LOCUS       NM_002699               2965 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens POU class 3 homeobox 1 (POU3F1), mRNA.
ACCESSION   NM_002699
VERSION     NM_002699.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2965)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   2  (bases 1 to 2965)
  AUTHORS   Hashimoto,Y., Tatsumi,S., Takeda,R., Naka,A., Ogane,N., Kameda,Y.,
            Kawachi,K., Shimizu,S., Sakai,M. and Kamoshida,S.
  TITLE     Expression of organic anion-transporting polypeptide 1A2 and
            organic cation transporter 6 as a predictor of pathologic response
            to neoadjuvant chemotherapy in triple negative breast cancer
  JOURNAL   Breast Cancer Res Treat 145 (1), 101-111 (2014)
   PUBMED   24671357
  REMARK    GeneRIF: Combined high OATP1A2/high OCT6 may be a potential
            predictor of response to anthracycline/taxane-based chemotherapy in
            breast cancer
REFERENCE   3  (bases 1 to 2965)
  AUTHORS   Velez Edwards,D.R., Naj,A.C., Monda,K., North,K.E., Neuhouser,M.,
            Magvanjav,O., Kusimo,I., Vitolins,M.Z., Manson,J.E.,
            O'Sullivan,M.J., Rampersaud,E. and Edwards,T.L.
  TITLE     Gene-environment interactions and obesity traits among
            postmenopausal African-American and Hispanic women in the Women's
            Health Initiative SHARe Study
  JOURNAL   Hum Genet 132 (3), 323-336 (2013)
   PUBMED   23192594
REFERENCE   4  (bases 1 to 2965)
  AUTHORS   Fox,C.S., Liu,Y., White,C.C., Feitosa,M., Smith,A.V.,
            Heard-Costa,N., Lohman,K., Johnson,A.D., Foster,M.C.,
            Greenawalt,D.M., Griffin,P., Ding,J., Newman,A.B., Tylavsky,F.,
            Miljkovic,I., Kritchevsky,S.B., Launer,L., Garcia,M.,
            Eiriksdottir,G., Carr,J.J., Gudnason,V., Harris,T.B., Cupples,L.A.
            and Borecki,I.B.
  CONSRTM   GIANT Consortium; MAGIC Consortium; GLGC Consortium
  TITLE     Genome-wide association for abdominal subcutaneous and visceral
            adipose reveals a novel locus for visceral fat in women
  JOURNAL   PLoS Genet 8 (5), e1002695 (2012)
   PUBMED   22589738
REFERENCE   5  (bases 1 to 2965)
  AUTHORS   Sun,J.Z., Yang,X.X., Li,X.H., Xu,W.W., Wang,Y., Zhu,W. and Li,M.
  TITLE     Aberrant CpG island hypermethylation and down-regulation of Oct-6
            mRNA expression in human hepatocellular carcinoma
  JOURNAL   Dig Dis Sci 56 (10), 3072-3077 (2011)
   PUBMED   21448695
  REMARK    GeneRIF: CpG island hypermethylation contributes to down-regulation
            of Oct-6 mRNA expression in hepatocellular carcinoma.
REFERENCE   6  (bases 1 to 2965)
  AUTHORS   Leger,H., Sock,E., Renner,K., Grummt,F. and Wegner,M.
  TITLE     Functional interaction between the POU domain protein Tst-1/Oct-6
            and the high-mobility-group protein HMG-I/Y
  JOURNAL   Mol Cell Biol 15 (7), 3738-3747 (1995)
   PUBMED   7791781
REFERENCE   7  (bases 1 to 2965)
  AUTHORS   Zwilling,S., Konig,H. and Wirth,T.
  TITLE     High mobility group protein 2 functionally interacts with the POU
            domains of octamer transcription factors
  JOURNAL   EMBO J 14 (6), 1198-1208 (1995)
   PUBMED   7720710
REFERENCE   8  (bases 1 to 2965)
  AUTHORS   Faus,I., Hsu,H.J. and Fuchs,E.
  TITLE     Oct-6: a regulator of keratinocyte gene expression in stratified
            squamous epithelia
  JOURNAL   Mol Cell Biol 14 (5), 3263-3275 (1994)
   PUBMED   7909356
REFERENCE   9  (bases 1 to 2965)
  AUTHORS   Suzuki,N., Rohdewohld,H., Neuman,T., Gruss,P. and Scholer,H.R.
  TITLE     Oct-6: a POU transcription factor expressed in embryonal stem cells
            and in the developing brain
  JOURNAL   EMBO J 9 (11), 3723-3732 (1990)
   PUBMED   1976514
REFERENCE   10 (bases 1 to 2965)
  AUTHORS   Monuki,E.S., Kuhn,R., Weinmaster,G., Trapp,B.D. and Lemke,G.
  TITLE     Expression and activity of the POU transcription factor SCIP
  JOURNAL   Science 249 (4974), 1300-1303 (1990)
   PUBMED   1975954
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL139158.11.
            
            On May 17, 2019 this sequence version replaced NM_002699.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: L26494.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373012.5/ ENSP00000362103.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AL139158.11        21211-21225         c
            16-2943             AL139158.11        18283-21210         c
            2944-2965           AL139158.11        18261-18282         c
FEATURES             Location/Qualifiers
     source          1..2965
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..2965
                     /gene="POU3F1"
                     /gene_synonym="OCT6; OTF6; SCIP"
                     /note="POU class 3 homeobox 1"
                     /db_xref="GeneID:5453"
                     /db_xref="HGNC:HGNC:9214"
                     /db_xref="MIM:602479"
     exon            1..2965
                     /gene="POU3F1"
                     /gene_synonym="OCT6; OTF6; SCIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1406
                     /gene="POU3F1"
                     /gene_synonym="OCT6; OTF6; SCIP"
                     /note="octamer-binding transcription factor 6; OTF-6;
                     octamer-binding protein 6; POU domain transcription factor
                     SCIP"
                     /codon_start=1
                     /product="POU domain, class 3, transcription factor 1"
                     /protein_id="NP_002690.3"
                     /db_xref="CCDS:CCDS30679.1"
                     /db_xref="GeneID:5453"
                     /db_xref="HGNC:HGNC:9214"
                     /db_xref="MIM:602479"
                     /translation="MATTAQYLPRGPGGGAGGTGPLMHPDAAAAAAAAAAAERLHAGA
                     AYREVQKLMHHEWLGAGAGHPVGLAHPQWLPTGGGGGGDWAGGPHLEHGKAGGGGTGR
                     ADDGGGGGGFHARLVHQGAAHAGAAWAQGSTAHHLGPAMSPSPGASGGHQPQPLGLYA
                     QAAYPGGGGGGLAGMLAAGGGGAGPGLHHALHEDGHEAQLEPSPPPHLGAHGHAHGHA
                     HAGGLHAAAAHLHPGAGGGGSSVGEHSDEDAPSSDDLEQFAKQFKQRRIKLGFTQADV
                     GLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEETDSSSGSPTNLDKIA
                     AQGRKRKKRTSIEVGVKGALESHFLKCPKPSAHEITGLADSLQLEKEVVRVWFCNRRQ
                     KEKRMTPAAGAGHPPMDDVYAPGELGPGGGGASPPSAPPPPPPAALHHHHHHTLPGSV
                     Q"
     regulatory      2929..2934
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POU3F1"
                     /gene_synonym="OCT6; OTF6; SCIP"
                     /note="hexamer: AGTAAA"
     polyA_site      2965
                     /gene="POU3F1"
                     /gene_synonym="OCT6; OTF6; SCIP"
                     /note="major polyA site"
ORIGIN      
        1 gcagacggag cggagcggcg gcggcggcgc ggcgcagggc gcggggcggc atggccacca
       61 ccgcgcagta cctgccgcgg ggccccggtg gcggagccgg gggcaccggg ccgcttatgc
      121 acccggacgc cgcggcggcg gcggcggcgg cggcggccgc ggagcgattg catgcagggg
      181 ccgcgtaccg cgaagtgcag aagctgatgc accacgagtg gctgggcgcg ggcgcgggcc
      241 accccgtggg cctagcgcac ccccagtggc tacccacggg aggaggcggc ggcggcgatt
      301 gggccggcgg cccgcaccta gaacacggca aggcaggcgg cggcggcacc ggccgagccg
      361 acgacggcgg cggcggcgga ggtttccacg cgcgcctggt gcaccagggg gcggcccacg
      421 cgggcgcggc atgggcgcag ggcagcacag cgcaccactt gggcccggcc atgtcgccct
      481 cgcccggggc cagcgggggc caccagcccc agccgctcgg gctgtacgcg caggcggcct
      541 acccgggggg cggcggcggc ggcctggccg ggatgctggc ggcgggcggt ggcggcgcgg
      601 ggccgggcct gcaccacgcg ctgcacgagg atggccacga ggcgcagctg gagccgtcgc
      661 cgccgccgca tctgggcgcc cacggacacg cacacggaca tgcacacgcg ggcggcctgc
      721 acgcggcggc ggcgcacctg cacccgggcg cgggcggcgg cggctcatcg gtgggcgagc
      781 actcggacga ggatgcgccc agctcggacg acctggagca gttcgccaag cagttcaagc
      841 agcggcgcat caagctgggc tttacgcagg ccgacgtggg gctggcgctg ggcacgctct
      901 acggtaacgt gttctcgcag accaccatct gccgcttcga ggccctgcag ctgagcttca
      961 agaacatgtg caagctcaag ccgctgctca acaagtggct ggaggagacc gactcgtcca
     1021 gcggcagccc caccaacctg gacaagatcg cggcgcaggg ccgcaagcgc aagaagcgca
     1081 cgtccatcga ggtgggggtc aaaggcgcgc tcgagagcca ctttctcaag tgccccaagc
     1141 cctcggcgca cgagatcacc ggcttggcag acagcctgca gctggagaag gaggtggtgc
     1201 gcgtctggtt ctgcaaccgg cggcagaagg agaagcgcat gacccctgcg gccggcgcgg
     1261 gccacccgcc catggacgat gtatacgcgc ctggggagct agggcctggc gggggcggcg
     1321 catcgccacc ctccgcgccc ccaccgcccc cgccggcggc gctgcaccac caccaccacc
     1381 acacactgcc cggctcagtg cagtgacccc gcgggccggg cccccgccgg cgcgctgcag
     1441 ggcgcgggcg cgcagcccgc ccgcgcggcc tggactcttt ttgttcggtt gctttggatt
     1501 ttacaaaaaa aaaaaaaagc ccagaaactt tcgaacaaaa ccaaacaccc ggacgaccct
     1561 ctccggtgag cggcgaagac agcccggtag gctgcgtcgc ccgagccccg ggagagagga
     1621 gcgaagatcc ggaactcgcc aactcacccc gggcatcctg cccgccgcct gctctctgcc
     1681 cccatcccct cgacgacccc cgcccctgcc cccccgggct gttcggggcc ggatcccggc
     1741 agcggcctcc ccaaagcgac aggtaacgca gtgcggggtt agggattccc cgggagagag
     1801 gacgaagcga ggagagttct ccatcccctc tccccgcgtg gactcctgag cctgcgggtc
     1861 cagggtgggg ggctgtcact ttattcgcta cacgcctctt ctctcctata aggatgcgcc
     1921 ccaccccgct ttcccctttc tccgggcttg gttttttacg gtttttattt attcgtggag
     1981 cctctcggct cctggggtcc ttctaactcc gcccgcgccc ttaatttaaa tcgcagtata
     2041 ctgtatttat cggggccccg gaggggaggt cgcgagagcc gcgtctgtgt ataaaagcag
     2101 gaaatagcca aagctttaat ctagcctaat ttatttttcc ccttatattt ccctacccta
     2161 ccctcccccc aaaaaaaagc aaaaaaaaaa aaaaaaaact aacaaaaaaa attcgagtgt
     2221 tcatttttcg tttcgtttca tccgagcccc ggcttggttc ccggccacgc cggaggggtc
     2281 tgcgctccca cacacccaga cgggaagggg cttctgccct gctgcagacc gaccgccgca
     2341 tagcgcggcc cctgctcccc gcggggccct gccctcctgg ccacaccaaa cgaaacttgg
     2401 aaaagttaga gagattgttt tttaaccagc tgtagaaata agccgttccc tgagaaccct
     2461 ccgcctgatt ccctgcagct tccctctgct ccctttccag cccgccggga tgcgggatgc
     2521 caggggaggc cgggagagaa attccccaag tttggggtga ggtgggaacc atgtaaatat
     2581 gtgagatatg tacacactgg cggggagaag aaacattttg tgcttggttt ttatttttgg
     2641 ttttccgggt tacccttcct tcctacccta aaggattttg tacactgact aatccgaaaa
     2701 agatatttta atatgatttc cgaatttctg acccatctct atttattttc tggatgtgtt
     2761 tggagcttcc cccttctccg tttcttcttc tgtttgttaa ggtttgaatt taaattttgt
     2821 tattttattt ttattatttt ttgaaacaat gtttcggtgc attctctttg tatctttatt
     2881 gaaaaaaaaa taatgtagac tgggaagttc cctttatatt tatgttatag taaatatttt
     2941 attactcaca taaacatgta cccca
//
