LOCUS       NM_006238               3734 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens peroxisome proliferator activated receptor delta
            (PPARD), transcript variant 1, mRNA.
ACCESSION   NM_006238 NM_001039694
VERSION     NM_006238.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3734)
  AUTHORS   Liang,M., Lyu,Z.S., Zhang,Y.Y., Tang,S.Q., Xing,T., Chen,Y.H.,
            Wang,Y., Jiang,Q., Xu,L.P., Zhang,X.H., Huang,X.J. and Kong,Y.
  TITLE     Activation of PPARdelta in bone marrow endothelial progenitor cells
            improves their hematopoiesis-supporting ability after
            myelosuppressive injury
  JOURNAL   Cancer Lett 592, 216937 (2024)
   PUBMED   38704134
  REMARK    GeneRIF: Activation of PPARdelta in bone marrow endothelial
            progenitor cells improves their hematopoiesis-supporting ability
            after myelosuppressive injury.
REFERENCE   2  (bases 1 to 3734)
  AUTHORS   Kalitin,N., Dudina,G., Kostritsa,N., Sivirinova,A., Vaiman,A. and
            Karamysheva,A.
  TITLE     Clinical Relevance of Differential RARalpha and PPARbeta/delta
            Expression in Myelodysplastic Syndromes
  JOURNAL   In Vivo 38 (2), 657-664 (2024)
   PUBMED   38418133
  REMARK    GeneRIF: Clinical Relevance of Differential RARalpha and
            PPARbeta/delta Expression in Myelodysplastic Syndromes.
REFERENCE   3  (bases 1 to 3734)
  AUTHORS   Lien,C.F., Lin,C.S., Shyue,S.K., Hsieh,P.S., Chen,S.J., Lin,Y.T.,
            Chien,S. and Tsai,M.C.
  TITLE     Peroxisome proliferator-activated receptor delta improves the
            features of atherosclerotic plaque vulnerability by regulating
            smooth muscle cell phenotypic switching
  JOURNAL   Br J Pharmacol 180 (16), 2085-2101 (2023)
   PUBMED   36942453
  REMARK    GeneRIF: Peroxisome proliferator-activated receptor delta improves
            the features of atherosclerotic plaque vulnerability by regulating
            smooth muscle cell phenotypic switching.
REFERENCE   4  (bases 1 to 3734)
  AUTHORS   Li,S., Zhang,Y., Xu,W., Lv,Z., Xu,L., Zhao,Z., Zhu,D. and Song,Y.
  TITLE     C Allele of the PPARdelta+294T>C Polymorphism Confers a Higher Risk
            of Hypercholesterolemia, but not Obesity and Insulin Resistance: A
            Systematic Review and Meta-Analysis
  JOURNAL   Horm Metab Res 55 (5), 355-366 (2023)
   PUBMED   37011890
  REMARK    GeneRIF: C Allele of the PPARdelta+294T>C Polymorphism Confers a
            Higher Risk of Hypercholesterolemia, but not Obesity and Insulin
            Resistance: A Systematic Review and Meta-Analysis.
REFERENCE   5  (bases 1 to 3734)
  AUTHORS   Huang,Y.M., Wang,W., Hsieh,P.P. and Chen,H.H.
  TITLE     Haplotype of ESR1 and PPARD Genes Is Associated with Higher
            Anthropometric Changes in Han Chinese Obesity by Adjusting Dietary
            Factors-An 18-Month Follow-Up
  JOURNAL   Nutrients 14 (20), 4425 (2022)
   PUBMED   36297109
  REMARK    GeneRIF: Haplotype of ESR1 and PPARD Genes Is Associated with
            Higher Anthropometric Changes in Han Chinese Obesity by Adjusting
            Dietary Factors-An 18-Month Follow-Up.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3734)
  AUTHORS   Kliewer,S.A., Sundseth,S.S., Jones,S.A., Brown,P.J., Wisely,G.B.,
            Koble,C.S., Devchand,P., Wahli,W., Willson,T.M., Lenhard,J.M. and
            Lehmann,J.M.
  TITLE     Fatty acids and eicosanoids regulate gene expression through direct
            interactions with peroxisome proliferator-activated receptors alpha
            and gamma
  JOURNAL   Proc Natl Acad Sci U S A 94 (9), 4318-4323 (1997)
   PUBMED   9113987
REFERENCE   7  (bases 1 to 3734)
  AUTHORS   Chu,R., Lin,Y., Rao,M.S. and Reddy,J.K.
  TITLE     Cloning and identification of rat deoxyuridine triphosphatase as an
            inhibitor of peroxisome proliferator-activated receptor alpha
  JOURNAL   J Biol Chem 271 (44), 27670-27676 (1996)
   PUBMED   8910358
REFERENCE   8  (bases 1 to 3734)
  AUTHORS   Yoshikawa,T., Brkanac,Z., Dupont,B.R., Xing,G.Q., Leach,R.J. and
            Detera-Wadleigh,S.D.
  TITLE     Assignment of the human nuclear hormone receptor, NUC1 (PPARD), to
            chromosome 6p21.1-p21.2
  JOURNAL   Genomics 35 (3), 637-638 (1996)
   PUBMED   8812511
REFERENCE   9  (bases 1 to 3734)
  AUTHORS   Jow,L. and Mukherjee,R.
  TITLE     The human peroxisome proliferator-activated receptor (PPAR) subtype
            NUC1 represses the activation of hPPAR alpha and thyroid hormone
            receptors
  JOURNAL   J Biol Chem 270 (8), 3836-3840 (1995)
   PUBMED   7876127
REFERENCE   10 (bases 1 to 3734)
  AUTHORS   Schmidt,A., Endo,N., Rutledge,S.J., Vogel,R., Shinar,D. and
            Rodan,G.A.
  TITLE     Identification of a new member of the steroid hormone receptor
            superfamily that is activated by a peroxisome proliferator and
            fatty acids
  JOURNAL   Mol Endocrinol 6 (10), 1634-1641 (1992)
   PUBMED   1333051
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA192442.1, AK122614.1 and
            BE503383.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006238.4.
            
            Summary: This gene encodes a member of the peroxisome
            proliferator-activated receptor (PPAR) family. The encoded protein
            is thought to function as an integrator of transcriptional
            repression and nuclear receptor signaling. It may inhibit the
            ligand-induced transcriptional activity of peroxisome proliferator
            activated receptors alpha and gamma, though evidence for this
            effect is inconsistent. Expression of this gene in colorectal
            cancer cells may be variable but is typically relatively low.
            Knockout studies in mice suggested a role for this protein in
            myelination of the corpus callosum, lipid metabolism,
            differentiation, and epidermal cell proliferation. Alternative
            splicing results in multiple transcript variants encoding distinct
            protein isoforms. [provided by RefSeq, Aug 2017].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Both variants 1 and 3 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122614.1, SRR1803611.137807.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360694.8/ ENSP00000353916.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 DA192442.1         1-7
            8-3732              AK122614.1         1-3725
            3733-3734           BE503383.1         16-17               c
FEATURES             Location/Qualifiers
     source          1..3734
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.31"
     gene            1..3734
                     /gene="PPARD"
                     /gene_synonym="FAAR; NR1C2; NUC1; NUCI; NUCII; PPARB"
                     /note="peroxisome proliferator activated receptor delta"
                     /db_xref="GeneID:5467"
                     /db_xref="HGNC:HGNC:9235"
                     /db_xref="MIM:600409"
     exon            1..124
                     /gene="PPARD"
                     /gene_synonym="FAAR; NR1C2; NUC1; NUCI; NUCII; PPARB"
                     /inference="alignment:Splign:2.1.0"
     exon            125..208
                     /gene="PPARD"
                     /gene_synonym="FAAR; NR1C2; NUC1; NUCI; NUCII; PPARB"
                     /inference="alignment:Splign:2.1.0"
     exon            209..439
                     /gene="PPARD"
                     /gene_synonym="FAAR; NR1C2; NUC1; NUCI; NUCII; PPARB"
                     /inference="alignment:Splign:2.1.0"
     CDS             310..1635
                     /gene="PPARD"
                     /gene_synonym="FAAR; NR1C2; NUC1; NUCI; NUCII; PPARB"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear hormone receptor 1; PPARD/MYO1D fusion; nuclear
                     receptor subfamily 1 group C member 2; PPAR-beta;
                     PPAR-delta; peroxisome proliferator-activated receptor
                     beta"
                     /codon_start=1
                     /product="peroxisome proliferator-activated receptor delta
                     isoform 1"
                     /protein_id="NP_006229.1"
                     /db_xref="CCDS:CCDS4803.1"
                     /db_xref="GeneID:5467"
                     /db_xref="HGNC:HGNC:9235"
                     /db_xref="MIM:600409"
                     /translation="MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTD
                     LSRSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTI
                     RMKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGL
                     TANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIET
                     LWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLN
                     DQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEF
                     AVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDA
                     QYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY"
     exon            440..594
                     /gene="PPARD"
                     /gene_synonym="FAAR; NR1C2; NUC1; NUCI; NUCII; PPARB"
                     /inference="alignment:Splign:2.1.0"
     exon            595..733
                     /gene="PPARD"
                     /gene_synonym="FAAR; NR1C2; NUC1; NUCI; NUCII; PPARB"
                     /inference="alignment:Splign:2.1.0"
     exon            734..936
                     /gene="PPARD"
                     /gene_synonym="FAAR; NR1C2; NUC1; NUCI; NUCII; PPARB"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1387
                     /gene="PPARD"
                     /gene_synonym="FAAR; NR1C2; NUC1; NUCI; NUCII; PPARB"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..3734
                     /gene="PPARD"
                     /gene_synonym="FAAR; NR1C2; NUC1; NUCI; NUCII; PPARB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3711..3716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPARD"
                     /gene_synonym="FAAR; NR1C2; NUC1; NUCI; NUCII; PPARB"
                     /note="hexamer: AATAAA"
     polyA_site      3734
                     /gene="PPARD"
                     /gene_synonym="FAAR; NR1C2; NUC1; NUCI; NUCII; PPARB"
                     /note="major polyA site"
ORIGIN      
        1 gcggagcgtg tgacgctgcg gccgccgcgg acctggggat taatgggaaa agttttggca
       61 ggagcgggag aattctgcgg agcctgcggg acggcggcgg tggcgccgta ggcagccggg
      121 acagtgttgt acagtgtttt gggcatgcac gtgatactca cacagtggct tctgctcacc
      181 aacagatgaa gacagatgca ccaacgaggc tgatgggaac caccctgtag aggtccatct
      241 gcgttcagac ccagacgatg ccagagctat gactgggcct gcaggtgtgg cgccgagggg
      301 agatcagcca tggagcagcc acaggaggaa gcccctgagg tccgggaaga ggaggagaaa
      361 gaggaagtgg cagaggcaga aggagcccca gagctcaatg ggggaccaca gcatgcactt
      421 ccttccagca gctacacaga cctctcccgg agctcctcgc caccctcact gctggaccaa
      481 ctgcagatgg gctgtgacgg ggcctcatgc ggcagcctca acatggagtg ccgggtgtgc
      541 ggggacaagg catcgggctt ccactacggt gttcatgcat gtgaggggtg caagggcttc
      601 ttccgtcgta cgatccgcat gaagctggag tacgagaagt gtgagcgcag ctgcaagatt
      661 cagaagaaga accgcaacaa gtgccagtac tgccgcttcc agaagtgcct ggcactgggc
      721 atgtcacaca acgctatccg ttttggtcgg atgccggagg ctgagaagag gaagctggtg
      781 gcagggctga ctgcaaacga ggggagccag tacaacccac aggtggccga cctgaaggcc
      841 ttctccaagc acatctacaa tgcctacctg aaaaacttca acatgaccaa aaagaaggcc
      901 cgcagcatcc tcaccggcaa agccagccac acggcgccct ttgtgatcca cgacatcgag
      961 acattgtggc aggcagagaa ggggctggtg tggaagcagt tggtgaatgg cctgcctccc
     1021 tacaaggaga tcagcgtgca cgtcttctac cgctgccagt gcaccacagt ggagaccgtg
     1081 cgggagctca ctgagttcgc caagagcatc cccagcttca gcagcctctt cctcaacgac
     1141 caggttaccc ttctcaagta tggcgtgcac gaggccatct tcgccatgct ggcctctatc
     1201 gtcaacaagg acgggctgct ggtagccaac ggcagtggct ttgtcacccg tgagttcctg
     1261 cgcagcctcc gcaaaccctt cagtgatatc attgagccta agtttgaatt tgctgtcaag
     1321 ttcaacgccc tggaacttga tgacagtgac ctggccctat tcattgcggc catcattctg
     1381 tgtggagacc ggccaggcct catgaacgtt ccacgggtgg aggctatcca ggacaccatc
     1441 ctgcgtgccc tcgaattcca cctgcaggcc aaccaccctg atgcccagta cctcttcccc
     1501 aagctgctgc agaagatggc tgacctgcgg caactggtca ccgagcacgc ccagatgatg
     1561 cagcggatca agaagaccga aaccgagacc tcgctgcacc ctctgctcca ggagatctac
     1621 aaggacatgt actaacggcg gcacccaggc ctccctgcag actccaatgg ggccagcact
     1681 ggaggggccc acccacatga cttttccatt gaccagccct tgagcacccg gcctggagca
     1741 gcagagtccc acgatcgccc tcagacacat gacacccacg gcctctggct ccctgtgccc
     1801 tctctcccgc ttcctccagc cagctctctt cctgtctttg ttgtctccct ctttctcagt
     1861 tcctctttct tttctaattc ctgttgctct gtttcttcct ttctgtaggt ttctctcttc
     1921 ccttctccct tgccctccct ttctctctcc accccccacg tctgtcctcc tttcttattc
     1981 tgtgagatgt tttgtattat ttcaccagca gcatagaaca ggacctctgc ttttgcacac
     2041 cttttcccca ggagcagaag agagtggggc ctgccctctg ccccatcatt gcacctgcag
     2101 gcttaggtcc tcacttctgt ctcctgtctt cagagcaaaa gacttgagcc atccaaagaa
     2161 acactaagct ctctgggcct gggttccagg gaaggctaag catggcctgg actgactgca
     2221 gccccctata gtcatggggt ccctgctgca aaggacagtg ggcaggaggc cccaggctga
     2281 gagccagatg cctccccaag actgtcattg cccctccgat gctgaggcca cccactgacc
     2341 caactgatcc tgctccagca gcacacctca gccccactga cacccagtgt ccttccatct
     2401 tcacactggt ttgccaggcc aatgttgctg atggccccct gcactggccg ctggacggca
     2461 ctctcccagc ttggaagtag gcagggttcc ctccaggtgg gcccccacct cactgaagag
     2521 gagcaagtct caagagaagg aggggggatt ggtggttgga ggaagcagca cacccaattc
     2581 tgcccctagg actcggggtc tgagtcctgg ggtcaggcca gggagagctc ggggcaggcc
     2641 ttccgccagc actcccactg cccccctgcc cagtagcagc cgcccacatt gtgtcagcat
     2701 ccagggccag ggcctggcct cacatccccc tgctcctttc tctagctggc tccacgggag
     2761 ttcaggcccc actccccctg aagctgcccc tccagcacac acacataagc actgaaatca
     2821 ctttacctgc aggctccatg cacctccctt ccctccctga ggcaggtgag aacccagaga
     2881 gaggggcctg caggtgagca ggcagggctg ggccaggtct ccggggaggc aggggtcctg
     2941 caggtcctgg tgggtcagcc cagcacctgc tcccagtggg agcttcccgg gataaactga
     3001 gcctgttcat tctgatgtcc atttgtccca atagctctac tgccctcccc ttccccttta
     3061 ctcagcccag ctggccacct agaagtctcc ctgcacagcc tctagtgtcc ggggaccttg
     3121 tgggaccagt cccacaccgc tggtccctgc cctcccctgc tcccaggttg aggtgcgctc
     3181 acctcagagc agggccaaag cacagctggg catgccatgt ctgagcggcg cagagccctc
     3241 caggcctgca ggggcaaggg gctggctgga gtctcagagc acagaggtag gagaactggg
     3301 gttcaagccc aggcttcctg ggtcctgcct ggtcctccct cccaaggagc cattctgtgt
     3361 gtgactctgg gtggaagtgc ccagcccctg cccctacggg cgctgcagcc tcccttccat
     3421 gccccaggat cactctctgc tggcaggatt cttcccgctc cccacctacc cagctgatgg
     3481 gggttggggt gcttcctttc aggccaaggc tatgaaggga cagctgctgg gacccacctc
     3541 cccctccccg gccacatgcc gcgtccctgc cccgacccgg gtctggtgct gaggatacag
     3601 ctcttctcag tgtctgaaca atctccaaaa ttgaaatgta tatttttgct aggagcccca
     3661 gcttcctgtg tttttaatat aaatagtgta cacagactga cgaaacttta aataaatggg
     3721 aattaaatat ttaa
//
