION     NM_013261.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6288)
  AUTHORS   Liang,F. and Huang,S.
  TITLE     PGC-1alpha inhibits NLRP3 signaling through transcriptional
            activation of POP1 to alleviate inflammation and strengthen
            osteogenic differentiation of lipopolysaccharide-induced human
            periodontal stem cells
  JOURNAL   Prostaglandins Other Lipid Mediat 174, 106853 (2024)
   PUBMED   38763227
  REMARK    GeneRIF: PGC-1alpha inhibits NLRP3 signaling through
            transcriptional activation of POP1 to alleviate inflammation and
            strengthen osteogenic differentiation of lipopolysaccharide-induced
            human periodontal stem cells.
REFERENCE   2  (bases 1 to 6288)
  AUTHORS   Kuang,J., Fang,J., Hu,S., Yang,X. and Fan,X.
  TITLE     MECHANISM OF MICRORNA-218-5P IN MITOCHONDRIAL BIOGENESIS OF
            SEPSIS-INDUCED ACUTE KIDNEY INJURY BY THE REGULATION OF PGC-1Alpha
  JOURNAL   Shock 62 (3), 426-436 (2024)
   PUBMED   38888503
  REMARK    GeneRIF: MECHANISM OF MICRORNA-218-5P IN MITOCHONDRIAL BIOGENESIS
            OF SEPSIS-INDUCED ACUTE KIDNEY INJURY BY THE REGULATION OF
            PGC-1Alpha.
REFERENCE   3  (bases 1 to 6288)
  AUTHORS   Mesarosova,L., Scheper,M., Iyer,A., Anink,J.J., Mills,J.D. and
            Aronica,E.
  TITLE     miR-193b-3p/ PGC-1alpha pathway regulates an insulin dependent
            anti-inflammatory response in Parkinson's disease
  JOURNAL   Neurobiol Dis 199, 106587 (2024)
   PUBMED   38950713
  REMARK    GeneRIF: miR-193b-3p/ PGC-1alpha pathway regulates an insulin
            dependent anti-inflammatory response in Parkinson's disease.
REFERENCE   4  (bases 1 to 6288)
  AUTHORS   Yu,T., Gao,Q., Zhang,G., Li,T., Liu,X., Li,C., Zheng,L., Sun,X.,
            Wu,J., Cao,H., Bi,F., Wang,R., Liang,H., Li,X., Zhou,Y., Lv,L. and
            Shan,H.
  TITLE     lncRNA Gm20257 alleviates pathological cardiac hypertrophy by
            modulating the PGC-1alpha-mitochondrial complex IV axis
  JOURNAL   Front Med 18 (4), 664-677 (2024)
   PUBMED   38926249
  REMARK    GeneRIF: lncRNA Gm20257 alleviates pathological cardiac hypertrophy
            by modulating the PGC-1alpha-mitochondrial complex IV axis.
REFERENCE   5  (bases 1 to 6288)
  AUTHORS   Zhou,S., Taskintuna,K., Hum,J., Gulati,J., Olaya,S., Steinman,J.
            and Golestaneh,N.
  TITLE     PGC-1alpha repression dysregulates lipid metabolism and induces
            lipid droplet accumulation in retinal pigment epithelium
  JOURNAL   Cell Death Dis 15 (6), 385 (2024)
   PUBMED   38824126
  REMARK    GeneRIF: PGC-1alpha repression dysregulates lipid metabolism and
            induces lipid droplet accumulation in retinal pigment epithelium.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6288)
  AUTHORS   Esterbauer,H., Oberkofler,H., Krempler,F. and Patsch,W.
  TITLE     Human peroxisome proliferator activated receptor gamma coactivator
            1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal
            localization, and tissue expression
  JOURNAL   Genomics 62 (1), 98-102 (1999)
   PUBMED   10585775
REFERENCE   7  (bases 1 to 6288)
  AUTHORS   Puigserver,P., Adelmant,G., Wu,Z., Fan,M., Xu,J., O'Malley,B. and
            Spiegelman,B.M.
  TITLE     Activation of PPARgamma coactivator-1 through transcription factor
            docking
  JOURNAL   Science 286 (5443), 1368-1371 (1999)
   PUBMED   10558993
REFERENCE   8  (bases 1 to 6288)
  AUTHORS   Wu,Z., Puigserver,P., Andersson,U., Zhang,C., Adelmant,G.,
            Mootha,V., Troy,A., Cinti,S., Lowell,B., Scarpulla,R.C. and
            Spiegelman,B.M.
  TITLE     Mechanisms controlling mitochondrial biogenesis and respiration
            through the thermogenic coactivator PGC-1
  JOURNAL   Cell 98 (1), 115-124 (1999)
   PUBMED   10412986
REFERENCE   9  (bases 1 to 6288)
  AUTHORS   Puigserver,P., Wu,Z., Park,C.W., Graves,R., Wright,M. and
            Spiegelman,B.M.
  TITLE     A cold-inducible coactivator of nuclear receptors linked to
            adaptive thermogenesis
  JOURNAL   Cell 92 (6), 829-839 (1998)
   PUBMED   9529258
REFERENCE   10 (bases 1 to 6288)
  AUTHORS   Spanos,N.P., Spillane,J. and McPeake,J.D.
  TITLE     Cognitive strategies and response to suggestion in hypnotic and
            task-motivated subjects
  JOURNAL   Am J Clin Hypn 18 (4), 254-262 (1976)
   PUBMED   1258810
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF106698.1, AC092834.3,
            AF186379.1 and BM976883.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_013261.4.
            
            Summary: The protein encoded by this gene is a transcriptional
            coactivator that regulates the genes involved in energy metabolism.
            This protein interacts with PPARgamma, which permits the
            interaction of this protein with multiple transcription factors.
            This protein can interact with, and regulate the activities of,
            cAMP response element binding protein (CREB) and nuclear
            respiratory factors (NRFs). It provides a direct link between
            external physiological stimuli and the regulation of mitochondrial
            biogenesis, and is a major factor that regulates muscle fiber type
            determination. This protein may be also involved in controlling
            blood pressure, regulating cellular cholesterol homoeostasis, and
            the development of obesity. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at an
            alternate start codon, compared to variant 1. The encoded isoform
            (2) has a distinct N-terminus and is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF106698.1, SRR11853560.21849.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264867.7/ ENSP00000264867.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1271              AF106698.1         31-1301
            1272-1272           AC092834.3         36602-36602         c
            1273-1673           AF106698.1         1303-1703
            1674-3017           AF186379.1         1623-2966
            3018-5680           AC092834.3         14930-17592         c
            5681-6288           BM976883.1         18-625              c
FEATURES             Location/Qualifiers
     source          1..6288
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p15.2"
     gene            1..6288
                     /gene="PPARGC1A"
                     /gene_synonym="LEM6; PGC-1(alpha); PGC-1alpha; PGC-1v;
                     PGC1; PGC1A; PPARGC1"
                     /note="PPARG coactivator 1 alpha"
                     /db_xref="GeneID:10891"
                     /db_xref="HGNC:HGNC:9237"
                     /db_xref="MIM:604517"
     exon            1..144
                     /gene="PPARGC1A"
                     /gene_synonym="LEM6; PGC-1(alpha); PGC-1alpha; PGC-1v;
                     PGC1; PGC1A; PPARGC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..2487
                     /gene="PPARGC1A"
                     /gene_synonym="LEM6; PGC-1(alpha); PGC-1alpha; PGC-1v;
                     PGC1; PGC1A; PPARGC1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ligand effect modulator-6; L-PGC-1alpha; PPAR gamma
                     coactivator variant form; PGC-1-alpha; PPARGC-1-alpha;
                     PPARAGCIalpha; PPARgamma coactivator 1alpha"
                     /codon_start=1
                     /product="peroxisome proliferator-activated receptor gamma
                     coactivator 1-alpha isoform 2"
                     /protein_id="NP_037393.1"
                     /db_xref="CCDS:CCDS3429.1"
                     /db_xref="GeneID:10891"
                     /db_xref="HGNC:HGNC:9237"
                     /db_xref="MIM:604517"
                     /translation="MAWDMCNQDSESVWSDIECAALVGEDQPLCPDLPELDLSELDVN
                     DLDTDSFLGGLKWCSDQSEIISNQYNNEPSNIFEKIDEENEANLLAVLTETLDSLPVD
                     EDGLPSFDALTDGDVTTDNEASPSSMPDGTPPPQEAEEPSLLKKLLLAPANTQLSYNE
                     CSGLSTQNHANHNHRIRTNPAIVKTENSWSNKAKSICQQQKPQRRPCSELLKYLTTND
                     DPPHTKPTENRNSSRDKCTSKKKSHTQSQSQHLQAKPTTLSLPLTPESPNDPKGSPFE
                     NKTIERTLSVELSGTAGLTPPTTPPHKANQDNPFRASPKLKSSCKTVVPPPSKKPRYS
                     ESSGTQGNNSTKKGPEQSELYAQLSKSSVLTGGHEERKTKRPSLRLFGDHDYCQSINS
                     KTEILINISQELQDSRQLENKDVSSDWQGQICSSTDSDQCYLRETLEASKQVSPCSTR
                     KQLQDQEIRAELNKHFGHPSQAVFDDEADKTGELRDSDFSNEQFSKLPMFINSGLAMD
                     GLFDDSEDESDKLSYPWDGTQSYSLFNVSPSCSSFNSPCRDSVSPPKSLFSQRPQRMR
                     SRSRSFSRHRSCSRSPYSRSRSRSPGSRSSSRSCYYYESSHYRHRTHRNSPLYVRSRS
                     RSPYSRRPRYDSYEEYQHERLKREEYRREYEKRESERAKQRERQRQKAIEERRVIYVG
                     KIRPDTTRTELRDRFEVFGEIEECTVNLRDDGDSYGFITYRYTCDAFAALENGYTLRR
                     SNETDFELYFCGRKQFFKSNYADLDSNSDDFDPASTKSKYDSLDFDSLLKEAQRSLRR
                     "
     exon            145..324
                     /gene="PPARGC1A"
                     /gene_synonym="LEM6; PGC-1(alpha); PGC-1alpha; PGC-1v;
                     PGC1; PGC1A; PPARGC1"
                     /inference="alignment:Splign:2.1.0"
     exon            325..519
                     /gene="PPARGC1A"
                     /gene_synonym="LEM6; PGC-1(alpha); PGC-1alpha; PGC-1v;
                     PGC1; PGC1A; PPARGC1"
                     /inference="alignment:Splign:2.1.0"
     exon            520..642
                     /gene="PPARGC1A"
                     /gene_synonym="LEM6; PGC-1(alpha); PGC-1alpha; PGC-1v;
                     PGC1; PGC1A; PPARGC1"
                     /inference="alignment:Splign:2.1.0"
     exon            643..847
                     /gene="PPARGC1A"
                     /gene_synonym="LEM6; PGC-1(alpha); PGC-1alpha; PGC-1v;
                     PGC1; PGC1A; PPARGC1"
                     /inference="alignment:Splign:2.1.0"
     exon            848..893
                     /gene="PPARGC1A"
                     /gene_synonym="LEM6; PGC-1(alpha); PGC-1alpha; PGC-1v;
                     PGC1; PGC1A; PPARGC1"
                     /inference="alignment:Splign:2.1.0"
     exon            894..967
                     /gene="PPARGC1A"
                     /gene_synonym="LEM6; PGC-1(alpha); PGC-1alpha; PGC-1v;
                     PGC1; PGC1A; PPARGC1"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1883
                     /gene="PPARGC1A"
                     /gene_synonym="LEM6; PGC-1(alpha); PGC-1alpha; PGC-1v;
                     PGC1; PGC1A; PPARGC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..1988
                     /gene="PPARGC1A"
                     /gene_synonym="LEM6; PGC-1(alpha); PGC-1alpha; PGC-1v;
                     PGC1; PGC1A; PPARGC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2109
                     /gene="PPARGC1A"
                     /gene_synonym="LEM6; PGC-1(alpha); PGC-1alpha; PGC-1v;
                     PGC1; PGC1A; PPARGC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2231
                     /gene="PPARGC1A"
                     /gene_synonym="LEM6; PGC-1(alpha); PGC-1alpha; PGC-1v;
                     PGC1; PGC1A; PPARGC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2383
                     /gene="PPARGC1A"
                     /gene_synonym="LEM6; PGC-1(alpha); PGC-1alpha; PGC-1v;
                     PGC1; PGC1A; PPARGC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..6288
                     /gene="PPARGC1A"
                     /gene_synonym="LEM6; PGC-1(alpha); PGC-1alpha; PGC-1v;
                     PGC1; PGC1A; PPARGC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6260..6265
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPARGC1A"
                     /gene_synonym="LEM6; PGC-1(alpha); PGC-1alpha; PGC-1v;
                     PGC1; PGC1A; PPARGC1"
                     /note="hexamer: AATAAA"
     polyA_site      6288
                     /gene="PPARGC1A"
                     /gene_synonym="LEM6; PGC-1(alpha); PGC-1alpha; PGC-1v;
                     PGC1; PGC1A; PPARGC1"
                     /note="major polyA site"
ORIGIN      
        1 agtaaggggc tggttgcctg catgagtgtg tgctctgtgt cactgtggat tggagttgaa
       61 aaagcttgac tggcgtcatt caggagctgg atggcgtggg acatgtgcaa ccaggactct
      121 gagtctgtat ggagtgacat cgagtgtgct gctctggttg gtgaagacca gcctctttgc
      181 ccagatcttc ctgaacttga tctttctgaa ctagatgtga acgacttgga tacagacagc
      241 tttctgggtg gactcaagtg gtgcagtgac caatcagaaa taatatccaa tcagtacaac
      301 aatgagcctt caaacatatt tgagaagata gatgaagaga atgaggcaaa cttgctagca
      361 gtcctcacag agacactaga cagtctccct gtggatgaag acggattgcc ctcatttgat
      421 gcgctgacag atggagacgt gaccactgac aatgaggcta gtccttcctc catgcctgac
      481 ggcacccctc caccccagga ggcagaagag ccgtctctac ttaagaagct cttactggca
      541 ccagccaaca ctcagctaag ttataatgaa tgcagtggtc tcagtaccca gaaccatgca
      601 aatcacaatc acaggatcag aacaaaccct gcaattgtta agactgagaa ttcatggagc
      661 aataaagcga agagtatttg tcaacagcaa aagccacaaa gacgtccctg ctcggagctt
      721 ctcaaatatc tgaccacaaa cgatgaccct cctcacacca aacccacaga gaacagaaac
      781 agcagcagag acaaatgcac ctccaaaaag aagtcccaca cacagtcgca gtcacaacac
      841 ttacaagcca aaccaacaac tttatctctt cctctgaccc cagagtcacc aaatgacccc
      901 aagggttccc catttgagaa caagactatt gaacgcacct taagtgtgga actctctgga
      961 actgcaggcc taactccacc caccactcct cctcataaag ccaaccaaga taaccctttt
     1021 agggcttctc caaagctgaa gtcctcttgc aagactgtgg tgccaccacc atcaaagaag
     1081 cccaggtaca gtgagtcttc tggtacacaa ggcaataact ccaccaagaa agggccggag
     1141 caatccgagt tgtatgcaca actcagcaag tcctcagtcc tcactggtgg acacgaggaa
     1201 aggaagacca agcggcccag tctgcggctg tttggtgacc atgactattg ccagtcaatt
     1261 aattccaaaa cagaaatact cattaatata tcacaggagc tccaagactc tagacaacta
     1321 gaaaataaag atgtctcctc tgattggcag gggcagattt gttcttccac agattcagac
     1381 cagtgctacc tgagagagac tttggaggca agcaagcagg tctctccttg cagcacaaga
     1441 aaacagctcc aagaccagga aatccgagcc gagctgaaca agcacttcgg tcatcccagt
     1501 caagctgttt ttgacgacga agcagacaag accggtgaac tgagggacag tgatttcagt
     1561 aatgaacaat tctccaaact acctatgttt ataaattcag gactagccat ggatggcctg
     1621 tttgatgaca gcgaagatga aagtgataaa ctgagctacc cttgggatgg cacgcaatcc
     1681 tattcattgt tcaatgtgtc tccttcttgt tcttctttta actctccatg tagagattct
     1741 gtgtcaccac ccaaatcctt attttctcaa agaccccaaa ggatgcgctc tcgttcaagg
     1801 tccttttctc gacacaggtc gtgttcccga tcaccatatt ccaggtcaag atcaaggtct
     1861 ccaggcagta gatcctcttc aagatcctgc tattactatg agtcaagcca ctacagacac
     1921 cgcacgcacc gaaattctcc cttgtatgtg agatcacgtt caagatcgcc ctacagccgt
     1981 cggcccaggt atgacagcta cgaggaatat cagcacgaga ggctgaagag ggaagaatat
     2041 cgcagagagt atgagaagcg agagtctgag agggccaagc aaagggagag gcagaggcag
     2101 aaggcaattg aagagcgccg tgtgatttat gtcggtaaaa tcagacctga cacaacacgg
     2161 acagaactga gggaccgttt tgaagttttt ggtgaaattg aggagtgcac agtaaatctg
     2221 cgggatgatg gagacagcta tggtttcatt acctaccgtt atacctgtga tgcttttgct
     2281 gctcttgaaa atggatacac tttgcgcagg tcaaacgaaa ctgactttga gctgtacttt
     2341 tgtggacgca agcaattttt caagtctaac tatgcagacc tagattcaaa ctcagatgac
     2401 tttgaccctg cttccaccaa gagcaagtat gactctctgg attttgatag tttactgaaa
     2461 gaagctcaga gaagcttgcg caggtaacat gttccctagc tgaggatgac agagggatgg
     2521 cgaatacctc atgggacagc gcgtccttcc ctaaagacta ttgcaagtca tacttaggaa
     2581 tttctcctac tttacactct ctgtacaaaa acaaaacaaa acaacaacaa tacaacaaga
     2641 acaacaacaa caataacaac aatggtttac atgaacacag ctgctgaaga ggcaagagac
     2701 agaatgatat ccagtaagca catgtttatt catgggtgtc agctttgctt ttcctggagt
     2761 ctcttggtga tggagtgtgc gtgtgtgcat gtatgtgtgt gtgtatgtat gtgtgtggtg
     2821 tgtgtgcttg gtttagggga agtatgtgtg ggtacatgtg aggactgggg gcacctgacc
     2881 agaatgcgca agggcaaacc atttcaaatg gcagcagttc catgaagaca cgcttaaaac
     2941 ctagaacttc aaaatgttcg tattctattc aaaaggaaat atatatatat atatatatat
     3001 atatatatat atatataaat taaaaaggaa agaaaactaa caaccaacca accaaccaac
     3061 caaccacaaa ccaccctaaa atgacagccg ctgatgtctg ggcatcagcc tttgtactct
     3121 gtttttttaa gaaagtgcag aatcaacttg aagcaagctt tctctcataa cgtaatgatt
     3181 atatgacaat cctgaagaaa ccacaggttc catagaacta atatcctgtc tctctctctc
     3241 tctctctctc tctctttttt ttttcttttt ccttttgcca tggaatctgg gtgggagagg
     3301 atactgcggg caccagaatg ctaaagtttc ctaacatttt gaagtttctg tagttcatcc
     3361 ttaatcctga cacccatgta aatgtccaaa atgttgatct tccactgcaa atttcaaaag
     3421 ccttgtcaat ggtcaagcgt gcagcttgtt cagcggttct ttctgaggag cggacaccgg
     3481 gttacattac taatgagagt tgggtagaac tctctgagat gtgttcagat agtgtaattg
     3541 ctacattctc tgatgtagtt aagtatttac agatgttaaa tggagtattt ttattttatg
     3601 tatatactat acaacaatgt tcttttttgt tacagctatg cactgtaaat gcagccttct
     3661 tttcaaaact gctaaatttt tcttaatcaa gaatattcaa atgtaattat gaggtgaaac
     3721 aattattgta cactaacata tttagaagct gaacttactg cttatatata tttgattgta
     3781 aaaacaaaaa gacagtgtgt gtgtctgttg agtgcaacaa gagcaaaatg atgctttccg
     3841 cacatccatc ccttaggtga gcttcaatct aagcatcttg tcaagaaata tcctagtccc
     3901 ctaaaggtat taaccacttc tgcgatattt ttccacattt tcttgtcgct tgtttttctt
     3961 tgaagtttta tacactggat ttgttagggg aatgaaattt tctcatctaa aatttttcta
     4021 gaagatatca tgattttatg taaagtctct caatgggtaa ccattaagaa atgtttttat
     4081 tttctctatc aacagtagtt ttgaaactag aagtcaaaaa tctttttaaa atgctgtttt
     4141 gttttaattt ttgtgatttt aatttgatac aaaatgctga ggtaataatt atagtatgat
     4201 ttttacaata attaatgtgt gtctgaagac tatctttgaa gccagtattt ctttcccttg
     4261 gcagagtatg acgatggtat ttatctgtat tttttacagt tatgcatcct gtataaatac
     4321 tgatatttca ttcctttgtt tactaaagag acatatttat cagttgcaga tagcctattt
     4381 attataaatt atgagatgat gaaaataata aagccagtgg aaattttcta cctaggatgc
     4441 atgacaattg tcaggttgga gtgtaagtgc ttcatttggg aaattcagct tttgcagaag
     4501 cagtgtttct acttgcacta gcatggcctc tgacgtgacc atggtgttgt tcttgatgac
     4561 attgcttctg ctaaatttaa taaaaacttc agaaaaacct ccattttgat catcaggatt
     4621 tcatctgagt gtggagtccc tggaatggaa ttcagtaaca tttggagtgt gtattcaagt
     4681 ttctaaattg agattcgatt actgtttggc tgacatgact tttctggaag acatgataca
     4741 cctactactc aattgttctt ttcctttctc tcgcccaaca cgatcttgta agatggattt
     4801 cacccccagg ccaatgcagc taattttgat agctgcattc atttatcacc agcatattgt
     4861 gttctgagtg aatccactgt ttgtcctgtc ggatgcttgc ttgatttttt ggcttcttat
     4921 ttctaagtag atagaaagca ataaaaatac tatgaaatga aagaacttgt tcacaggttc
     4981 tgcgttacaa cagtaacaca tctttaatcc gcctaattct tgttgttctg taggttaaat
     5041 gcaggtattt taactgtgtg aacgccaaac taaagtttac agtctttctt tctgaatttt
     5101 gagtatcttc tgttgtagaa taataataaa aagactatta agagcaataa attattttta
     5161 agaaatcgag atttagtaaa tcctattatg tgttcaagga ccacatgtgt tctctatttt
     5221 gcctttaaat ttttgtgaac caattttaaa tacattctcc tttttgccct ggattgttga
     5281 catgagtgga atacttggtt tcttttctta cttatcaaaa gacagcacta cagatatcat
     5341 attgaggatt aatttatccc ccctaccccc agcctgacaa atattgttac catgaagata
     5401 gttttcctca atggacttca aattgcatct agaattagtg gagcttttgt atcttctgca
     5461 gacactgtgg gtagcccatc aaaatgtaag ctgtgctcct ctcattttta tttttatttt
     5521 tttgggagag aatatttcaa atgaacacgt gcaccccatc atcactggag gcaaatttca
     5581 gcatagatct gtaggatttt tagaagaccg tgggccattg ccttcatgcc gtggtaagta
     5641 ccacatctac aattttggta accgaactgg tgctttagta atgtggattt ttttcttttt
     5701 taaaagagat gtagcagaat aattcttcca gtgcaacaaa atcaattttt tgctaaacga
     5761 ctccgagaac aacagttggg ctgtcaacat tcaaagcagc agagagggaa ctttgcacta
     5821 ttggggtatg atgtttgggt cagttgataa aaggaaacct tttcatgcct ttagatgtga
     5881 gcttccagta ggtaatgatt atgtgtcctt tcttgatggc tgtaatgaga acttcaatca
     5941 ctgtagtcta agacctgatc tatagatgac ctagaatagc catgtactat aatgtgatga
     6001 ttctaaattt gtacctatgt gacagacatt ttcaataatg tgaactgctg atttgatgga
     6061 gctactttaa gatttgtagg tgaaagtgta atactgttgg ttgaactatg ctgaagaggg
     6121 aaagtgagcg attagttgag cccttgccgg gccttttttc cacctgccaa ttctacatgt
     6181 attgttgtgg ttttattcat tgtatgaaaa ttcctgtgat tttttttaaa tgtgcagtac
     6241 acatcagcct cactgagcta ataaagggaa acgaatgttt caaatcta
//
