LOCUS       NM_001330422            5615 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens POU class 6 homeobox 1 (POU6F1), transcript variant 3,
            mRNA.
ACCESSION   NM_001330422 XM_017019515
VERSION     NM_001330422.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5615)
  AUTHORS   Wang,J., Jia,Q., Jiang,S., Lu,W. and Ning,H.
  TITLE     POU6F1 promotes ferroptosis by increasing lncRNA-CASC2
            transcription to regulate SOCS2/SLC7A11 signaling in gastric cancer
  JOURNAL   Cell Biol Toxicol 40 (1), 3 (2024)
   PUBMED   38267746
  REMARK    GeneRIF: POU6F1 promotes ferroptosis by increasing lncRNA-CASC2
            transcription to regulate SOCS2/SLC7A11 signaling in gastric
            cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5615)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5615)
  AUTHORS   Karthigeyan,D., Bose,A., Boopathi,R., Rao,V.J., Shima,H.,
            Bharathy,N., Igarashi,K., Taneja,R., Trivedi,A.K. and Kundu,T.K.
  TITLE     Aurora kinase A-mediated phosphorylation of mPOU at a specific site
            drives skeletal muscle differentiation
  JOURNAL   J Biochem 167 (2), 195-201 (2020)
   PUBMED   31665313
  REMARK    GeneRIF: results signify mPOU as a negative regulator of skeletal
            muscle differentiation and strengthen the importance of AurkA in
            skeletal myogenesis
REFERENCE   4  (bases 1 to 5615)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   5  (bases 1 to 5615)
  AUTHORS   Suzuki,N., Yoshioka,N., Uekawa,A., Matsumura,N., Tozawa,A.,
            Koike,J., Konishi,I., Kiguchi,K. and Ishizuka,B.
  TITLE     Transcription factor POU6F1 is important for proliferation of clear
            cell adenocarcinoma of the ovary and is a potential new molecular
            target
  JOURNAL   Int J Gynecol Cancer 20 (2), 212-219 (2010)
   PUBMED   20134265
  REMARK    GeneRIF: POU6F1 siRNA dose-dependently suppressed the proliferation
            of clear cell adenocarcinoma cell lines.
REFERENCE   6  (bases 1 to 5615)
  AUTHORS   Wey,E. and Schafer,B.W.
  TITLE     Identification of novel DNA binding sites recognized by the
            transcription factor mPOU (POU6F1)
  JOURNAL   Biochem Biophys Res Commun 220 (2), 274-279 (1996)
   PUBMED   8645295
REFERENCE   7  (bases 1 to 5615)
  AUTHORS   Abdel-Rahman,B., Fiddler,M., Rappolee,D. and Pergament,E.
  TITLE     Expression of transcription regulating genes in human
            preimplantation embryos
  JOURNAL   Hum Reprod 10 (10), 2787-2792 (1995)
   PUBMED   8567814
REFERENCE   8  (bases 1 to 5615)
  AUTHORS   Wey,E., Lyons,G.E. and Schafer,B.W.
  TITLE     A human POU domain gene, mPOU, is expressed in developing brain and
            specific adult tissues
  JOURNAL   Eur J Biochem 220 (3), 753-762 (1994)
   PUBMED   7908264
REFERENCE   9  (bases 1 to 5615)
  AUTHORS   Messier,H., Brickner,H., Gaikwad,J. and Fotedar,A.
  TITLE     A novel POU domain protein which binds to the T-cell receptor beta
            enhancer
  JOURNAL   Mol Cell Biol 13 (9), 5450-5460 (1993)
   PUBMED   8102789
REFERENCE   10 (bases 1 to 5615)
  AUTHORS   Takeda,J., Seino,S. and Bell,G.I.
  TITLE     Human Oct3 gene family: cDNA sequences, alternative splicing, gene
            organization, chromosomal location, and expression at low levels in
            adult tissues
  JOURNAL   Nucleic Acids Res 20 (17), 4613-4620 (1992)
   PUBMED   1408763
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139768.14.
            
            On Jan 8, 2019 this sequence version replaced NM_001330422.1.
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longer isoform (2).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.146515.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333640.12/ ENSP00000330190.11
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-421               AC139768.14        27893-28313
            422-516             AC139768.14        39072-39166
            517-712             AC139768.14        41588-41783
            713-834             AC139768.14        46088-46209
            835-1060            AC139768.14        47181-47406
            1061-1314           AC139768.14        47933-48186
            1315-1443           AC139768.14        49029-49157
            1444-1647           AC139768.14        49783-49986
            1648-1789           AC139768.14        53485-53626
            1790-1958           AC139768.14        54192-54360
            1959-5615           AC139768.14        55364-59020
FEATURES             Location/Qualifiers
     source          1..5615
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..5615
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /note="POU class 6 homeobox 1"
                     /db_xref="GeneID:5463"
                     /db_xref="HGNC:HGNC:9224"
                     /db_xref="MIM:618043"
     exon            1..421
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /inference="alignment:Splign:2.1.0"
     exon            422..516
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             469..2304
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /note="isoform 2 is encoded by transcript variant 3; POU
                     domain, class 6, transcription factor 1; brain-5; mPOU
                     homeobox protein; brain-specific homeobox/POU domain
                     protein 5"
                     /codon_start=1
                     /product="POU domain, class 6, transcription factor 1
                     isoform 2"
                     /protein_id="NP_001317351.1"
                     /db_xref="CCDS:CCDS81691.1"
                     /db_xref="GeneID:5463"
                     /db_xref="HGNC:HGNC:9224"
                     /db_xref="MIM:618043"
                     /translation="MDPGAGSETSLTVNEQVIVMSGHETIRVLEVGVDAQLPAEEESK
                     GLEGVAAEGSQSGDPAEASQAAGEAGPDNLGSSAEATVKSPPGIPPSPATAIATFSQA
                     PSQPQASQTLTPLAVQAAPQVLTQENLATVLTGVMVPAGAVTQPLLIPISIAGQVAGQ
                     QGLAVWTIPTATVAALPGLTAASPTGGVFKPPLAGLQAAAVLNTALPAPVQAAAPVQA
                     SSTAQPRPPAQPQTLFQTQPLLQTTPAILPQPTAATAAAPTPKPVDTPPQITVQPAGF
                     AFSPGIISAASLGGQTQILGSLTTAPVITSAIPSMPGISSQILTNAQGQVIGTLPWVV
                     NSASVAAPAPAQSLQVQAVTPQLLLNAQGQVIATLASSPLPPPVAVRKPSTPESPAKS
                     EVQPIQPTPTVPQPAVVIASPAPAAKPSASAPIPITCSETPTVSQLVSKPHTPSLDED
                     GINLEEIREFAKNFKIRRLSLGLTQTQVGQALTATEGPAYSQSAICRFEKLDITPKSA
                     QKLKPVLEKWLNEAELRNQEGQQNLMEFVGGEPSKKRKRRTSFTPQAIEALNAYFEKN
                     PLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKNTSKLNVFQIP"
     exon            517..712
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /inference="alignment:Splign:2.1.0"
     exon            713..834
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /inference="alignment:Splign:2.1.0"
     exon            835..1060
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1314
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1443
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1647
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1789
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1958
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..5615
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3350..3355
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /note="hexamer: AATAAA"
     polyA_site      3371
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /note="major polyA site"
     regulatory      5591..5596
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /note="hexamer: AATAAA"
     polyA_site      5615
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
ORIGIN      
        1 gcataaatta tgctcatgac gcagcagcta aaaaaatcca agtagcagaa ggagggaaaa
       61 aaggggggga gggaaaaggg gggggtcgtg gaagggggaa cgaagaaaaa tatatacctg
      121 accgcccccc cacccggctt ccccttcccg cttcccggcc gtcccctctc cgcccggctt
      181 agcctgcgga gcccccttcg gctctgccca gcccaggctg ggggcctggg ggcggcggcg
      241 ggtcccgacc agctcccggg ccgagccgag cccagccaag ccgcactggc ttctttgtct
      301 gcgggcggcg gccgccgtgg ccccggcccc ggccccggcc ccctggcccg ggctgtgaga
      361 tgaatctcta atcggtggcc gccagacacc cgcggcgaag gcggctcggg ctcgggctcc
      421 ggatgtgcta ggtgtgggcc ggcccccacc cgaccctgac aagtgaccat ggatcctgga
      481 gccgggtcag agacatctct gactgtcaat gagcaggtca tcgtgatgtc aggtcatgag
      541 accatccgag tgctggaagt cggagtggat gcccaactcc ctgctgagga agagagcaaa
      601 ggactggagg gtgtggccgc cgagggctcc cagagcggag accctgctga agccagtcaa
      661 gctgctggtg aagctgggcc agacaacctg ggctcctctg cagaggcaac tgtgaagtca
      721 cccccgggga tccctccgag ccctgccact gccattgcca ccttcagcca agccccaagc
      781 cagcctcagg catcgcagac cctgacgcca ctggctgtac aagctgcccc ccaggtcttg
      841 actcaggaaa acttagccac agttctgaca ggagttatgg ttccagcagg ggcagttact
      901 caacctcttc ttatccccat cagtattgca ggtcaagtgg ctggtcagca ggggctggcc
      961 gtgtggacaa ttcctacagc aactgtggct gccctcccag gactgaccgc tgcttctcct
     1021 acggggggag tgttcaagcc acctttagcc ggtctccaag cagctgctgt gctgaacacc
     1081 gctcttccgg caccggtaca agctgccgca ccagtacagg cctcctcgac ggcccaaccc
     1141 cggccaccag cccagcccca gacgctgttc cagacccagc cgctgctgca gaccacacct
     1201 gccatcctcc cgcagcccac tgctgccacc gctgctgccc ctacccccaa gccagtggac
     1261 acccccccac agatcaccgt ccagcctgca ggcttcgcat ttagcccagg aatcatcagt
     1321 gctgcttccc tcgggggaca gacccagatc ctggggtccc tcactacagc tccagtcatt
     1381 accagcgcca ttcccagcat gccagggatc agcagtcaga tcctcaccaa tgctcaggga
     1441 caggttattg gaacccttcc atgggtagtg aactcagcta gtgtggcggc cccagcacca
     1501 gcccaaagcc tgcaggtcca ggccgtgacc ccccagctgt tgttgaacgc ccagggccag
     1561 gtgattgcga ccctggctag cagccccctg cctccacctg tggctgtccg gaagccaagc
     1621 acacctgagt cccctgctaa gagtgaggtg cagcccatcc agcccacacc aaccgtgccc
     1681 cagcctgctg tggtcattgc cagcccagct ccagccgcca agccatctgc ctctgctcct
     1741 atcccaatta cctgctcaga gacccccacc gtcagccagt tggtgtccaa gccacatact
     1801 ccaagtctgg atgaggatgg gatcaactta gaagagatcc gggagtttgc caagaacttt
     1861 aagatccggc ggctctcgct gggccttaca cagacccagg tgggtcaggc tctgactgca
     1921 acggaaggtc cagcctacag ccagtcagcc atctgccggt tcgagaagct agacatcaca
     1981 cccaagagtg cccagaagct aaagccggtg ctggaaaagt ggctaaacga agctgaactg
     2041 cggaaccagg aaggccagca gaacctgatg gagtttgtgg gaggcgagcc ctccaagaaa
     2101 cgcaaacgcc gcacctcctt caccccccag gccatagagg ctctcaatgc ctattttgag
     2161 aagaacccac tgcccacagg ccaggagatc actgaaattg ctaaggagct caactacgac
     2221 cgtgaggtag tgcgggtctg gttctgcaat cggcgccaga cgctcaagaa caccagcaag
     2281 ctgaacgtct ttcagatccc ttagggctca gcccctggcc ctgtgttcta gcactttgtc
     2341 catttcccgt ggcatccggc tgcagccact gccatgacag cacctgtcat tttgccacgt
     2401 gcagctgtgc tcaccccagg tcatcagact ccaccgtgtg catgtgcatc aatgtccctc
     2461 ttttctccca cacatctcac atcatgggga ggccagaggg ggccacacga gagctccagg
     2521 ctctgggctg gtcactccga agaagaggat ttgtgacgtc acttagagaa gcaccttgct
     2581 agcatggttt ctgaagggtg aattctggtg gggaaccaga aactccctgt ctttggggca
     2641 gggctaaagc agctcctaag gaccactggc cattagctct tgcttttgat ggcattctct
     2701 ttccaccttg tcttctcctt tgctcctctg tgttagtgtg gcaggtatga caactcatcc
     2761 agtggaaaca cagcctcaca ctgcccttcc gccccccaca ctttgcctgc aggtgcaccg
     2821 aaaggacctg ggagataaaa ttcaaaaaag tgtgatgtgc tgctcagaag gtcagactcc
     2881 atgtctgcct tgacctcaag gtcagaaggt tcccaaaccc ctggggctgg aacatgggat
     2941 ctcctcttcc acctcttcct ggttcctttg cggggaaaat tgcactaaaa cagaaccttt
     3001 tcttaatcca tgttggaagg aagcaacagt gaactctacc tgttctggag ttctcctggg
     3061 tctgcagaag gttgggaatt tagaaaataa ggctgttctt tcatatttta atttaatctc
     3121 tgtcaatggc catccctccc acaaaaaaac gtgggttaag agaacttgca gactggatat
     3181 gcaagcaaac gggcaactct ggagaaaaat aaggaaagga atgctgactt tctctttctt
     3241 tctcttgtcc ccacacccat tcccaaccca atactggggc cttctcaaaa ggagcaaatt
     3301 aaacaataaa ccagacagca aggccctggg ggaaaggaca acatcctgaa ataaatgatg
     3361 gagcccagga aggtctcttg tggaagttga cttaactcta attttctttg taactttaag
     3421 ccttggatac gggaggagaa atctcatttt gtcgagtctc agaccatgtc tgtgtgtaag
     3481 caatccccac agtgtcctct gagccaagga cacccccaga tcagattgag ttttgcttct
     3541 agacggggta gctatggtac cttgggggtt agctctcatc caagctgtta agtgagtttc
     3601 cagcctcact gtggctggaa agcccctaaa attcagtatg taactccagg aagtcaggag
     3661 agaactgaga tttgcctaga tgaccacagg cttgcggtgt agattatccc taaagggccc
     3721 caagtcacgg gggtcaacca cccctgtctt cagtactctt atccttacag aggctggtct
     3781 ctaacagctg cctccagtgg acctcccatg atccaccctg agggaaggac cgtcagctgg
     3841 ggacacatca ccacctctgt cagtcactgg tgcagagcca cctcctagcc tagcttcctc
     3901 tggtgtcctg tttcctttcc cacttactgt tggtgcctcc caggccctgc agtgccagcg
     3961 tggccaccct cttggtagcc tggccagtaa gaggaggaca gttgtgtgct gaattagcac
     4021 acgcacgtgc agcgcgcaca gacgcgcgca cacacacaca catacacgct ctgctgcatt
     4081 tggacaaacc atgcctgcca gagtgtagca gaggtgagga agcaggtggg cagcttgcct
     4141 gacccagctt ttcaggagag cgtgtctcca acagagagtc tccacactct agttcagggt
     4201 tatcgacctg cctcaatgag atgacagact catttgggag gggtgttgca aacaagtttt
     4261 cagtgagaat agttaagttc cagagcttgt aaaggattca gtgactgaca cttcagtaaa
     4321 ttaggccagg cacattggct tatgcctgta attccaacac tttggaaggc cgaggtgggc
     4381 ggatcatttg aggtctggag ttcgagacca gcctgaccaa catggtgaaa ccccgtctct
     4441 actaaaaata caaaaattag ccaggtgtgg tagtgcacat ctgtaatccc agctacttgg
     4501 gaggtggagg caggagaatt gcttgaaccc tggaggttgc aatgagctga gatcacacta
     4561 cttcactcca gcctgggtga cagagcaaga ctcggtctca aacaaacaaa aacttatggc
     4621 gatgcaggtt ttcatgctca gacgcttgca ttcaggtatg ctttcttttt tgagagagac
     4681 aaatgggtca cagctggcac cctgggaata gcacataatc cagggtgtgt ctgtggtggt
     4741 ggacgtgcag gggaacacca tctgtcctgt gtcatgatgg gaaaacaatc atgaaccact
     4801 ggtctaaatt aggcctggcc atgctttctc agcccctccc tcatttaaat ttgtcttccc
     4861 aaagctgagc taaaactaaa ccatttctcc tctgctggaa tgatggattg gtcattcaga
     4921 ggaacaatac caggggtggg aggtttgcag gctgagttcc ccaggcatgg gggtgcaggg
     4981 tgtccctgag gtttacccaa agcacagctc gctggcctgt gacctctgcc cttcctccca
     5041 cagtgtaaga ccccccagga agcagctggg gcctgaacct ctcacctagg aggtaggttt
     5101 attttatttt ttgttagcat caggctctga aggagttggt atacattttg ttttgaaaac
     5161 atcttctgga cttacaccag agcttagtgt cgtctttact atggaaagag aggagaatgg
     5221 acagaaatgg tttaactgtg tggagttttg tttgttttgt tttaaatgga agaaagacca
     5281 aaactttcct ggtggatcag ctagggcctt tgaccctgca ttaccacggc attttatcca
     5341 ggtgaagtcc agggaaagaa ctcagccaaa tggactaagg aacacacgag tttggaatgc
     5401 gagactctga catttttgtg ttcttggaaa tccaattacc ttcccatgcc cagatttcct
     5461 tcctgcctct tggaccaggc tctggcactg aggttctcac tgttcccaac acagacaaag
     5521 cttcctgagg gctggagggg cagcaagggg agaggagaat ggggaagaag cgcttgatgt
     5581 agttgtgtgg aataaacagt attttttctt ttgta
//
