LOCUS       NM_001277406            6682 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens POTE ankyrin domain family member I (POTEI),
            transcript variant 2, mRNA.
ACCESSION   NM_001277406 XM_928585
VERSION     NM_001277406.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6682)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   2  (bases 1 to 6682)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   3  (bases 1 to 6682)
  AUTHORS   Chang,K.W., Yang,P.Y., Lai,H.Y., Yeh,T.S., Chen,T.C. and Yeh,C.T.
  TITLE     Identification of a novel actin isoform in hepatocellular carcinoma
  JOURNAL   Hepatol Res 36 (1), 33-39 (2006)
   PUBMED   16824795
REFERENCE   4  (bases 1 to 6682)
  AUTHORS   Hahn,Y., Bera,T.K., Pastan,I.H. and Lee,B.
  TITLE     Duplication and extensive remodeling shaped POTE family genes
            encoding proteins containing ankyrin repeat and coiled coil domains
  JOURNAL   Gene 366 (2), 238-245 (2006)
   PUBMED   16364570
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC013269.10 and AC132479.2.
            
            On Jul 29, 2019 this sequence version replaced NM_001277406.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            CCDS Note: This CCDS representation lacks full-length human
            transcript support and it is therefore inferred, but the
            full-length exon combination it is supported by partial human
            transcripts and the full-length paralogous transcript EF523384.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.51727.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2142586 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000451531.7/ ENSP00000392718.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-614               AC013269.10        46739-47352         c
            615-729             AC013269.10        41804-41918         c
            730-903             AC013269.10        41470-41643         c
            904-1010            AC013269.10        38560-38666         c
            1011-1148           AC013269.10        37108-37245         c
            1149-1219           AC013269.10        34576-34646         c
            1220-1290           AC013269.10        28694-28764         c
            1291-1335           AC013269.10        27259-27303         c
            1336-1502           AC013269.10        26056-26222         c
            1503-1573           AC013269.10        20027-20097         c
            1574-1644           AC013269.10        14655-14725         c
            1645-1689           AC013269.10        12931-12975         c
            1690-1871           AC013269.10        12402-12583         c
            1872-1992           AC013269.10        3676-3796           c
            1993-4160           AC013269.10        1-2168              c
            4161-6682           AC132479.2         135451-137972       c
FEATURES             Location/Qualifiers
     source          1..6682
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q21.1"
     gene            1..6682
                     /gene="POTEI"
                     /gene_synonym="POTE2beta"
                     /note="POTE ankyrin domain family member I"
                     /db_xref="GeneID:653269"
                     /db_xref="HGNC:HGNC:37093"
     exon            1..614
                     /gene="POTEI"
                     /gene_synonym="POTE2beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..3321
                     /gene="POTEI"
                     /gene_synonym="POTE2beta"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="POTE ankyrin domain family member I isoform 2"
                     /protein_id="NP_001264335.1"
                     /db_xref="CCDS:CCDS59431.1"
                     /db_xref="GeneID:653269"
                     /db_xref="HGNC:HGNC:37093"
                     /translation="MVAEVDSMPAASSVKKPFVLRSKMGKWCRHCFPCCRGSGKSNVG
                     TSGDQDDSTMKTLRSKMGKWCCHCFPCCRGSGKSNVGTSGDHDDSAMKTLRSKMGKWC
                     CHCFPCCRGSGKSNVGAWGDYDDSAFVEPRYHVRREDLDKLHRAAWWGKVARKDLIVM
                     LRDTDVNKQDKQKRTALHLASANGNSGVVKLLLDRRCQLNVLDNKKRTALTKAVQCQE
                     DECALMLLEHGTDPNIPDEYGNTTLHYAIYNEDKLMAKALLLYGADIESKNKHGLTPL
                     LLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVSLLLEQNIDVSSQ
                     DLSGQTAREYAVSSHHHVICQLLSDYKEKQMLKISSENSNPEQDLKLTSEEESQRFKG
                     SENSQPEKMSQEPEINKDGDREVEEEMKKHESNNVGLLENLSNGVTAGNGDDGLIPQR
                     KSRTPENQQFPDNESEEYHRICELVSDYKEKQMPKYSSENSNPEQDLKLTSEEESQRL
                     KGSENGQPEKRSQEPEINKDGDRELENFMAIEEMKKHGSTHVGFPENLTNGATAGNGD
                     DGLIPPRKSRTPESQQFPDTENEEYHSDEQNDTQKQFCEEQNTGILHDEILIHEEKQI
                     EVVEKMNSELSLSCKKEKDFLHENSTLREEIAMLRLELDTMKHQSQLRKKKYLEDIES
                     VKKKNDNLLKALQLNELTMDDDTAVLVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRQ
                     QGMMGGMHQKESYVGKEAQSKRGILTLKYPMEHGIITNWDDMEKIWHHTFYNELRVAP
                     EEHPILLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAMLSLYTSGRTTGIVMDSG
                     DGVTHTVPIYDGNALPHATLRLDLAGRELTDYLMKILTERGYRFTTMAEREIVRDIKE
                     KLCYVALDFEQEMAMAASSSSLEKSYELPDGQVITIGNEWFRCPEALFQPCFLGMESC
                     GIHETTFNSIMKSDVDIRKDLYTNTVLSGGTTMYPGMAHRMQKEIAALAPSMLKIRII
                     APPKRKYSVWVGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF"
     exon            615..729
                     /gene="POTEI"
                     /gene_synonym="POTE2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            730..903
                     /gene="POTEI"
                     /gene_synonym="POTE2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1010
                     /gene="POTEI"
                     /gene_synonym="POTE2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1148
                     /gene="POTEI"
                     /gene_synonym="POTE2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1219
                     /gene="POTEI"
                     /gene_synonym="POTE2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1290
                     /gene="POTEI"
                     /gene_synonym="POTE2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1335
                     /gene="POTEI"
                     /gene_synonym="POTE2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1502
                     /gene="POTEI"
                     /gene_synonym="POTE2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1573
                     /gene="POTEI"
                     /gene_synonym="POTE2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1644
                     /gene="POTEI"
                     /gene_synonym="POTE2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1689
                     /gene="POTEI"
                     /gene_synonym="POTE2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1871
                     /gene="POTEI"
                     /gene_synonym="POTE2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..1992
                     /gene="POTEI"
                     /gene_synonym="POTE2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..6682
                     /gene="POTEI"
                     /gene_synonym="POTE2beta"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attggaaacc cggagttacc tgctagttgg tgaaactggt tggtagacgt gatctgctcg
       61 ctactaccgg cctccccagg ctgttaaaag cagatggtag ctgaggttga ttcaatgccg
      121 gctgcctctt ctgtgaagaa gccatttgtt ctcaggagca agatgggcaa gtggtgccgc
      181 cactgcttcc cctgctgcag ggggagcggc aagagcaacg tgggcacttc tggagaccag
      241 gacgactcca ctatgaagac actcaggagc aagatgggca agtggtgctg ccactgcttc
      301 ccctgctgca gggggagtgg caagagcaac gtgggcactt ctggagacca cgacgactcc
      361 gctatgaaga cgctcaggag caagatgggc aagtggtgct gccactgctt cccctgctgc
      421 agggggagcg gcaagagcaa cgtgggtgct tggggagact acgacgacag cgccttcgtg
      481 gagccgagat accacgtccg tcgagaagat ctggacaagc tccacagagc tgcctggtgg
      541 ggtaaagtcg ccagaaagga tctgatcgtc atgctcaggg acactgacgt gaacaagcag
      601 gacaagcaaa agaggactgc tctacatctg gcctctgcca atgggaattc aggagtagta
      661 aaactcctgc tggacagacg atgtcaactt aatgtccttg acaacaaaaa gaggacagct
      721 ctgacaaagg ccgtacaatg ccaggaagat gaatgtgcgt taatgttgct ggaacatggc
      781 actgatccaa acattccaga tgagtatgga aataccactc tacactacgc tatctacaat
      841 gaagataaat taatggccaa agcactgctc ttatacggtg ctgatatcga atcaaaaaac
      901 aagcatggcc tcacaccact gctacttggt gtacatgagc aaaaacagca agtggtgaaa
      961 tttttaatca agaaaaaagc gaatttaaat gcgctggata gatatggaag aactgctctc
     1021 atacttgctg tatgttgtgg atcagcaagt atagtcagcc ttctacttga gcaaaatatt
     1081 gatgtatctt ctcaagatct atctggacag acggccagag agtatgctgt ttctagtcat
     1141 catcatgtaa tttgccagtt actttctgac tacaaagaaa aacagatgct aaaaatctct
     1201 tctgaaaaca gcaatccaga acaagactta aagctgacat cagaggaaga gtcacaaagg
     1261 ttcaaaggca gtgaaaatag ccagccagag aaaatgtctc aagaaccaga aataaataag
     1321 gatggtgata gagaggttga agaagaaatg aagaagcatg aaagtaataa tgtgggatta
     1381 ctagaaaacc tgagtaatgg tgtcactgct ggcaatggtg atgatggatt aattcctcaa
     1441 aggaagagca gaacacctga aaatcagcaa tttcctgaca acgaaagtga agagtatcac
     1501 agaatttgcg aattagtttc tgactacaaa gaaaaacaga tgccaaaata ctcttctgaa
     1561 aacagcaacc cagaacaaga cttaaagctg acatcagagg aagagtcaca aaggcttaaa
     1621 ggcagtgaaa atggccagcc agagaaaaga tctcaagaac cagaaataaa taaggatggt
     1681 gatagagagc tagaaaattt tatggctatc gaagaaatga agaagcacgg aagtactcac
     1741 gtcggattcc cagaaaacct gactaatggt gccactgctg gcaatggtga tgatggatta
     1801 attcctccaa ggaagagcag aacacctgaa agccagcaat ttcctgacac tgagaatgaa
     1861 gagtatcaca gtgacgaaca aaatgatact cagaagcaat tttgtgaaga acagaacact
     1921 ggaatattac acgatgagat tctgattcat gaagaaaagc agatagaagt ggttgaaaaa
     1981 atgaattctg agctttctct tagttgtaag aaagaaaaag acttcttgca tgaaaatagt
     2041 acgttgcggg aagaaattgc catgctaaga ctggagctag acacaatgaa acatcagagc
     2101 cagctaagaa aaaagaaata tttggaggat attgaaagtg tgaaaaaaaa gaatgataat
     2161 cttttaaagg ctctacaatt gaatgagctc accatggatg atgataccgc cgtgctcgtc
     2221 attgacaacg gctctggcat gtgcaaggcc ggctttgcgg gcgacgatgc cccccgggct
     2281 gtcttccctt ccatcgtggg gcgccccagg cagcagggca tgatgggggg catgcatcag
     2341 aaagagtcct atgtgggcaa ggaggcccag agcaagagag gcatcctgac cctgaagtac
     2401 cccatggaac acggcatcat caccaactgg gatgacatgg agaagatctg gcaccacacc
     2461 ttctacaacg agctgcgtgt ggcccctgag gagcacccca tcctgctgac cgaggccccc
     2521 ctgaacccca aggccaaccg cgagaagatg acccagatca tgtttgagac cttcaacacc
     2581 ccagccatgt acgtggccat ccaggccatg ctgtccctgt acacctctgg ccgtactact
     2641 ggcatcgtga tggactctgg tgacggggtc acccacactg tgcccatcta tgatgggaat
     2701 gccctccccc atgccaccct gcgcctagac ctggctgggc gggaactgac tgactacctc
     2761 atgaagatcc tcaccgagcg tggctatagg ttcaccacca tggccgagcg ggaaatcgtg
     2821 cgtgacatca aagagaagct gtgctatgtt gccctggact tcgagcagga gatggccatg
     2881 gcggcctcca gctcctccct agagaagagc tacgagctgc ccgatggcca ggtcatcacc
     2941 atcggcaacg agtggttccg ctgccccgag gcgctcttcc agccttgctt cctgggcatg
     3001 gaatcctgtg gcatccatga aactaccttc aactccatca tgaagtctga tgtggacatc
     3061 cgcaaagacc tgtacaccaa cacagtgctg tctggcggca ccaccatgta ccctggcatg
     3121 gcccacagaa tgcagaagga gatcgctgcc ctggcgccta gcatgttgaa gatcaggatc
     3181 attgctcctc ccaagcgcaa gtactccgtg tgggtcggtg gctccatcct ggcctcgctg
     3241 tccaccttcc agcagatgtg gatcagcaag caggagtatg atgagtcagg cccctccatt
     3301 gtccaccgca aatgcttcta ggtggactct gacttagttg cgttacaccc tttcttgaca
     3361 aaaccaaact tctcagaaaa caacatgaga ttggcatggc tttatttgtt ttcttgtttc
     3421 attttttgtt ttgtttttta ttggcttgac tcaggattta aaaaccggaa tggtgaaggt
     3481 gacagcagtc ggttggagga agcttcctcc aaagttctac aatgtggcca aggactttga
     3541 ttgtacattg ttcttctttt caatagtcat tccaaatatt gtgagacgca ttgtttcagg
     3601 aagccccttg ccctgctaaa agccacccca cttctctcta aggagaatgg cccagtcctc
     3661 tccctagttc acacagggga ggtgatagca ttgcttttgt gcagattaca taatgcaaaa
     3721 ttttttgaat cttcgcctta atacttttta attttgtttt attttgaatg atcagccttc
     3781 gtggcccccc tcttttgtac cccaacttgg ggtgtatgaa ggcttttggt ctccctgaga
     3841 gtggctggag gcagccaggg cttacctgta ctctgacttg aggagagttg gataaaagtg
     3901 cacaccttaa aaaaaattga ggaagcacag tatttcagta cagtggacag cttagcatgt
     3961 tgacaactga gaataaaatg ctcagttctg aactggacaa tgtaagacac aacgaggaaa
     4021 caccggaaat ggaaattcaa ttacgtcatt gtagactggc tgctgctcta catgattgtg
     4081 accaaagtca gatagctgaa agagacttct ttccagagaa caagacatga acaggtttat
     4141 ttacagaaga caatgaattc tcatttatct cacctaaaag agaacagatt ctttctcaac
     4201 aagtctaacg tagacagtaa aatcaacagg ctaaaaatta agctccatga aacaagataa
     4261 aactctgaga gaaaagacgg ggcaggccgc catctttccc gttcaggcaa cttagtcatt
     4321 ccagcctgcg ggctttggag agtacaaacc gacgagggac agaagagatc ccacagcaca
     4381 gcatagctgc tttaccaaat catggccaga ctgcttctgt aagcaggccc ctgatcctgt
     4441 tccatctcac tggacaggac ctcccaactg gggcctccag ctacccccac cagcattcct
     4501 tggccaatgg aaatgtgaaa tgttcctggg acagagctcc cggagagggg caggccccca
     4561 cctttgctct ttcggtgact agccattctg gcctgcgggc tttggagagc ccaagctgac
     4621 aaggggtgga agaggtacct cagcacagca cagccacgct accaaaacgt ggccagactc
     4681 ttgtttacgt cagtccctga ccacatttct agtcagtggg tgaagtcttt caaccagggt
     4741 ctctggctac cttgactgct gttctctggc cgacagaggt ctcaggcctc cctgagtcag
     4801 agctcccagg gggaggacca gattgtcatc tttgctgttg gggcgaccca ggcatttcag
     4861 ccttagggct tcagagtgtc tgaggcggac caggggctga agtgaacccc cagcacagca
     4921 cagctgctct ataaaaacgt ggccagactt ttctttttga agcaagtccc tgttcttgtt
     4981 cgtcctgact aggtaagact tctcaacttg cctccagcca catcttatag gtgtgttcag
     5041 attggcaaca ggttcgtacc tcagtggtac agagcttcca gaggaagggg cagactatca
     5101 tcttccctgg aaaatacaag gcaattaggg actggagggg acccccagca taccacagca
     5161 gccctacaga aaagtggcca ggctctctac ttgatgggca gatcctcctg gcctgggtct
     5221 ctagccagcc caccactgga gctatcaagc cagtagcaac tctgcagttc ctgggacaga
     5281 gcttccagga gcaaatgaaa tcctttctgc cactgcctct gcagtggaac tgcccttgct
     5341 gccctcagaa gatgcaaggg agcaaagacc ctaagtgccc tatcaacacc tccaataagc
     5401 tgcagttgac ccaaagaaca agccagtcca tctcccacgg gtaccacaca ccctccacta
     5461 ctcatcacca gacagggaac cctggcttgg gcccacagca cagaccctcc atcctgggct
     5521 gattacacta agtgattgct aactcacatg tctctgggat ggagcaccca ggaaacaagc
     5581 aaagtggtgg agcagcaagt caggtgatgt ggagcccaga ggtcagggat ggctgtctct
     5641 ctagggtcca cttgcccttg tgagacactt tatcccagca ctttaggaat actgaggtca
     5701 taccagccac atcttatatg caagattgcc cagcagagat caggtccgag agttcccttt
     5761 ttaaaaaaag gagacttgct taataaaaga agtctagcca cgtttgtgta gagcggctgt
     5821 gctgtgctgg gggttcactt ttgagagagt tctcctctga gacctgatct ctggaggctg
     5881 ggcaatcttg cacttgagat ggggctggtc tgatctcagc actccttagt ctgctcgcct
     5941 ctcccatggc cccagcctgg ccacacctgc ttacggggca ctcttagatg cccacaccat
     6001 agcttccgtg ctagtggact gtaccatatc agtggagagc tgcagcaagg tggcccctag
     6061 agccacgcac cagcctgcac attgcctctc catacggcag ccctttattt ggaaacttcc
     6121 taaatcactt tgctgtgtgt gtttacacgg gtgggttttg ctttacttgc cctgagagca
     6181 cacaggagtg cagcacacac cccaacccac atcaactgcc attaaagaaa agaaatttca
     6241 gcccagaatt tcatgtccag caaaattaag catcataagt gaaggagaaa taagatcctt
     6301 ttcagacaag caagtgctga gggaatttgg tatcaccaga tctaccttac gagagctcct
     6361 gaaggaagca ctaaatatgg aaagaaaaga tcatcacctg ctactacaaa aacacactga
     6421 agtacacagt ccaatgatgc taaaaagcaa gcacatatgt aagtctgcaa aataaccagc
     6481 tgacagcatg acgacaggat aaaatccaca cataccatta ctaaccttaa atgtaaatgg
     6541 gctaaatgct cccattgaaa gacacggggc aagctgggta aagaaccaag acccactgga
     6601 gtatgccgtc ttcaagcaac ccatctcacg tgcagtgcca tacataggct caaaataaag
     6661 gaatggagaa aaatatttca ag
//
