LOCUS       NM_020230               2302 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens peter pan homolog (PPAN), transcript variant 1, mRNA.
ACCESSION   NM_020230
VERSION     NM_020230.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2302)
  AUTHORS   Chen,X., Zhang,Q., Yang,Z., Yu,H., Qu,Y., Tan,R., Gao,Y., He,Y. and
            Li,L.
  TITLE     An SNP reducing SNORD105 and PPAN expression decreases the risk of
            hepatocellular carcinoma in a Chinese population
  JOURNAL   J Clin Lab Anal 35 (12), e24095 (2021)
   PUBMED   34741342
  REMARK    GeneRIF: An SNP reducing SNORD105 and PPAN expression decreases the
            risk of hepatocellular carcinoma in a Chinese population.
REFERENCE   2  (bases 1 to 2302)
  AUTHORS   Dannheisig,D.P., Beck,E., Calzia,E., Walther,P., Behrends,C. and
            Pfister,A.S.
  TITLE     Loss of Peter Pan (PPAN) Affects Mitochondrial Homeostasis and
            Autophagic Flux
  JOURNAL   Cells 8 (8), 894 (2019)
   PUBMED   31416196
  REMARK    GeneRIF: The study uncovers that PPAN knockdown is linked to
            mitochondrial damage and stimulates autophagy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2302)
  AUTHORS   Keil,M., Meyer,M.T., Dannheisig,D.P., Maerz,L.D., Philipp,M. and
            Pfister,A.S.
  TITLE     Loss of Peter Pan protein is associated with cell cycle defects and
            apoptotic events
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1866 (5), 882-895 (2019)
   PUBMED   30716409
  REMARK    GeneRIF: data underline the notion that the PPAN-mediated,
            p53-independent nucleolar stress response has multiple facets.
REFERENCE   4  (bases 1 to 2302)
  AUTHORS   Pfister,A.S., Keil,M. and Kuhl,M.
  TITLE     The Wnt Target Protein Peter Pan Defines a Novel p53-independent
            Nucleolar Stress-Response Pathway
  JOURNAL   J Biol Chem 290 (17), 10905-10918 (2015)
   PUBMED   25759387
  REMARK    GeneRIF: a novel nucleolar stress-response pathway involving PPAN,
            NPM, and BAX to guarantee cell survival in a p53-independent
            manner.
            Erratum:[J Biol Chem. 2023 Jan;299(1):102808. doi:
            10.1016/j.jbc.2022.102808.. PMID: 36566638]
REFERENCE   5  (bases 1 to 2302)
  AUTHORS   Han,F., Faraco,J., Dong,X.S., Ollila,H.M., Lin,L., Li,J., An,P.,
            Wang,S., Jiang,K.W., Gao,Z.C., Zhao,L., Yan,H., Liu,Y.N., Li,Q.H.,
            Zhang,X.Z., Hu,Y., Wang,J.Y., Lu,Y.H., Lu,C.J., Zhou,W.,
            Hallmayer,J., Huang,Y.S., Strohl,K.P., Pollmacher,T. and Mignot,E.
  TITLE     Genome wide analysis of narcolepsy in China implicates novel immune
            loci and reveals changes in association prior to versus after the
            2009 H1N1 influenza pandemic
  JOURNAL   PLoS Genet 9 (10), e1003880 (2013)
   PUBMED   24204295
REFERENCE   6  (bases 1 to 2302)
  AUTHORS   Communi,D., Suarez-Huerta,N., Dussossoy,D., Savi,P. and
            Boeynaems,J.M.
  TITLE     Cotranscription and intergenic splicing of human P2Y11 and SSF1
            genes
  JOURNAL   J Biol Chem 276 (19), 16561-16566 (2001)
   PUBMED   11278528
REFERENCE   7  (bases 1 to 2302)
  AUTHORS   Suarez-Huerta,N., Boeynaems,J.M. and Communi,D.
  TITLE     Cloning, genomic organization, and tissue distribution of human
            Ssf-1
  JOURNAL   Biochem Biophys Res Commun 275 (1), 37-42 (2000)
   PUBMED   10944437
REFERENCE   8  (bases 1 to 2302)
  AUTHORS   Welch,P.J., Marcusson,E.G., Li,Q.X., Beger,C., Kruger,M., Zhou,C.,
            Leavitt,M., Wong-Staal,F. and Barber,J.R.
  TITLE     Identification and validation of a gene involved in
            anchorage-independent cell growth control using a library of
            randomized hairpin ribozymes
  JOURNAL   Genomics 66 (3), 274-283 (2000)
   PUBMED   10873382
REFERENCE   9  (bases 1 to 2302)
  AUTHORS   Migeon,J.C., Garfinkel,M.S. and Edgar,B.A.
  TITLE     Cloning and characterization of peter pan, a novel Drosophila gene
            required for larval growth
  JOURNAL   Mol Biol Cell 10 (6), 1733-1744 (1999)
   PUBMED   10359593
  REMARK    GeneRIF: The functional analysis of the Drosophila homolog. [LH]
REFERENCE   10 (bases 1 to 2302)
  AUTHORS   Communi,D., Govaerts,C., Parmentier,M. and Boeynaems,J.M.
  TITLE     Cloning of a human purinergic P2Y receptor coupled to phospholipase
            C and adenylyl cyclase
  JOURNAL   J Biol Chem 272 (51), 31969-31973 (1997)
   PUBMED   9405388
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC033202.1 and AC020931.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_020230.6.
            
            Summary: The protein encoded by this gene is an evolutionarily
            conserved protein similar to yeast SSF1 as well as to the gene
            product of the Drosophila gene peter pan (ppan). SSF1 is known to
            be involved in the second step of mRNA splicing. Both SSF1 and ppan
            are essential for cell growth and proliferation. Exogenous
            expression of this gene was reported to reduce the
            anchorage-independent growth of some tumor cells. Read-through
            transcription of this gene with P2RY11/P2Y(11), an adjacent
            downstream gene that encodes an ATP receptor, has been found. These
            read-through transcripts are ubiquitously present and up-regulated
            during granulocyte differentiation. [provided by RefSeq, Nov 2010].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.163791.1,
                                           SRR1660805.148204.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000253107.12/ ENSP00000253107.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1584              BC033202.1         74-1657
            1585-2302           AC020931.6         97247-97964
FEATURES             Location/Qualifiers
     source          1..2302
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..2302
                     /gene="PPAN"
                     /gene_synonym="BXDC3; SSF; SSF-1; SSF1; SSF2"
                     /note="peter pan homolog"
                     /db_xref="GeneID:56342"
                     /db_xref="HGNC:HGNC:9227"
                     /db_xref="MIM:607793"
     exon            1..51
                     /gene="PPAN"
                     /gene_synonym="BXDC3; SSF; SSF-1; SSF1; SSF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1455
                     /gene="PPAN"
                     /gene_synonym="BXDC3; SSF; SSF-1; SSF1; SSF2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     suppressor of sterile four 1; homolog of S. cerevisiae
                     SSF1; suppressor of SWI4 1 homolog; second-step splicing
                     factor 1; brix domain-containing protein 3"
                     /codon_start=1
                     /product="suppressor of SWI4 1 homolog isoform 1"
                     /protein_id="NP_064615.3"
                     /db_xref="CCDS:CCDS12225.1"
                     /db_xref="GeneID:56342"
                     /db_xref="HGNC:HGNC:9227"
                     /db_xref="MIM:607793"
                     /translation="MGQSGRSRHQKRARAQAQLRNLEAYAANPHSFVFTRGCTGRNIR
                     QLSLDVRRVMEPLTASRLQVRKKNSLKDCVAVAGPLGVTHFLILSKTETNVYFKLMRL
                     PGGPTLTFQVKKYSLVRDVVSSLRRHRMHEQQFAHPPLLVLNSFGPHGMHVKLMATMF
                     QNLFPSINVHKVNLNTIKRCLLIDYNPDSQELDFRHYSIKVVPVGASRGMKKLLQEKF
                     PNMSRLQDISELLATGAGLSESEAEPDGDHNITELPQAVAGRGNMRAQQSAVRLTEIG
                     PRMTLQLIKVQEGVGEGKVMFHSFVSKTEEELQAILEAKEKKLRLKAQRQAQQAQNVQ
                     RKQEQREAHRKKSLEGMKKARVGGSDEEASGIPSRTASLELGEDDDEQEDDDIEYFCQ
                     AVGEAPSEDLFPEAKQKRLAKSPGRKRKRWEMDRGRGRLCDQKFPKTKDKSQGAQARR
                     GPRGASRDGGRGRGRGRPGKRVA"
     exon            52..222
                     /gene="PPAN"
                     /gene_synonym="BXDC3; SSF; SSF-1; SSF1; SSF2"
                     /inference="alignment:Splign:2.1.0"
     exon            223..324
                     /gene="PPAN"
                     /gene_synonym="BXDC3; SSF; SSF-1; SSF1; SSF2"
                     /inference="alignment:Splign:2.1.0"
     exon            325..375
                     /gene="PPAN"
                     /gene_synonym="BXDC3; SSF; SSF-1; SSF1; SSF2"
                     /inference="alignment:Splign:2.1.0"
     exon            376..546
                     /gene="PPAN"
                     /gene_synonym="BXDC3; SSF; SSF-1; SSF1; SSF2"
                     /inference="alignment:Splign:2.1.0"
     exon            547..623
                     /gene="PPAN"
                     /gene_synonym="BXDC3; SSF; SSF-1; SSF1; SSF2"
                     /inference="alignment:Splign:2.1.0"
     exon            624..731
                     /gene="PPAN"
                     /gene_synonym="BXDC3; SSF; SSF-1; SSF1; SSF2"
                     /inference="alignment:Splign:2.1.0"
     exon            732..855
                     /gene="PPAN"
                     /gene_synonym="BXDC3; SSF; SSF-1; SSF1; SSF2"
                     /inference="alignment:Splign:2.1.0"
     exon            856..934
                     /gene="PPAN"
                     /gene_synonym="BXDC3; SSF; SSF-1; SSF1; SSF2"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1064
                     /gene="PPAN"
                     /gene_synonym="BXDC3; SSF; SSF-1; SSF1; SSF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1234
                     /gene="PPAN"
                     /gene_synonym="BXDC3; SSF; SSF-1; SSF1; SSF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..2302
                     /gene="PPAN"
                     /gene_synonym="BXDC3; SSF; SSF-1; SSF1; SSF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1566..1571
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPAN"
                     /gene_synonym="BXDC3; SSF; SSF-1; SSF1; SSF2"
                     /note="hexamer: AGTAAA"
     polyA_site      1584
                     /gene="PPAN"
                     /gene_synonym="BXDC3; SSF; SSF-1; SSF1; SSF2"
                     /note="major polyA site"
     regulatory      2241..2246
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPAN"
                     /gene_synonym="BXDC3; SSF; SSF-1; SSF1; SSF2"
                     /note="hexamer: AATAAA"
     polyA_site      2259
                     /gene="PPAN"
                     /gene_synonym="BXDC3; SSF; SSF-1; SSF1; SSF2"
     polyA_site      2302
                     /gene="PPAN"
                     /gene_synonym="BXDC3; SSF; SSF-1; SSF1; SSF2"
ORIGIN      
        1 ggacgcagga ggcctcgtgg aggacacagc agcatgggac agtcagggag gtcccggcac
       61 cagaagcgcg cccgcgccca ggcgcagctc cgcaacctcg aggcctatgc cgcgaacccg
      121 cactcgttcg tgttcacgcg aggctgcacg ggtcgcaaca tccggcagct cagcctggac
      181 gtgcggcggg tcatggagcc gctcactgcc agccgtctgc aggttcgtaa gaagaactcg
      241 ctgaaggact gcgtggcagt ggctgggccc ctcggggtca cacactttct gatcctgagc
      301 aaaacagaga ccaatgtcta ctttaagctg atgcgcctcc caggaggccc caccttgacc
      361 ttccaggtca agaagtactc gctggtgcgt gatgtggtct cctcactgcg ccggcaccgc
      421 atgcacgagc agcagtttgc ccacccaccc ctcctggtac tcaacagctt tggcccccat
      481 ggtatgcatg tgaagctcat ggccaccatg ttccagaacc tgttcccctc catcaacgtg
      541 cacaaggtga acctgaacac catcaagcgc tgcctcctca tcgactacaa ccccgactcc
      601 caggagctgg acttccgcca ctatagcatc aaagttgttc ctgtgggcgc gagtcgcggg
      661 atgaagaagc tgctccagga gaagttcccc aacatgagcc gcctgcagga catcagcgag
      721 ctgctggcca cgggcgcggg gctgtcggag agcgaggcag agcctgacgg cgaccacaac
      781 atcacagagc tgcctcaggc tgtcgctggc cgtggcaaca tgcgggccca gcagagtgca
      841 gtgcggctca ccgagatcgg cccgcggatg acactgcagc tcatcaaggt ccaggagggc
      901 gtcggggagg gcaaagtgat gttccacagt tttgtgagca agacggagga ggagctgcag
      961 gccatcctgg aagccaagga gaagaagctg cggctgaagg cgcagaggca ggcccagcag
     1021 gcccagaatg tgcagcgcaa gcaggagcag cgggaggccc acagaaagaa gagcctggag
     1081 ggcatgaaga aggcacgggt cgggggtagt gatgaagagg cctctgggat cccttcaagg
     1141 acggcgagcc tggagttggg tgaggacgat gatgaacagg aagatgatga catcgagtat
     1201 ttctgccagg cggtgggcga ggcgcccagt gaggacctgt tccccgaggc caagcagaaa
     1261 cggcttgcca agtctccagg gcggaagcgg aagcggtggg aaatggatcg aggcaggggt
     1321 cgcctttgtg accagaagtt tcccaagacc aaggacaagt cccagggagc ccaggccagg
     1381 cgggggccca gaggggcttc ccgggatggt gggcgaggcc ggggccgggg ccgcccaggg
     1441 aagagagtgg cctgagccca agccgcaccg gagcagcggc tggattgaac gccccagatt
     1501 ggggcccgag atgtggccct cggtttcctt tcataaagga gttgtgtccc cagcccttcc
     1561 actccagtaa agaactgaat tggccagggg tccacgtcag cgtttgggat gggggattct
     1621 ggagccatac aaagcaaccc agagagtcct gggccggcca cacccgagag tccctcccac
     1681 ctggtttctt cctggaagct gggtctctcc cctaccctgc acggggttgg tttcattggt
     1741 ggcagcagca gccatgagtg gcccctcccc ccagtcccac caaagagccg tgcaagcaga
     1801 caggtcacac tttcagcaga tgagcttgaa cctcaggagg gttgtggcac aatgaggaag
     1861 gaaacgtggg tggaaaggca cgctggcctg ctctgctggc tgggccagta actggggatg
     1921 gggctggggc agggcccact aagccactgg tgactggggg aggggctggg gaactgggta
     1981 gcagacacag gctgaggatc ggcacgggag catggcagcc aacgtctcgg gtaaggagaa
     2041 ggcatgttgg ctgtctctgg gggtctgcag attgtcagga ggtgggggta gtgggtattg
     2101 gtaaaacacc taggtctggg gctgggcacg gtggctcacg cctgtaatcc cagcactttg
     2161 ggaggtcgag gggggtggaa cacgaggtca ggggttcgag accaccctga ccaacaagga
     2221 gaaaccccgt ctctactaaa aataaaaaaa ttagctgggc ctggtggcac atgcctgtaa
     2281 tcccagctac tcgggaggct ga
//
