LOCUS       NM_198498               1343 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens POU class 2 homeobox associating factor 2 (POU2AF2),
            mRNA.
ACCESSION   NM_198498 XM_011542803 XM_291835
VERSION     NM_198498.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1343)
  AUTHORS   Szczepanski,A., Tsuboyama,N., Lyu,H., Wang,P., Beytullahoglu,O.,
            Zhang,T., Singer,B.D., Yue,F., Zhao,Z. and Wang,L.
  TITLE     A SWI/SNF-dependent transcriptional regulation mediated by
            POU2AF2/C11orf53 at enhancer
  JOURNAL   Nat Commun 15 (1), 2067 (2024)
   PUBMED   38453939
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1343)
  AUTHORS   Zhou,C., Huang,H., Wang,Y., Sendinc,E. and Shi,Y.
  TITLE     Selective regulation of tuft cell-like small cell lung cancer by
            novel transcriptional co-activators C11orf53 and COLCA2
  JOURNAL   Cell Discov 8 (1), 112 (2022)
   PUBMED   36253350
  REMARK    GeneRIF: COLCA2 (POU2AF3) and likely C11orf53 (POU2AF2) function as
            transcriptional co-activators of POU2F3 in tuft cell-like small
            cell lung cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1343)
  AUTHORS   Szczepanski,A.P., Tsuboyama,N., Watanabe,J., Hashizume,R., Zhao,Z.
            and Wang,L.
  TITLE     POU2AF2/C11orf53 functions as a coactivator of POU2F3 by
            maintaining chromatin accessibility and enhancer activity
  JOURNAL   Sci Adv 8 (40), eabq2403 (2022)
   PUBMED   36197978
REFERENCE   4  (bases 1 to 1343)
  AUTHORS   Wu,X.S., He,X.Y., Ipsaro,J.J., Huang,Y.H., Preall,J.B., Ng,D.,
            Shue,Y.T., Sage,J., Egeblad,M., Joshua-Tor,L. and Vakoc,C.R.
  TITLE     OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell
            lineage
  JOURNAL   Nature 607 (7917), 169-175 (2022)
   PUBMED   35576971
  REMARK    GeneRIF: OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft
            cell lineage.
REFERENCE   5  (bases 1 to 1343)
  AUTHORS   Delgado,A.P., Brandao,P., Chapado,M.J., Hamid,S. and Narayanan,R.
  TITLE     Open reading frames associated with cancer in the dark matter of
            the human genome
  JOURNAL   Cancer Genomics Proteomics 11 (4), 201-213 (2014)
   PUBMED   25048349
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP002448.3.
            
            On or before Jan 4, 2019 this sequence version replaced
            XM_011542803.2, NM_198498.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2152568 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000280325.7/ ENSP00000280325.6
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               AP002448.3         76794-76932
            140-249             AP002448.3         87052-87161
            250-292             AP002448.3         112467-112509
            293-594             AP002448.3         115145-115446
            595-1343            AP002448.3         116722-117470
FEATURES             Location/Qualifiers
     source          1..1343
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.1"
     gene            1..1343
                     /gene="POU2AF2"
                     /gene_synonym="C11orf53; OCA-T1; OCAT1"
                     /note="POU class 2 homeobox associating factor 2"
                     /db_xref="GeneID:341032"
                     /db_xref="HGNC:HGNC:30527"
                     /db_xref="MIM:620671"
     exon            1..139
                     /gene="POU2AF2"
                     /gene_synonym="C11orf53; OCA-T1; OCAT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..996
                     /gene="POU2AF2"
                     /gene_synonym="C11orf53; OCA-T1; OCAT1"
                     /note="uncharacterized protein C11orf53; protein POU2AF2;
                     oct coactivator from tuft cells 1"
                     /codon_start=1
                     /product="POU domain class 2-associating factor 2"
                     /protein_id="NP_940900.2"
                     /db_xref="CCDS:CCDS31674.2"
                     /db_xref="GeneID:341032"
                     /db_xref="HGNC:HGNC:30527"
                     /db_xref="MIM:620671"
                     /translation="MESVPGDYSKRVYQGVRVKHTVKDLLAEKRSGQTSNSRLNGSVS
                     SSQSPFVQMPGSPVTSGYYGVRRSFLSDSDFHNSKQFSNDVYTSSVGKPFPCESSAGQ
                     SHAALLEPYFPQEPYGDYRPPALTPNAGSLFSASPLPPLLPPPFPGDPAHFLFRDSWE
                     QTLPDGLSQPDPVSADALLTLPPSTSCLSQLESGSIAQHRGSSWGSSLAGAQSYSLHA
                     LEDLHHTPGYPTPPPYPFTPFMTVSNDLPPKVGPLSPDEEADTGSLHDPSPWVKEDGS
                     IAWGSYECRRAY"
     exon            140..249
                     /gene="POU2AF2"
                     /gene_synonym="C11orf53; OCA-T1; OCAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            250..292
                     /gene="POU2AF2"
                     /gene_synonym="C11orf53; OCA-T1; OCAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            293..594
                     /gene="POU2AF2"
                     /gene_synonym="C11orf53; OCA-T1; OCAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            595..1343
                     /gene="POU2AF2"
                     /gene_synonym="C11orf53; OCA-T1; OCAT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1168..1173
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POU2AF2"
                     /gene_synonym="C11orf53; OCA-T1; OCAT1"
                     /note="hexamer: AATAAA"
     polyA_site      1190
                     /gene="POU2AF2"
                     /gene_synonym="C11orf53; OCA-T1; OCAT1"
                     /note="major polyA site"
     regulatory      1322..1327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POU2AF2"
                     /gene_synonym="C11orf53; OCA-T1; OCAT1"
                     /note="hexamer: ATTAAA"
     polyA_site      1343
                     /gene="POU2AF2"
                     /gene_synonym="C11orf53; OCA-T1; OCAT1"
                     /note="major polyA site"
ORIGIN      
        1 gcagaaggct ttcccaccag ggtcaggctg agctttctag cagaccagga ccccttacca
       61 aggagtgaac accattcaca agaaattctg cactgctgtt aagaaggaaa tccaccagaa
      121 acatccagaa tggaaagtgt cccaggagac tacagcaaac gagtgtatca aggagtgaga
      181 gtgaagcata cagtcaaaga tctcctggca gaaaaacgat ccgggcagac aagtaactca
      241 agacttaatg gcagcgtcag ttcctctcag tctccatttg tgcagatgcc aggttcgccg
      301 gtcacgtcag gttactacgg tgtcagaaga tctttcttat ctgactcaga cttccacaac
      361 agtaaacagt tttcaaatga cgtctacacc tccagcgtgg ggaagccgtt tccctgtgag
      421 tcctccgcag ggcagagcca tgcggctctc ctggagccct acttccccca ggagccctac
      481 ggagactacc ggcctccggc gctgacgccc aacgcgggct ctctgttcag cgcctcgccc
      541 ctaccgccgc tcctgccacc gcccttcccc ggagacccag ctcacttcct atttagggac
      601 tcatgggagc agacgttgcc tgacggtctc agccagcctg accctgtgtc tgccgatgcc
      661 ctgctgacct tgccacccag cacgagttgc ctctcccagc ttgagtccgg gagcatcgcc
      721 cagcacaggg gctcaagctg ggggtcatcc ctggctgggg ctcagtcata ctcgctgcat
      781 gctctggaag atctgcacca cactccgggg taccctaccc cgcctcctta ccccttcacc
      841 cctttcatga cggtgtcaaa tgacctaccg cccaaggtgg ggccactctc cccagatgag
      901 gaagcagaca ccggttccct ccatgaccct tccccttggg tgaaagaaga tgggagtatt
      961 gcctgggggt catatgaatg ccgcagagct tattgagggg agggccaaat gacttctggg
     1021 tttttcttta acttgaggtg tattccaaag attgttttag gtgtgtcagc ccattcagga
     1081 ctggattttc agaataagcc tcaatgctgc tctttgttag tggacgaggg catttatttg
     1141 taatcctctc cactgtaacc ccactgaaat aaaacagaat gttaattaaa tgtgtcagag
     1201 accgtattct agtaagataa ccttacaatg tggtcttttt ggaactgttg taacccatta
     1261 cgttctgaat cttctgttat ctttgaagta tcatttttgg cactgatttt tcttaaatta
     1321 cattaaaaag tttatgcaga tca
//
