LOCUS       NM_014352               3068 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens POU class 2 homeobox 3 (POU2F3), transcript variant 1,
            mRNA.
ACCESSION   NM_014352
VERSION     NM_014352.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3068)
  AUTHORS   Duplaquet,L., So,K., Ying,A.W., Pal Choudhuri,S., Li,X., Xu,G.D.,
            Li,Y., Qiu,X., Li,R., Singh,S., Wu,X.S., Hamilton,S., Chien,V.D.,
            Liu,Q., Qi,J., Somerville,T.D.D., Heiling,H.M., Mazzola,E., Lee,Y.,
            Zoller,T., Vakoc,C.R., Doench,J.G., Forrester,W.C., Abrams,T.,
            Long,H.W., Niederst,M.J., Drapkin,B.J., Kadoch,C. and Oser,M.G.
  TITLE     Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes
            a targetable dependency in small cell lung cancer
  JOURNAL   Cancer Cell 42 (8), 1352-1369 (2024)
   PUBMED   39029464
  REMARK    GeneRIF: Mammalian SWI/SNF complex activity regulates POU2F3 and
            constitutes a targetable dependency in small cell lung cancer.
REFERENCE   2  (bases 1 to 3068)
  AUTHORS   Jimbo,N., Ohbayashi,C., Takeda,M., Fujii,T., Mitsui,S.,
            Tsukamoto,R., Tanaka,Y., Itoh,T. and Maniwa,Y.
  TITLE     POU2F3-Expressing Small Cell Lung Carcinoma and Large Cell
            Neuroendocrine Carcinoma Show Morphologic and Phenotypic Overlap
  JOURNAL   Am J Surg Pathol 48 (1), 4-15 (2024)
   PUBMED   37904277
  REMARK    GeneRIF: POU2F3-Expressing Small Cell Lung Carcinoma and Large Cell
            Neuroendocrine Carcinoma Show Morphologic and Phenotypic Overlap.
REFERENCE   3  (bases 1 to 3068)
  AUTHORS   D'Angelo,E., Pastrello,C., Biccari,A., Marangio,A., Sensi,F.,
            Crotti,S., Fassan,M., Jurisica,I., Pucciarelli,S. and Agostini,M.
  TITLE     An integrated multiomics analysis of rectal cancer patients
            identified POU2F3 as a putative druggable target and entinostat as
            a cytotoxic enhancer of 5-fluorouracil
  JOURNAL   Int J Cancer 153 (2), 437-449 (2023)
   PUBMED   36815540
  REMARK    GeneRIF: An integrated multiomics analysis of rectal cancer
            patients identified POU2F3 as a putative druggable target and
            entinostat as a cytotoxic enhancer of 5-fluorouracil.
REFERENCE   4  (bases 1 to 3068)
  AUTHORS   Chen,Y.Q., Gao,L.L., Kong,L.C., Guan,X.H., Yang,H., Li,Y.F.,
            Lv,Z.Y., Zhang,X.C., Liang,H.Y., Chen,H.J., Wu,Y.L., Huang,J. and
            Yang,J.J.
  TITLE     The predictive value of YAP-1 and POU2F3 for the efficacy of
            immuno-chemotherapy in extensive-stage SCLC patients
  JOURNAL   Cancer Treat Res Commun 35, 100684 (2023)
   PUBMED   36716535
  REMARK    GeneRIF: The predictive value of YAP-1 and POU2F3 for the efficacy
            of immuno-chemotherapy in extensive-stage SCLC patients.
REFERENCE   5  (bases 1 to 3068)
  AUTHORS   Zhang,Z., Huettner,P.C., Nguyen,L., Bidder,M., Funk,M.C., Li,J. and
            Rader,J.S.
  TITLE     Aberrant promoter methylation and silencing of the POU2F3 gene in
            cervical cancer
  JOURNAL   Oncogene 25 (39), 5436-5445 (2006)
   PUBMED   16607278
  REMARK    GeneRIF: POU2F3 in cervical cancer cells may be CC-related tumor
            suppressor genes, which are disrupted by both epigenetic and
            genetic mechanisms.
REFERENCE   6  (bases 1 to 3068)
  AUTHORS   Sugihara,T.M., Kudryavtseva,E.I., Kumar,V., Horridge,J.J. and
            Andersen,B.
  TITLE     The POU domain factor Skin-1a represses the keratin 14 promoter
            independent of DNA binding. A possible role for interactions
            between Skn-1a and CREB-binding protein/p300
  JOURNAL   J Biol Chem 276 (35), 33036-33044 (2001)
   PUBMED   11429405
REFERENCE   7  (bases 1 to 3068)
  AUTHORS   Hildesheim,J., Kuhn,U., Yee,C.L., Foster,R.A., Yancey,K.B. and
            Vogel,J.C.
  TITLE     The hSkn-1a POU transcription factor enhances epidermal
            stratification by promoting keratinocyte proliferation
  JOURNAL   J Cell Sci 114 (Pt 10), 1913-1923 (2001)
   PUBMED   11329378
REFERENCE   8  (bases 1 to 3068)
  AUTHORS   Hildesheim,J., Foster,R.A., Chamberlin,M.E. and Vogel,J.C.
  TITLE     Characterization of the regulatory domains of the human
            skn-1a/Epoc-1/Oct-11 POU transcription factor
  JOURNAL   J Biol Chem 274 (37), 26399-26406 (1999)
   PUBMED   10473598
REFERENCE   9  (bases 1 to 3068)
  AUTHORS   Andersen,B., Weinberg,W.C., Rennekampff,O., McEvilly,R.J.,
            Bermingham,J.R. Jr., Hooshmand,F., Vasilyev,V., Hansbrough,J.F.,
            Pittelkow,M.R., Yuspa,S.H. and Rosenfeld,M.G.
  TITLE     Functions of the POU domain genes Skn-1a/i and Tst-1/Oct-6/SCIP in
            epidermal differentiation
  JOURNAL   Genes Dev 11 (14), 1873-1884 (1997)
   PUBMED   9242494
REFERENCE   10 (bases 1 to 3068)
  AUTHORS   Goldsborough,A.S., Healy,L.E., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Willison,K.R. and Ashworth,A.
  TITLE     Cloning, chromosomal localization and expression pattern of the POU
            domain gene Oct-11
  JOURNAL   Nucleic Acids Res 21 (1), 127-134 (1993)
   PUBMED   8441607
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000679.7, AK291993.1,
            BC101649.1 and AP001150.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_014352.3.
            
            Summary: This gene encodes a member of the POU domain family of
            transcription factors. POU domain transcription factors bind to a
            specific octamer DNA motif and regulate cell type-specific
            differentiation pathways. The encoded protein is primarily
            expressed in the epidermis, and plays a critical role in
            keratinocyte proliferation and differentiation. The encoded protein
            is also a candidate tumor suppressor protein, and aberrant promoter
            methylation of this gene may play a role in cervical cancer.
            Alternatively spliced transcript variants encoding multiple
            isoforms have been observed for this gene. [provided by RefSeq, Sep
            2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the shorter isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF133895.1, AF162278.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333, SAMEA2144335
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000543440.7/ ENSP00000441687.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                AP000679.7         127732-127785
            55-119              AK291993.1         1-65
            120-1557            BC101649.1         1-1438
            1558-3068           AP001150.5         88084-89594
FEATURES             Location/Qualifiers
     source          1..3068
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..3068
                     /gene="POU2F3"
                     /gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
                     Skn-1a"
                     /note="POU class 2 homeobox 3"
                     /db_xref="GeneID:25833"
                     /db_xref="HGNC:HGNC:19864"
                     /db_xref="MIM:607394"
     exon            1..232
                     /gene="POU2F3"
                     /gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
                     Skn-1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..1515
                     /gene="POU2F3"
                     /gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
                     Skn-1a"
                     /note="isoform 1 is encoded by transcript variant 1; POU
                     domain, class 2, transcription factor 3; octamer-binding
                     protein 11; transcription factor PLA-1; transcription
                     factor Skn-1; octamer-binding transcription factor 11; POU
                     domain transcription factor OCT11a"
                     /codon_start=1
                     /product="POU domain, class 2, transcription factor 3
                     isoform 1"
                     /protein_id="NP_055167.2"
                     /db_xref="CCDS:CCDS8431.1"
                     /db_xref="GeneID:25833"
                     /db_xref="HGNC:HGNC:19864"
                     /db_xref="MIM:607394"
                     /translation="MVNLESMHTDIKMSGDVADSTDARSTLSQVEPGNDRNGLDFNRQ
                     IKTEDLSDSLQQTLSHRPCHLSQGPAMMSGNQMSGLNASPCQDMASLHPLQQLVLVPG
                     HLQSVSQFLLSQTQPGQQGLQPNLLPFPQQQSGLLLPQTGPGLASQAFGHPGLPGSSL
                     EPHLEASQHLPVPKHLPSSGGADEPSDLEELEKFAKTFKQRRIKLGFTQGDVGLAMGK
                     LYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAESSPSDPSVSTPSSYPSLSE
                     VFGRKRKKRTSIETNIRLTLEKRFQDNPKPSSEEISMIAEQLSMEKEVVRVWFCNRRQ
                     KEKRINCPVATPIKPPVYNSRLVSPSGSLGPLSVPPVHSTMPGTVTSSCSPGNNSRPS
                     SPGSGLHASSPTASQNNSKAAVNSASSFNSSGSWYRWNHSTYLH"
     exon            233..301
                     /gene="POU2F3"
                     /gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
                     Skn-1a"
                     /inference="alignment:Splign:2.1.0"
     exon            302..336
                     /gene="POU2F3"
                     /gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
                     Skn-1a"
                     /inference="alignment:Splign:2.1.0"
     exon            337..462
                     /gene="POU2F3"
                     /gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
                     Skn-1a"
                     /inference="alignment:Splign:2.1.0"
     exon            463..565
                     /gene="POU2F3"
                     /gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
                     Skn-1a"
                     /inference="alignment:Splign:2.1.0"
     exon            566..648
                     /gene="POU2F3"
                     /gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
                     Skn-1a"
                     /inference="alignment:Splign:2.1.0"
     exon            649..831
                     /gene="POU2F3"
                     /gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
                     Skn-1a"
                     /inference="alignment:Splign:2.1.0"
     exon            832..973
                     /gene="POU2F3"
                     /gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
                     Skn-1a"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1110
                     /gene="POU2F3"
                     /gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
                     Skn-1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1272
                     /gene="POU2F3"
                     /gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
                     Skn-1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1339
                     /gene="POU2F3"
                     /gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
                     Skn-1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1475
                     /gene="POU2F3"
                     /gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
                     Skn-1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..3068
                     /gene="POU2F3"
                     /gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
                     Skn-1a"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2454
                     /gene="POU2F3"
                     /gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
                     Skn-1a"
                     /note="major polyA site"
     regulatory      3039..3044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POU2F3"
                     /gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
                     Skn-1a"
                     /note="hexamer: AATAAA"
     polyA_site      3068
                     /gene="POU2F3"
                     /gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
                     Skn-1a"
ORIGIN      
        1 agtgtggcaa tcctggcggc gccgagtgtt gcccgggccg gagcagcgga gcgcgcgaca
       61 gtggcggcga cggctccggc agcggctccc gcggcggcgg cggccgggaa ctggaggaag
      121 gagaccctgg cttcgcaggg gccccggctg gggcagaggc gaggggcctg ggggggcgct
      181 ggctttggcc ccgcctgggg caggatggtg aatctggagt ccatgcacac agatatcaag
      241 atgagtgggg atgtagccga ttccacggat gctcgcagca ctctcagcca ggtggagcca
      301 ggaaatgatc gaaatggcct agatttcaac aggcagatta aaaccgaaga tctcagtgac
      361 tccctgcagc agaccctctc ccatcggcca tgccacctga gtcaaggacc tgccatgatg
      421 tccggaaacc aaatgtctgg gctaaatgcc agcccatgtc aggacatggc ttccctccat
      481 ccgctccagc agcttgtgct ggttcccggc cacttacagt ctgtatccca gttcctgcta
      541 tctcagaccc agcctgggca gcaaggtctg cagccaaatc tcctcccctt tccacagcaa
      601 caaagcggtc tcctcctccc acagactggg ccgggactgg catcccaggc atttgggcac
      661 cctgggctgc caggatcctc tttagaaccc cacctggaag catcccagca tctcccagtg
      721 cccaagcatc tacccagctc tggaggggcc gatgagccca gtgacctcga ggagctggag
      781 aagtttgcca agaccttcaa gcagaggcgc attaagctgg gcttcacaca gggagatgtg
      841 gggctggcga tgggaaagct gtatggcaac gacttcagcc agaccaccat ctcacgattt
      901 gaggccctca acctgagctt caagaacatg tgcaagctca agcccctgct ggagaagtgg
      961 ctgaatgatg cagagtcctc tccgtcagac ccctcagtga gcacgcccag ctcctacccc
     1021 agcctcagtg aagtatttgg taggaagaga aagaaacgga ccagcatcga gaccaacatc
     1081 cgcctgactc tggagaagag gtttcaagat aacccaaaac ccagctcgga ggagatctcc
     1141 atgattgcag agcagttgtc catggagaag gaggtggtga gggtctggtt ctgcaaccga
     1201 cgccaaaagg agaagcgaat caactgccct gtggccacac ccatcaaacc acctgtctac
     1261 aactcccggc tggtatctcc ctcagggtct ctgggccccc tctctgtccc tcctgtccac
     1321 agtaccatgc ctggaacagt aacgtcatcc tgttcccctg ggaacaacag caggccttca
     1381 tctcctggct caggactcca cgccagcagc cccactgcat ctcaaaataa ctccaaagca
     1441 gcagtgaact ccgcctccag ttttaactct tcaggatctt ggtaccgatg gaatcattcc
     1501 acctacctcc actgagacca aaaagtttct cctactccag ctggccctgt attccccctg
     1561 gaaggaaggg aatcatgcct tctatataca gacagattgc cttcagaaga gtggaagaaa
     1621 atctccacta tcaatgaacc cagactcttg tcttcttcaa gagcaagggc ctccggagat
     1681 ccaaactgtg attgaaccaa gtgcagactc ctaatgctct tgaaatacac agcccctcct
     1741 aggagcttac cattttcacc ttccttgcct atgcccttgc cttctagttc caaatatttt
     1801 agccagcttc actgtggcaa tagtctttca gagaaaagac ttcttgctgt tattctccaa
     1861 ctcatccgtg ggcttctggg gacagccatt tggctggggt gccaaacacc agaaggggag
     1921 ataatagttt tgactctgaa cttggccaca acccctgaac tgatcccaaa atctgtgaaa
     1981 agatttgaat ctgatatctc caccaaagcc ttgatgtttt ctctgtacag ctaagttttc
     2041 tgatggaatc ttcatctcac cccattttct ttttaacctc gccccctttt ctacaatcaa
     2101 atccattcat tattgcgccc tccaggtccc ctcctttttg cagaaggtgt aaaagagctg
     2161 cccttggtgg gtgccctggg catgttgcaa cgcctgctgg tgcccttctg tctgtccacg
     2221 tctgcctagg gctcaggagt gcttgttctt tcccttcctc cctgtgtttc tctttatcct
     2281 gtcccctctc ctttctcctg gcagcagaaa aggaagaaca caagagcaaa cacacaacaa
     2341 tgatggtggc aaagtacctg tatatagccc tttcccattt tttgcattat gttcttaact
     2401 ccttaatgtg gaattttcca gcaaaatgtt taactcaggt gtgatttttg aaaatgtctc
     2461 tgtaatattt tatcttcttt aaaaaaaagg gggggaaata ccaaagtgtg aaatactgtg
     2521 ctaccttcca gagttcccac atgggctggg attttttttt ctttttcttt tttttttttt
     2581 tttttgagac agtcttgctc cagcccaggc tggagtgcag tggcatgatc ttggctcact
     2641 gcatgctctg ccacttgggt tcaagcgatt ctcctgcctc agcctctcaa gtagcgggat
     2701 tacaggcgcc caccaccaaa aattagccca gctaattttt gtatttttag tagagatggg
     2761 gtttcaccat gttggtcagg ctggtcttga actcctgacc tcctgatcca cccacctcag
     2821 cgtcccgaag tgctgggatt acaggtgtga gccaccgcgc ctggcctggg ctgggaatct
     2881 ttgttgactt ctttgggaac attatctcta gagtctgctt ttttgtgggc cagtttgtag
     2941 agatgtaaca tgaagccatt ccagaaatgg taacttaaaa aaaaaaagac tacatgtcta
     3001 ggaaactgtt gagattcaaa ggaatctcac tgttcctaaa taaatgtgta tagtgattat
     3061 gaaaagta
//
