LOCUS       NM_002701               1409 bp    mRNA    linear   PRI 09-JUL-2024
DEFINITION  Homo sapiens POU class 5 homeobox 1 (POU5F1), transcript variant 1,
            mRNA.
ACCESSION   NM_002701
VERSION     NM_002701.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1409)
  AUTHORS   Perez-Moreno,P., Riquelme,I., Bizama,C., Vergara-Gomez,L.,
            Tapia,J.C., Brebi,P., Garcia,P. and Roa,J.C.
  TITLE     LINC00662 Promotes Aggressive Traits by Modulating OCT4 Expression
            through miR-335-5p in Gallbladder Cancer Cells
  JOURNAL   Int J Mol Sci 25 (12), 6740 (2024)
   PUBMED   38928444
  REMARK    GeneRIF: LINC00662 Promotes Aggressive Traits by Modulating OCT4
            Expression through miR-335-5p in Gallbladder Cancer Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1409)
  AUTHORS   Rosner,M. and Hengstschlager,M.
  TITLE     Oct4 controls basement membrane development during human
            embryogenesis
  JOURNAL   Dev Cell 59 (11), 1439-1456 (2024)
   PUBMED   38579716
  REMARK    GeneRIF: Oct4 controls basement membrane development during human
            embryogenesis.
REFERENCE   3  (bases 1 to 1409)
  AUTHORS   Wang,X. and Dai,J.
  TITLE     Concise review: isoforms of OCT4 contribute to the confusing
            diversity in stem cell biology
  JOURNAL   Stem Cells 28 (5), 885-893 (2010)
   PUBMED   20333750
  REMARK    GeneRIF: This review article underscores the importance of
            identifying and discriminating the expression and functions of OCT4
            isoforms in stem cell research.
            Review article
REFERENCE   4  (bases 1 to 1409)
  AUTHORS   Zhang,W., Wang,X., Xiao,Z., Liu,W., Chen,B. and Dai,J.
  TITLE     Mapping of the minimal internal ribosome entry site element in the
            human embryonic stem cell gene OCT4B mRNA
  JOURNAL   Biochem Biophys Res Commun 394 (3), 750-754 (2010)
   PUBMED   20230781
  REMARK    GeneRIF: a 30-nt sequence (nt 201-231), which is sufficient to
            promote internal initiation of translation of OCT4B mRNA in
            embryonic stem cells was mapped.
REFERENCE   5  (bases 1 to 1409)
  AUTHORS   Wang,X., Zhao,Y., Xiao,Z., Chen,B., Wei,Z., Wang,B., Zhang,J.,
            Han,J., Gao,Y., Li,L., Zhao,H., Zhao,W., Lin,H. and Dai,J.
  TITLE     Alternative translation of OCT4 by an internal ribosome entry site
            and its novel function in stress response
  JOURNAL   Stem Cells 27 (6), 1265-1275 (2009)
   PUBMED   19489092
  REMARK    GeneRIF: OCT4 gene, by the regulation of alternative splicing and
            alternative translation initiation, may carry out more crucial
            roles in many biological events.
            GeneRIF: Shows that isoform OCT4B-190 initiates at a non-AUG (CUG)
            translation initiation codon.
REFERENCE   6  (bases 1 to 1409)
  AUTHORS   Atlasi,Y., Mowla,S.J., Ziaee,S.A., Gokhale,P.J. and Andrews,P.W.
  TITLE     OCT4 spliced variants are differentially expressed in human
            pluripotent and nonpluripotent cells
  JOURNAL   Stem Cells 26 (12), 3068-3074 (2008)
   PUBMED   18787205
  REMARK    GeneRIF: OCT4 spliced variants are differentially expressed in
            human pluripotent and nonpluripotent cells
REFERENCE   7  (bases 1 to 1409)
  AUTHORS   Lee,J., Kim,H.K., Rho,J.Y., Han,Y.M. and Kim,J.
  TITLE     The human OCT-4 isoforms differ in their ability to confer
            self-renewal
  JOURNAL   J Biol Chem 281 (44), 33554-33565 (2006)
   PUBMED   16951404
  REMARK    GeneRIF: DNA binding, transactivation, and abilities to confer
            self-renewal of the human OCT-4 isoforms differ
REFERENCE   8  (bases 1 to 1409)
  AUTHORS   Wey,E., Lyons,G.E. and Schafer,B.W.
  TITLE     A human POU domain gene, mPOU, is expressed in developing brain and
            specific adult tissues
  JOURNAL   Eur J Biochem 220 (3), 753-762 (1994)
   PUBMED   7908264
REFERENCE   9  (bases 1 to 1409)
  AUTHORS   Takeda,J., Seino,S. and Bell,G.I.
  TITLE     Human Oct3 gene family: cDNA sequences, alternative splicing, gene
            organization, chromosomal location, and expression at low levels in
            adult tissues
  JOURNAL   Nucleic Acids Res 20 (17), 4613-4620 (1992)
   PUBMED   1408763
REFERENCE   10 (bases 1 to 1409)
  AUTHORS   Schoorlemmer,J. and Kruijer,W.
  TITLE     Octamer-dependent regulation of the kFGF gene in embryonal
            carcinoma and embryonic stem cells
  JOURNAL   Mech Dev 36 (1-2), 75-86 (1991)
   PUBMED   1723621
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD247724.1, BC117435.1,
            DQ486517.1 and AI811039.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002701.5.
            
            Summary: This gene encodes a transcription factor containing a POU
            homeodomain that plays a key role in embryonic development and stem
            cell pluripotency. Aberrant expression of this gene in adult
            tissues is associated with tumorigenesis. This gene can participate
            in a translocation with the Ewing's sarcoma gene on chromosome 21,
            which also leads to tumor formation. Alternative splicing, as well
            as usage of alternative AUG and non-AUG translation initiation
            codons, results in multiple isoforms. One of the AUG start codons
            is polymorphic in human populations. Related pseudogenes have been
            identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq,
            Oct 2013].
            
            Transcript Variant: This variant (1, also known as OCT4A)
            represents the shortest transcript and encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z11898.1, BC069246.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259915.13/ ENSP00000259915.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 CD247724.1         35-42
            9-1197              BC117435.1         1-1189
            1198-1395           DQ486517.1         844-1041
            1396-1409           AI811039.1         11-24               c
FEATURES             Location/Qualifiers
     source          1..1409
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..1409
                     /gene="POU5F1"
                     /gene_synonym="Oct-3; Oct-4; OCT3; Oct3/4; OCT4; OTF-3;
                     OTF3; OTF4"
                     /note="POU class 5 homeobox 1"
                     /db_xref="GeneID:5460"
                     /db_xref="HGNC:HGNC:9221"
                     /db_xref="MIM:164177"
     exon            1..467
                     /gene="POU5F1"
                     /gene_synonym="Oct-3; Oct-4; OCT3; Oct3/4; OCT4; OTF-3;
                     OTF3; OTF4"
                     /inference="alignment:Splign:2.1.0"
     exon            468..588
                     /gene="POU5F1"
                     /gene_synonym="Oct-3; Oct-4; OCT3; Oct3/4; OCT4; OTF-3;
                     OTF3; OTF4"
                     /inference="alignment:Splign:2.1.0"
     exon            589..719
                     /gene="POU5F1"
                     /gene_synonym="Oct-3; Oct-4; OCT3; Oct3/4; OCT4; OTF-3;
                     OTF3; OTF4"
                     /inference="alignment:Splign:2.1.0"
     exon            720..878
                     /gene="POU5F1"
                     /gene_synonym="Oct-3; Oct-4; OCT3; Oct3/4; OCT4; OTF-3;
                     OTF3; OTF4"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1409
                     /gene="POU5F1"
                     /gene_synonym="Oct-3; Oct-4; OCT3; Oct3/4; OCT4; OTF-3;
                     OTF3; OTF4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1372..1377
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POU5F1"
                     /gene_synonym="Oct-3; Oct-4; OCT3; Oct3/4; OCT4; OTF-3;
                     OTF3; OTF4"
                     /note="hexamer: AATAAA"
     polyA_site      1409
                     /gene="POU5F1"
                     /gene_synonym="Oct-3; Oct-4; OCT3; Oct3/4; OCT4; OTF-3;
                     OTF3; OTF4"
                     /note="major polyA site"
ORIGIN      
        1 gagtagtccc ttcgcaagcc ctcatttcac caggcccccg gcttggggcg ccttccttcc
       61 ccatggcggg acacctggct tcggatttcg ccttctcgcc ccctccaggt ggtggaggtg
      121 atgggccagg ggggccggag ccgggctggg ttgatcctcg gacctggcta agcttccaag
      181 gccctcctgg agggccagga atcgggccgg gggttgggcc aggctctgag gtgtggggga
      241 ttcccccatg ccccccgccg tatgagttct gtggggggat ggcgtactgt gggccccagg
      301 ttggagtggg gctagtgccc caaggcggct tggagacctc tcagcctgag ggcgaagcag
      361 gagtcggggt ggagagcaac tccgatgggg cctccccgga gccctgcacc gtcacccctg
      421 gtgccgtgaa gctggagaag gagaagctgg agcaaaaccc ggaggagtcc caggacatca
      481 aagctctgca gaaagaactc gagcaatttg ccaagctcct gaagcagaag aggatcaccc
      541 tgggatatac acaggccgat gtggggctca ccctgggggt tctatttggg aaggtattca
      601 gccaaacgac catctgccgc tttgaggctc tgcagcttag cttcaagaac atgtgtaagc
      661 tgcggccctt gctgcagaag tgggtggagg aagctgacaa caatgaaaat cttcaggaga
      721 tatgcaaagc agaaaccctc gtgcaggccc gaaagagaaa gcgaaccagt atcgagaacc
      781 gagtgagagg caacctggag aatttgttcc tgcagtgccc gaaacccaca ctgcagcaga
      841 tcagccacat cgcccagcag cttgggctcg agaaggatgt ggtccgagtg tggttctgta
      901 accggcgcca gaagggcaag cgatcaagca gcgactatgc acaacgagag gattttgagg
      961 ctgctgggtc tcctttctca gggggaccag tgtcctttcc tctggcccca gggccccatt
     1021 ttggtacccc aggctatggg agccctcact tcactgcact gtactcctcg gtccctttcc
     1081 ctgaggggga agcctttccc cctgtctccg tcaccactct gggctctccc atgcattcaa
     1141 actgaggtgc ctgcccttct aggaatgggg gacaggggga ggggaggagc tagggaaaga
     1201 aaacctggag tttgtgccag ggtttttggg attaagttct tcattcacta aggaaggaat
     1261 tgggaacaca aagggtgggg gcaggggagt ttggggcaac tggttggagg gaaggtgaag
     1321 ttcaatgatg ctcttgattt taatcccaca tcatgtatca cttttttctt aaataaagaa
     1381 gcctgggaca cagtagatag acacactta
//
