LOCUS       NM_005604               4885 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens POU class 3 homeobox 2 (POU3F2), mRNA.
ACCESSION   NM_005604
VERSION     NM_005604.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4885)
  AUTHORS   Choi,W., Choe,M.S., Kim,S.M., Kim,S.J., Lee,J., Lee,Y., Lee,S.M.,
            Dho,S.H., Lee,M.Y. and Kim,L.K.
  TITLE     RFX4 is an intrinsic factor for neuronal differentiation through
            induction of proneural genes POU3F2 and NEUROD1
  JOURNAL   Cell Mol Life Sci 81 (1), 99 (2024)
   PUBMED   38386071
  REMARK    GeneRIF: RFX4 is an intrinsic factor for neuronal differentiation
            through induction of proneural genes POU3F2 and NEUROD1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4885)
  AUTHORS   Kao,Y., Zhu,H., Yang,Y., Shen,W., Song,W., Zhang,R., Liu,Y., Liu,H.
            and Kong,X.
  TITLE     CREB1 Facilitates GABAergic Neural Differentiation of Human
            Mesenchymal Stem Cells through BRN2 for Pain Alleviation and
            Locomotion Recovery after Spinal Cord Injury
  JOURNAL   Cells 13 (1), 67 (2023)
   PUBMED   38201271
  REMARK    GeneRIF: CREB1 Facilitates GABAergic Neural Differentiation of
            Human Mesenchymal Stem Cells through BRN2 for Pain Alleviation and
            Locomotion Recovery after Spinal Cord Injury.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4885)
  AUTHORS   Schonauer,R., Jin,W., Findeisen,C., Valenzuela,I., Devlin,L.A.,
            Murrell,J., Bedoukian,E.C., Poschla,L., Hantmann,E.,
            Riedhammer,K.M., Hoefele,J., Platzer,K., Biemann,R., Campeau,P.M.,
            Munch,J., Heyne,H., Hoffmann,A., Ghosh,A., Sun,W., Dong,H., Noe,F.,
            Wolfrum,C., Woods,E., Parker,M.J., Neatu,R., Le Guyader,G.,
            Bruel,A.L., Perrin,L., Spiewak,H., Missotte,I., Fourgeaud,M.,
            Michaud,V., Lacombe,D., Paolucci,S.A., Buchan,J.G., Glissmeyer,M.,
            Popp,B., Bluher,M., Sayer,J.A. and Halbritter,J.
  CONSRTM   Genomics England Research Consortium
  TITLE     Monoallelic intragenic POU3F2 variants lead to neurodevelopmental
            delay and hyperphagic obesity, confirming the gene's candidacy in
            6q16.1 deletions
  JOURNAL   Am J Hum Genet 110 (6), 998-1007 (2023)
   PUBMED   37207645
  REMARK    GeneRIF: Monoallelic intragenic POU3F2 variants lead to
            neurodevelopmental delay and hyperphagic obesity, confirming the
            gene's candidacy in 6q16.1 deletions.
REFERENCE   4  (bases 1 to 4885)
  AUTHORS   Yao,J. and Wang,L.
  TITLE     Integrin alpha3 Mediates Stemness and Invasion of Glioblastoma by
            Regulating POU3F2
  JOURNAL   Curr Protein Pept Sci 24 (3), 247-256 (2023)
   PUBMED   36843258
  REMARK    GeneRIF: Integrin alpha3 Mediates Stemness and Invasion of
            Glioblastoma by Regulating POU3F2.
REFERENCE   5  (bases 1 to 4885)
  AUTHORS   Eisen,T., Easty,D.J., Bennett,D.C. and Goding,C.R.
  TITLE     The POU domain transcription factor Brn-2: elevated expression in
            malignant melanoma and regulation of melanocyte-specific gene
            expression
  JOURNAL   Oncogene 11 (10), 2157-2164 (1995)
   PUBMED   7478537
REFERENCE   6  (bases 1 to 4885)
  AUTHORS   Atanasoski,S., Toldo,S.S., Malipiero,U., Schreiber,E., Fries,R. and
            Fontana,A.
  TITLE     Isolation of the human genomic brain-2/N-Oct 3 gene (POUF3) and
            assignment to chromosome 6q16
  JOURNAL   Genomics 26 (2), 272-280 (1995)
   PUBMED   7601453
REFERENCE   7  (bases 1 to 4885)
  AUTHORS   Schreiber,E., Tobler,A., Malipiero,U., Schaffner,W. and Fontana,A.
  TITLE     cDNA cloning of human N-Oct3, a nervous-system specific POU domain
            transcription factor binding to the octamer DNA motif
  JOURNAL   Nucleic Acids Res 21 (2), 253-258 (1993)
   PUBMED   8441633
REFERENCE   8  (bases 1 to 4885)
  AUTHORS   Hara,Y., Rovescalli,A.C., Kim,Y. and Nirenberg,M.
  TITLE     Structure and evolution of four POU domain genes expressed in mouse
            brain
  JOURNAL   Proc Natl Acad Sci U S A 89 (8), 3280-3284 (1992)
   PUBMED   1565620
REFERENCE   9  (bases 1 to 4885)
  AUTHORS   Schreiber,E., Harshman,K., Kemler,I., Malipiero,U., Schaffner,W.
            and Fontana,A.
  TITLE     Astrocytes and glioblastoma cells express novel octamer-DNA binding
            proteins distinct from the ubiquitous Oct-1 and B cell type Oct-2
            proteins
  JOURNAL   Nucleic Acids Res 18 (18), 5495-5503 (1990)
   PUBMED   2216722
REFERENCE   10 (bases 1 to 4885)
  AUTHORS   He,X., Treacy,M.N., Simmons,D.M., Ingraham,H.A., Swanson,L.W. and
            Rosenfeld,M.G.
  TITLE     Expression of a large family of POU-domain regulatory genes in
            mammalian brain development
  JOURNAL   Nature 340 (6228), 35-41 (1989)
   PUBMED   2739723
  REMARK    Erratum:[Nature 1989 Aug 24;340(6235):662]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL022395.2, DA491157.1 and
            BC051699.1.
            
            On May 17, 2019 this sequence version replaced NM_005604.3.
            
            Summary: This gene encodes a member of the POU-III class of neural
            transcription factors. The encoded protein is involved in neuronal
            differentiation and enhances the activation of
            corticotropin-releasing hormone regulated genes. Overexpression of
            this protein is associated with an increase in the proliferation of
            melanoma cells. [provided by RefSeq, Mar 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC051699.1, Z11933.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328345.8/ ENSP00000329170.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               AL022395.2         123444-123573       c
            131-161             DA491157.1         1-31
            162-488             BC051699.1         1-327
            489-489             AL022395.2         123085-123085       c
            490-918             BC051699.1         329-757
            919-927             AL022395.2         122647-122655       c
            928-1160            BC051699.1         767-999
            1161-1161           AL022395.2         122413-122413       c
            1162-2109           BC051699.1         1001-1948
            2110-3175           AL022395.2         120399-121464       c
            3176-4217           BC051699.1         3012-4053
            4218-4885           AL022395.2         118689-119356       c
FEATURES             Location/Qualifiers
     source          1..4885
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q16.1"
     gene            1..4885
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /note="POU class 3 homeobox 2"
                     /db_xref="GeneID:5454"
                     /db_xref="HGNC:HGNC:9215"
                     /db_xref="MIM:600494"
     exon            1..4885
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..1632
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /note="brain-2; octamer-binding protein 7; octamer-binding
                     transcription factor 7; brain-specific homeobox/POU domain
                     protein 2; nervous system-specific octamer-binding
                     transcription factor N-Oct-3"
                     /codon_start=1
                     /product="POU domain, class 3, transcription factor 2"
                     /protein_id="NP_005595.2"
                     /db_xref="CCDS:CCDS5040.1"
                     /db_xref="GeneID:5454"
                     /db_xref="HGNC:HGNC:9215"
                     /db_xref="MIM:600494"
                     /translation="MATAASNHYSLLTSSASIVHAEPPGGMQQGAGGYREAQSLVQGD
                     YGALQSNGHPLSHAHQWITALSHGGGGGGGGGGGGGGGGGGGGGDGSPWSTSPLGQPD
                     IKPSVVVQQGGRGDELHGPGALQQQHQQQQQQQQQQQQQQQQQQQQQRPPHLVHHAAN
                     HHPGPGAWRSAAAAAHLPPSMGASNGGLLYSQPSFTVNGMLGAGGQPAGLHHHGLRDA
                     HDEPHHADHHPHPHSHPHQQPPPPPPPQGPPGHPGAHHDPHSDEDTPTSDDLEQFAKQ
                     FKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEE
                     ADSSSGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITSLADSLQ
                     LEKEVVRVWFCNRRQKEKRMTPPGGTLPGAEDVYGGSRDTPPHHGVQTPVQ"
     regulatory      4196..4201
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /note="hexamer: CATAAA"
     polyA_site      4217
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /note="major polyA site"
     regulatory      4369..4374
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /note="hexamer: AATAAA"
     polyA_site      4393
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /note="major polyA site"
     regulatory      4512..4517
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /note="hexamer: ATTAAA"
     polyA_site      4534
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
     regulatory      4867..4872
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /note="hexamer: CATAAA"
     polyA_site      4885
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
ORIGIN      
        1 agagagctgg agagagcagg gagagggggg agcgccgagc tagtcagaga gtgagcgaga
       61 gcgagaagga gggagaggag gagaaagaga gcgagggcgg gcgggaggcg gcggcggcgg
      121 cagcagcagc agtaatagca ggagcagcaa cagaaggcgt cggagcgggc gtcggagctg
      181 cccgctgtgg gagagagagg agacagaaag agcgagcgag gagagggagc ccgaggcgaa
      241 aaagtaactg tcaaatgcgc ggctccttta accggagcgc tcagtccggc tccgagagtc
      301 atggcgaccg cagcgtctaa ccactacagc ctgctcacct ccagcgcctc catcgtgcac
      361 gccgagccgc ccggcggcat gcagcagggc gcggggggct accgcgaagc gcagagcctg
      421 gtgcagggcg actacggcgc tctgcagagc aacggacacc cgctcagcca cgctcaccag
      481 tggatcaccg cgctgtccca cggcggcggc ggcgggggcg gtggcggcgg cggggggggc
      541 gggggcggcg gcgggggcgg cggcgacggc tccccgtggt ccaccagccc cctgggccag
      601 ccggacatca agccctcggt ggtggtgcag cagggcggcc gcggagacga gctgcacggg
      661 ccaggcgccc tgcagcagca gcatcagcag cagcaacagc aacagcagca gcaacagcag
      721 caacagcagc agcagcagca gcaacagcgg ccgccgcatc tggtgcacca cgccgctaac
      781 caccacccgg gacccggggc atggcggagc gcggcggctg cagcgcacct cccaccctcc
      841 atgggagcgt ccaacggcgg cttgctctac tcgcagccca gcttcacggt gaacggcatg
      901 ctgggcgccg gcgggcagcc ggccggtctg caccaccacg gcctgcggga cgcgcacgac
      961 gagccacacc atgccgacca ccacccgcac ccgcactcgc acccacacca gcagccgccg
     1021 cccccgccgc ccccgcaggg tccgcctggc cacccaggcg cgcaccacga cccgcactcg
     1081 gacgaggaca cgccgacctc ggacgacctg gagcagttcg ccaagcagtt caagcagcgg
     1141 cggatcaaac tgggatttac ccaagcggac gtggggctgg ctctgggcac cctgtatggc
     1201 aacgtgttct cgcagaccac catctgcagg tttgaggccc tgcagctgag cttcaagaac
     1261 atgtgcaagc tgaagccttt gttgaacaag tggttggagg aggcggactc gtcctcgggc
     1321 agccccacga gcatagacaa gatcgcagcg caagggcgca agcggaaaaa gcggacctcc
     1381 atcgaggtga gcgtcaaggg ggctctggag agccatttcc tcaaatgccc caagccctcg
     1441 gcccaggaga tcacctccct cgcggacagc ttacagctgg agaaggaggt ggtgagagtt
     1501 tggttttgta acaggagaca gaaagagaaa aggatgaccc ctcccggagg gactctgccg
     1561 ggcgccgagg atgtgtacgg ggggagtagg gacactccac cacaccacgg ggtgcagacg
     1621 cccgtccagt gaactcgagc tgggggaggg gcagagcgcg gggctccccc tccccttcgg
     1681 tccttggccc tttcccggcc ctcttgttcc ctctctaact tctgattgtt cttttatttt
     1741 taattattat ttccccgtcc cttaaaaaga caaaaaaaat aaggcaaaag gaaagcaact
     1801 aagacactgg actatccttt aaaggtagca ggtgtaatga tgtgttttga cctttgcagg
     1861 cgagtaacca ggcaatggag tggagtgtct cctggagaga gtgaggagag tgtgtgatag
     1921 ctagaaagag agagagacag agagatggca agcactgaga taaatacctg gcaaaactaa
     1981 ataaattacc aaaaaggaaa aaaaatccac caaaccatga taaacacaaa atgcagcttc
     2041 ctgatgctta gagttggcac atgctgctgt gtttatttat tgtggattcc catcaggaaa
     2101 gaggaaaaaa tacacatgtt ctttcatata ggcaaaattt aaccacataa atttgcactg
     2161 caagaaaatt gaagtttacg tgaacaaatt catgagcata ttttctcttt ctccccaccg
     2221 ttaatttggg agttgccgtt ttgggggatt ttgttttgct ttgctttatt catcggagag
     2281 agttgaagcc agctcttggc cactctccat ttctaatgtt cttgtgttgc cccttcttcg
     2341 tactgtttgt gaactttggt taccttcaca ttccccttac gagggtgtaa catctatttg
     2401 ttcctcttac caaagcaaaa ggattggctt catacaaaat agacaattct ctgatttcag
     2461 gaaatgtgca tggtctaccc gctttatcga aggcaagaat ccggtttgga atataaaaat
     2521 aagcattggt tgttcttacc agccacaaag taaacttcat tttcaggcag tgtttctggg
     2581 ggaggttatg gagggaagaa aaaagaaaaa tcgatagtga gtgactgatt gcttcatttt
     2641 atcaggcggg cccattgtga aagagctcag gggaaatgtg gaggttaaat atatttccag
     2701 agttgtccag cagaaagaaa gtggcacttt gaagagaact agggaagtac atatcttcag
     2761 atatccctat atagttctct accttcagtt ttagtaacaa ttatgaagaa ttatttgtgc
     2821 tgacagcagc agttaaactt tgtttctcta atagcttttt ttttacataa aaaaagaccc
     2881 aggaacttaa tagtgtatgc ataagactgt gttttttagc acacagatac ccacagcata
     2941 cactgacgat ctccacgcag tagacaggtt ttgtcttcac tagctcattt gtttatcaag
     3001 tcatatttag ggtcccacac cctcttttcc tgtaatttat tgcagaatac accactttga
     3061 cttggacagc tttctgcccc ctctttcact aaggaaggca aatgaagtga aaaaaaaaaa
     3121 tgccattttc aatccttcct ttctcccctt tgttaatagt tttaagtgaa tttttgacct
     3181 tatcttaatg gaaaacggtt aactccaaac acaaaagact ctactggaaa gtgtaggtga
     3241 aaaaacttgt aactgtattg aaaataaata ccattaaact gtgatcagtt aaaatttaaa
     3301 agaaaaatca gcacaaaagg gcgctaaaag ggaaaacact ttttattaat cttaaaagtt
     3361 tgggggtttt tttccagtta ggtattagat aaatttttat tttaaaaaat gaaagtctca
     3421 ctaccataaa attatggttc agcatcagat tagcattgca ctcagtagtc tttaaggttt
     3481 taggaaatat gctttatatt gtcttttcaa acacctgtga ttgtttcatt ttccatgttt
     3541 ttgcaagata aatggtgact tataatgggc atatttattt gcctgtattt catttccccc
     3601 aatgaatgtc acaaggagat gggcacggag ctgcttcggg tgcatcacgc tgctcgttcc
     3661 tgaggtatgg gaactggcct ttagtgaagc tatccagagc agggcaaata gccactggta
     3721 aagggaggaa atgaatttcc agatacttat taccaagtag gtaaggtcag aagctggagt
     3781 tcagagaatg tgtctacagc ttctctgact cttataggtt tactaagatg aaagttacca
     3841 ctgaacctta ccactatgta tatatgttta atatctgtct tttgaaatgc agaaatagtt
     3901 taaatgtttc tttgtctatt tttctttttt tttaatgcta cccagggaaa tattttcata
     3961 tcatttttaa gtggcctgcc tcaatgtata tttatttctt ttgaaacaaa aaggttctgg
     4021 aaactgtttt tctgtagctt taaatgaata ggtgagcaaa atctatatgg gatgtaattt
     4081 ttttgttcag tctcttaaaa aatactttgt tttggtacat ttggttgtgc ttgtggggaa
     4141 aataaaaacg cagagatcct tatatattta tgttaaagta atattttatt atctacataa
     4201 aacagaaatg cacaatacct tcatagtttg ttctaattat tgaaatatct ttattttatt
     4261 tttaaagata gtgccaagtt ttaagggggg aaaaccctag accttaaatt gactgagttg
     4321 agttgtgtgt aaaacacttc ccttccttta tacttcataa agttttggaa taaattttat
     4381 gcatatactg ccagatttga tgttcataac tttcagaggc tttttttttt tttaatggag
     4441 actactggtc taattcactt tactttgcaa aaactatcag tcccaaatct ttcagtcact
     4501 atgcctgtag cattaaattg aaatggtcat tgggtttgag cttcaatttg cttgccattt
     4561 catggtccta caaagagatg tttgtcccct ttaaacatat gcagatatgc ctgcatcttc
     4621 tttccaggtt aactatacct tattcgattg tgctgttttg gagaacatca gtggaactag
     4681 gtggactttg atctctaccc ataggtcctc aaataatttg ggatctacag aaaagcagga
     4741 tttagtagat tattattttt aataatttac aaatatctct taacaaagaa taaccctgat
     4801 agtatactat tgtgagttta ctaaatgatt agaagtagat cctatacatt attcctgttt
     4861 ggtttgcata aaaagatgaa tttta
//
