LOCUS       NM_138711               1774 bp    mRNA    linear   PRI 15-NOV-2024
DEFINITION  Homo sapiens peroxisome proliferator activated receptor gamma
            (PPARG), transcript variant 3, mRNA.
ACCESSION   NM_138711
VERSION     NM_138711.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1774)
  AUTHORS   Xue,Y., Xia,Y., Cheng,D., Shi,T., Mei,P. and Hong,S.
  TITLE     Association between genetically proxied PPARG activation and
            psoriasis vulgaris: a Mendelian randomization study
  JOURNAL   J Dermatolog Treat 35 (1), 2381763 (2024)
   PUBMED   39034037
  REMARK    GeneRIF: Association between genetically proxied PPARG activation
            and psoriasis vulgaris: a Mendelian randomization study.
REFERENCE   2  (bases 1 to 1774)
  AUTHORS   de Oliveira,V.M., Malospirito,C.C., da Silva,F.B., Videira,N.B.,
            Dias,M.M.G., Sanches,M.N., Leite,V.B.P. and Figueira,A.C.M.
  TITLE     Exploring the molecular pathways of the activation process in
            PPARgamma recurrent bladder cancer mutants
  JOURNAL   J Chem Phys 161 (16) (2024)
   PUBMED   39440760
  REMARK    GeneRIF: Exploring the molecular pathways of the activation process
            in PPARgamma recurrent bladder cancer mutants.
REFERENCE   3  (bases 1 to 1774)
  AUTHORS   Abdulqadir,R., Al-Sadi,R., Haque,M., Gupta,Y., Rawat,M. and Ma,T.Y.
  TITLE     Bifidobacterium bifidum Strain BB1 Inhibits Tumor Necrosis
            Factor-alpha-Induced Increase in Intestinal Epithelial Tight
            Junction Permeability via Toll-Like Receptor-2/Toll-Like Receptor-6
            Receptor Complex-Dependent Stimulation of Peroxisome
            Proliferator-Activated Receptor gamma and Suppression of NF-kappaB
            p65
  JOURNAL   Am J Pathol 194 (9), 1664-1683 (2024)
   PUBMED   38885924
  REMARK    GeneRIF: Bifidobacterium bifidum Strain BB1 Inhibits Tumor Necrosis
            Factor-alpha-Induced Increase in Intestinal Epithelial Tight
            Junction Permeability via Toll-Like Receptor-2/Toll-Like Receptor-6
            Receptor Complex-Dependent Stimulation of Peroxisome
            Proliferator-Activated Receptor gamma and Suppression of NF-kappaB
            p65.
REFERENCE   4  (bases 1 to 1774)
  AUTHORS   Konger,R.L., Xuei,X., Derr-Yellin,E., Fang,F., Gao,H. and Liu,Y.
  TITLE     The Loss of PPARgamma Expression and Signaling Is a Key Feature of
            Cutaneous Actinic Disease and Squamous Cell Carcinoma: Association
            with Tumor Stromal Inflammation
  JOURNAL   Cells 13 (16), 1356 (2024)
   PUBMED   39195246
  REMARK    GeneRIF: The Loss of PPARgamma Expression and Signaling Is a Key
            Feature of Cutaneous Actinic Disease and Squamous Cell Carcinoma:
            Association with Tumor Stromal Inflammation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1774)
  AUTHORS   Zhu,X., Chan,E., Turski,M.L., Mendez,C.E., Hsu,S.C., Kumar,V.,
            Shipp,C., Jindal,T., Chang,K., Onodera,C., Devine,W.P.,
            Grenert,J.P., Stohr,B.A., Ding,C.C., Stachler,M.D., Quigley,D.A.,
            Feng,F.Y., Chu,C.E., Porten,S.P., Chou,J., Friedlander,T.W. and
            Koshkin,V.S.
  TITLE     HER2 overexpression in urothelial carcinoma with GATA3 and PPARG
            copy number gains
  JOURNAL   Oncologist 29 (8), e1094-e1097 (2024)
   PUBMED   38908022
  REMARK    GeneRIF: HER2 overexpression in urothelial carcinoma with GATA3 and
            PPARG copy number gains.
REFERENCE   6  (bases 1 to 1774)
  AUTHORS   Adams,M., Reginato,M.J., Shao,D., Lazar,M.A. and Chatterjee,V.K.
  TITLE     Transcriptional activation by peroxisome proliferator-activated
            receptor gamma is inhibited by phosphorylation at a consensus
            mitogen-activated protein kinase site
  JOURNAL   J Biol Chem 272 (8), 5128-5132 (1997)
   PUBMED   9030579
REFERENCE   7  (bases 1 to 1774)
  AUTHORS   Elbrecht,A., Chen,Y., Cullinan,C.A., Hayes,N., Leibowitz,Md.,
            Moller,D.E. and Berger,J.
  TITLE     Molecular cloning, expression and characterization of human
            peroxisome proliferator activated receptors gamma 1 and gamma 2
  JOURNAL   Biochem Biophys Res Commun 224 (2), 431-437 (1996)
   PUBMED   8702406
REFERENCE   8  (bases 1 to 1774)
  AUTHORS   Greene,M.E., Blumberg,B., McBride,O.W., Yi,H.F., Kronquist,K.,
            Kwan,K., Hsieh,L., Greene,G. and Nimer,S.D.
  TITLE     Isolation of the human peroxisome proliferator activated receptor
            gamma cDNA: expression in hematopoietic cells and chromosomal
            mapping
  JOURNAL   Gene Expr 4 (4-5), 281-299 (1995)
   PUBMED   7787419
REFERENCE   9  (bases 1 to 1774)
  AUTHORS   Tontonoz,P., Hu,E. and Spiegelman,B.M.
  TITLE     Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a
            lipid-activated transcription factor
  JOURNAL   Cell 79 (7), 1147-1156 (1994)
   PUBMED   8001151
  REMARK    Erratum:[Cell 1995 Mar 24;80(6):following 957]
REFERENCE   10 (bases 1 to 1774)
  AUTHORS   Tontonoz,P., Graves,R.A., Budavari,A.I., Erdjument-Bromage,H.,
            Lui,M., Hu,E., Tempst,P. and Spiegelman,B.M.
  TITLE     Adipocyte-specific transcription factor ARF6 is a heterodimeric
            complex of two nuclear hormone receptors, PPAR gamma and RXR alpha
  JOURNAL   Nucleic Acids Res 22 (25), 5628-5634 (1994)
   PUBMED   7838715
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091492.2, AC093174.2 and
            AC090947.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Mar 23, 2020 this sequence version replaced NM_138711.5.
            
            Summary: This gene encodes a member of the peroxisome
            proliferator-activated receptor (PPAR) subfamily of nuclear
            receptors. PPARs form heterodimers with retinoid X receptors (RXRs)
            and these heterodimers regulate transcription of various genes.
            Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and
            PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a
            regulator of adipocyte differentiation. Additionally, PPAR-gamma
            has been implicated in the pathology of numerous diseases including
            obesity, diabetes, atherosclerosis and cancer. Alternatively
            spliced transcript variants that encode different isoforms have
            been described. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) differs in the 5' UTR and 5'
            coding region compared to variant 2. Variants 1, 3, 4, 6, 7, 13,
            and 14 all encode the same isoform (1), which has a shorter,
            distinct N-terminus compared to isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006811.1, AB472042.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000651735.1/
                                                ENSP00000498313.1
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AC091492.2         139315-139379
            66-139              AC091492.2         162625-162698
            140-367             AC093174.2         109929-110156
            368-537             AC093174.2         111547-111716
            538-676             AC093174.2         122839-122977
            677-876             AC090947.2         90705-90904         c
            877-1327            AC090947.2         79632-80082         c
            1328-1774           AC090947.2         62442-62888         c
FEATURES             Location/Qualifiers
     source          1..1774
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.2"
     gene            1..1774
                     /gene="PPARG"
                     /gene_synonym="CIMT1; FPLD3; GLM1; NR1C3; PPARG1; PPARG2;
                     PPARG5; PPARgamma"
                     /note="peroxisome proliferator activated receptor gamma"
                     /db_xref="GeneID:5468"
                     /db_xref="HGNC:HGNC:9236"
                     /db_xref="MIM:601487"
     exon            1..65
                     /gene="PPARG"
                     /gene_synonym="CIMT1; FPLD3; GLM1; NR1C3; PPARG1; PPARG2;
                     PPARG5; PPARgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            66..139
                     /gene="PPARG"
                     /gene_synonym="CIMT1; FPLD3; GLM1; NR1C3; PPARG1; PPARG2;
                     PPARG5; PPARgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            140..367
                     /gene="PPARG"
                     /gene_synonym="CIMT1; FPLD3; GLM1; NR1C3; PPARG1; PPARG2;
                     PPARG5; PPARgamma"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..1575
                     /gene="PPARG"
                     /gene_synonym="CIMT1; FPLD3; GLM1; NR1C3; PPARG1; PPARG2;
                     PPARG5; PPARgamma"
                     /note="isoform 1 is encoded by transcript variant 3;
                     nuclear receptor subfamily 1 group C member 3; PPAR-gamma;
                     peroxisome proliferator-activated receptor-gamma 5;
                     peroxisome proliferator-activated receptor-gamma splicing"
                     /codon_start=1
                     /product="peroxisome proliferator-activated receptor gamma
                     isoform 1"
                     /protein_id="NP_619725.3"
                     /db_xref="CCDS:CCDS2610.3"
                     /db_xref="GeneID:5468"
                     /db_xref="HGNC:HGNC:9236"
                     /db_xref="MIM:601487"
                     /translation="MVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSIS
                     TPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSN
                     SLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKC
                     QYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYD
                     SYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVA
                     IRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNK
                     DGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILS
                     GDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQL
                     LQVIKKTETDMSLHPLLQEIYKDLY"
     exon            368..537
                     /gene="PPARG"
                     /gene_synonym="CIMT1; FPLD3; GLM1; NR1C3; PPARG1; PPARG2;
                     PPARG5; PPARgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            538..676
                     /gene="PPARG"
                     /gene_synonym="CIMT1; FPLD3; GLM1; NR1C3; PPARG1; PPARG2;
                     PPARG5; PPARgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            677..876
                     /gene="PPARG"
                     /gene_synonym="CIMT1; FPLD3; GLM1; NR1C3; PPARG1; PPARG2;
                     PPARG5; PPARgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1327
                     /gene="PPARG"
                     /gene_synonym="CIMT1; FPLD3; GLM1; NR1C3; PPARG1; PPARG2;
                     PPARG5; PPARgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1774
                     /gene="PPARG"
                     /gene_synonym="CIMT1; FPLD3; GLM1; NR1C3; PPARG1; PPARG2;
                     PPARG5; PPARgamma"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1751..1756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPARG"
                     /gene_synonym="CIMT1; FPLD3; GLM1; NR1C3; PPARG1; PPARG2;
                     PPARG5; PPARgamma"
                     /note="hexamer: ATTAAA"
     polyA_site      1774
                     /gene="PPARG"
                     /gene_synonym="CIMT1; FPLD3; GLM1; NR1C3; PPARG1; PPARG2;
                     PPARG5; PPARgamma"
                     /note="major polyA site"
ORIGIN      
        1 gccttaacct ctgctggtga ccagaagcct gcatttctgc attctgctta attccctttc
       61 cttagatttg aaagaagcca acactaaacc acaaatatac aacaaggcca ttttctcaaa
      121 cgagagtcag cctttaacga aatgaccatg gttgacacag agatgccatt ctggcccacc
      181 aactttggga tcagctccgt ggatctctcc gtaatggaag accactccca ctcctttgat
      241 atcaagccct tcactactgt tgacttctcc agcatttcta ctccacatta cgaagacatt
      301 ccattcacaa gaacagatcc agtggttgca gattacaagt atgacctgaa acttcaagag
      361 taccaaagtg caatcaaagt ggagcctgca tctccacctt attattctga gaagactcag
      421 ctctacaata agcctcatga agagccttcc aactccctca tggcaattga atgtcgtgtc
      481 tgtggagata aagcttctgg atttcactat ggagttcatg cttgtgaagg atgcaagggt
      541 ttcttccgga gaacaatcag attgaagctt atctatgaca gatgtgatct taactgtcgg
      601 atccacaaaa aaagtagaaa taaatgtcag tactgtcggt ttcagaaatg ccttgcagtg
      661 gggatgtctc ataatgccat caggtttggg cggatgccac aggccgagaa ggagaagctg
      721 ttggcggaga tctccagtga tatcgaccag ctgaatccag agtccgctga cctccgggcc
      781 ctggcaaaac atttgtatga ctcatacata aagtccttcc cgctgaccaa agcaaaggcg
      841 agggcgatct tgacaggaaa gacaacagac aaatcaccat tcgttatcta tgacatgaat
      901 tccttaatga tgggagaaga taaaatcaag ttcaaacaca tcacccccct gcaggagcag
      961 agcaaagagg tggccatccg catctttcag ggctgccagt ttcgctccgt ggaggctgtg
     1021 caggagatca cagagtatgc caaaagcatt cctggttttg taaatcttga cttgaacgac
     1081 caagtaactc tcctcaaata tggagtccac gagatcattt acacaatgct ggcctccttg
     1141 atgaataaag atggggttct catatccgag ggccaaggct tcatgacaag ggagtttcta
     1201 aagagcctgc gaaagccttt tggtgacttt atggagccca agtttgagtt tgctgtgaag
     1261 ttcaatgcac tggaattaga tgacagcgac ttggcaatat ttattgctgt cattattctc
     1321 agtggagacc gcccaggttt gctgaatgtg aagcccattg aagacattca agacaacctg
     1381 ctacaagccc tggagctcca gctgaagctg aaccaccctg agtcctcaca gctgtttgcc
     1441 aagctgctcc agaaaatgac agacctcaga cagattgtca cggaacacgt gcagctactg
     1501 caggtgatca agaagacgga gacagacatg agtcttcacc cgctcctgca ggagatctac
     1561 aaggacttgt actagcagag agtcctgagc cactgccaac atttcccttc ttccagttgc
     1621 actattctga gggaaaatct gacacctaag aaatttactg tgaaaaagca ttttaaaaag
     1681 aaaaggtttt agaatatgat ctattttatg catattgttt ataaagacac atttacaatt
     1741 tacttttaat attaaaaatt accatattat gaaa
//
