LOCUS       NM_004575               3144 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens POU class 4 homeobox 2 (POU4F2), mRNA.
ACCESSION   NM_004575
VERSION     NM_004575.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3144)
  AUTHORS   Lee,J.S., Jeoung,J.W., Oh,S., Kim,D.M., Ahn,J.H., Kim,M.J.,
            Seong,M.W., Park,S.S. and Kim,J.Y.
  TITLE     No association between POU4F1, POU4F2, ISL1 polymorphisms and
            normal-tension glaucoma
  JOURNAL   Ophthalmic Genet 41 (5), 427-431 (2020)
   PUBMED   32597291
  REMARK    GeneRIF: No association between POU4F1, POU4F2, ISL1 polymorphisms
            and normal-tension glaucoma.
REFERENCE   2  (bases 1 to 3144)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3144)
  AUTHORS   Wang,Y., Yu,Y., Ye,R., Zhang,D., Li,Q., An,D., Fang,L., Lin,Y.,
            Hou,Y., Xu,A., Fu,Y., Lu,W., Chen,X., Chen,M., Zhang,M., Jiang,H.,
            Zhang,C., Dong,P., Li,C., Chen,J., Yang,G., Liu,C., Cai,Z., Zhou,F.
            and Wu,S.
  TITLE     An epigenetic biomarker combination of PCDH17 and POU4F2 detects
            bladder cancer accurately by methylation analyses of urine sediment
            DNA in Han Chinese
  JOURNAL   Oncotarget 7 (3), 2754-2764 (2016)
   PUBMED   26700620
  REMARK    GeneRIF: DNA methylation in a combination of POU4F2/PCDH17 has
            yielded the highest sensitivity and specificity of 90.00% and
            93.96% in all the 312 individuals, showing the capability of
            detecting bladder cancer effectively among pathologically varied
            sample groups.
REFERENCE   4  (bases 1 to 3144)
  AUTHORS   Nurminen,V., Neme,A., Ryynanen,J., Heikkinen,S., Seuter,S. and
            Carlberg,C.
  TITLE     The transcriptional regulator BCL6 participates in the secondary
            gene regulatory response to vitamin D
  JOURNAL   Biochim Biophys Acta 1849 (3), 300-308 (2015)
   PUBMED   25482012
  REMARK    GeneRIF: The genes BCL6, NFE2, POU4F2 and ELF4 are primary
            1,25(OH)2D3 targets in THP-1 cells
REFERENCE   5  (bases 1 to 3144)
  AUTHORS   Zhang,L., Wahlin,K., Li,Y., Masuda,T., Yang,Z., Zack,D.J. and
            Esumi,N.
  TITLE     RIT2, a neuron-specific small guanosine triphosphatase, is
            expressed in retinal neuronal cells and its promoter is modulated
            by the POU4 transcription factors
  JOURNAL   Mol Vis 19, 1371-1386 (2013)
   PUBMED   23805044
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3144)
  AUTHORS   Smith,M.D., Dawson,S.J. and Latchman,D.S.
  TITLE     Inhibition of neuronal process outgrowth and neuronal specific gene
            activation by the Brn-3b transcription factor
  JOURNAL   J Biol Chem 272 (2), 1382-1388 (1997)
   PUBMED   8995448
REFERENCE   7  (bases 1 to 3144)
  AUTHORS   Xiang,M., Zhou,L., Macke,J.P., Yoshioka,T., Hendry,S.H., Eddy,R.L.,
            Shows,T.B. and Nathans,J.
  TITLE     The Brn-3 family of POU-domain factors: primary structure, binding
            specificity, and expression in subsets of retinal ganglion cells
            and somatosensory neurons
  JOURNAL   J Neurosci 15 (7 Pt 1), 4762-4785 (1995)
   PUBMED   7623109
REFERENCE   8  (bases 1 to 3144)
  AUTHORS   Bhargava,A.K., Li,Z. and Weissman,S.M.
  TITLE     Differential expression of four members of the POU family of
            proteins in activated and phorbol 12-myristate 13-acetate-treated
            Jurkat T cells
  JOURNAL   Proc Natl Acad Sci U S A 90 (21), 10260-10264 (1993)
   PUBMED   8234287
REFERENCE   9  (bases 1 to 3144)
  AUTHORS   Xiang,M., Zhou,L., Peng,Y.W., Eddy,R.L., Shows,T.B. and Nathans,J.
  TITLE     Brn-3b: a POU domain gene expressed in a subset of retinal ganglion
            cells
  JOURNAL   Neuron 11 (4), 689-701 (1993)
   PUBMED   7691107
REFERENCE   10 (bases 1 to 3144)
  AUTHORS   Ring,C.J. and Latchman,D.S.
  TITLE     The human Brn-3b POU transcription factor shows only limited
            homology to the Brn-3a/RDC-1 factor outside the conserved POU
            domain
  JOURNAL   Nucleic Acids Res 21 (12), 2946 (1993)
   PUBMED   8332509
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB082745.1, BY796838.2,
            U06233.1, X71488.1 and AC093887.3.
            
            On Nov 22, 2018 this sequence version replaced NM_004575.2.
            
            Summary: The protein encoded by this gene is a member of the
            POU-domain transcription factor family and may be involved in
            maintaining visual system neurons in the retina. The level of the
            encoded protein is also elevated in a majority of breast cancers,
            resulting in accelerated tumor growth. [provided by RefSeq, Sep
            2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU439706.1, U06233.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000281321.3/ ENSP00000281321.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-448               DB082745.1         1-448
            449-638             BY796838.2         438-627
            639-741             U06233.1           606-708
            742-793             X71488.1           62-113
            794-2552            U06233.1           761-2519
            2553-3141           U06233.1           2522-3110
            3142-3144           AC093887.3         108509-108511
FEATURES             Location/Qualifiers
     source          1..3144
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.22"
     gene            1..3144
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /note="POU class 4 homeobox 2"
                     /db_xref="GeneID:5458"
                     /db_xref="HGNC:HGNC:9219"
                     /db_xref="MIM:113725"
     exon            1..536
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..1478
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /note="Brn3b POU domain transcription factor; POU domain
                     protein; brain-3B; brain-specific homeobox/POU domain
                     protein 3B"
                     /codon_start=1
                     /product="POU domain, class 4, transcription factor 2"
                     /protein_id="NP_004566.2"
                     /db_xref="CCDS:CCDS34074.1"
                     /db_xref="GeneID:5458"
                     /db_xref="HGNC:HGNC:9219"
                     /db_xref="MIM:113725"
                     /translation="MMMMSLNSKQAFSMPHGGSLHVEPKYSALHSTSPGSSAPIAPSA
                     SSPSSSSNAGGGGGGGGGGGGGGGRSSSSSSSGSSGGGGSEAMRRACLPTPPSNIFGG
                     LDESLLARAEALAAVDIVSQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVP
                     ISHPSALAGTHHHHHHHHHHHHQPHQALEGELLEHLSPGLALGAMAGPDGAVVSTPAH
                     APHMATMNPMHQAALSMAHAHGLPSHMGCMSDVDADPRDLEAFAERFKQRRIKLGVTQ
                     ADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEKSHREKL
                     TKPELFNGAEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVW
                     FCNQRQKQKRMKYSAGI"
     exon            537..3144
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3127..3132
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /note="hexamer: ATTAAA"
     polyA_site      3144
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /note="major polyA site"
ORIGIN      
        1 agtttcgggt gccgaggtct gcagctagcg gcaagcggag tcaggcatcc gttcagactg
       61 acagcagagg cggcgaagga gcgcgtagcc gagatcaggc gtacagagtc cggaggcggc
      121 ggcgggtgag ctcaacttcg cacagccctt cccagctcca gccccggctg gcccggcact
      181 tctcggaggg tcccggcagc cgggaccagt gagtgcctct acggaccagc gccccggcgg
      241 gcgggaagat gatgatgatg tccctgaaca gcaagcaggc gtttagcatg ccgcacggcg
      301 gcagcctgca cgtggagccc aagtactcgg cactgcacag cacctcgccg ggctcctcgg
      361 ctcccatcgc gccctcggcc agctccccca gcagctcgag caacgctggt ggtggcggcg
      421 gcggcggcgg cggcggcggc ggcggcggag gccgaagcag cagctccagc agcagtggca
      481 gcagcggcgg cgggggctcg gaggctatgc ggagagcctg tcttccaacc ccaccgagca
      541 atatattcgg cgggctggat gagagtctgc tggcccgcgc cgaggctctg gcagccgtgg
      601 acatcgtctc ccagagcaag agccaccacc accatccacc ccaccacagc cccttcaaac
      661 cggacgccac ctaccacact atgaatacca tcccgtgcac gtcggccgcc tcttcttcat
      721 cggtgcccat ctcgcaccct tccgcgttgg cgggcacgca ccaccaccac caccatcacc
      781 accaccacca ccaccaaccg caccaggcgc tggagggcga gctgctggag cacctgagtc
      841 ccgggctggc cctgggcgct atggcgggcc ccgacggcgc tgtggtgtcc acgccggctc
      901 acgcgccgca catggccacc atgaacccca tgcaccaagc agcgctcagc atggcccacg
      961 cgcacgggct gccgtcgcac atgggctgca tgagcgacgt ggacgccgac ccgcgggacc
     1021 tggaggcatt cgccgagcgc ttcaagcagc gacgcatcaa gctgggggtg acccaggcag
     1081 atgtgggctc cgcgctggcc aacctcaaga tccccggcgt gggctcgctt agccagagca
     1141 ccatctgcag gttcgagtcc ctcacactgt cccacaataa tatgatcgcg ctcaaaccca
     1201 tcctgcaggc atggctcgag gaggccgaga agtcccaccg cgagaagctc accaagcctg
     1261 aactcttcaa tggcgcggag aagaagcgca agcgcacgtc catcgctgcg ccagagaagc
     1321 gctcgctcga agcctacttt gccattcagc ctcggccctc ctctgaaaag atcgccgcca
     1381 tcgcggagaa gctggacctg aagaaaaacg tggtgcgcgt ctggttctgc aaccagaggc
     1441 agaaacagaa aagaatgaaa tattccgccg gcatttagaa gactcttggc ctctccagag
     1501 acgccccttt cctcgtccgc tcttttctct cctctcttct gcctcttttc acttttggcg
     1561 actagaaaca attccagtaa atgtgaatct cgacaaatcg aggactgaag agggagcgaa
     1621 cgagcgaaca actgagccca agccggtgag aatgtgaaac agtttctcaa aggaaagaat
     1681 aacaaaagat ggtatttgtc tgttgtagca aagttgtccc tttgaacccc acctcggctt
     1741 cttcagagga agtgtggaga tggctgtttg caggaaggca gacgagacag tgtttaaaaa
     1801 gtccacaaga atgatcaagt aagatttgtt tttattctta cagacatcac ccgtgttcaa
     1861 gtttaaaagt acactttgca actatttttc agaaatagaa attgattcag gactaaaact
     1921 ttaaactaga gttgatgctt aatgtgatag agacatctct aaagtatttt gaattttaaa
     1981 aaaagatggc agattttctg catttacact gtatattata tatatatttt tattgtggtt
     2041 cttaccccct tttccttctc tgaagtgtta atgcttaaga aaagagttgc gcctgctgtg
     2101 ttcactgatc ttgaaagcta ttattagatt attgcagaac aaccctctgt aaattattaa
     2161 tttatctctc tagcaactta attttgtgca cattctaatt aattaaactt cttccgtcta
     2221 aaaaaagtgg gggaaatgta tagctagtaa cgttcaaaaa attttgtttg atgagtttac
     2281 cgaattttta cagctttcct cctatactgt gttccttttg acccatttgt atattctcac
     2341 ttgaatgaag attgtttttt tctttgtttt tactggtagt gttctgattt gtgagtcgac
     2401 actcagtaat ggatgtctta atcgtgtaga cctgattcac tgtctgaagt attgtttact
     2461 tcgttacata tttaatgggg attcccacat tgtccccatg acacatgagc gctctcactt
     2521 acccttacac acacacacac acacacacac acctctaaca gaagggaaga agcagttgga
     2581 agcatgaccg atgcaccatt ttctagtttt aggtgcattt gccacttggt gtttgccctt
     2641 cagattttag atttcaccaa ggtatttcag tcttccagtt ttcaattgct ttgttggcta
     2701 catgttaata tttataggaa tacttcagtt tttccttttg gaggtttgtt tgtagaaaaa
     2761 ctaatttgaa ctataagaaa gacagtgcac tgcttgtaaa ttcacattgt ttggaaaaat
     2821 tcttttggaa caaaaaatta ggtacatgat aactggtacc ttatctactg taaatatttc
     2881 attaaaaatg atgcacacat agatatattc ttacaaattt tgctgtattg ctgttctctt
     2941 tgaggctctc caaagtcttg agttctgtat atggcctggt ttcttgtttt tattaataga
     3001 tggtttattt actatggtaa tgtattaatt tatttttggt gttgttcgat tgtctttcat
     3061 tgaagagata attttaatgt tttattggca acgtatgctg ctttttcatt aaaatatgct
     3121 attaaaatta aatggctttt aaaa
//
