LOCUS       NM_001252657            2119 bp    mRNA    linear   PRI 17-DEC-2024
DEFINITION  Homo sapiens protein phosphatase 2C like domain containing 1
            (PP2D1), transcript variant 1, mRNA.
ACCESSION   NM_001252657
VERSION     NM_001252657.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2119)
  AUTHORS   Robertson,M.J., Kent,K., Tharp,N., Nozawa,K., Dean,L., Mathew,M.,
            Grimm,S.L., Yu,Z., Legare,C., Fujihara,Y., Ikawa,M., Sullivan,R.,
            Coarfa,C., Matzuk,M.M. and Garcia,T.X.
  TITLE     Large-scale discovery of male reproductive tract-specific genes
            through analysis of RNA-seq datasets
  JOURNAL   BMC Biol 18 (1), 103 (2020)
   PUBMED   32814578
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC097635.4.
            
            On May 17, 2019 this sequence version replaced NM_001252657.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and is protein coding.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were inferred from macaque AB168689.1 and chimp AK305631.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.49376.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151119 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389050.5/ ENSP00000373702.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               AC097635.4         153581-153795       c
            216-1282            AC097635.4         142561-143627       c
            1283-2119           AC097635.4         126877-127713       c
FEATURES             Location/Qualifiers
     source          1..2119
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p24.3"
     gene            1..2119
                     /gene="PP2D1"
                     /gene_synonym="C3orf48"
                     /note="protein phosphatase 2C like domain containing 1"
                     /db_xref="GeneID:151649"
                     /db_xref="HGNC:HGNC:28406"
                     /db_xref="MIM:621037"
     exon            1..215
                     /gene="PP2D1"
                     /gene_synonym="C3orf48"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..2085
                     /gene="PP2D1"
                     /gene_synonym="C3orf48"
                     /codon_start=1
                     /product="protein phosphatase 2C-like domain-containing
                     protein 1"
                     /protein_id="NP_001239586.1"
                     /db_xref="CCDS:CCDS58817.1"
                     /db_xref="GeneID:151649"
                     /db_xref="HGNC:HGNC:28406"
                     /db_xref="MIM:621037"
                     /translation="MSTNNALRVFWKSREWNMKTSTFDSDEDILLLPKRKRFRKKKSR
                     PVRHTKRHEEEQVYEQGTTLPCSICKHEIDLTGIFLHKKQHVALATLGFQWMGRKKPQ
                     PSVIAVQRQFMISKLLSSFMFTEKTLQSINNAFELLWKKQIPAYYKIFDNIDRSVIYS
                     QKICHLLIKGVGICEDRNSTWKADMNDKFTVVSNFGNKPNVCFFGLFDGHHGASAAEL
                     TSMELPVLLLHQLSKFDPSYQMTTDEQQIINSFYTVFREEYAAIEDLFSAINKTEAVR
                     CEYEDTHKAFAKAFWRMDRLLGLGRKEVSRVQWSGCSAVTCILEGKPKSPYAHKNWKR
                     KNTHDGLAESSPSQEMPKIISGILHVANTGNVQAVLCRNGKGFCLTKEHTTRNTNERR
                     RILQNGAVISSNEPYGLVEGQVKTTRGLGFHGNLKLKKSIIPAPQTISVPIDDLCQFL
                     IVATNGLWEVLDKEEVTALAMTTFHMYKETYCPIIPNKSPSKGPLLFSTSEPNLTKSQ
                     SNIHVLFQYKSVSEVRVSTTNSKENLSDSNYSKYCIYNPENVETFPAETTHRKPCSEK
                     VTDRPTSVNDVATNEKESDTKSFYEGAAEYVSHELVNAALLAGSRDNITVMVIFLNGS
                     EYQLLT"
     exon            216..1282
                     /gene="PP2D1"
                     /gene_synonym="C3orf48"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..2119
                     /gene="PP2D1"
                     /gene_synonym="C3orf48"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2089..2094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PP2D1"
                     /gene_synonym="C3orf48"
                     /note="hexamer: AATAAA"
     polyA_site      2119
                     /gene="PP2D1"
                     /gene_synonym="C3orf48"
                     /note="major polyA site"
ORIGIN      
        1 attccacaca gggagctcta ccatcaagtg aggggaatgc ccaccatcgc tatcatcacc
       61 atcaccacta cttctgccac agccatcaca ttcacctcta cctccaccat caccatcact
      121 actcaagttg gagaaataga ggccagggga aggggataaa gggagggcaa agaaaggtaa
      181 ttccaaagga acatgagcac caataatgct ttaagagtgt tttggaaatc aagagaatgg
      241 aatatgaaaa catcaacatt tgattcagat gaggatattc tacttttacc caaaagaaaa
      301 cgttttagaa agaaaaagtc aagaccagtg agacacacca aacgccatga agaggagcag
      361 gtctatgagc aagggaccac attaccctgt tccatatgca agcacgaaat tgacctaact
      421 ggtatttttc tccataagaa gcaacatgta gctctggcca cgctgggttt ccaatggatg
      481 ggtagaaaga aaccacagcc ctcagtgatt gctgttcaga gacagttcat gatttctaaa
      541 ctattgtcat cttttatgtt cactgaaaaa accctacaga gcattaataa tgcttttgag
      601 ctgctttgga aaaaacaaat accagcatac tataagattt ttgataacat tgacaggagt
      661 gtcatatatt ctcaaaaaat atgtcatctg ttaattaaag gagtgggcat ttgtgaagac
      721 aggaattcta catggaaagc tgacatgaat gataaattca ctgtagtgag taattttggt
      781 aacaaaccta atgtgtgttt ttttggtttg tttgatggac atcacggtgc ctcagcggca
      841 gagttgacat caatggaact cccagtttta cttctccatc agctttccaa atttgatcct
      901 tcttaccaaa tgacaactga tgagcaacaa ataatcaatt ccttttacac tgtgtttaga
      961 gaagaatacg cagcaataga agacctcttt tctgccataa acaaaacaga agcagtgagg
     1021 tgtgagtatg aggacacaca caaagccttt gcaaaagcat tttggagaat ggataggctt
     1081 ttaggtcttg gaagaaaaga agtgtccagg gttcaatgga gtggctgctc tgcagttact
     1141 tgtatattgg aaggcaaacc taaaagtcct tatgctcata agaattggaa aagaaaaaat
     1201 acccatgatg ggttggcaga gagctcccct tcccaggaga tgccaaaaat aatttctgga
     1261 atattacatg ttgcaaacac tggtaatgtg caagcagtct tatgcagaaa tgggaaaggt
     1321 ttttgcctaa ccaaagaaca tactacacga aacacaaatg aaagaagaag aatacttcag
     1381 aatggagcag tcattagttc aaatgaacca tacgggcttg tagaggggca agtaaaaact
     1441 acacgaggac ttggatttca tggaaatctc aagctgaaaa aatccattat cccagcacct
     1501 caaactattt ctgtccctat agatgaccta tgtcaattcc ttattgtagc tactaatgga
     1561 ctttgggaag ttttggataa agaggaagtt actgccctgg caatgacaac atttcacatg
     1621 tataaagaaa catactgtcc tatcatacct aacaaatcac catccaaagg gcctctgctt
     1681 ttttcaacca gtgaaccaaa ccttactaaa tcacagagta atatccacgt attgtttcag
     1741 tataaatctg tatctgaagt acgtgtgtca actacaaatt ccaaagaaaa tttatccgat
     1801 tcaaactatt ctaaatactg tatttataac cctgagaatg tagaaacatt tccagcagaa
     1861 acgactcatc gtaaaccttg cagtgaaaaa gtaactgaca gaccaactag tgtaaatgat
     1921 gtggcaacaa atgaaaaaga atcagacact aagagtttct atgaaggcgc agctgagtat
     1981 gttagccatg aacttgtaaa tgctgcttta ctggctggct ccagagacaa cattacagtt
     2041 atggtaatat ttctcaatgg aagtgaatat cagcttctga cataaaaaaa taaagttcca
     2101 attatccaga gcaccaaaa
//
