LOCUS       NM_001365848           14342 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens POU class 2 homeobox 1 (POU2F1), transcript variant 5,
            mRNA.
ACCESSION   NM_001365848
VERSION     NM_001365848.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 14342)
  AUTHORS   Nazarov,I.B., Zilov,D.S., Gordeev,M.N., Potapenko,E.V.,
            Yeremenko,N. and Tomilin,A.N.
  TITLE     Transcriptional Coactivator BOB1 (OBF1, OCA-B) Modulates the
            Specificity of DNA Recognition by the POU-Domain Factors OCT1 and
            OCT2 in a Monomeric Configuration
  JOURNAL   Biomolecules 14 (1), 123 (2024)
   PUBMED   38254723
  REMARK    GeneRIF: Transcriptional Coactivator BOB1 (OBF1, OCA-B) Modulates
            the Specificity of DNA Recognition by the POU-Domain Factors OCT1
            and OCT2 in a Monomeric Configuration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 14342)
  AUTHORS   Kamhieh-Milz,J., Chen,L., Goettsch,C., Pfefferkorn,A.M.,
            Hofmann,A., Brunssen,C., Muller,G.M., Walther,T., Ashraf,M.I.,
            Moll,G., Morawietz,H., Witowski,J. and Catar,R.
  TITLE     Ang II Promotes ET-1 Production by Regulating NOX2 Activity Through
            Transcription Factor Oct-1
  JOURNAL   Arterioscler Thromb Vasc Biol 43 (8), 1429-1440 (2023)
   PUBMED   37381986
  REMARK    GeneRIF: Ang II Promotes ET-1 Production by Regulating NOX2
            Activity Through Transcription Factor Oct-1.
REFERENCE   3  (bases 1 to 14342)
  AUTHORS   Takasawa,S., Shobatake,R., Itaya-Hironaka,A., Makino,M.,
            Uchiyama,T., Sakuramoto-Tsuchida,S., Takeda,Y., Ota,H. and
            Yamauchi,A.
  TITLE     Upregulation of IL-8, osteonectin, and myonectin mRNAs by
            intermittent hypoxia via OCT1- and NRF2-mediated mechanisms in
            skeletal muscle cells
  JOURNAL   J Cell Mol Med 26 (24), 6019-6031 (2022)
   PUBMED   36457269
  REMARK    GeneRIF: Upregulation of IL-8, osteonectin, and myonectin mRNAs by
            intermittent hypoxia via OCT1- and NRF2-mediated mechanisms in
            skeletal muscle cells.
REFERENCE   4  (bases 1 to 14342)
  AUTHORS   Wang,Y., Tan,K., Hu,W., Hou,Y. and Yang,G.
  TITLE     LncRNA AC026401.3 interacts with OCT1 to intensify sorafenib and
            lenvatinib resistance by activating E2F2 signaling in
            hepatocellular carcinoma
  JOURNAL   Exp Cell Res 420 (1), 113335 (2022)
   PUBMED   36084669
  REMARK    GeneRIF: LncRNA AC026401.3 interacts with OCT1 to intensify
            sorafenib and lenvatinib resistance by activating E2F2 signaling in
            hepatocellular carcinoma.
REFERENCE   5  (bases 1 to 14342)
  AUTHORS   Doetsch,D.A., Ansari,S., Jensen,O., Gebauer,L., Ducker,C.,
            Brockmoller,J. and Sachkova,A.
  TITLE     Substrates of the Human Brain Proton-Organic Cation Antiporter and
            Comparison with Organic Cation Transporter 1 Activities
  JOURNAL   Int J Mol Sci 23 (15), 8430 (2022)
   PUBMED   35955563
  REMARK    GeneRIF: Substrates of the Human Brain Proton-Organic Cation
            Antiporter and Comparison with Organic Cation Transporter 1
            Activities.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 14342)
  AUTHORS   Nakshatri,H., Nakshatri,P. and Currie,R.A.
  TITLE     Interaction of Oct-1 with TFIIB. Implications for a novel response
            elicited through the proximal octamer site of the lipoprotein
            lipase promoter
  JOURNAL   J Biol Chem 270 (33), 19613-19623 (1995)
   PUBMED   7642649
REFERENCE   7  (bases 1 to 14342)
  AUTHORS   Cox,M., van Tilborg,P.J., de Laat,W., Boelens,R., van Leeuwen,H.C.,
            van der Vliet,P.C. and Kaptein,R.
  TITLE     Solution structure of the Oct-1 POU homeodomain determined by NMR
            and restrained molecular dynamics
  JOURNAL   J Biomol NMR 6 (1), 23-32 (1995)
   PUBMED   7663141
REFERENCE   8  (bases 1 to 14342)
  AUTHORS   Roberts,S.B., Segil,N. and Heintz,N.
  TITLE     Differential phosphorylation of the transcription factor Oct1
            during the cell cycle
  JOURNAL   Science 253 (5023), 1022-1026 (1991)
   PUBMED   1887216
REFERENCE   9  (bases 1 to 14342)
  AUTHORS   Hsieh,C.L., Sturm,R., Herr,W. and Francke,U.
  TITLE     The gene for the ubiquitous octamer-binding protein Oct-1 is on
            human chromosome 1, region cen-q32, and near Ly-22 and Ltw-4 on
            mouse chromosome 1
  JOURNAL   Genomics 6 (4), 666-672 (1990)
   PUBMED   2341156
REFERENCE   10 (bases 1 to 14342)
  AUTHORS   Sturm,R.A., Das,G. and Herr,W.
  TITLE     The ubiquitous octamer-binding protein Oct-1 contains a POU domain
            with a homeo box subdomain
  JOURNAL   Genes Dev 2 (12A), 1582-1599 (1988)
   PUBMED   2905684
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL451050.8, AK091438.1, AL136984.20 and AL359962.15.
            
            Summary: The OCT1 transcription factor was among the first
            identified members of the POU transcription factor family
            (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of
            this family contain the POU domain, a 160-amino acid region
            necessary for DNA binding to the octameric sequence
            ATGCAAAT.[supplied by OMIM, Jul 2010].
            
            Transcript Variant: This variant (5), as well as variant 6, encodes
            isoform 4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK091438.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AL451050.8         90765-90774
            11-215              AK091438.1         2-206
            216-216             AL451050.8         111428-111428
            217-1694            AK091438.1         208-1685
            1695-1695           AL136984.20        147517-147517
            1696-2883           AK091438.1         1687-2874
            2884-7160           AL136984.20        165351-169627
            7161-14342          AL359962.15        2001-9182
FEATURES             Location/Qualifiers
     source          1..14342
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.2"
     gene            1..14342
                     /gene="POU2F1"
                     /gene_synonym="oct-1B; OCT1; Oct1Z; OTF1"
                     /note="POU class 2 homeobox 1"
                     /db_xref="GeneID:5451"
                     /db_xref="HGNC:HGNC:9212"
                     /db_xref="MIM:164175"
     exon            1..74
                     /gene="POU2F1"
                     /gene_synonym="oct-1B; OCT1; Oct1Z; OTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            75..278
                     /gene="POU2F1"
                     /gene_synonym="oct-1B; OCT1; Oct1Z; OTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            279..344
                     /gene="POU2F1"
                     /gene_synonym="oct-1B; OCT1; Oct1Z; OTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            345..633
                     /gene="POU2F1"
                     /gene_synonym="oct-1B; OCT1; Oct1Z; OTF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             582..2807
                     /gene="POU2F1"
                     /gene_synonym="oct-1B; OCT1; Oct1Z; OTF1"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 5; Octamer-binding transcription factor-1; POU
                     domain, class 2, transcription factor 1; NF-A1; OTF-1;
                     oct-1; octamer-binding protein 1; octamer-binding
                     transcription factor 1"
                     /codon_start=1
                     /product="POU domain, class 2, transcription factor 1
                     isoform 4 precursor"
                     /protein_id="NP_001352777.1"
                     /db_xref="GeneID:5451"
                     /db_xref="HGNC:HGNC:9212"
                     /db_xref="MIM:164175"
                     /translation="MKTRMKIFVMIHFHLMNSTQTNGLDFQKQPVPVGGAISTAQAQA
                     FLGHLHQVQLAGTSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLML
                     AGGQITGLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMT
                     QIPLSQPIQIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQ
                     AQNLLTQLPQQSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPS
                     LEEPSDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSF
                     KNMCKLKPLLEKWLNDAENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSIETNIRVAL
                     EKSFLENQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKA
                     IFPSPTSLVATTPSLVTSSAATTLTVSPVLPLTSAAVTNLSVTGTSDTTSNNTATVIS
                     TAPPASSAVTSPSLSPSPSASASTSEASSASETSTTQTTSTPLSSPLGTSQVMVTASG
                     LQTAAAAALQGAAQLPANASLAAMAAAAGLNPSLMAPSQFAAGGALLSLNPGTLSGAL
                     SPALMSNSTLATIQALASGGSLPITSLDATGNLVFANAGGAPNIVTAPLFLNPQNLSL
                     LTSNPVSLVSAAAASAGNSAPVASLHATSTSAESIQNSLFTVASASGAASTTTTASKA
                     Q"
     exon            634..734
                     /gene="POU2F1"
                     /gene_synonym="oct-1B; OCT1; Oct1Z; OTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            735..788
                     /gene="POU2F1"
                     /gene_synonym="oct-1B; OCT1; Oct1Z; OTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            789..908
                     /gene="POU2F1"
                     /gene_synonym="oct-1B; OCT1; Oct1Z; OTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1097
                     /gene="POU2F1"
                     /gene_synonym="oct-1B; OCT1; Oct1Z; OTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1224
                     /gene="POU2F1"
                     /gene_synonym="oct-1B; OCT1; Oct1Z; OTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1319
                     /gene="POU2F1"
                     /gene_synonym="oct-1B; OCT1; Oct1Z; OTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1493
                     /gene="POU2F1"
                     /gene_synonym="oct-1B; OCT1; Oct1Z; OTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1635
                     /gene="POU2F1"
                     /gene_synonym="oct-1B; OCT1; Oct1Z; OTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1775
                     /gene="POU2F1"
                     /gene_synonym="oct-1B; OCT1; Oct1Z; OTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1955
                     /gene="POU2F1"
                     /gene_synonym="oct-1B; OCT1; Oct1Z; OTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2061
                     /gene="POU2F1"
                     /gene_synonym="oct-1B; OCT1; Oct1Z; OTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2407
                     /gene="POU2F1"
                     /gene_synonym="oct-1B; OCT1; Oct1Z; OTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2408..2496
                     /gene="POU2F1"
                     /gene_synonym="oct-1B; OCT1; Oct1Z; OTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..14342
                     /gene="POU2F1"
                     /gene_synonym="oct-1B; OCT1; Oct1Z; OTF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      13410..13415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POU2F1"
                     /gene_synonym="oct-1B; OCT1; Oct1Z; OTF1"
                     /note="hexamer: AATAAA"
     polyA_site      13431
                     /gene="POU2F1"
                     /gene_synonym="oct-1B; OCT1; Oct1Z; OTF1"
                     /note="major polyA site"
     regulatory      14312..14317
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POU2F1"
                     /gene_synonym="oct-1B; OCT1; Oct1Z; OTF1"
                     /note="hexamer: ATTAAA"
     polyA_site      14337
                     /gene="POU2F1"
                     /gene_synonym="oct-1B; OCT1; Oct1Z; OTF1"
                     /note="major polyA site"
ORIGIN      
        1 taaaatattc aaaatggcgg acggaggagc agcgagtcaa gatgagagtt cagccgcggc
       61 ggcagcagca gcagctacta ctgggctgta aacagtgatg ccagcaaaat gttacttcag
      121 ctgatgaagt gatgctgttt cgagaatttg aaagcaattt ttcagtggat aaagaagttg
      181 acagcacgat ttgttggatg tgatgaagga ttaatgagca tacaccttca cttgtattag
      241 cttaagatgg aatggttctg ggcaatataa aataacagac tcaagaatga acaatccgtc
      301 agaaaccagt aaaccatcta tggagagtgg agatggcaac acagcatgga cccttttatg
      361 atatgggcac tgaaactaaa gcacatggtg gaagaaggat tggtagcata tagaaacatt
      421 tttagacaaa tgaaaaagca aaaaagtcag aaattacagt gtatttccat aaagttacac
      481 caagtgtgcc tgcctctcct gcctcccctt ccagcttttt gtcttctgcc atttctgagt
      541 cagcaagacc cctcctgttc ctccttctca gcctactcag catgaagaca aggatgaaga
      601 tctttgtgat gatccacttc cacttaatga atagcacaca aaccaatggt ctggactttc
      661 agaagcagcc tgtgcctgta ggaggagcaa tctcaacagc ccaggcgcag gctttccttg
      721 gacatctcca tcaggtccaa ctcgctggaa caagtttaca ggctgctgct cagtctttaa
      781 atgtacagtc taaatctaat gaagaatcgg gggattcgca gcagccaagc cagccttccc
      841 agcagccttc agtgcaggca gccattcccc agacccagct tatgctagct ggaggacaga
      901 taactgggct tactttgacg cctgcccagc aacagttact actccagcag gcacaggcac
      961 aggcacagct gctggctgct gcagtgcagc agcactccgc cagccagcag cacagtgctg
     1021 ctggagccac catctccgcc tctgctgcca cgcccatgac gcagatcccc ctgtctcagc
     1081 ccatacagat cgcacaggat cttcaacaac tgcaacagct tcaacagcag aatctcaacc
     1141 tgcaacagtt tgtgttggtg catccaacca ccaatttgca gccagcgcag tttatcatct
     1201 cacagacgcc ccagggccag cagggtctcc tgcaagcgca aaatcttcta acgcaactac
     1261 ctcagcaaag ccaagccaac ctcctacagt cgcagccaag catcaccctc acctcccagc
     1321 cagcaacccc aacacgcaca atagcagcaa ccccaattca gacacttcca cagagccagt
     1381 caacaccaaa gcgaattgat actcccagct tggaggagcc cagtgacctt gaggagcttg
     1441 agcagtttgc caagaccttc aaacaaagac gaatcaaact tggattcact cagggtgatg
     1501 ttgggctcgc tatggggaaa ctatatggaa atgacttcag ccaaactacc atctctcgat
     1561 ttgaagcctt gaacctcagc tttaagaaca tgtgcaagtt gaagccactt ttagagaagt
     1621 ggctaaatga tgcagagaac ctctcatctg attcgtccct ctccagccca agtgccctga
     1681 attctccagg aattgagggc ttgagccgta ggaggaagaa acgcaccagc atagagacca
     1741 acatccgtgt ggccttagag aagagtttct tggagaatca aaagcctacc tcggaagaga
     1801 tcactatgat tgctgatcag ctcaatatgg aaaaagaggt gattcgtgtt tggttctgta
     1861 accgccgcca gaaagaaaaa agaatcaacc caccaagcag tggtgggacc agcagctcac
     1921 ctattaaagc aattttcccc agcccaactt cactggtggc gaccacacca agccttgtga
     1981 ctagcagtgc agcaactacc ctcacagtca gccctgtcct ccctctgacc agtgctgctg
     2041 tgacgaatct ttcagttaca ggcacttcag acaccacctc caacaacaca gcaaccgtga
     2101 tttccacagc gcctccagct tcctcagcag tcacgtcccc ctctctgagt ccctcccctt
     2161 ctgcctcagc ctccacctcc gaggcatcca gtgccagtga gaccagcaca acacagacca
     2221 cctccactcc tttgtcctcc cctcttggga ccagccaggt gatggtgaca gcatcaggtt
     2281 tgcaaacagc agcagctgct gcccttcaag gagctgcaca gttgccagca aatgccagtc
     2341 ttgctgccat ggcagctgct gcaggactaa acccaagcct gatggcaccc tcacagtttg
     2401 cggctggagg tgccttactc agtctgaatc cagggaccct gagcggtgct ctcagcccag
     2461 ctctaatgag caacagtaca ctggcaacta ttcaagctct tgcttctggt ggctctcttc
     2521 caataacatc acttgatgca actgggaacc tggtatttgc caatgcggga ggagccccca
     2581 acatcgtgac tgcccctctg ttcctgaacc ctcagaacct ctctctgctc accagcaacc
     2641 ctgttagctt ggtctctgcc gccgcagcat ctgcagggaa ctctgcacct gtagccagcc
     2701 ttcacgccac ctccacctct gctgagtcca tccagaactc tctcttcaca gtggcctctg
     2761 ccagcggggc tgcgtccacc accaccaccg cctccaaggc acagtgagct gggcagagct
     2821 gggctgccag aagccttttt cactctgcag tgtgattgga ctgccagcca ggttaataaa
     2881 ctgaaaaatg tgattggctt cctctcgccg tgttgtgagg gcaaaggaga gaagggagaa
     2941 aaaaaaaaaa aaaccacaca cacccataca cacataccag aaaaagaaag aaaggatgga
     3001 gacggaacat ttgcctaatt ttgtaataaa acactgtctt ttcaggattg cttcatggat
     3061 tggagaactt tctaaccaaa aattaaaaaa aaaaaaaaaa aaagaaacaa aaaaatcaaa
     3121 aacaaacaaa aataagtgaa aggactactt atcatttcca gcagtcatga tgacaagtta
     3181 aggtgggtta ccaattccaa tataggaagg ggatttcttg tttgtctaaa tttctttttt
     3241 tcttaaaaaa aaaaaatcat ttttatgggt ctgttgtaca ggccattaag tcataacaag
     3301 gtgtttataa tcgtatcaat tgtgttgggg gttcctttct taactggtac aatttaggca
     3361 ggcctgtatt actgtattat tattgttgtt gttgttattg ttttatatat atagtttgga
     3421 catgtttatt atctcttgct cctggatcct atttcagtga gctcccacac tgtggggagg
     3481 gagggttttg gggtaagggg agacttctgt tcttaactgt ggggaatgtt cttgctggtt
     3541 tccttatcct tgatgactct tacagaggtg ctagaaaatt attttctttt gccacttatg
     3601 caagaggctt ggtgcagaag ctgaaggcag tgtgtgcaaa cactcccatt ccacacacgc
     3661 cccttcccct ccccacatca ggtggtgcct ttggagcact tttgtgtagg aaggaattcc
     3721 tgctgaactg tagctctcac tcacccccaa atcattgaat gaccctgagg cccagttcct
     3781 gtggtgcaac agtgctgctt tctgctactt tcaatgggaa cagctgtaca tgttgcaggg
     3841 caggatttgg ttcccaagag caaagactac tgcagacacc tgacttggtg gttctcctga
     3901 tttcttatct cctgaaaaat gctcctgctg ttggtgtgtt tgtttgtttg ttccattttg
     3961 tggaagtttt tcatccaaac tttaactaac ttggcaaaga aaaaaaactg acttactgaa
     4021 attgggaaac ttttcccttc ttttattttc taaaggaatt ctactagact attttccatt
     4081 gataatatat acaaaagagg tgtgatgaga agggtataag gttaccacct tttcctctag
     4141 agagccacag acttcctttc cactggatgg tttataaatt cctctaaccc tgagattctt
     4201 cttggttctc tgactaaagg aggcacttat tagccgggct gggatctgta gaacctttga
     4261 agaaggactt tgagcaggaa ctttgcacac accttaagtg tctccttggt ttgttcatga
     4321 tgctcctgct aggtaggtct aaatggcaat acacatctct ttattcaatg tagaaagtaa
     4381 ttagctctgt aattattttc agggtgtttg tagactatat aaatgagccc attgaaaagg
     4441 aagagtttgt gaaagtggat gaagaggaat aagggtaact tggagattaa attccttttt
     4501 ttgtcagtgt actgttgtta tgccatctgt accaaaaaat tttccaaaag actggatcac
     4561 tgcagtgcag ctcatctaag ttccccttct tattggagtt aaaggttccc atttggtggc
     4621 tgtgggtgct tgcttaaatc tctggtggtc ccaagactgc actttttctc cctttcgagc
     4681 tggggatgta gagagaactt acaggtgatt tttattctga ttgcttttgt ttgtgtccac
     4741 aagggagctt ggattctgtg tacttgtctc tttcccattg tccagtaagg cagtaaatac
     4801 agacacaatg tgtacttttg tgtgtgattc aagtgggaga cagtctgtta aaaggtcaga
     4861 aacattttag tcccctttaa aatatttctt ttagtttatt tctatcgtgt tttatttcac
     4921 agatatttaa ttaccacccc taaatttcct cctcttaccc ttcaccttcc ctaaaatcct
     4981 tccaaaatca gtgaactgca agcagggaaa ctaacaaatg tccattcacc ctttttgtgt
     5041 ggtgtgtttt tttatgtttt gttttgtttt ttaactaagc ttgaaccaaa gtcaattttt
     5101 agcaagctgc tgtactaatg gactagttga taacgtgcag ttcagacaca tcgaggagat
     5161 agatgctact gacaatttct ttttcatttg tctttattaa ttttatatga aagttgctgc
     5221 ttgtttttaa tcttttatgt tggtaaattg tgatatcctc tgggcagaca ttaacttgat
     5281 gtttaactag tttattaggt tggtgtgtaa atagaatgac aatgtcaatt actaatttct
     5341 ctcctctcca ttcacttttt ctctgttgta gttaaattta atcttctatc ctgacttgac
     5401 atctctacct ttagtctgtg gaaatgattt tagggctatc agtaatgctg tagctgccca
     5461 taataatgag tccctccctt gggagtggtg aaacttagaa ggaaggattc agggagggaa
     5521 atgctggtac ccagtatact ggattagaag ttatagcatt aatttctcaa aattgctacc
     5581 aaaggaagtg tggagtccca agggactcaa gctcagtgag gtaagacaaa gggcaaggaa
     5641 aggctgtttg ggtggttttt ttttccccac atatggttta gaaaatgatc cctttcccaa
     5701 acaaaactca ccaacagact ttaatattag aaaagatact aagctttaaa tgtcaataca
     5761 gtggtctttt attccctgcc ctgtctatat tttctactca atttgggata aggggatttt
     5821 atgtgaagca cttgatgagg gtagaccagc ataaaaaatc tgtttaaaag aagaaataat
     5881 ctttaggaaa agataaatct ttagataaaa ataaattttt ttctcttttt ttacttattt
     5941 aaaaataagt tgtgaaatga aaggtacatt tacacatgta cacacgaaac actaatatag
     6001 ctttttggtg gttgtttagt ttaaaatcaa ctccctatcc atcatcccta gatattctac
     6061 ttatcgtatt gcttcatgaa caccttagtc attttttact ttacgtatat atttttttat
     6121 catctcaaga aatgcatttt gaattgaatg aactatcttc taagctaaga tactcaaatt
     6181 taacttttag ccaccttata tgggagagcc tggaaactaa aggggaccag ggaccatttg
     6241 accaaaagag gtgtttggtg gagtttctgc atttcaaaga agaaaggcca gataggtcat
     6301 cacaattcat tgtattattc tttttttttc cccttaatgt ttatgcaaat tttattttat
     6361 atttctgaat ttggttagca catactaagc caaagactat tctaaatgca tttatagtga
     6421 atactatgta tgcccatggt aatgggtcct ccctaaggag tggtgaatgt aattgtgtga
     6481 atcctgctta tcacaagtgg tgcaatttgg tcataaactt tatttatacc ctgtatacat
     6541 ctgaataaca gagcagaaag acctaaaaaa gggcttctca caggaacaat attactatgt
     6601 tgttctaaga aaaaataagt tgagtgctgt attagtttaa gtgtttctaa agttctatag
     6661 gcagcatttt agaattaaga attgtgtata tccattaact gatataattc acatgtcctt
     6721 ttatttgtta tcagaaagat caatactatc ccaatttatt caacttgtta cccaagaaat
     6781 ggaaccaaag gaatccaact ttcattttgt gtagaatcat acctacttat acttaatgct
     6841 agcactgtaa gaaataagtc ttttttgttt aaaaaaggga agataagatt aaagattctt
     6901 agtgagatca tcttgccaat ttgttgtaca tctctcattc attgttgggg gaaaaaaaag
     6961 cacaactata cctctttaat gttattttct tccattatcc ctcatttatt tggaaagata
     7021 agggaaacct tgtctgtatt atccagaagc acagatattt gcttgacaca atatttaaat
     7081 tcagcccaat ctttaacatt aaaaaatttt ctttttaact tgctggaaaa gttggataca
     7141 ttggcaaata tagggaattc atgtcttttt tttttttttt tttctggtct tgctctgttg
     7201 cctaggctag agtgcaacgg catgatctcg gctcactgca acctctgcct cccgggttca
     7261 agcaattctc ctgcttcagc ctcccaagta gctgggatta caggcgccca ccaccgcacc
     7321 cggctaattt ttgtattttt agtagggacg ggatttctcc gtgttggcca ggctttttga
     7381 actcctgacc ttaggtgatc tgcctgcctt ggcctcccaa agtgctggga ttacaggtat
     7441 gagccactgt gcccatcctc atgtcaattt ttaaagtgat aaatcctgat attatacatt
     7501 gcaattagtg tagaataaac gcttggctta tagaactctc tgttcttagt ctaaagctgt
     7561 tcccaaacca ggtcatcctc acgaaacatt cttgaccaag aaaaaagata aggtcattga
     7621 gataggaaga cagaggaaaa gcctcttgct gttgtttctt cccaagaaag gagaagccct
     7681 gccagggaga agtcagtagt attgctgact cactgtatca ctgagtgtag ggtgtggtag
     7741 caaggaggag gcaggggatt cacgctgaca ggtggctctg gcctggctct tggggggcct
     7801 tctgaagacc agtctgcagt ttgaggaagg gccccaacaa ttcatttgga gagcttggcc
     7861 aaatactttc tcattaaatc agcacctaaa cttgatgaac ttaaagtttg tttattagag
     7921 ttgaaaacat taaaagatga ctgatactaa tgggagaaaa atactaaaga cccaaaattt
     7981 aaaattttcc aaaatggaca agaattgatg ggttaatttg ctcataactg atatgagttt
     8041 gcttttatgt gtgtgtggaa agcatttaat gtgtgatgct gttcatagtc ctggctattt
     8101 gatgtcattt tcagttttac aacattttga ggatgacact ttataaaatg gtaaatcttt
     8161 ctcagcgttt acaaacttgg cttttgagaa gggaaaaatc ctctttgcta tttctgtaag
     8221 aagaataact gagatcagct attatatagg tttgcatgga tggtgtccac aatacaaatg
     8281 taaacttgga caggaatagg ataaataaat tgctttcatc ataaaggcca atcatccatt
     8341 tcttagtcca aggagattaa atataaatag gacacccctg agatttccag taaggtattt
     8401 gaaaggattc cactgggagg gcagggaata tattttttct cagagcatcc agtttgtacc
     8461 cagttttcta tatggtttgt gaactgtagc ttttaaaaaa aaattttgta gttttcttct
     8521 aaccttattc attaagtagt tccttgtttt ggcccttcta ctcttggcct tagctaaaag
     8581 cagtaaatgt gagtgaattt tatgttgatt atgtcacctg gatctccttt ccttcccttc
     8641 tttttctcat tgaatggtgg taccttaatt tgggtaacag ctagcttctg gcaccttcat
     8701 aaaatacctc agaatagctt agcattgttg caaaactggt tttaaactaa aaaccaaata
     8761 aataagtgaa aaaattttat aaatagtgga aataattcta gctgtagcat ttagttgaac
     8821 taatgtttat tatgatcgat aaacaagatt gatgctgtat gtatttggga tcctgtttat
     8881 aggttacaat ttatagggtt agggagggtt gggtggggga agaggagatg ttgattatgt
     8941 tagaaggaaa acattgctcg tgtgtgtgtt tgttttttct tatatctgtc ttgccaaagg
     9001 aaacttgatt ttccctgtga ttggctttgg cctctgtggt ctggtctgca gcagtgtgtg
     9061 gtggcatgca ggtaacatat ggggtgtcca gtaggttcag ggaccctgag ggtgcattta
     9121 catcccttcc tatggttgcc catgcccccc agaccctgcc aacctctcct aatgattcat
     9181 tacctctgta catagcaaaa gcataggcaa aggatgaatg cgtgaatgcc tggatgtgca
     9241 gttgagaaac agaggcagac atagacatgc accaattaat ttggagccaa gaggtgagtg
     9301 attgatgtat cttaaatcta ggaaagttaa agtgaaacag gttctttgtg ttgccctctg
     9361 tcaagttact gaatgttgtg ctaataacac aacactttaa aaccttactt acttttctca
     9421 taccaaggct agttctttct agaccaaaaa cacaaacagg ataaaaagca aaccaagaag
     9481 ttgaaagcta acctgcccac ctcacccctg tgatacaaag tgtgaacctt aaggattagt
     9541 tggtgggatt gaggagagaa ttattcttgg tgggaacatg aatgagaaat gatgctggct
     9601 taggaaaaat cacaagccct ttctgcccat actctgggac aaactttctt ggctccctga
     9661 gttcggatat agactgtatc tctagaaagg ctattttttt aaataaatga tcccacagaa
     9721 cttaagtggg atttggttta gataccaaag acactgctaa tgtcattgct tatccttaag
     9781 ttttcaaaac aggcagaggg aataggagca aaaagccaaa atttggaaaa gctttacttt
     9841 atctctttcc ttcccttttc cccttttccc agtcccctgc tttttgaagg aagtcttctt
     9901 ggttatcctg gctttggaaa agagatttat tttgttttgc tctgctggct ctttaaagat
     9961 ggatagttgc tcaatctagc agtgatgttc ttggaattgc tgagaaattt ggggagggca
    10021 aaagataggg gtagaatttt ttcattattt ccctttatct aatactttta aatagaacca
    10081 acacagccta tatgagttca gacaatattt agatgtggta tctccatctg tctcctgtaa
    10141 aagataagaa ttttcaagaa caggattacg tggaaaacca aaagatcttc ccttactctc
    10201 ctataaatgt tttgttccaa atgtttttat atatgggctc tagggagtca ggtagttcat
    10261 tgtttcggtg tactattgat aggacacaga aagggagaga gggtaaagaa atgtatcact
    10321 ctctgaatat tgcatcaaaa atgattaggt tgcagaactt catgaaagct ttactaataa
    10381 tcttattgtt ctgacattat gtaaaggtgg tattaatatt gtatgacttg tcaaagtgct
    10441 agataggttt ataagtaggt aatagggatg ttgaagatta gagcacttga aacagaagtt
    10501 ctgggaaaac aaggtgtgtg taatggaaca ccactttgag cacagaaaca aaggtccctt
    10561 ggacctggta gggaagatgt gatttatgat tgtttctgtg tccctgtatc tgcccaccct
    10621 gcacagggct ccaccaccca gggccacctt ctggtttaaa cccaggacac tgtcaaaaag
    10681 ttaagacccc aaaactaatt tactgtaaaa aacattgagg actgctgcaa agttttccct
    10741 tgttttcttt gtgtacttgt tcatcattgt ataagttagc cacagcttca caagagcagc
    10801 ttaaggcttc tttcataaat tggcagtggc attgagttct caaacattat atcccaaagt
    10861 ctgcaggcag acagctggat acagcgctgt gtataaatga gacgtccaaa cacttgagtt
    10921 tcttaagatt gggatctctt tcaaatgaaa aaggacagag ccaagtagag aaaagacttt
    10981 gtgctcccac ccagccttaa tgagtctcat ggtctaaaag tataggaaga aatgaaatgc
    11041 actttcagaa gctaaaatga cagtgtctgc tacaaaaggc tgtagttgta ggcagtcggg
    11101 gatgccatgt ccttggttcc attcctgcgt gagtctgcag aaggcacaca ctttgtaaga
    11161 gtagagtgga ctagtgccag cctgaatagg tttaaaactg caaacagttg gagaacatgg
    11221 aacaggttgg tgcaggaagc ctaagatttt gcaatcatat tataacattg gcttttgaca
    11281 acataaatgt tgtatcttcc ctaaggtcag gtcggggaaa gaaagacttc cagcttctta
    11341 cctctgcgtg catgggcacg tgtgcattgc tcagtccgca ggaggtctca ctccgcagga
    11401 aacgctctcc tcccgcataa gtctgtactt ccatcccctc atctgtggta gtagtgaagg
    11461 ctaggtgagt aagcgtgggc tgttctaccc accagaagtc caggagctgt tgtatacctc
    11521 atttctaact cgtgaccgag tgacttgctt taactttctc gaaatcctac agagttgcca
    11581 agtctgccct ccctcctcag tcatgttaaa ctctggccta tagcatcatg ggacctgtag
    11641 cctagggtgg gaccccctaa agcctctgaa tgtcgctgct taaaagctac tgcaaactga
    11701 gggcaaattg caatcttcta ttcctttttg ttgcaagggg tcttcacagg tctcttaaca
    11761 tctgctttcc ctgccaccct gcctttaggg gctggccagc tatccacacc cctaacccac
    11821 cctgtgtttc tgacagctgg ccacacgtca acttctgtac ttgccttttc cttggtgggg
    11881 tagaggccaa ccccttctcc tctgaggcct cagggttctg tttcttttca ggactttggg
    11941 tagaagggaa gacaccaaag gctcctttaa gctgactgct gcatacacat ttcacttttt
    12001 ttcctttgac atgaccaaaa atatccaaat atttaagttt attattatta ttattattat
    12061 ttgacaatct tatatccaat gggctctcta gaagctgcat ccccagccct ttcacctttt
    12121 ctttgaatgt agttcccaac cttcaattcc cacccctaat gctgacaaaa agcttagcca
    12181 ggtcatgata ctgctgctat aagccagggg agggtggttt ctttgttttg ttttgttttg
    12241 ttttgttttt caaatttcca gccaaaacca aagatttctt aatgattgta taaactcaaa
    12301 acaaacaaaa gaaccaaaga aaagggaagt cttcagcatc agtccagtct gtggtgtcct
    12361 ggcacttaga agagtgaggc cagggaaggt ggggcggggg gaccctctga ctggatcaga
    12421 aagggcaggc aagctgctta ccaccttcca gggtccagca caggtgcatg cccctagctt
    12481 tggccctcac aaacttgtga gcatgccctg aaacaaattg gcatttcaga ttttccaaaa
    12541 caaaagtcaa aaaaccccat caccaccatc atccacccta caccaaccag ggtcactatg
    12601 gggacttagc acagggccta gggagggtgg gagctgctgc tggactggcc cgaggactcc
    12661 acagagtggg ggacgttgaa gacactggcg cacgattggc tgctctgctg ggtgctttaa
    12721 cctctggggc tgggcgaatg cacgccacgg tgcccttctg agcctttttt tcttttcctg
    12781 tactggaact gcttggaagt ggctgtcctg tttgtgagaa aacatgcaga aagattatca
    12841 agcttttcat ttctctttat tgtagttttc tttccttttt gcagcaccac tgtgcaacta
    12901 tgcattgtac ttcacaacct tttgtgctag gtagatgcct gtgacttttt aacttggggg
    12961 gtggggggat tgcaaatgaa ggaacttttt acatggatct ttttaatctc agttggttgg
    13021 gggagggggg tacttggttc ttgggtcaca caagctctat cccaaagcaa aatccaaatg
    13081 ttaataatat tagcctgatg cagataccaa agataatttc tttcctgcag aaccttagac
    13141 tcgtgtatta agtacgatta cccagcactt gcattagtct aacctcagta attccaaagc
    13201 ttagatgtat attttggtat atttctggga tattaaaaaa aaaatgtcgt ttaacttctt
    13261 gtttgtttca gtgtaatgct cttaaagtca tagcatgaaa ataattgaac tgtcctattc
    13321 ttagtagttt gaaataatag tatttttgta tgttttgggt gtgtctatgt atgtattaac
    13381 ataacagttt tcactgccta ggtgttcata ataaaaaaga aaatgaaaaa agttctgagt
    13441 gtacataata ttcaataata atctcccacc aggtgtcaat ttagattgca tattcctcat
    13501 tactgttccc aactgggatt ttgttttctt ttaaagagac agtgatcgtg tttttctaaa
    13561 gatgttttct ttctctcttt caatatctta actcactttt tttttcttcc ttttttgtct
    13621 taattattaa ttcaggggtg tttgtccact gttgtcaaag gaggggcaca aggggaattg
    13681 gcccccggcc tcctagaact ttttgtttta tgtactttaa aatgtgagtt tgagttcttc
    13741 tttgtggaaa cttaagatgt ggtgtaaatg attctttcca aaattgtcca gcagcttgaa
    13801 tgaggcagtg acaattctga ggtggtttat tgggagtcct tctacatttc tcttagataa
    13861 ctctgcactc tgggtggcta ttgtgtagcc ttactgcccc agagtgcctg ttagccaaat
    13921 atttcccctc tgataggaat attttctaag aatcagctga taacttgcgt gctggacctt
    13981 gttatctgtg cccctgggag acacacgttt tcttggtttt gaaaacctga aacacaggca
    14041 actttacatt ttggggaatt agctgatgcc tcctgaagcc tgaggaggtg gcggggaata
    14101 tgagcggtgc tgtctctctc aaaagtgccc tttagatgat tccccctcct agggctgcct
    14161 gcaggggctg taggcttggg aaagattgtg taggtgacag tgaatcagaa tgaagtggta
    14221 gattttgtgt agatgcattt gtctgctgta attttttata tatatattaa acttactgta
    14281 actgtacagt tcatttctgt tgtaaaacat cattaaacca tcttccaagt gttttcacat
    14341 tg
//
