LOCUS       NM_001277083            3370 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens POTE ankyrin domain family member J (POTEJ), mRNA.
ACCESSION   NM_001277083 XM_003960309 XM_929706
VERSION     NM_001277083.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3370)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   2  (bases 1 to 3370)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   3  (bases 1 to 3370)
  AUTHORS   Wang,Y. and Leung,F.C.
  TITLE     Discovery of a long inverted repeat in human POTE genes
  JOURNAL   Genomics 94 (4), 278-283 (2009)
   PUBMED   19463943
REFERENCE   4  (bases 1 to 3370)
  AUTHORS   Bera,T.K., Saint Fleur,A., Ha,D., Yamada,M., Lee,Y., Lee,B.,
            Hahn,Y., Kaufman,D.S., Pera,M. and Pastan,I.
  TITLE     Selective POTE paralogs on chromosome 2 are expressed in human
            embryonic stem cells
  JOURNAL   Stem Cells Dev 17 (2), 325-332 (2008)
   PUBMED   18447647
REFERENCE   5  (bases 1 to 3370)
  AUTHORS   Lee,Y., Ise,T., Ha,D., Saint Fleur,A., Hahn,Y., Liu,X.F.,
            Nagata,S., Lee,B., Bera,T.K. and Pastan,I.
  TITLE     Evolution and expression of chimeric POTE-actin genes in the human
            genome
  JOURNAL   Proc Natl Acad Sci U S A 103 (47), 17885-17890 (2006)
   PUBMED   17101985
REFERENCE   6  (bases 1 to 3370)
  AUTHORS   Chang,K.W., Yang,P.Y., Lai,H.Y., Yeh,T.S., Chen,T.C. and Yeh,C.T.
  TITLE     Identification of a novel actin isoform in hepatocellular carcinoma
  JOURNAL   Hepatol Res 36 (1), 33-39 (2006)
   PUBMED   16824795
REFERENCE   7  (bases 1 to 3370)
  AUTHORS   Hahn,Y., Bera,T.K., Pastan,I.H. and Lee,B.
  TITLE     Duplication and extensive remodeling shaped POTE family genes
            encoding proteins containing ankyrin repeat and coiled coil domains
  JOURNAL   Gene 366 (2), 238-245 (2006)
   PUBMED   16364570
REFERENCE   8  (bases 1 to 3370)
  AUTHORS   Bera,T.K., Saint Fleur,A., Lee,Y., Kydd,A., Hahn,Y., Popescu,N.C.,
            Zimonjic,D.B., Lee,B. and Pastan,I.
  TITLE     POTE paralogs are induced and differentially expressed in many
            cancers
  JOURNAL   Cancer Res 66 (1), 52-56 (2006)
   PUBMED   16397215
REFERENCE   9  (bases 1 to 3370)
  AUTHORS   Bera,T.K., Zimonjic,D.B., Popescu,N.C., Sathyanarayana,B.K.,
            Kumar,V., Lee,B. and Pastan,I.
  TITLE     POTE, a highly homologous gene family located on numerous
            chromosomes and expressed in prostate, ovary, testis, placenta, and
            prostate cancer
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16975-16980 (2002)
   PUBMED   12475935
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1462]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140481.3.
            
            On Jul 29, 2019 this sequence version replaced NM_001277083.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409602.2/ ENSP00000387176.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-503               AC140481.3         178707-179209       c
            504-618             AC140481.3         173745-173859       c
            619-792             AC140481.3         173411-173584       c
            793-899             AC140481.3         170498-170604       c
            900-1037            AC140481.3         169046-169183       c
            1038-1108           AC140481.3         166515-166585       c
            1109-1179           AC140481.3         160630-160700       c
            1180-1224           AC140481.3         159196-159240       c
            1225-1391           AC140481.3         157993-158159       c
            1392-1462           AC140481.3         151960-152030       c
            1463-1533           AC140481.3         146596-146666       c
            1534-1578           AC140481.3         144868-144912       c
            1579-1760           AC140481.3         144339-144520       c
            1761-1881           AC140481.3         135608-135728       c
            1882-3370           AC140481.3         132612-134100       c
FEATURES             Location/Qualifiers
     source          1..3370
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q21.1"
     gene            1..3370
                     /gene="POTEJ"
                     /gene_synonym="POTE2beta"
                     /note="POTE ankyrin domain family member J"
                     /db_xref="GeneID:653781"
                     /db_xref="HGNC:HGNC:37094"
     exon            1..503
                     /gene="POTEJ"
                     /gene_synonym="POTE2beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..3210
                     /gene="POTEJ"
                     /gene_synonym="POTE2beta"
                     /codon_start=1
                     /product="POTE ankyrin domain family member J"
                     /protein_id="NP_001264012.1"
                     /db_xref="CCDS:CCDS59432.1"
                     /db_xref="GeneID:653781"
                     /db_xref="HGNC:HGNC:37094"
                     /translation="MVAEVDSMPAASSVKKPFVLRSKMGKWCRHCFPCCRGSGKSNVG
                     TSGDQDDSTMKTLRSKMGKWCCHCFPCCRGSGKSNVGAWGDYDDSAFVEPRYHVRRED
                     LDKLHRAAWWGKVARKDLIVMLRDTDVNKQDKQKRTALHLASANGNSGVVKLLLDRRC
                     QLNVLDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLHYAIYNEDKLMA
                     KALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILAV
                     CCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLSDYKEKQMLKISSE
                     NSNPEQDLKLTSEEESQRFKGSENSQPEKMSQEPEINKDGDREVEEEMKKHESNNVGL
                     LENLSNGVTAGNGDDGLIPQRKSRTPENQQFPDNESEEYHRICELVSDYKEKQMPKYS
                     SENSNPEQDLKLTSEEESQRLKGSENGQPEKRSQEPEINKDGDRELENFMAIEEMKKH
                     GSTHVGFPENLTNGATAGNGDDGLIPPRKSRTPESQQFPDTENEEYHSDEQNDTQKQF
                     CEEQNTGILHDEILIHEEKQIEVVEKMNSELSLSCKKERDFLHENSMLREEIAMLRLE
                     LDTMKHQSQLRKKKYLEDIESVKKKNDNLLKALQLNELTMDDDTAVLVIDNGSGMCKA
                     GFAGDDAPRAVFPSIVGCPRQQGMMGGMHQKESYVGKEAQSKRGILTLKYPMEHGIIT
                     NWDDMEKIWHHTFYNELRVAPEEHPILLTEAPLNPKANREKMTQIMFETFNTPAMYVA
                     IQAMLSLYTSGRTTGIVMDSGDGVTHTVPIYDGNALPHATLRLDLAGRELTDYLMKIL
                     TERGYRFTTMAEREIVRDIKEKLCYVALDFEQEMAMVASSSSLEKSYELPDGQVITIS
                     NEWFRCPEALFQPCFLGMESCGIHETTFNSIMKSDVDIRKDLYTNTVLSGGTTMYPGM
                     AHRMQKEIAALAPSMMKIRIIAPPKRKYSVWVGGSILASLSTFQQMWISKQEYDESGP
                     SIVHRKCF"
     exon            504..618
                     /gene="POTEJ"
                     /gene_synonym="POTE2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            619..792
                     /gene="POTEJ"
                     /gene_synonym="POTE2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            793..899
                     /gene="POTEJ"
                     /gene_synonym="POTE2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1037
                     /gene="POTEJ"
                     /gene_synonym="POTE2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1108
                     /gene="POTEJ"
                     /gene_synonym="POTE2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1179
                     /gene="POTEJ"
                     /gene_synonym="POTE2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1224
                     /gene="POTEJ"
                     /gene_synonym="POTE2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1391
                     /gene="POTEJ"
                     /gene_synonym="POTE2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1462
                     /gene="POTEJ"
                     /gene_synonym="POTE2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1533
                     /gene="POTEJ"
                     /gene_synonym="POTE2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1578
                     /gene="POTEJ"
                     /gene_synonym="POTE2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1760
                     /gene="POTEJ"
                     /gene_synonym="POTE2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1881
                     /gene="POTEJ"
                     /gene_synonym="POTE2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..3370
                     /gene="POTEJ"
                     /gene_synonym="POTE2beta"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attggaaacc cggagttacc tgctagttgg tgaaactggt tggtagacgt gatctgctcg
       61 ctactaccgg cctccccagg ctgttaaaag cagatggtag ctgaggttga ttcaatgccg
      121 gctgcctctt ctgtgaagaa gccatttgtt ctcaggagca agatgggcaa gtggtgccgc
      181 cactgcttcc cctgctgcag ggggagcggc aagagcaacg tgggcacttc tggagaccag
      241 gacgactcca ctatgaagac actcaggagc aagatgggca agtggtgctg ccactgcttc
      301 ccctgctgca gggggagcgg caagagcaac gtgggtgctt ggggagacta cgacgacagc
      361 gccttcgtgg agccgagata ccacgtccgt cgagaagatc tggacaagct ccacagagct
      421 gcctggtggg gtaaagtcgc cagaaaggat ctgatcgtca tgctcaggga cactgacgtg
      481 aacaagcagg acaagcaaaa gaggactgct ctacatctgg cctctgccaa tgggaattca
      541 ggagtagtaa aactcctgct ggacagacga tgtcaactta atgtccttga caacaaaaag
      601 aggacagctc tgacaaaggc cgtacaatgc caggaagatg aatgtgcgtt aatgttgctg
      661 gaacatggca ctgatccaaa cattccagat gagtatggaa ataccactct acactacgct
      721 atctacaatg aagataaatt aatggccaaa gcactgctct tatacggtgc tgatatcgaa
      781 tcaaaaaaca agcatggcct cacaccactg ctacttggtg tacatgagca aaaacagcaa
      841 gtggtgaaat ttttaatcaa gaaaaaagcg aatttaaatg cactggatag atatggaaga
      901 actgctctca tacttgctgt atgttgtgga tcagcaagta tagtcagcct tctacttgag
      961 caaaatattg atgtatcttc tcaagatcta tctggacaga cggccagaga gtatgctgtt
     1021 tctagtcatc atcatgtaat ttgccagtta ctttctgact acaaagaaaa acagatgcta
     1081 aaaatctctt ctgaaaacag caatccagaa caagacttaa agctgacatc agaggaagag
     1141 tcacaaaggt tcaaaggcag tgaaaatagc cagccagaga aaatgtctca agaaccagaa
     1201 ataaataagg atggtgatag agaggttgaa gaagaaatga agaagcatga aagtaataat
     1261 gtgggattac tagaaaacct gagtaatggt gtcactgctg gcaatggtga tgatggatta
     1321 attcctcaaa ggaagagcag aacacctgaa aatcagcaat ttcctgacaa cgaaagtgaa
     1381 gagtatcaca gaatttgcga attagtttct gactacaaag aaaaacagat gccaaaatac
     1441 tcttctgaaa acagcaaccc agaacaagac ttaaagctga catcagagga agagtcacaa
     1501 aggcttaaag gcagtgaaaa tggccagcca gagaaaagat ctcaagaacc agaaataaat
     1561 aaggatggtg atagagagct agaaaatttt atggctatcg aagaaatgaa gaagcacgga
     1621 agtactcacg tcggattccc agaaaacctg actaatggtg ccactgctgg caatggtgat
     1681 gatggattaa ttcctccaag gaagagcaga acacctgaaa gccagcaatt tcctgacact
     1741 gagaatgaag agtatcacag tgacgaacaa aatgatactc agaagcaatt ttgtgaagaa
     1801 cagaacactg gaatattaca cgatgagatt ctgattcatg aagaaaagca gatagaagtg
     1861 gttgaaaaaa tgaattctga gctttctctt agttgtaaga aagaaagaga cttcttgcat
     1921 gaaaatagta tgttgcggga agaaattgcc atgctaagac tggagctaga cacaatgaaa
     1981 catcagagcc agctaagaaa aaagaaatat ttggaggata ttgaaagtgt gaaaaaaaag
     2041 aatgataatc ttttaaaggc tctacaattg aatgagctca ccatggatga tgataccgct
     2101 gtgctcgtca ttgacaacgg ctctggcatg tgcaaggccg gctttgcggg cgacgatgcc
     2161 ccccgggctg tcttcccttc catcgtgggg tgccccaggc agcagggcat gatggggggc
     2221 atgcatcaga aagagtccta tgtgggcaag gaggcccaga gcaagagagg catcctgacc
     2281 ctgaagtacc ccatggaaca cggcatcatc accaactggg atgacatgga gaagatctgg
     2341 caccacacct tctacaacga gctgcgtgtg gcccccgagg agcaccccat cctgctgacc
     2401 gaggcccccc tgaaccccaa ggccaaccgc gagaagatga cccagatcat gtttgagacc
     2461 ttcaacaccc cagccatgta cgtggccatc caggccatgc tgtccctgta cacctctggc
     2521 cgtactactg gcatcgtgat ggactctggt gacggggtca cccacactgt gcccatctat
     2581 gatgggaatg ccctccccca tgccaccctg cgcctagacc tggctgggcg ggaactgact
     2641 gactacctca tgaagatcct caccgagcgt ggctataggt tcaccaccat ggccgagcgg
     2701 gaaatcgtgc gtgacatcaa agagaagctg tgctatgttg ccctggactt cgagcaggag
     2761 atggccatgg tggcctccag ctcctcccta gagaagagct acgagctgcc cgatggccag
     2821 gtcatcacca tcagcaacga gtggttccgc tgccccgagg cgctcttcca gccttgcttc
     2881 ctgggcatgg aatcctgtgg catccatgaa actaccttca actccatcat gaagtctgat
     2941 gtggacatcc gcaaagacct gtacaccaac acagtgctgt ctggcggcac caccatgtac
     3001 cctggcatgg cccacagaat gcagaaggag atcgctgccc tggcgcctag catgatgaag
     3061 atcaggatca ttgctcctcc caagcgcaag tactccgtgt gggtcggtgg ctccatcctg
     3121 gcctcgctgt ccaccttcca gcagatgtgg atcagcaagc aggagtatga tgagtcaggc
     3181 ccctccattg tccaccgcaa atgcttctag gtggactctg acttagttgc gttacaccct
     3241 ttcttgacaa aaccaaactt ctcagaaaac aacatgagat tggcatggct ttatttgttt
     3301 tcttgtttca ttttttgttt tgttttttat tggcttgact caggatttaa aaaccggaat
     3361 ggtgaaggtg
//
