LOCUS       NM_005036              10118 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens peroxisome proliferator activated receptor alpha
            (PPARA), transcript variant 5, mRNA.
ACCESSION   NM_005036
VERSION     NM_005036.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10118)
  AUTHORS   AmeliMojarad,M., AmeliMojarad,M. and Cui,X.
  TITLE     Weighted gene co-expression network analysis identified GBP2
            connected to PPARalpha activity and liver cancer
  JOURNAL   Sci Rep 14 (1), 20745 (2024)
   PUBMED   39251636
  REMARK    GeneRIF: Weighted gene co-expression network analysis identified
            GBP2 connected to PPARalpha activity and liver cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10118)
  AUTHORS   Zulinska,S., Strosznajder,A.K. and Strosznajder,J.B.
  TITLE     Current View on PPAR-alpha and Its Relation to Neurosteroids in
            Alzheimer's Disease and Other Neuropsychiatric Disorders: Promising
            Targets in a Therapeutic Strategy
  JOURNAL   Int J Mol Sci 25 (13), 7106 (2024)
   PUBMED   39000217
  REMARK    GeneRIF: Current View on PPAR-alpha and Its Relation to
            Neurosteroids in Alzheimer's Disease and Other Neuropsychiatric
            Disorders: Promising Targets in a Therapeutic Strategy.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10118)
  AUTHORS   Clavreul,L., Bernard,L., Cotte,A.K., Hennuyer,N., Bourouh,C.,
            Devos,C., Helleboid,A., Haas,J.T., Verrijken,A., Gheeraert,C.,
            Derudas,B., Guille,L., Chevalier,J., Eeckhoute,J., Vallez,E.,
            Dorchies,E., Van Gaal,L., Lassailly,G., Francque,S., Staels,B. and
            Paumelle,R.
  TITLE     The ubiquitin-like modifier FAT10 is induced in MASLD and impairs
            the lipid-regulatory activity of PPARalpha
  JOURNAL   Metabolism 151, 155720 (2024)
   PUBMED   37926201
  REMARK    GeneRIF: The ubiquitin-like modifier FAT10 is induced in MASLD and
            impairs the lipid-regulatory activity of PPARalpha.
REFERENCE   4  (bases 1 to 10118)
  AUTHORS   Kim,H., Lee,S.K., Hong,S., Park,T.S., Kim,J., Kim,S. and Kim,T.M.
  TITLE     Pan PPAR agonist stimulation of induced MSCs produces extracellular
            vesicles with enhanced renoprotective effect for acute kidney
            injury
  JOURNAL   Stem Cell Res Ther 15 (1), 9 (2024)
   PUBMED   38167146
  REMARK    GeneRIF: Pan PPAR agonist stimulation of induced MSCs produces
            extracellular vesicles with enhanced renoprotective effect for
            acute kidney injury.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10118)
  AUTHORS   Kazanci,D., Polat,T., Kaynar,O., Bilici,M.F., Tacal Aslan,B. and
            Ulucan,K.
  TITLE     PPARA and IL6: exploring associations with athletic performance and
            genotype polymorphism
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (11), 69-75 (2023)
   PUBMED   38015538
  REMARK    GeneRIF: PPARA and IL6: exploring associations with athletic
            performance and genotype polymorphism.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10118)
  AUTHORS   Tugwood,J.D., Aldridge,T.C., Lambe,K.G., Macdonald,N. and
            Woodyatt,N.J.
  TITLE     Peroxisome proliferator-activated receptors: structures and
            function
  JOURNAL   Ann N Y Acad Sci 804, 252-265 (1996)
   PUBMED   8993548
REFERENCE   7  (bases 1 to 10118)
  AUTHORS   Chu,R., Lin,Y., Rao,M.S. and Reddy,J.K.
  TITLE     Cloning and identification of rat deoxyuridine triphosphatase as an
            inhibitor of peroxisome proliferator-activated receptor alpha
  JOURNAL   J Biol Chem 271 (44), 27670-27676 (1996)
   PUBMED   8910358
REFERENCE   8  (bases 1 to 10118)
  AUTHORS   Miyata,K.S., McCaw,S.E., Patel,H.V., Rachubinski,R.A. and
            Capone,J.P.
  TITLE     The orphan nuclear hormone receptor LXR alpha interacts with the
            peroxisome proliferator-activated receptor and inhibits peroxisome
            proliferator signaling
  JOURNAL   J Biol Chem 271 (16), 9189-9192 (1996)
   PUBMED   8621574
REFERENCE   9  (bases 1 to 10118)
  AUTHORS   Mukherjee,R., Jow,L., Noonan,D. and McDonnell,D.P.
  TITLE     Human and rat peroxisome proliferator activated receptors (PPARs)
            demonstrate similar tissue distribution but different
            responsiveness to PPAR activators
  JOURNAL   J Steroid Biochem Mol Biol 51 (3-4), 157-166 (1994)
   PUBMED   7981125
REFERENCE   10 (bases 1 to 10118)
  AUTHORS   Sher,T., Yi,H.F., McBride,O.W. and Gonzalez,F.J.
  TITLE     cDNA cloning, chromosomal mapping, and functional characterization
            of the human peroxisome proliferator activated receptor
  JOURNAL   Biochemistry 32 (21), 5598-5604 (1993)
   PUBMED   7684926
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from FP325332.1 and AL078611.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_005036.5.
            
            Summary: Peroxisome proliferators include hypolipidemic drugs,
            herbicides, leukotriene antagonists, and plasticizers; this term
            arises because they induce an increase in the size and number of
            peroxisomes. Peroxisomes are subcellular organelles found in plants
            and animals that contain enzymes for respiration and for
            cholesterol and lipid metabolism. The action of peroxisome
            proliferators is thought to be mediated via specific receptors,
            called PPARs, which belong to the steroid hormone receptor
            superfamily. PPARs affect the expression of target genes involved
            in cell proliferation, cell differentiation and in immune and
            inflammation responses. Three closely related subtypes (alpha,
            beta/delta, and gamma) have been identified. This gene encodes the
            subtype PPAR-alpha, which is a nuclear transcription factor.
            Multiple alternatively spliced transcript variants have been
            described for this gene, although the full-length nature of only
            two has been determined. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR1660805.45423.1, HQ692862.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1965299, SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000407236.6/ ENSP00000385523.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               FP325332.1         58557-58683
            128-210             FP325332.1         59919-60001
            211-294             FP325332.1         84784-84867
            295-544             FP325332.1         106373-106622
            545-705             FP325332.1         123204-123364
            706-844             AL078611.1         40649-40787         c
            845-1047            AL078611.1         39036-39238         c
            1048-1495           AL078611.1         26811-27258         c
            1496-10118          AL078611.1         15295-23917         c
FEATURES             Location/Qualifiers
     source          1..10118
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.31"
     gene            1..10118
                     /gene="PPARA"
                     /gene_synonym="hPPAR; NR1C1; PPAR; PPAR-alpha; PPARalpha"
                     /note="peroxisome proliferator activated receptor alpha"
                     /db_xref="GeneID:5465"
                     /db_xref="HGNC:HGNC:9232"
                     /db_xref="MIM:170998"
     exon            1..127
                     /gene="PPARA"
                     /gene_synonym="hPPAR; NR1C1; PPAR; PPAR-alpha; PPARalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            128..210
                     /gene="PPARA"
                     /gene_synonym="hPPAR; NR1C1; PPAR; PPAR-alpha; PPARalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            211..294
                     /gene="PPARA"
                     /gene_synonym="hPPAR; NR1C1; PPAR; PPAR-alpha; PPARalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            295..544
                     /gene="PPARA"
                     /gene_synonym="hPPAR; NR1C1; PPAR; PPAR-alpha; PPARalpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             337..1743
                     /gene="PPARA"
                     /gene_synonym="hPPAR; NR1C1; PPAR; PPAR-alpha; PPARalpha"
                     /note="isoform 1 is encoded by transcript variant 5;
                     peroxisome proliferative activated receptor, alpha;
                     nuclear receptor subfamily 1 group C member 1"
                     /codon_start=1
                     /product="peroxisome proliferator-activated receptor alpha
                     isoform 1"
                     /protein_id="NP_005027.2"
                     /db_xref="CCDS:CCDS33669.1"
                     /db_xref="GeneID:5465"
                     /db_xref="HGNC:HGNC:9232"
                     /db_xref="MIM:170998"
                     /translation="MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGED
                     SSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIEC
                     RICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHK
                     CLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNF
                     NMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCC
                     QCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAY
                     GNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLL
                     NVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKT
                     ESDAALHPLLQEIYRDMY"
     exon            545..705
                     /gene="PPARA"
                     /gene_synonym="hPPAR; NR1C1; PPAR; PPAR-alpha; PPARalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            706..844
                     /gene="PPARA"
                     /gene_synonym="hPPAR; NR1C1; PPAR; PPAR-alpha; PPARalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1047
                     /gene="PPARA"
                     /gene_synonym="hPPAR; NR1C1; PPAR; PPAR-alpha; PPARalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1495
                     /gene="PPARA"
                     /gene_synonym="hPPAR; NR1C1; PPAR; PPAR-alpha; PPARalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..10118
                     /gene="PPARA"
                     /gene_synonym="hPPAR; NR1C1; PPAR; PPAR-alpha; PPARalpha"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10097..10102
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPARA"
                     /gene_synonym="hPPAR; NR1C1; PPAR; PPAR-alpha; PPARalpha"
                     /note="hexamer: AATAAA"
     polyA_site      10118
                     /gene="PPARA"
                     /gene_synonym="hPPAR; NR1C1; PPAR; PPAR-alpha; PPARalpha"
                     /note="major polyA site"
ORIGIN      
        1 gtggacgcgg cggccccgcg gcgggggcag cgggcggcgg gggcggaggc ggccgctagc
       61 gccctgcccg gcgccgcctc cttcggcgtt cgccccacgg accggcaggc ggcggaccgc
      121 ggcccaggct gaagctcagg gccctgtctg ctctgtggac tcaacagttt gtggcaagac
      181 aagctcagaa ctgagaagct gtcaccacag ttctggaggc tgggaagttc aagatcaaag
      241 tgccagcaga ttcagtgtca tgtgaggacg tgcttcctgc ttcatagata agagtagctt
      301 ggagctcggc ggcacaacca gcaccatctg gtcgcgatgg tggacacgga aagcccactc
      361 tgccccctct ccccactcga ggccggcgat ctagagagcc cgttatctga agagttcctg
      421 caagaaatgg gaaacatcca agagatttcg caatccatcg gcgaggatag ttctggaagc
      481 tttggcttta cggaatacca gtatttagga agctgtcctg gctcagatgg ctcggtcatc
      541 acggacacgc tttcaccagc ttcgagcccc tcctcggtga cttatcctgt ggtccccggc
      601 agcgtggacg agtctcccag tggagcattg aacatcgaat gtagaatctg cggggacaag
      661 gcctcaggct atcattacgg agtccacgcg tgtgaaggct gcaagggctt ctttcggcga
      721 acgattcgac tcaagctggt gtatgacaag tgcgaccgca gctgcaagat ccagaaaaag
      781 aacagaaaca aatgccagta ttgtcgattt cacaagtgcc tttctgtcgg gatgtcacac
      841 aacgcgattc gttttggacg aatgccaaga tctgagaaag caaaactgaa agcagaaatt
      901 cttacctgtg aacatgacat agaagattct gaaactgcag atctcaaatc tctggccaag
      961 agaatctacg aggcctactt gaagaacttc aacatgaaca aggtcaaagc ccgggtcatc
     1021 ctctcaggaa aggccagtaa caatccacct tttgtcatac atgatatgga gacactgtgt
     1081 atggctgaga agacgctggt ggccaagctg gtggccaatg gcatccagaa caaggaggcg
     1141 gaggtccgca tctttcactg ctgccagtgc acgtcagtgg agaccgtcac ggagctcacg
     1201 gaattcgcca aggccatccc aggcttcgca aacttggacc tgaacgatca agtgacattg
     1261 ctaaaatacg gagtttatga ggccatattc gccatgctgt cttctgtgat gaacaaagac
     1321 gggatgctgg tagcgtatgg aaatgggttt ataactcgtg aattcctaaa aagcctaagg
     1381 aaaccgttct gtgatatcat ggaacccaag tttgattttg ccatgaagtt caatgcactg
     1441 gaactggatg acagtgatat ctcccttttt gtggctgcta tcatttgctg tggagatcgt
     1501 cctggccttc taaacgtagg acacattgaa aaaatgcagg agggtattgt acatgtgctc
     1561 agactccacc tgcagagcaa ccacccggac gatatctttc tcttcccaaa acttcttcaa
     1621 aaaatggcag acctccggca gctggtgacg gagcatgcgc agctggtgca gatcatcaag
     1681 aagacggagt cggatgctgc gctgcacccg ctactgcagg agatctacag ggacatgtac
     1741 tgagttcctt cagatcagcc acaccttttc caggagttct gaagctgaca gcactacaaa
     1801 ggagacgggg gagcagcacg attttgcaca aatatccacc actttaacct tagagcttgg
     1861 acagtctgag ctgtaggtaa ccggcatatt attccatatc tttgttttaa ccagtacttc
     1921 taagagcata gaactcaaat gctgggggta ggtggctaat ctcaggactg ggaagattac
     1981 ggcgaattat gctcaatggt ctgattttaa ctcacccgat gttaatcaat gcacattgct
     2041 ttagatcaca ttcgtgattt accatttaat taactggtaa cctcaaaatt cgtggcctgt
     2101 cttcccattc accccgcttt tgactattgt gctcctttat aattctgaaa actaatcagc
     2161 actttttaac aatgtttata atcctataag tctagatgta tccaaaggtg aagtatgtaa
     2221 aaagcagcaa aatatttatt tcaaagactt cacttctgtt tcctgaatct aaagaaagac
     2281 aacatgctgc tttttaatca taggatggag aattttaaag aactgtttgg gccaggcaca
     2341 gtcgctcata cttgtaatcc cagcactttg ggaggccgag gcgggtggat cacaaggtca
     2401 gcagatcgag accatcctgg ccaacatggt gaaaccctgt ctctactaaa aatacaaaaa
     2461 ttagccgggt gtggtggcac atgcctgtaa tcccagctac tcgggaagct gaggcaggag
     2521 aattgcttga accagggagt tggaggttgc agtgagctaa gactgcacca ctgcactcca
     2581 gcctggtgac agaacgagac tctgtcttaa aaacaaacaa acaaaaaaaa aatctgttag
     2641 ataagctatc aaaatgcagc tgttgttttg tttttggctc actgttttcg tggttgtaac
     2701 taatatgtgg aaaggcccat ttccaggttt gcgtagaaga gcccagaaaa cagagtctca
     2761 agacccccgc tctggactgt cataagctag cacccgtggt aagcgggacg agacaagctc
     2821 ccgaagcccg ccagcttcct gctccactca gctccgtcca gtcaacctga acccacccag
     2881 tccagctgtc tgtgggaatg gtggtgttct tagggacaga ctgacacctt acttgtcagt
     2941 gttcctccgg gccccatttg gcagctcccg tatcttttgt tatgttgctt ttaaagatat
     3001 gatgttttat tgttttaact cttggtgaca gtagatgctc tctggagcgc agacgaggca
     3061 catgtgtctt catagcctgg gctgggtggg agccagtcac cctgcggatc gagagagggg
     3121 gtagagtctt cttcaaatgg cagttttact tcaaatggca gatttcacaa gagttggtta
     3181 ttttttacaa tggtttaggt tgttaagtct cctttgtatg taaggtagtt ttttcaacat
     3241 ctaaaatttt tgttttagcc ttcaaaacca acttaccaac ctcagtccag ctgggaaggc
     3301 agcgttgatt atggtagttt gtcaagaata tatggacctg gaaacacttt ctctctctgt
     3361 ccacctggta gataaattgt cctgttgaga atttttagat ctggactgga actgccagga
     3421 ccaccgcctc cagggagtcg ctgggcacct ggaggtatcg tcgatgcctc tcccccatct
     3481 ttagaaaatt tggctcttct gaggtcatta ttattttaag aatgattagg attgataagg
     3541 gtcccatgac cagcattatg aaaatgcgag agtgggaagg acacagtgtg agacttccac
     3601 tagaaaaaag tgaaagttag ggttaggaca tcctttttta aaaattacaa atttagtccg
     3661 ttttggtttt tgtaatcagg ctaggcacag tggctcacac atggaatccc agcactttgg
     3721 gaggccgagg tgggaggatc acttgagccc aggagttcga gaccagccta ggcaacatag
     3781 caagaccctg tctgtacaca aaatttaaaa attagttcat cggggtggca cacatcagta
     3841 gtcccagcta ctctgcaggc tgaggtggga ggattgcttg aacccaggag gtcgaggctg
     3901 cagtgagctg tgatctcacc actgcattcc agcctgggtg acagagttag attccaccct
     3961 ctcccacccc ggcaaaaaaa aaaaaaaaag atgcaatcaa aggggctgtt ggccagcaat
     4021 ggcagcagca gcggcgggca gtctgcccaa gtgtcttagg aaccaaaagc aaataaaagt
     4081 gtttccatat atgccaccag ccaagtggcc atcctaattc agaaagaagc tagcctttga
     4141 gtgtctgtca tggtgcatcc gtttcagtat tatttcctaa aatgagaagc ccctgtgtca
     4201 acaagatcca ggggctggag cccaatgcca agcctgtgtt gtccccagcg accctgcagc
     4261 tgctcgctct gatgtaccct gtgccattca aggagatgtg gtccaggaaa gtgagcctca
     4321 tggttttcag agaagtcatt gttctgttta cattttcata aaacctgttt aaaatagctc
     4381 cccgtctcag gctttcagca gtaacagtga gctgactggc aagttcgatg ttagctcccg
     4441 ggacactcag cagcgatggt gagcattttg gtttccttaa ggcccagcaa gacttccagg
     4501 gacatctctg gtgaagccag aatggagaca cccgtgacct caggctgaaa gtcactcgac
     4561 attggtctct tgtgttgata gggaaggaaa tcaggcattc ctatttcttt aaataacaaa
     4621 accactaatt gccactcaat gctggaatat tttgggtcac ctaatcatag atttctcagg
     4681 gcatcaatac tcaaatatag gctgattatg ccccagttca aatgggaact attaacagag
     4741 tgcatttctt gcttgctggg tttcaacaga catcagccaa aagaacaaaa gagatgtcag
     4801 gacagattcc aggagtgtcg gagcacatgt gtggcacccg ctccctctgg cagcgaatgt
     4861 aggaagtcgc caaatttacc cactcttcaa caagtcattg tttaaacacg gtttttcatt
     4921 ttctcaactt ttaatagcaa aaagtgccaa agtcctcaga gacctaacag ccttggtcta
     4981 ccgtgctgac cagggtgaag gcacggcgag ggactcctcc cagacgtgcc tcttgtgtgc
     5041 cagctggctg tggctcggga gcagacgcag gcctctccat tgtccagggg agcctggcgg
     5101 cgcatccctc ctctcccacc tcctggcact tccagctggg tgtcccacat gttggattcc
     5161 gtccccacca cacttccaga gaccggagaa ctgtgcaggg cctaaggccg tttggatgaa
     5221 ttgtcaaaac aagatgcttc cagttacagc ggcaggagcg ggactgggag cacgggctga
     5281 cggctgctgg tgcctttctt cccacctcgc ttgcctgttt ccgcttgacc cttcctccag
     5341 ctccgatgag aagagtataa agcatcttcc taacgggtgt gtttgctata cgaacataat
     5401 ggacgtgaag tggggcagaa acccagaact cagcattcaa ggatgcccag gagagctgtc
     5461 cctgttttaa agagctgtgt tttgttttgt ttcgcattta gagagcagac aaggcaccct
     5521 tctgctgcgc tgatacgttt cttacactgg gccattttag acccccaggg aaacagcctt
     5581 cctggagcgt tgtctggagg ttccagggac agggcagcct cccagagccg agcaagagct
     5641 caaggtacaa atgagagatt tgctataccg tgagaagtca acaacttagc caccacttcc
     5701 ccgcaatgga ccatgtaaca aatacctcag caggccctgc aaaaggccat gctagagctg
     5761 aggcgcacag cctgtggcct ctgtagttag ggcaggtggg atggagactc cttgagtgca
     5821 cacacctgag cctgcccaca cacaggggag cagcatctcg tatgacgtct ggaaggaact
     5881 tcggttgtgt aaagggagcc ttgaagatac gtgcaaaagg tgctacccca atttggtgaa
     5941 actgacattg ggcacgtctt gggcttagga gaagcggccg atggtcccgg cctgcagtga
     6001 caaacccccc tccccgcacc gcccccagca ccccctctcc tcttcacctc ttcctgctgg
     6061 ccacgaggaa gccacttcct cagagagacc ctaccagatg cggatggaaa cagatgcacc
     6121 aaagcaagcc ctgatgaaac cgcgacttcc taaggtctgt ctcctctgaa cttgcacctg
     6181 ggcctctctg tgtttggttc caagcacttc ccacctcaaa ctcccatttt caaaccactg
     6241 tatctctgcg cacatctgct acttaccagc cgcatacatg atggagggtt ttttggtcct
     6301 gatccagtgg ccacacctgt ctttgaaatg tctcactgaa ctccagtttt aaaatagatt
     6361 cattgcttca acacagcaag cccaatgcac ccagctaaga ctggcttgac cgacagcctg
     6421 gcctttggtg gggggcttcc tggggcctgg ggaaagctgg ccaccttcaa cagctggtac
     6481 ctcttcaaca gtgtggcctt tcaaaatgca gatgccacca ggagaacatg cccacagctc
     6541 accacctatg gatgccatgg ctctgggcag ctttcaaagc aggttcctgt ggtctcctca
     6601 gctgtttgag ggggtaacag caaatcagcc tccattttaa aatgaaaaca ccagcctcca
     6661 gatgtagggc ctgctgggtg ttgctagccg ctggtcccca ggcacggtgc actttctcca
     6721 cctcctgcag cctccctgtt gtttctagac tcttgcacct ggtgagtgca aggataggtg
     6781 acccaggggc ctgcagcctt gtcctcagct cccatctcct ggactgccag cctcaccctc
     6841 tgcagttagc atggttggcc tgatgcaggg atcccgaggg attacttttt agaccttctt
     6901 tcacattcag aaaagtagta tagattcagg agaggcaaga aaattatgct gtccatagaa
     6961 gtcacccatg aagactgatg ccaccacctg aaggctcatg attgttaaaa atgtccacgg
     7021 gaacctctcg tccacaggag gtttgtctca acacttccca tttttacggc attggcattg
     7081 ccaagcatgg ggaagtatct gctcttctca tgttaaaagt ggcccagctt ttcttaactc
     7141 agtccaagct gacttgttta gctgcactgg aatttcttac caaccaaata tttgcatcga
     7201 gcaaaggggg ctgtgtgcac ctccctaatg gcagcgatga tggctgctgt cattcaagcc
     7261 catcttcaga cgtcacagtc tggaagtgaa atgtccacaa acatctgtgg cagaaaaggc
     7321 tatacggacc acccagttgt gctgcagctt tacagagcaa ggaagggttg tggcaaataa
     7381 atgattaacc tgcctcgact gtgctgaggg caacaaaggc catctcacca aaggattatt
     7441 cgatgccatt aaatcatccc gtgaccttcc tgcttccgag tccatggcct ttgcccaggg
     7501 catgtactcc cctgagaggc cttctgccta gaaagatcta tgactgggtt ccaaagttga
     7561 ggcctaggtt tttgctggga tttagatatt ttcaggcacc attttgacag cattcaggaa
     7621 aacggttatt gaccccatag actagggtaa gaataaaggc aataaatttg gtctgactca
     7681 gaatatagga gatccatata tttctctgga aaccacagtg tacactaaaa tgtgaaattg
     7741 aaggttttgt taaaaagaaa aagataatga gcttcatgct ttgtttaatt acataatgat
     7801 ttccattacg ctatttctgt gaaatgcagc aggttcttaa acgttatttc agtggcatgg
     7861 gctggaagct tatcacaaaa agccatgtgt gtggccttat cagaacagaa agagacaggc
     7921 tggtgcccaa ggctgctgcc tgctccacct tttgccagct ctggacatct gaggacgtcc
     7981 cggcagatct ggaatggggc cctcaactga ccatttgctt ctcagaattt cagtttgaga
     8041 catgagaggt ataatcagtt acttttctcc ccccagagaa acccttttgt gaggggagag
     8101 gagctatggt atgtggttca gctgaaacac atacaactgc atccttttgg agtcctttgc
     8161 caacaaaaac agaccaacag accagatggt gtccatgttc aatatcatgt cttgatggac
     8221 gcagctgatg acctcaaata cttgagtggt ctcatggctg ttagatggat tatttgaaaa
     8281 aaaaaaaaaa aaaagagaga aaaaataatt gatttttaca tcagagatag caaactaaga
     8341 cctggggagg ggggtcagct tttattttat tttatttttt ttaagtttgc tagttgggtc
     8401 aaatgtgagg aggagggagt ctacctgcca cctcttctct tgcccctctt ctgcccacac
     8461 atccagcatc caaaatccat tcatttaatg aattgataaa gtgccgtgca aactggtgca
     8521 caaacaggcc cccagtccac gcagcctggc tcctaggaaa agtggtgacc gggcgtgggg
     8581 gggcatgccg cagccctggg acacagtcgg gcaccttccc cggaccccca ggccttggct
     8641 gtgcctcaag tcagagaggg tcagccttca ggccccggag acgagtgact ggccgatcat
     8701 ttcacaataa aatcactcac ttttggcaac ttcacttttt ttaaggcaca gtcagttcct
     8761 tttctcatgt acctcacaaa agatgaagac catgtagtac tctttttggt aaagttacag
     8821 tgttcatgtt aaatatcact tttttctaca ttgtgtggta aaaagaacta cgttaatagc
     8881 tatatcttaa atactgtgat ttgacttttt gaaaaatatc ctaatacaaa tattttacta
     8941 acttacaatc actcatttaa taagaaacat ttggattctt ttgaaatcag tgttaattga
     9001 ctcatattct taaaagcctg gctcttgacc ctattggaaa cacaaaggaa gctgaaatca
     9061 aacatctaaa atacactgcg tacacgtgtg cgtgcacaca cacacacaca cacacacaca
     9121 cacagctctt catttctcct gagccatgca gaatttactt tcaatgtgga aatctgttcc
     9181 ctttaccaca ctgtatatgc acagagcaca agagaggcta tctctagtca cttccaccag
     9241 cgaggcctta gactccgtat tagaggccac cgatttcata caacagtgtt tcgctaaaga
     9301 cccttcacta ttcttgttta gtaaatagct gtctgctctt cagggaactg ttacctatgg
     9361 gttattacca aagaacgctg gcaattggaa atgtcctgat ggaaattctt tgcacgtgcc
     9421 ggttctctgg catcctccag gtggcccaac ccaaagcaga aagcagaaac cacagacccc
     9481 gtgagtctcc ccataccttg tttccaataa cttggcaaaa cttcttggtg catattggtt
     9541 acaccctctg ggattcataa tgccattagg ctaaaaccct aagagagagg gttgacagaa
     9601 acacacgcga gaatgaggca gatcccagag caaggactgg gcccagactc tccacatgtg
     9661 ctctactagt gagtgcctta tactctcagt attttggggc ttacagcttc ttatttgtgc
     9721 taaaaaggtg cagttccaaa gtaggaactg ccacacaggc cccagcatcc tctctccaac
     9781 ttcatacctc tctcctggtg gggggagcgg gcatccagga cctccggaat caaggatgtg
     9841 cagagaagag cgaaagtaat ttttctagtc acatgaactg attggttcca ggcaattaga
     9901 aaatggctat aaaataacct taattttaaa aaaaaatctt gggtcttcgt tttcctatta
     9961 ggagactgaa ctgaccacat gtattgattt atatcctgaa tatatgggaa cttctgtgtt
    10021 tgggatgtcc tactgtaaga ctgatgaatg tacagagtta atttcagggt acagttttgc
    10081 cttaatggtt ttaaaaaata aactattttt taaaattt
//
