LOCUS       NM_153216               8381 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens POU domain class 5, transcription factor 2 (POU5F2),
            mRNA.
ACCESSION   NM_153216
VERSION     NM_153216.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8381)
  AUTHORS   Song,X. and Ma,J.
  TITLE     SRRM1 promotes the proliferation, migration, and invasion of
            hepatocellular carcinoma cells by regulating the JAK/STAT signaling
            pathway
  JOURNAL   Tissue Cell 79, 101954 (2022)
   PUBMED   36270072
  REMARK    GeneRIF: SRRM1 promotes the proliferation, migration, and invasion
            of hepatocellular carcinoma cells by regulating the JAK/STAT
            signaling pathway.
REFERENCE   2  (bases 1 to 8381)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 8381)
  AUTHORS   Wey,E., Lyons,G.E. and Schafer,B.W.
  TITLE     A human POU domain gene, mPOU, is expressed in developing brain and
            specific adult tissues
  JOURNAL   Eur J Biochem 220 (3), 753-762 (1994)
   PUBMED   7908264
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK098546.1 and AC108102.2.
            
            On May 17, 2019 this sequence version replaced NM_153216.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK098546.1, BC029532.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000606183.4/ ENSP00000489796.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1292              AK098546.1         4-1295
            1293-8381           AC108102.2         42671-49759
FEATURES             Location/Qualifiers
     source          1..8381
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q15"
     gene            1..8381
                     /gene="POU5F2"
                     /gene_synonym="SPRM-1"
                     /note="POU domain class 5, transcription factor 2"
                     /db_xref="GeneID:134187"
                     /db_xref="HGNC:HGNC:26367"
     exon            1..8381
                     /gene="POU5F2"
                     /gene_synonym="SPRM-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1024
                     /gene="POU5F2"
                     /gene_synonym="SPRM-1"
                     /note="sperm 1 POU domain transcription factor"
                     /codon_start=1
                     /product="POU domain, class 5, transcription factor 2"
                     /protein_id="NP_694948.1"
                     /db_xref="CCDS:CCDS59489.1"
                     /db_xref="GeneID:134187"
                     /db_xref="HGNC:HGNC:26367"
                     /translation="MAGHRPSNHFCPLPGSGGGGPRGPMPLRVDTLTWLSTQAAPGRV
                     MVWPAVRPGICPGPDVWRIPLGPLPHEFRGWIAPCRPRLGASEAGDWLRRPSEGALPG
                     PYIALRSIPKLPPPEDISGILKELQQLAKELRQKRLSLGYSQADVGIAVGALFGKVLS
                     QTTICRFEAQQLSVANMWKLRPLLKKWLKEVEAENLLGLCKMEMILQQSGKWRRASRE
                     RRIGNSLEKFFQRCPKPTPQQISHIAGCLQLQKDVVRVWFYNRSKMGSRPTNDASPRE
                     IVGTAGPPCPGAPVCFHLGLGLPVDIPHYTRLYSAGVAHSSAPATTLGLLRF"
     regulatory      1270..1275
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POU5F2"
                     /gene_synonym="SPRM-1"
                     /note="hexamer: ATTACA"
     polyA_site      1293
                     /gene="POU5F2"
                     /gene_synonym="SPRM-1"
                     /note="major polyA site"
     regulatory      1312..1317
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POU5F2"
                     /gene_synonym="SPRM-1"
                     /note="hexamer: ATTAAA"
     polyA_site      1331
                     /gene="POU5F2"
                     /gene_synonym="SPRM-1"
     regulatory      3737..3742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POU5F2"
                     /gene_synonym="SPRM-1"
                     /note="hexamer: ATTAAA"
     polyA_site      3759
                     /gene="POU5F2"
                     /gene_synonym="SPRM-1"
ORIGIN      
        1 agttcctacc agagccgctg cgggtgccat tccacccatg gccggacaca ggccctcaaa
       61 ccacttctgc ccccttccag gcagtggtgg gggcggcccc agagggccga tgcccctgcg
      121 ggttgacact ctgacctggt tgagcaccca ggcggcccct ggcagggtga tggtctggcc
      181 ggcagtcagg ccagggatct gcccaggccc tgacgtgtgg aggattcccc tgggtcccct
      241 gccacacgaa ttccggggct ggatagcacc ctgcaggccc cgtcttggag ctagtgaggc
      301 aggggactgg ttgcgacgcc cctccgaagg cgccctcccg gggccctaca ttgccctgcg
      361 gagcattccg aagttgccgc cgccagagga catctcgggc atactgaaag agttgcagca
      421 attggccaag gagttgaggc agaagaggtt gagcctaggg tactcgcagg ccgatgtggg
      481 gatcgctgtg ggagctctgt ttgggaaggt gcttagccag acgaccatct gccgcttcga
      541 ggcccagcag ctaagcgtcg ccaacatgtg gaagctgcga ccactgctga aaaagtggct
      601 gaaggaagtg gaagcagaga accttctggg cttatgcaaa atggagatga tcctgcaaca
      661 gtctgggaag tggagacggg caagcagaga gcgacgaatc ggaaacagcc tggagaaatt
      721 cttccagcgg tgccctaagc ccacacccca gcaaatcagc cacattgctg ggtgcctcca
      781 gctgcagaag gatgtggttc gagtttggtt ctataaccgc agcaagatgg gcagtcgacc
      841 aaccaatgat gcttccccac gggagattgt ggggacagcc gggcctcctt gcccaggagc
      901 accagtgtgc tttcacctgg gactggggct cccagtggat atcccccact atacacgtct
      961 ctactctgca ggggtagccc actcctctgc cccagccacc actctgggcc tcctcagatt
     1021 ttagggctga ggggcttgcc cttcacggca cggttggaga ggggagaaga agggaaaacc
     1081 caggaaatgt ccctagggtt catttgaggg cttttagtat taatttctca ttcactgtct
     1141 aaagaagtta aggatacata gtagggaatg ggggtgggaa ttgttcaaga aaaacctggg
     1201 agagaagatg aagtttattg cagttttgtg ttttcccttt gtttttccct agcattggtt
     1261 taaaggtaca ttacagtata tagatggttt cgatattttg ttcctttttt tattaaatat
     1321 tgtgtctgtt attccttgtg gttatcagta aacatagggt ttaaattttt tcataaacac
     1381 aatactaagt gaaaaactca agtcacagaa gactacctta gtatacaatt ttttacttaa
     1441 aatcaagcag aactctgtgt aaacacaaac acaaaatcca ggataatagt tatcttgagg
     1501 gaatgacttg agaatgtgat agggaagaaa cacacagagc ccacctagag cccttgctga
     1561 aacacctgag ctttcttgga agattttttt tttttttttt ttttctgatt taccttttca
     1621 tttctggtgc cccagcttca tgtcagggtc tcagttcctc tccctacttt atgtagtccc
     1681 atgggactat gtcttgtcct gccacagtca ctgtattcta aactcctttg ttactgaggt
     1741 tggcaagctg gacttcagag cttcggtccc agctgtagct tactcctcct gttttcacct
     1801 ctatttggtt ccctgggaat ttcccttact ttctcttgat ctcttataat ggttttgaga
     1861 ggatatttgt aatagtttat ccaaacttcc ctggtggttt ttgccattaa acgtcaaata
     1921 actcttctaa tttcatctct gaaattggtc ttttcagttt tccacttcta ctttggtcaa
     1981 ttttggtcac catatactaa atggaaacca tttagtacct ctgtgttttc aaatctgctg
     2041 tcacacacct gcatgctcta tttattgtcc tagaattcta tcagtatgta ttatatcaga
     2101 gtttatgtct tatttctgga tagtaatctt gtcaatgttt gctttttttg tgatcagtct
     2161 tgcaaatgtt ttatctatag gtattttcaa agtataagct tttttactta ttctacttac
     2221 tacaattttt attccctagt taattaattt ttacttcatt cttcttaatt ttttcctagt
     2281 ttcttctggt ttctttcatt gttctttttt agataatttt tagatgagta cttagtttct
     2341 ttctttcttt cttttttttt ctggtggctg tatagagaat aactcttgtg ggcccaagag
     2401 tgcaaaccag gagcccaata agagacttaa ctctgggccg ggcatggtgg ctcatgcctg
     2461 taatcccagc actttgggag accaaggcag gcagatcaca aggtcaagag atcgagagtt
     2521 aactctgatc ttctgacctc aagtccaggg ataattttac tgtcacacaa gtcaggtgtg
     2581 actaagcttt ttatttaatc ttttcttcat gagactgtag aaactttacc tttgcctatt
     2641 tttgtgtgtg tgataaaata taaaatttgc cattgtaatg attttaagtg taaattcagt
     2701 gacattaatt acattcacaa tgttaggcaa ccatcaccac tatccatttc caacattttt
     2761 ccatcactcc aaacataaac tcttctcatt aagcaataac tccattcccc tatcccctac
     2821 ccctggtaac ctttctgtga atttgccagt tctaagcagt tcatattcat ggaaccatac
     2881 aacatttgac cttttgtatc tggcttattt cacttagcac attttcaagg ttcatctgtg
     2941 ttgtagtgtg tatcagaact tcattccttt tttatgactg aataatattc cattgtatgg
     3001 atatatacca cattttgttt atccattcct ctgatgatgg gcacttagat tgttttcatt
     3061 aatagccaat gggctattgt gaatgatact gctatgaaca tttacatata ataatctatt
     3121 tgtttatctg ttgtttcagt tctcttggat gtatacatag gagtggaatt tctgagtcat
     3181 acagtaattc tatgcttaac tttttgggaa actaccaaac tgttttccat agtgaaggca
     3241 ccattttaca ttcccaccag caatctacaa gagttctagt ttttccatat ccctggcaac
     3301 acttgttatt ttttaaaaaa ttatagccat cttggtagct gttaagtggt gtctcattgt
     3361 ggttttgatt tgtatttctc taatgactaa tgatgttgag catcttttca tatgcttatt
     3421 gtctattttg tatcttcttt aaagaaatgt ctattcaagt cctttgccta tttttaaaac
     3481 tgggttgttt gtcttttctt catagagtct ggatattaag cccttatcag atagatggtt
     3541 tgcaagtatt ttctcccatt ctgtgggttg tccttttact cttttgactg tatcttttga
     3601 tgcagacaga ctttaatttt tattaagtcc agcttatcca ttttttcttt tgttgcttag
     3661 gcttttcatg ttgccaaatg caaagtcatg aagatttgct cctgtgtttt cttctatgaa
     3721 ttttacagtt ttatttatta aatttaggac tttgatccat ttcaagttaa tttttgtata
     3781 cggtatgagg taagtgccca acttcattct tttgcatgtg gatagccagt tttcccagca
     3841 ccatttgttg aggagatgtt ctttctgcat tgaatgatct tagcaccctt gtcaaaaatc
     3901 agttgaccac acatgtgagg gattatttct gggctctcaa ctctcttctg ttggtctata
     3961 tgtctgtctt tatgccagta ccacactgtt ttgactactg tagctttgca gtaagttttg
     4021 aaatggggaa gtgtgagtct tccaattttg ttcttccata tatatatata tggcacgtat
     4081 atatatatgg catatatata catgccatat gtatatatac acacacacac cattgtgggt
     4141 tacttgaaat ttcataggaa ttttaggatc agtttttcca tttctgccca aaacaccatt
     4201 gagattttgt tacagagtgc attgaaccct catattgctt tagggagtgt tgtcatctta
     4261 gcaattttaa gtcttccaat ccatgaacac aggctgtctt tccacttatg tcttctttaa
     4321 tttctttgag cagtgtttta gttttcagtg tacaagcctt tcactttctt aaagttattt
     4381 gtgggcattt tattcttttg gatactactg taaatggaat agtttccttc atttcctttt
     4441 gaaattgttc atcgctaatg gatagaaata caactgattt tcctgtgttg attttgtatc
     4501 ctgcgactta tgcagattta gttctaacca gttttttggt gcattcttta gggttttcta
     4561 catataaatc atatcatctg tgaataaaga tagttttgct tcttcctttc cgatttggat
     4621 accctttctt tttcttactc acttgctctg gcaaaaatgt gtagtactgt gttgtataaa
     4681 agtagcagaa gaggacatcc ttgtcttgtt tttgttctta ggagaaaaac ttttagtctt
     4741 ttcaccattg agtatgacat tagctctggc tttttcatac gtactctaca tgttgaggaa
     4801 gttccttttt tcttaggtta ttgaatgttt tatatgcgag ggtatgggtt tttgacagtt
     4861 tctctggaat aaatgaaaaa tgcttaaggg aaatatgaaa tcctatgact atttcataag
     4921 attatgctaa ctaccagtac cactacttcc ttccccagta ctaccatcac cattgcaccc
     4981 acacctaaga gacctaaact ttttttttcc tccgactcta agggtggtta tttttctgtt
     5041 ttgagggatc tcattctcat gacatctttg tgtaagagta aatgactcac ccggggtgat
     5101 gaaaataagt tttaaaccag atcttccata gtccacaaca tgaagtagcc cagatgtagc
     5161 tcagctttca ggaatgaact tttggtgaag tactttaaaa acaaaagtca agtaaatatt
     5221 aatgctgcac ttacattctt ctaactcttt aaaaagatta cttaattata aacaaattgt
     5281 aacaacttta gttttcagaa cacacctata agctgtattg tttcaggtgg acaatggagg
     5341 tgtatcaaga ttacacatat acacttgtat aagattagct tgagttccca gtttatttac
     5401 tcaagaatat agaatcacat tggaaatatg atggccacaa agcaagtgta aatgaaccgt
     5461 atatatcagc acagcttccc atggtccagc gtccttgatg acaatgccca aaatacggca
     5521 ctggataaaa agtgtggaaa tgaattccac actacagctt ttttatcctt agggctacat
     5581 cagtgctcaa gaaaaactta atgtctgctc ttaatgcttc catttaagag aatgtttgga
     5641 gatattaagc ttcttctggt tcttggacca aactcactac agtgaatcca caacatcatc
     5701 aagcagaaga atctgaatta gtgcctgggt ctctgatccc agcttacaac atcacagtga
     5761 gaccatttcc tccacacaag ctacagggac ccagcttaac aaatgtatgc tttttcttct
     5821 tgtcagtgtc taaaggtaga gcactgagga tccacataag ttagtgaaaa taaagccaaa
     5881 tcctaattgc ttagctttag attctatagg tgactaatca cttgctgttg gattatccca
     5941 ttaaaagtca cacagcacca actccatttc ctccttttcc tagacagccc ttctggaaag
     6001 ccttagaaag gagatgtttc agcagagtca gaccatgttg aatgccagaa taaacaactc
     6061 tgattgtgtt gtgaacataa gagctgtaaa gaggcactga cctcagctgc tccttcagtt
     6121 cttctgcagc ctctacagat gtggagaaat tgtgatgagc tctcaatctc agggaacagc
     6181 tcctagagtc catctcagcc cccgcatagc tgcatcattg acacagctgc cccacctctg
     6241 cttaggcaaa gcctctatgt gtcactaatc agcttcacat aatttaaaag attttctatc
     6301 actagatctc ttgacttgct gtgaaaagag aaaaggctgg accttaggga aaacttcata
     6361 ctgaagtgat ttcagatttt tcagagattt aagatgatat gtagaaactt taatcagaag
     6421 atcccttaaa cagaagaata actaccctta gagttgggag aaaaccaaga ctatattgtt
     6481 aagtagttaa caatgttaaa tgttacagag atcaagtaac ataagaaatc aaccaagata
     6541 cattggccag gtgcggtggc tcatgcctgt aattccagca ctttgggagg ccgaggtgga
     6601 cagatcactt gaggtcagga gttcgagacc agcctggcca acatggtgaa accccgtctc
     6661 tactaaaagt acaaaaatta gccgggcatg gtggtgtgca ccttaatccc agctactcag
     6721 gaggctgagg cagtagaatc gcagcctggg caacaaagtg agactctgtc tcaaaaaaaa
     6781 aaagcaaaag aaaaagaaat ctactaagcc atatcatttc aataactaag atgccattga
     6841 tacctttagt aataatttca gtggcataat tagtaaaggc agatgtcaaa cactccaaag
     6901 tcttcatatt tgcccagatt ttcccctgcc ttaattttaa aaataaattt caactcccga
     6961 ctccaataga tcttcactgt cattctgaaa atgtttcatt atcaaacatt ttggttatct
     7021 tgtatttcct atagacaagg caagtatttt taatctgaag atgctgagcc cctttagagt
     7081 ataagcagaa taatgttttt gtacatatgt gcattttctt taaagatggt tcatagcctt
     7141 catcacatat tcaaagagga ccgtggctct tctttagatc tacagtttca gaatttaaga
     7201 agcaccttcc cttttgccac tttttcaaat gatttctttt gacagtacct atataatagg
     7261 taatttctgg ttttctttga atctatattt tctagatatc accagctcag tgtcatatga
     7321 aggccctgag ttgcatttta cataagtctt gtaagttcag actaaataat gtattgatta
     7381 ttgcctttct tgttcttaca cttttatcaa tccttggcac tttaattaaa atcttatcat
     7441 aaggaacaat ttctcttttt cctagaagtt ttcttattct ctaagaaatc atgaggtgtt
     7501 tggatacctg cccttatttc aaagcatgat ctttttcttg aattagcatc tgtttcgata
     7561 atttaatttt tttgaaagag atatactgta tatccttgtt tattatacca agtctgtctc
     7621 atggggattt gtttttcaga atagccactt ttgtttatgc ctttcttcta gaaatagtct
     7681 tgcctactaa acagtattgg ttttcttggc aaaatctatt caagattaat tcttttcaga
     7741 atgcaaaatg gtgttattta tgtcaaactg tgtttttaaa gtgaaaacta caaaaccatt
     7801 gcaattaaac ctagtggaaa tgtccttgac aaagtgattc taaactgaaa gaataaaact
     7861 taggaagata gttaaggaaa tttcgaaggt aaagatttag gtggccaatt atttaacagt
     7921 gtgacggtgg tggtggttat gggcaaaata acgtaaacaa atatttattt attggaaagt
     7981 gaattggtgc aaccttcatg aaaggctgtt aggtaattca tatggaaatc ttttaaaatg
     8041 tgcatttcca ttggcccatc atttcaactt ttaagaattt ttataagaaa ataattgtgt
     8101 gtagccaggt gcagtggctc actcctgtaa tcccagcact ttgggaggct gaggcgggca
     8161 gatcacaagg tcaagatatc aagaccatcc tggtctacat ggtaaaaacc catctctact
     8221 aaaaatacaa aagttagctg cgtgtggtga tgcatgcctg tagtcccagc tactcaggag
     8281 gctgagacag gagaatggcg tgaacccggg aggcggaggt tgcagtgagc caagatcatg
     8341 cccctggact ccagtctggc aatggagcaa gactccgtct c
//
