LOCUS       NM_006235               2875 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens POU class 2 homeobox associating factor 1 (POU2AF1),
            mRNA.
ACCESSION   NM_006235
VERSION     NM_006235.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2875)
  AUTHORS   Nazarov,I.B., Zilov,D.S., Gordeev,M.N., Potapenko,E.V.,
            Yeremenko,N. and Tomilin,A.N.
  TITLE     Transcriptional Coactivator BOB1 (OBF1, OCA-B) Modulates the
            Specificity of DNA Recognition by the POU-Domain Factors OCT1 and
            OCT2 in a Monomeric Configuration
  JOURNAL   Biomolecules 14 (1), 123 (2024)
   PUBMED   38254723
  REMARK    GeneRIF: Transcriptional Coactivator BOB1 (OBF1, OCA-B) Modulates
            the Specificity of DNA Recognition by the POU-Domain Factors OCT1
            and OCT2 in a Monomeric Configuration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2875)
  AUTHORS   Schule,S., Bristy,E.A., Muhtadi,R., Kaletka,G., Stewart,S.,
            Ostheim,P., Hermann,C., Asang,C., Pleimes,D., Port,M. and Abend,M.
  TITLE     Four Genes Predictive for the Severity of Hematological Damage
            Reveal a Similar Response after X Irradiation and Chemotherapy
  JOURNAL   Radiat Res 199 (2), 115-123 (2023)
   PUBMED   36480042
  REMARK    GeneRIF: Four Genes Predictive for the Severity of Hematological
            Damage Reveal a Similar Response after X Irradiation and
            Chemotherapy.
REFERENCE   3  (bases 1 to 2875)
  AUTHORS   Wang,Y., Wang,L., Su,Z., Sun,W., Zhang,M., Yang,C., Zhou,J.,
            Jiang,L. and Kong,X.
  TITLE     POU2AF1 promotes MSCs adipogenesis by inhibiting HDAC1 expression
  JOURNAL   Adipocyte 10 (1), 251-263 (2021)
   PUBMED   33949290
  REMARK    GeneRIF: POU2AF1 promotes MSCs adipogenesis by inhibiting HDAC1
            expression.
REFERENCE   4  (bases 1 to 2875)
  AUTHORS   King,H.W., Wells,K.L., Shipony,Z., Kathiria,A.S., Wagar,L.E.,
            Lareau,C., Orban,N., Capasso,R., Davis,M.M., Steinmetz,L.M.,
            James,L.K. and Greenleaf,W.J.
  TITLE     Integrated single-cell transcriptomics and epigenomics reveals
            strong germinal center-associated etiology of autoimmune risk loci
  JOURNAL   Sci Immunol 6 (64), eabh3768 (2021)
   PUBMED   34623901
  REMARK    GeneRIF: Integrated single-cell transcriptomics and epigenomics
            reveals strong germinal center-associated etiology of autoimmune
            risk loci.
REFERENCE   5  (bases 1 to 2875)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 2875)
  AUTHORS   Junker,S., Brondum-Nielsen,K., Newell,J.W., Matthias,P. and
            Tommerup,N.
  TITLE     Assignment of the human gene for Oct-binding factor-1 (OBF1), a
            B-cell-specific coactivator of octamer-binding transcription
            factors 1 and 2, to 11q23.1 by somatic cell hybridization and in
            situ hybridization
  JOURNAL   Genomics 33 (1), 143-145 (1996)
   PUBMED   8617501
REFERENCE   7  (bases 1 to 2875)
  AUTHORS   Galiegue-Zouitina,S., Quief,S., Hildebrand,M.P., Denis,C.,
            Lecocq,G., Collyn-d'Hooghe,M., Bastard,C., Yuille,M., Dyer,M.J. and
            Kerckaert,J.P.
  TITLE     Fusion of the LAZ3/BCL6 and BOB1/OBF1 genes by t(3; 11) (q27; q23)
            chromosomal translocation
  JOURNAL   C R Acad Sci III 318 (11), 1125-1131 (1995)
   PUBMED   8574789
REFERENCE   8  (bases 1 to 2875)
  AUTHORS   Luo,Y. and Roeder,R.G.
  TITLE     Cloning, functional characterization, and mechanism of action of
            the B-cell-specific transcriptional coactivator OCA-B
  JOURNAL   Mol Cell Biol 15 (8), 4115-4124 (1995)
   PUBMED   7623806
REFERENCE   9  (bases 1 to 2875)
  AUTHORS   Strubin,M., Newell,J.W. and Matthias,P.
  TITLE     OBF-1, a novel B cell-specific coactivator that stimulates
            immunoglobulin promoter activity through association with
            octamer-binding proteins
  JOURNAL   Cell 80 (3), 497-506 (1995)
   PUBMED   7859290
REFERENCE   10 (bases 1 to 2875)
  AUTHORS   Gstaiger,M., Knoepfel,L., Georgiev,O., Schaffner,W. and Hovens,C.M.
  TITLE     A B-cell coactivator of octamer-binding transcription factors
  JOURNAL   Nature 373 (6512), 360-362 (1995)
   PUBMED   7779176
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Z49194.1, X83504.1 and AP002451.5.
            
            On Nov 22, 2018 this sequence version replaced NM_006235.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z49194.1, SRR1163655.18236.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2151358
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393067.8/ ENSP00000376786.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                Z49194.1           426-455
            31-1042             X83504.1           1-1012
            1043-2875           AP002451.5         8880-10712          c
FEATURES             Location/Qualifiers
     source          1..2875
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.1"
     gene            1..2875
                     /gene="POU2AF1"
                     /gene_synonym="BOB1; OBF-1; OBF1; OCAB"
                     /note="POU class 2 homeobox associating factor 1"
                     /db_xref="GeneID:5450"
                     /db_xref="HGNC:HGNC:9211"
                     /db_xref="MIM:601206"
     exon            1..114
                     /gene="POU2AF1"
                     /gene_synonym="BOB1; OBF-1; OBF1; OCAB"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..869
                     /gene="POU2AF1"
                     /gene_synonym="BOB1; OBF-1; OBF1; OCAB"
                     /note="BOB-1; POU class 2 associating factor 1; OCA-B;
                     OCT-binding factor 1; B-cell-specific coactivator OBF-1"
                     /codon_start=1
                     /product="POU domain class 2-associating factor 1"
                     /protein_id="NP_006226.2"
                     /db_xref="CCDS:CCDS31675.1"
                     /db_xref="GeneID:5450"
                     /db_xref="HGNC:HGNC:9211"
                     /db_xref="MIM:601206"
                     /translation="MLWQKPTAPEQAPAPARPYQGVRVKEPVKELLRRKRGHASSGAA
                     PAPTAVVLPHQPLATYTTVGPSCLDMEGSVSAVTEEAALCAGWLSQPTPATLQPLAPW
                     TPYTEYVPHEAVSCPYSADMYVQPVCPSYTVVGPSSVLTYASPPLITNVTTRSSATPA
                     VGPPLEGPEHQAPLTYFPWPQPLSTLPTSTLQYQPPAPALPGPQFVQLPISIPEPVLQ
                     DMEDPRRAASSLTIDKLLLEEEDSDAYALNHTLSVEGF"
     exon            115..245
                     /gene="POU2AF1"
                     /gene_synonym="BOB1; OBF-1; OBF1; OCAB"
                     /inference="alignment:Splign:2.1.0"
     exon            246..288
                     /gene="POU2AF1"
                     /gene_synonym="BOB1; OBF-1; OBF1; OCAB"
                     /inference="alignment:Splign:2.1.0"
     exon            289..554
                     /gene="POU2AF1"
                     /gene_synonym="BOB1; OBF-1; OBF1; OCAB"
                     /inference="alignment:Splign:2.1.0"
     exon            555..2875
                     /gene="POU2AF1"
                     /gene_synonym="BOB1; OBF-1; OBF1; OCAB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1292..1297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POU2AF1"
                     /gene_synonym="BOB1; OBF-1; OBF1; OCAB"
                     /note="hexamer: ATTATA"
     polyA_site      1336
                     /gene="POU2AF1"
                     /gene_synonym="BOB1; OBF-1; OBF1; OCAB"
                     /note="major polyA site"
     regulatory      1852..1857
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POU2AF1"
                     /gene_synonym="BOB1; OBF-1; OBF1; OCAB"
                     /note="hexamer: ACTAAA"
     polyA_site      1874
                     /gene="POU2AF1"
                     /gene_synonym="BOB1; OBF-1; OBF1; OCAB"
     regulatory      2857..2862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POU2AF1"
                     /gene_synonym="BOB1; OBF-1; OBF1; OCAB"
                     /note="hexamer: AATAAA"
     polyA_site      2875
                     /gene="POU2AF1"
                     /gene_synonym="BOB1; OBF-1; OBF1; OCAB"
                     /note="major polyA site"
ORIGIN      
        1 aagcggtggc tccactggag gaaaacacac cccggtctca cattaaagaa gccaaactgt
       61 cggcttcaaa gagaaaaggc aacatcctgt cacaggccat gctctggcaa aaacccacag
      121 ctccggagca agccccagcc ccggcccggc cataccaggg cgtccgtgtg aaggagccag
      181 tgaaggaact gctgaggagg aagcgaggcc acgccagcag tggggcagca cctgcaccta
      241 cggcggtggt gctgccccat cagcccctgg cgacctacac cacagtgggt ccttcctgcc
      301 tggacatgga aggttctgtg tctgcagtga cagaggaggc tgccctgtgt gccggctggc
      361 tctcccagcc caccccggcc accctgcagc ccctggcccc atggacacct tacaccgagt
      421 atgtgcccca tgaagctgtc agctgcccct actcagctga catgtatgtg cagcccgtgt
      481 gccccagcta cacggtggtg gggccctcct cagtgttgac ctatgcctct ccgccactca
      541 tcaccaatgt cacgacaaga agctccgcca cgcccgcagt ggggcccccg ctggagggcc
      601 cagagcacca ggcacccctc acctatttcc cgtggcctca gcccctttcc acactaccca
      661 cctccaccct gcagtaccag cctccggccc cagccctacc tgggccccag tttgtccagc
      721 tccccatctc tatcccagag ccagtccttc aggacatgga agaccccaga agagccgcca
      781 gctcgttgac catcgacaag ctgcttttgg aggaagagga tagcgacgcc tatgcgctta
      841 accacactct ctctgtggaa ggcttttagg cgtggctccc acctgagtcc tgttccctga
      901 aactgggatt ttaaaatgag cctggaattg agccccaggt tcatgcttgt ttggagtagt
      961 catttcatga ctacactttc tacgcacagc tagaattgta gacctgtaaa ccttccttcc
     1021 cttcttcctt cccctccctc cctcacttcc tccctctccc ccatccttcc attcttcccc
     1081 tccctccctt cttcctttcc aaccccttcc ttccttttcc tccctccctt ccttccctcc
     1141 ttcccttctc cctttccaac cccttccttc cttttcctcc ctcccttcct tccctccttc
     1201 ccttctccct ttccttcttt acctccctcc ctccctcgct tcttctctct ttcttacttc
     1261 ttttttcaat tctgttccat tttgggaggt aattataggg attttagcaa taacatttta
     1321 tgtcaaatgt tgccaagtct gtggtccatg ggctttcatt tctgtcacat ttcatttctt
     1381 ggaaaaggcc tccttcctcc agtgcctgct gaaccatctt agggtcactc acaccctctg
     1441 taattttaag atgtatgtgg tggccggcgg gaagaccagc cccgacagca cctcctgaga
     1501 aagtcagcca agggcctacc ctgatgccag agtccttgag ctgtcagttc ccacagttgc
     1561 tcctttgttt gctcttctca gcctcggcca gatttacagt ccaggcagca aaatctcaag
     1621 gcctggggct cagagtagta aggggtggga agtgggtggc agggagaaaa gaacatcagg
     1681 gtgggtgggg acaggccagt gacgaagaga gggacagagg agggatggga acaggctgtg
     1741 catcttagtt ggagagaggg gtgtgggagg aagcttgagt ttgatgcagg gaggaggaag
     1801 gctgaggaat gacttggctc cagattactt ggttattaag aagaacaata aactaaagga
     1861 aagcattgct tgaagagatg gttttgctgc tctccttgag gatacgtgca agggaagttg
     1921 ggctgttgta aacagggtga agggtgtgtt tggtcggcca tttctgtctc acctctaggc
     1981 cctctgctgg tgctgtggag gccaagaccc cattaagcct aaaggtgatg ggtcctcgcc
     2041 taggcttagt gctaccatgt gggttttgtt tctttccttc cttccttcct tccttccttc
     2101 cttccttcct tccttccttc cttccttcct tccttctttc cttccttcct tccttccttc
     2161 cttcctctct ctttctttct tttttttggt tttttttggg acggagtctc actccattgc
     2221 ccaggctgga gtacaatggt gcgatcttgg ctcactgcac ctctgtctcc caagttcaag
     2281 tgattctcct gcctgagcct cccgagtagc tgggattaca ggtgcatgcc accatgcctg
     2341 gctaattttt gtatttttag tagagacggg gtttcaccat gttggccagg ctggtctcga
     2401 actcctgacc ttgtgatccg cccgcctcag cctctcagag tgctgggatc acaggcgtga
     2461 gccaccgcac ccagcctttt accatgtggg tttctttagt gtcttaaaag cgtccataag
     2521 ccaccattct gtggaaccaa ggccccctcc acgcaaacac cctccctcct ggggacctct
     2581 ggagcctcag ccagaagtac cattaggttt aattttaatt tgttttgctg gagaaacatc
     2641 aggtttgtag gagactgagt tgttagcagg tgtgcttagc tcttgatagt gaacgtgtac
     2701 cttgggaact ggctcaccca cctgctaata gcaccatcgt cactattaag cagacatttc
     2761 agttggtaga atccatgtag aagtcatgga cttttctggg aaatgacttt tctgggaaat
     2821 gacagtttct ttgacatatt ttctttgccc actttaaata aaaactctgg agaaa
//
