LOCUS       NM_001040664            3052 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens PPAN-P2RY11 readthrough (PPAN-P2RY11), transcript
            variant 1, mRNA.
ACCESSION   NM_001040664
VERSION     NM_001040664.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3052)
  AUTHORS   Han,F., Faraco,J., Dong,X.S., Ollila,H.M., Lin,L., Li,J., An,P.,
            Wang,S., Jiang,K.W., Gao,Z.C., Zhao,L., Yan,H., Liu,Y.N., Li,Q.H.,
            Zhang,X.Z., Hu,Y., Wang,J.Y., Lu,Y.H., Lu,C.J., Zhou,W.,
            Hallmayer,J., Huang,Y.S., Strohl,K.P., Pollmacher,T. and Mignot,E.
  TITLE     Genome wide analysis of narcolepsy in China implicates novel immune
            loci and reveals changes in association prior to versus after the
            2009 H1N1 influenza pandemic
  JOURNAL   PLoS Genet 9 (10), e1003880 (2013)
   PUBMED   24204295
REFERENCE   2  (bases 1 to 3052)
  AUTHORS   Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
            Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
            Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
            Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
            Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
            Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
            Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
            D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
            Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
            Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
            Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
            Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
            Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
            Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
            Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
            Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
            Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
            Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
            Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
            Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
            Vermeire,S., Barrett,J.C. and Cho,J.H.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   3  (bases 1 to 3052)
  AUTHORS   Prakash,T., Sharma,V.K., Adati,N., Ozawa,R., Kumar,N., Nishida,Y.,
            Fujikake,T., Takeda,T. and Taylor,T.D.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3052)
  AUTHORS   Duhant,X., Schandene,L., Bruyns,C., Gonzalez,N.S., Goldman,M.,
            Boeynaems,J.M. and Communi,D.
  TITLE     Extracellular adenine nucleotides inhibit the activation of human
            CD4+ T lymphocytes
  JOURNAL   J Immunol 169 (1), 15-21 (2002)
   PUBMED   12077223
REFERENCE   5  (bases 1 to 3052)
  AUTHORS   Communi,D., Suarez-Huerta,N., Dussossoy,D., Savi,P. and
            Boeynaems,J.M.
  TITLE     Cotranscription and intergenic splicing of human P2Y11 and SSF1
            genes
  JOURNAL   J Biol Chem 276 (19), 16561-16566 (2001)
   PUBMED   11278528
REFERENCE   6  (bases 1 to 3052)
  AUTHORS   Communi,D., Govaerts,C., Parmentier,M. and Boeynaems,J.M.
  TITLE     Cloning of a human purinergic P2Y receptor coupled to phospholipase
            C and adenylyl cyclase
  JOURNAL   J Biol Chem 272 (51), 31969-31973 (1997)
   PUBMED   9405388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020931.6 and AJ300588.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001040664.2.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the adjacent PPAN and P2RY11 genes.
            Alternative splicing results in two transcript variants, one of
            which encodes a fusion protein that shares sequence identity with
            each individual gene product. This transcript is found to be
            ubiquitously expressed and is up-regulated by agents inducing
            granulocytic differentiation. However, its functional significance
            in vivo remains unclear. [provided by RefSeq, Nov 2010].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the longer isoform (1), which is a fusion of
            the PPAN and P2RY11 products.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ300588.1, SRR3476690.907116.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2145774
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 5032, 56342
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AC020931.6         92314-92346
            34-368              AJ300588.1         1-335
            369-369             AC020931.6         93800-93800
            370-1529            AJ300588.1         337-1496
            1530-1530           AC020931.6         99802-99802
            1531-2418           AJ300588.1         1498-2385
            2419-3052           AC020931.6         100691-101324
FEATURES             Location/Qualifiers
     source          1..3052
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..3052
                     /gene="PPAN-P2RY11"
                     /gene_synonym="BXDC3; P2RY11; P2Y11; PPAN; Ssf-1; SSF1"
                     /note="PPAN-P2RY11 readthrough"
                     /db_xref="GeneID:692312"
                     /db_xref="HGNC:HGNC:33526"
     exon            1..51
                     /gene="PPAN-P2RY11"
                     /gene_synonym="BXDC3; P2RY11; P2Y11; PPAN; Ssf-1; SSF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..2418
                     /gene="PPAN-P2RY11"
                     /gene_synonym="BXDC3; P2RY11; P2Y11; PPAN; Ssf-1; SSF1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     PPAN-P2RY11 readthrough transcript; SSF1/P2Y11 protein;
                     P2Y purinoceptor 11; Suppressor of SWI4 1 homolog; Brix
                     domain-containing protein 3; Peter Pan homolog"
                     /codon_start=1
                     /product="PPAN-P2RY11 protein isoform 1"
                     /protein_id="NP_001035754.1"
                     /db_xref="GeneID:692312"
                     /db_xref="HGNC:HGNC:33526"
                     /translation="MGQSGRSRHQKRARAQAQLRNLEAYAANPHSFVFTRGCTGRNIR
                     QLSLDVRRVMEPLTASRLQVRKKNSLKDCVAVAGPLGVTHFLILSKTETNVYFKLMRL
                     PGGPTLTFQVKKYSLVRDVVSSLRRHRMHEQQFAHPPLLVLNSFGPHGMHVKLMATMF
                     QNLFPSINVHKVNLNTIKRCLLIDYNPDSQELDFRHYSIKVVPVGASRGMKKLLQEKF
                     PNMSRLQDISELLATGAGLSESEAEPDGDHNITELPQAVAGRGNMRAQQSAVRLTEIG
                     PRMTLQLIKVQEGVGEGKVMFHSFVSKTEEELQAILEAKEKKLRLKAQRQAQQAQNVQ
                     RKQEQREAHRKKSLEGMKKARVGGSDEEASGIPSRTASLELGEDDDEQEDDDIEYFCQ
                     AVGEAPSEDLFPEAKQKRLAKSPGRKRKRWEMDRGAKSCPANFLAAADDKLSGFQGDF
                     LWPILVVEFLVAVASNGLALYRFSIRKQRPWHPAVVFSVQLAVSDLLCALTLPPLAAY
                     LYPPKHWRYGEAACRLERFLFTCNLLGSVIFITCISLNRYLGIVHPFFARSHLRPKHA
                     WAVSAAGWVLAALLAMPTLSFSHLKRPQQGAGNCSVARPEACIKCLGTADHGLAAYRA
                     YSLVLAGLGCGLPLLLTLAAYGALGRAVLRSPGMTVAEKLRVAALVASGVALYASSYV
                     PYHIMRVLNVDARRRWSTRCPSFADIAQATAALELGPYVGYQVMRGLMPLAFCVHPLL
                     YMAAVPSLGCCCRHCPGYRDSWNPEDAKSTGQALPLNATAAPKPSEPQSRELSQ"
     exon            52..222
                     /gene="PPAN-P2RY11"
                     /gene_synonym="BXDC3; P2RY11; P2Y11; PPAN; Ssf-1; SSF1"
                     /inference="alignment:Splign:2.1.0"
     exon            223..324
                     /gene="PPAN-P2RY11"
                     /gene_synonym="BXDC3; P2RY11; P2Y11; PPAN; Ssf-1; SSF1"
                     /inference="alignment:Splign:2.1.0"
     exon            325..375
                     /gene="PPAN-P2RY11"
                     /gene_synonym="BXDC3; P2RY11; P2Y11; PPAN; Ssf-1; SSF1"
                     /inference="alignment:Splign:2.1.0"
     exon            376..546
                     /gene="PPAN-P2RY11"
                     /gene_synonym="BXDC3; P2RY11; P2Y11; PPAN; Ssf-1; SSF1"
                     /inference="alignment:Splign:2.1.0"
     exon            547..623
                     /gene="PPAN-P2RY11"
                     /gene_synonym="BXDC3; P2RY11; P2Y11; PPAN; Ssf-1; SSF1"
                     /inference="alignment:Splign:2.1.0"
     exon            624..731
                     /gene="PPAN-P2RY11"
                     /gene_synonym="BXDC3; P2RY11; P2Y11; PPAN; Ssf-1; SSF1"
                     /inference="alignment:Splign:2.1.0"
     exon            732..855
                     /gene="PPAN-P2RY11"
                     /gene_synonym="BXDC3; P2RY11; P2Y11; PPAN; Ssf-1; SSF1"
                     /inference="alignment:Splign:2.1.0"
     exon            856..934
                     /gene="PPAN-P2RY11"
                     /gene_synonym="BXDC3; P2RY11; P2Y11; PPAN; Ssf-1; SSF1"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1064
                     /gene="PPAN-P2RY11"
                     /gene_synonym="BXDC3; P2RY11; P2Y11; PPAN; Ssf-1; SSF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1234
                     /gene="PPAN-P2RY11"
                     /gene_synonym="BXDC3; P2RY11; P2Y11; PPAN; Ssf-1; SSF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1312
                     /gene="PPAN-P2RY11"
                     /gene_synonym="BXDC3; P2RY11; P2Y11; PPAN; Ssf-1; SSF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..3052
                     /gene="PPAN-P2RY11"
                     /gene_synonym="BXDC3; P2RY11; P2Y11; PPAN; Ssf-1; SSF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3027..3032
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPAN-P2RY11"
                     /gene_synonym="BXDC3; P2RY11; P2Y11; PPAN; Ssf-1; SSF1"
                     /note="hexamer: AATAAA"
     polyA_site      3052
                     /gene="PPAN-P2RY11"
                     /gene_synonym="BXDC3; P2RY11; P2Y11; PPAN; Ssf-1; SSF1"
                     /note="major polyA site"
ORIGIN      
        1 ggacgcagga ggcctcgtgg aggacacagc agcatgggac agtcagggag gtcccggcac
       61 cagaagcgcg cccgcgccca ggcgcagctc cgcaacctcg aggcctatgc cgcgaacccg
      121 cactcgttcg tgttcacgcg aggctgcacg ggtcgcaaca tccggcagct cagcctggac
      181 gtgcggcggg tcatggagcc gctcactgcc agccgtctgc aggttcgtaa gaagaactcg
      241 ctgaaggact gcgtggcagt ggctgggccc ctcggggtca cacactttct gatcctgagc
      301 aaaacagaga ccaatgtcta ctttaagctg atgcgcctcc caggaggccc caccttgacc
      361 ttccaggtca agaagtactc gctggtgcgt gatgtggtct cctcactgcg ccggcaccgc
      421 atgcacgagc agcagtttgc ccacccaccc ctcctggtac tcaacagctt tggcccccat
      481 ggtatgcatg tgaagctcat ggccaccatg ttccagaacc tgttcccctc catcaacgtg
      541 cacaaggtga acctgaacac catcaagcgc tgcctcctca tcgactacaa ccccgactcc
      601 caggagctgg acttccgcca ctatagcatc aaagttgttc ctgtgggcgc gagtcgcggg
      661 atgaagaagc tgctccagga gaagttcccc aacatgagcc gcctgcagga catcagcgag
      721 ctgctggcca cgggcgcggg gctgtcggag agcgaggcag agcctgacgg cgaccacaac
      781 atcacagagc tgcctcaggc tgtcgctggc cgtggcaaca tgcgggccca gcagagtgca
      841 gtgcggctca ccgagatcgg cccgcggatg acactgcagc tcatcaaggt ccaggagggc
      901 gtcggggagg gcaaagtgat gttccacagt tttgtgagca agacggagga ggagctgcag
      961 gccatcctgg aagccaagga gaagaagctg cggctgaagg cgcagaggca ggcccagcag
     1021 gcccagaatg tgcagcgcaa gcaggagcag cgggaggccc acagaaagaa gagcctggag
     1081 ggcatgaaga aggcacgggt cgggggtagt gatgaagagg cctctgggat cccttcaagg
     1141 acggcgagcc tggagttggg tgaggacgat gatgaacagg aagatgatga catcgagtat
     1201 ttctgccagg cggtgggcga ggcgcccagt gaggacctgt tccccgaggc caagcagaaa
     1261 cggcttgcca agtctccagg gcggaagcgg aagcggtggg aaatggatcg aggtgccaag
     1321 tcctgccctg ccaacttctt ggcagctgcc gacgacaaac tcagtgggtt ccagggggac
     1381 ttcctgtggc ccatactggt ggttgagttc ctggtggccg tggccagcaa tggcctggcc
     1441 ctgtaccgct tcagcatccg gaagcagcgc ccatggcacc ccgccgtggt cttctctgtc
     1501 cagctggcag tcagcgacct gctctgcgcc ctgacgctgc ccccgctggc cgcctacctc
     1561 tatcccccca agcactggcg ctatggggag gccgcgtgcc gcctggagcg cttcctcttc
     1621 acctgcaacc tgctgggcag cgtcatcttc atcacctgca tcagcctcaa ccgctacctg
     1681 ggcatcgtgc accccttctt cgcccgaagc cacctgcgac ccaagcacgc ctgggccgtg
     1741 agcgctgccg gctgggtcct ggccgccctg ctggccatgc ccacactcag cttctcccac
     1801 ctgaagaggc cgcagcaggg ggcgggcaac tgcagcgtgg ccaggcccga ggcctgcatc
     1861 aagtgtctgg ggacagcaga ccacgggctg gcggcctaca gagcgtatag cctggtgctg
     1921 gcggggttgg gctgcggcct gccgctgctg ctcacgctgg cagcctacgg cgccctcggg
     1981 cgggccgtgc tacgcagccc aggcatgact gtggccgaga agctgcgtgt ggcagcgttg
     2041 gtggccagtg gtgtggccct ctacgccagc tcctatgtgc cctaccacat catgcgggtg
     2101 ctcaacgtgg atgctcggcg gcgctggagc acccgctgcc cgagctttgc agacatagcc
     2161 caggccacag cagccctgga gctggggccc tacgtgggct accaggtgat gcggggcctc
     2221 atgcccctgg ccttctgtgt ccaccctcta ctctacatgg ccgcagtgcc cagcctgggc
     2281 tgctgctgcc gacactgccc cggctacagg gacagctgga acccagagga cgccaagagc
     2341 actggccaag ccctgcccct caatgccaca gccgccccta aaccgtcaga gccccagtcc
     2401 cgtgagctga gccaatgatg tggcctagcg gaagctgcct cctcacccta ggtgttgctg
     2461 gagaaccctg agggcagggc ccgagccccg acacatccct tcccccaaaa agcaacacct
     2521 gtgcttgcag ccaggtcagg cccagctgca gcccaggcag gagcagtcgc ctttcccacc
     2581 cacagcgctg gccacagggc tccctgcagg gtcagggacc agaccacgcc cagaggaggg
     2641 gaggcactgg cccccgccac aggactggag acgcaagaac aaaaagaacc aagtagagag
     2701 agtggagctg ctttattgcc cttggagccc gcgctctcgg aggctgtctt ctgtcgccaa
     2761 gggtcccgga ccgagtacac agtggcagct ggcttagttg gtggacggcc tggggtaggg
     2821 gagggtggca ggtataagac ttctgggggc accccaagac cccagacacc caagtggcat
     2881 cttgggggtg ggtgggcaga ggacggggta atgtgaggac gaagcgggca cggagccaga
     2941 tggccagtct ccaggcctgg tccacggact ggcagggacc ccaggcacaa gagctgccac
     3001 ccctctgccc ggttttggaa aaaaacaata aaggactgtc ccctcaaaac ca
//
