LOCUS       NM_001159542            1080 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens POU class 5 homeobox 1B (POU5F1B), mRNA.
ACCESSION   NM_001159542
VERSION     NM_001159542.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1080)
  AUTHORS   Simo-Riudalbas,L., Offner,S., Planet,E., Duc,J., Abrami,L.,
            Dind,S., Coudray,A., Coto-Llerena,M., Ercan,C., Piscuoglio,S.,
            Andersen,C.L., Bramsen,J.B. and Trono,D.
  TITLE     Transposon-activated POU5F1B promotes colorectal cancer growth and
            metastasis
  JOURNAL   Nat Commun 13 (1), 4913 (2022)
   PUBMED   35987910
  REMARK    GeneRIF: Transposon-activated POU5F1B promotes colorectal cancer
            growth and metastasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1080)
  AUTHORS   Tao,H.C., Wang,C., Ma,N., Zhu,X. and Zhou,X.J.
  TITLE     Recurrent Superenhancer of the Oncogene POU5F1B in Colorectal
            Cancers
  JOURNAL   Biomed Res Int 2021, 5405060 (2021)
   PUBMED   34934770
  REMARK    GeneRIF: Recurrent Superenhancer of the Oncogene POU5F1B in
            Colorectal Cancers.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1080)
  AUTHORS   Yi,J., Zhou,L.Y., Yi,Y.Y., Zhu,X., Su,X.Y., Zhao,Q., Lin,J.,
            Qian,J. and Deng,Z.Q.
  TITLE     Low Expression of Pseudogene POU5F1B Affects Diagnosis and
            Prognosis in Acute Myeloid Leukemia (AML)
  JOURNAL   Med Sci Monit 25, 4952-4959 (2019)
   PUBMED   31271156
  REMARK    GeneRIF: POU5F1B was underexpressed in AML compared with controls
            (P<0.001). The receiver operating characteristic (ROC) curve
            revealed that the POU5F1B transcript level was able to
            differentiate AML patients from healthy individuals (AUC=0.682). In
            non-APL AML patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1080)
  AUTHORS   Meng,B., Xing,Y., Li,H., Gao,F. and Liu,Y.C.
  TITLE     Knockdown of Long Noncoding RNA POU5F1B Promotes Radiosensitivity
            in Esophageal Carcinoma
  JOURNAL   Med Sci Monit 25, 1214-1219 (2019)
   PUBMED   30763293
  REMARK    GeneRIF: Radiotherapy contributed to the decline in the expression
            level of POU5F1B in plasma, which was upregulated in ECA109,
            ECA9706, KYSE410, and KYSE510, but not in HEEPIC. The knockdown of
            POU5F1B increased the radiosensitivity of esophageal cancer cell
            lines.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1080)
  AUTHORS   Panagopoulos,I., Moller,E., Collin,A. and Mertens,F.
  TITLE     The POU5F1P1 pseudogene encodes a putative protein similar to
            POU5F1 isoform 1
  JOURNAL   Oncol Rep 20 (5), 1029-1033 (2008)
   PUBMED   18949397
  REMARK    GeneRIF: that a putative POU5F1P1 protein is localized in the
            nucleus, acts as a transcriptional activator and regulates the
            expression in a similar way to the POU5F1 isoform 1
REFERENCE   6  (bases 1 to 1080)
  AUTHORS   Firsova,N.V., Markintantova,Iu.V., Smirnova,Iu.A., Panova,I.G.,
            Sukhikh,G.T., Zinov'eva,R.D. and Mitashov,V.I.
  TITLE     [Identification of the OCT4-pg1 retrogene and NANOG gene expression
            in the human embryonic eye]
  JOURNAL   Izv Akad Nauk Ser Biol (2), 134-138 (2008)
   PUBMED   18946985
REFERENCE   7  (bases 1 to 1080)
  AUTHORS   Suo,G., Han,J., Wang,X., Zhang,J., Zhao,Y., Zhao,Y. and Dai,J.
  TITLE     Oct4 pseudogenes are transcribed in cancers
  JOURNAL   Biochem Biophys Res Commun 337 (4), 1047-1051 (2005)
   PUBMED   16229821
REFERENCE   8  (bases 1 to 1080)
  AUTHORS   Marques,A.C., Dupanloup,I., Vinckenbosch,N., Reymond,A. and
            Kaessmann,H.
  TITLE     Emergence of young human genes after a burst of retroposition in
            primates
  JOURNAL   PLoS Biol 3 (11), e357 (2005)
   PUBMED   16201836
REFERENCE   9  (bases 1 to 1080)
  AUTHORS   Pain,D., Chirn,G.W., Strassel,C. and Kemp,D.M.
  TITLE     Multiple retropseudogenes from pluripotent cell-specific gene
            expression indicates a potential signature for novel gene
            identification
  JOURNAL   J Biol Chem 280 (8), 6265-6268 (2005)
   PUBMED   15640145
REFERENCE   10 (bases 1 to 1080)
  AUTHORS   Takeda,J., Seino,S. and Bell,G.I.
  TITLE     Human Oct3 gene family: cDNA sequences, alternative splicing, gene
            organization, chromosomal location, and expression at low levels in
            adult tissues
  JOURNAL   Nucleic Acids Res 20 (17), 4613-4620 (1992)
   PUBMED   1408763
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC016883.14.
            
            On Aug 6, 2021 this sequence version replaced NM_001159542.2.
            
            Summary: This intronless gene was thought to be a transcribed
            pseudogene of POU class 5 homeobox 1, however, it has been reported
            that this gene can encode a functional protein. The encoded protein
            is nearly the same length as and highly similar to the POU class 5
            homeobox 1 transcription factor, has been shown to be a weak
            transcriptional activator and may play a role in carcinogenesis and
            eye development. [provided by RefSeq, Apr 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF268615.1, AF268618.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000696633.1/ ENSP00000512769.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1080              AC016883.14        100513-101592
FEATURES             Location/Qualifiers
     source          1..1080
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.21"
     gene            1..1080
                     /gene="POU5F1B"
                     /gene_synonym="OCT4-PG1; OCT4PG1; OTF3C; OTF3P1; POU5F1P1;
                     POU5F1P4; POU5FLC20; POU5FLC8"
                     /note="POU class 5 homeobox 1B"
                     /db_xref="GeneID:5462"
                     /db_xref="HGNC:HGNC:9223"
                     /db_xref="MIM:615739"
     CDS             1..1080
                     /gene="POU5F1B"
                     /gene_synonym="OCT4-PG1; OCT4PG1; OTF3C; OTF3P1; POU5F1P1;
                     POU5F1P4; POU5FLC20; POU5FLC8"
                     /note="POU class 5 homeobox 1 pseudogene 1; POU domain,
                     class 5, transcription factor 1 pseudogene 1; POU 5 domain
                     protein; POU domain transcription factor Oct-4; POU domain
                     transcription factor OCT4-pg1; octamer binding protein
                     3_like sequence"
                     /codon_start=1
                     /product="putative POU domain, class 5, transcription
                     factor 1B"
                     /protein_id="NP_001153014.1"
                     /db_xref="CCDS:CCDS55274.1"
                     /db_xref="GeneID:5462"
                     /db_xref="HGNC:HGNC:9223"
                     /db_xref="MIM:615739"
                     /translation="MAGHLASDFAFSPPPGGGGDGPWGAEPGWVDPLTWLSFQGPPGG
                     PGIGPGVGPGSEVWGIPPCPPPYELCGGMAYCGPQVGVGLVPQGGLETSQPESEAGVG
                     VESNSNGASPEPCTVPPGAVKLEKEKLEQNPEKSQDIKALQKELEQFAKLLKQKRITL
                     GYTQADVGLILGVLFGKVFSQKTICRFEALQLSFKNMCKLRPLLQKWVEEADNNENLQ
                     EICKAETLMQARKRKRTSIENRVRGNLENLFLQCPKPTLQISHIAQQLGLEKDVVRVW
                     FCNRRQKGKRSSSDYAQREDFEAAGSPFSGGPVSFPPAPGPHFGTPGYGSPHFTALYS
                     SVPFPEGEVFPPVSVITLGSPMHSN"
     exon            1..1080
                     /gene="POU5F1B"
                     /gene_synonym="OCT4-PG1; OCT4PG1; OTF3C; OTF3P1; POU5F1P1;
                     POU5F1P4; POU5FLC20; POU5FLC8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcgggac acctggcttc ggatttcgcc ttctcgcccc ctccaggcgg tgggggtgat
       61 gggccatggg gggcggagcc gggctgggtt gatcctctga cctggctaag cttccaaggc
      121 cctcctggag ggccaggaat cgggccgggg gttgggccag gctctgaggt gtgggggatt
      181 cccccttgcc ccccgccgta tgagttatgt ggggggatgg cgtactgtgg gcctcaggtt
      241 ggagtggggc tagtgcccca aggcggcttg gagacctctc agcctgagag cgaagcagga
      301 gtcggggtgg agagcaactc caatggggcc tccccggaac cctgcaccgt cccccctggt
      361 gccgtgaagc tggagaagga gaagctagag caaaacccgg agaagtccca ggacatcaaa
      421 gctctgcaga aagaactcga gcaatttgcc aagctcctga agcagaagag gatcaccctg
      481 ggatatacac aggccgatgt ggggctcatc ctgggggttc tatttgggaa ggtgttcagc
      541 caaaagacca tctgccgctt tgaggctctg cagcttagct tcaagaacat gtgtaagctg
      601 cggcccttgc tgcagaagtg ggtggaggaa gctgacaaca atgaaaatct tcaggagata
      661 tgcaaagcag aaaccctcat gcaggcccga aagagaaagc gaaccagtat cgagaaccga
      721 gtgagaggca acctggagaa tttgttcctg cagtgcccga aacccacact gcagatcagc
      781 cacatcgccc agcagcttgg gctcgagaag gatgtggtcc gagtgtggtt ctgtaaccgg
      841 cgccagaagg gcaagcgatc aagcagcgac tatgcacaac gagaggattt tgaggctgct
      901 gggtctcctt tctcaggggg accagtgtcc tttcctccgg ccccagggcc ccattttggt
      961 accccaggct atgggagccc tcacttcact gcactgtact cctcagtccc tttccctgag
     1021 ggggaagtct ttcccccagt ctccgtcatc actctgggct ctcccatgca ttcaaactga
//
