LOCUS       NM_001099771            4337 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens POTE ankyrin domain family member F (POTEF), mRNA.
ACCESSION   NM_001099771 XM_001130062
VERSION     NM_001099771.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4337)
  AUTHORS   Reed,A.E., Peraza,J., van den Haak,F., Hernandez,E.R., Gibbs,R.A.,
            Chinn,I.K., Lupski,J.R., Marchi,E., Reshef,R., Alobeid,B.,
            Mace,E.M. and Orange,J.S.
  TITLE     beta-Actin G342D as a Cause of NK Cell Deficiency Impairing Lytic
            Synapse Termination
  JOURNAL   J Immunol 212 (6), 962-973 (2024)
   PUBMED   38315012
  REMARK    GeneRIF: beta-Actin G342D as a Cause of NK Cell Deficiency
            Impairing Lytic Synapse Termination.
REFERENCE   2  (bases 1 to 4337)
  AUTHORS   Al-Fakhar,M.S.Q., Bilgin,N., Moesgaard,L., Witecka,A., Drozak,J.,
            Kongsted,J. and Mecinovic,J.
  TITLE     The Role of Trp79 in beta-Actin on Histidine Methyltransferase
            SETD3 Catalysis
  JOURNAL   Chembiochem 24 (21), e202300490 (2023)
   PUBMED   37581408
  REMARK    GeneRIF: The Role of Trp79 in beta-Actin on Histidine
            Methyltransferase SETD3 Catalysis.
REFERENCE   3  (bases 1 to 4337)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4337)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 4337)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   6  (bases 1 to 4337)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   7  (bases 1 to 4337)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   8  (bases 1 to 4337)
  AUTHORS   Liu,X.F., Bera,T.K., Liu,L.J. and Pastan,I.
  TITLE     A primate-specific POTE-actin fusion protein plays a role in
            apoptosis
  JOURNAL   Apoptosis 14 (10), 1237-1244 (2009)
   PUBMED   19669888
  REMARK    GeneRIF: POTE gene family encodes a new family of proapoptotic
            proteins.
REFERENCE   9  (bases 1 to 4337)
  AUTHORS   Lee,Y., Ise,T., Ha,D., Saint Fleur,A., Hahn,Y., Liu,X.F.,
            Nagata,S., Lee,B., Bera,T.K. and Pastan,I.
  TITLE     Evolution and expression of chimeric POTE-actin genes in the human
            genome
  JOURNAL   Proc Natl Acad Sci U S A 103 (47), 17885-17890 (2006)
   PUBMED   17101985
REFERENCE   10 (bases 1 to 4337)
  AUTHORS   Chang,K.W., Yang,P.Y., Lai,H.Y., Yeh,T.S., Chen,T.C. and Yeh,C.T.
  TITLE     Identification of a novel actin isoform in hepatocellular carcinoma
  JOURNAL   Hepatol Res 36 (1), 33-39 (2006)
   PUBMED   16824795
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC018804.9 and AC018865.4.
            
            On Aug 20, 2009 this sequence version replaced NM_001099771.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF523384.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2142853 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409914.7/ ENSP00000386786.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               AC018804.9         109206-109356
            152-307             AC018804.9         110564-110719
            308-921             AC018804.9         117820-118433
            922-1036            AC018804.9         123100-123214
            1037-1210           AC018804.9         123374-123547
            1211-1317           AC018804.9         126327-126433
            1318-1455           AC018804.9         127748-127885
            1456-1526           AC018865.4         164018-164088       c
            1527-1597           AC018865.4         158119-158189       c
            1598-1642           AC018865.4         156685-156729       c
            1643-1809           AC018865.4         155479-155645       c
            1810-1880           AC018865.4         149447-149517       c
            1881-1951           AC018865.4         144076-144146       c
            1952-1996           AC018865.4         142352-142396       c
            1997-2178           AC018865.4         141823-142004       c
            2179-2299           AC018865.4         133090-133210       c
            2300-4337           AC018865.4         129544-131581       c
FEATURES             Location/Qualifiers
     source          1..4337
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q21.1"
     gene            1..4337
                     /gene="POTEF"
                     /gene_synonym="A26C1B; ACTB; POTE2alpha; POTEACTIN"
                     /note="POTE ankyrin domain family member F"
                     /db_xref="GeneID:728378"
                     /db_xref="HGNC:HGNC:33905"
     exon            1..151
                     /gene="POTEF"
                     /gene_synonym="A26C1B; ACTB; POTE2alpha; POTEACTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            152..307
                     /gene="POTEF"
                     /gene_synonym="A26C1B; ACTB; POTE2alpha; POTEACTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            308..921
                     /gene="POTEF"
                     /gene_synonym="A26C1B; ACTB; POTE2alpha; POTEACTIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             401..3628
                     /gene="POTEF"
                     /gene_synonym="A26C1B; ACTB; POTE2alpha; POTEACTIN"
                     /note="prostate, ovary, testis expressed protein on
                     chromosome 2; POTE-2 alpha-actin; chimeric POTE-actin
                     protein; ANKRD26-like family C member 1B; beta actin"
                     /codon_start=1
                     /product="POTE ankyrin domain family member F"
                     /protein_id="NP_001093241.1"
                     /db_xref="CCDS:CCDS46409.1"
                     /db_xref="GeneID:728378"
                     /db_xref="HGNC:HGNC:33905"
                     /translation="MVVEVDSMPAASSVKKPFGLRSKMGKWCCRCFPCCRESGKSNVG
                     TSGDHDDSAMKTLRSKMGKWCRHCFPCCRGSGKSNVGASGDHDDSAMKTLRNKMGKWC
                     CHCFPCCRGSSKSKVGAWGDYDDSAFMEPRYHVRGEDLDKLHRAAWWGKVPRKDLIVM
                     LRDTDVNKQDKQKRTALHLASANGNSEVVKLLLDRRCQLNVLDNKKRTALIKAVQCQE
                     DECALMLLEHGTDPNIPDEYGNTTLHYAIYNEDKLMAKALLLYGADIESKNKHGLTPL
                     LLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVSLLLEQNIDVSSQ
                     DLSGQTAREYAVSSHHHVICQLLSDYKEKQMLKISSENSNPEQDLKLTSEEESQRFKG
                     SENSQPEKMSQEPEINKDGDREVEEEMKKHESNNVGLLENLTNGVTAGNGDNGLIPQR
                     KSRTPENQQFPDNESEEYHRICELLSDYKEKQMPKYSSENSNPEQDLKLTSEEESQRL
                     KGSENGQPEKRSQEPEINKDGDRELENFMAIEEMKKHRSTHVGFPENLTNGATAGNGD
                     DGLIPPRKSRTPESQQFPDTENEEYHSDEQNDTQKQFCEEQNTGILHDEILIHEEKQI
                     EVVEKMNSELSLSCKKEKDILHENSTLREEIAMLRLELDTMKHQSQLREKKYLEDIES
                     VKKRNDNLLKALQLNELTMDDDTAVLVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRQ
                     QGMMGGMHQKESYVGKEAQSKRGILTLKYPMEHGIITNWDDMEKIWHHTFYNELRVAP
                     EEHPVLLTEATLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYTSGRTTGIVMDSG
                     DGVTHTVPIYEGNALPHATLRLDLAGRELPDYLMKILTEHGYRFTTMAEREIVRDIKE
                     KLCYVALDFEQEMATVASSSSLEKSYELPDGQVITIGNERFRCPEALFQPCFLGMESC
                     GIHETTFNSIMKSDVDIRKDLYTNTVLSGGTTMYPGMAHRMQKEIAALAPSMMKIRII
                     APPKRKYSVWVGGSILASLSTFQQMWISKQEYDESGPSIVHRKCL"
     exon            922..1036
                     /gene="POTEF"
                     /gene_synonym="A26C1B; ACTB; POTE2alpha; POTEACTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1210
                     /gene="POTEF"
                     /gene_synonym="A26C1B; ACTB; POTE2alpha; POTEACTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1317
                     /gene="POTEF"
                     /gene_synonym="A26C1B; ACTB; POTE2alpha; POTEACTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1455
                     /gene="POTEF"
                     /gene_synonym="A26C1B; ACTB; POTE2alpha; POTEACTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1526
                     /gene="POTEF"
                     /gene_synonym="A26C1B; ACTB; POTE2alpha; POTEACTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1597
                     /gene="POTEF"
                     /gene_synonym="A26C1B; ACTB; POTE2alpha; POTEACTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1642
                     /gene="POTEF"
                     /gene_synonym="A26C1B; ACTB; POTE2alpha; POTEACTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1809
                     /gene="POTEF"
                     /gene_synonym="A26C1B; ACTB; POTE2alpha; POTEACTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1880
                     /gene="POTEF"
                     /gene_synonym="A26C1B; ACTB; POTE2alpha; POTEACTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..1951
                     /gene="POTEF"
                     /gene_synonym="A26C1B; ACTB; POTE2alpha; POTEACTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..1996
                     /gene="POTEF"
                     /gene_synonym="A26C1B; ACTB; POTE2alpha; POTEACTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2178
                     /gene="POTEF"
                     /gene_synonym="A26C1B; ACTB; POTE2alpha; POTEACTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2299
                     /gene="POTEF"
                     /gene_synonym="A26C1B; ACTB; POTE2alpha; POTEACTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..4337
                     /gene="POTEF"
                     /gene_synonym="A26C1B; ACTB; POTE2alpha; POTEACTIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4198..4203
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POTEF"
                     /gene_synonym="A26C1B; ACTB; POTE2alpha; POTEACTIN"
                     /note="hexamer: GATAAA"
     polyA_site      4223
                     /gene="POTEF"
                     /gene_synonym="A26C1B; ACTB; POTE2alpha; POTEACTIN"
                     /note="major polyA site"
ORIGIN      
        1 gcgggagctt ctcctgccag gcaggaagac gagtagaagg gagcggcatg ctggaggctg
       61 gagcctgagc ccctggggct cgccttgctg tgtttggtgg tgacgtggga cactgcagct
      121 cggccagagt ggtagaaatg tcctggtgta ggcttttctg gctttgcccg tctagctgct
      181 ccaagccagg ctggaggagg aggagaagga atcacctgtg gtacgctgga gcctgcatgt
      241 ggcgtgactc tgcagctcgc ctcgtgtgac tgatggcagc cacggagact gcagctcgac
      301 aggagtgatt ggaaacccgg agttacctgc tagttggtga aactggttgg tagacgcgat
      361 ctgttggcta ctactggctt ctcctggctg ttaaaagcag atggtggttg aggttgattc
      421 catgccggct gcctcttctg tgaagaagcc atttggtctc aggagcaaga tgggcaagtg
      481 gtgctgccgt tgcttcccct gctgcaggga gagcggcaag agcaacgtgg gcacttctgg
      541 agaccacgac gactctgcta tgaagacact caggagcaag atgggcaagt ggtgccgcca
      601 ctgcttcccc tgctgcaggg ggagtggcaa gagcaacgtg ggcgcttctg gagaccacga
      661 cgactctgct atgaagacac tcaggaacaa gatgggcaag tggtgctgcc actgcttccc
      721 ctgctgcagg gggagcagca agagcaaggt gggcgcttgg ggagactacg atgacagtgc
      781 cttcatggag cccaggtacc acgtccgtgg agaagatctg gacaagctcc acagagctgc
      841 ctggtggggt aaagtcccca gaaaggatct catcgtcatg ctcagggaca ctgacgtgaa
      901 caagcaggac aagcaaaaga ggactgctct acatctggcc tctgccaatg ggaattcaga
      961 agtagtaaaa ctcctgctgg acagacgatg tcaacttaat gtccttgaca acaaaaagag
     1021 gacagctctg ataaaggccg tacaatgcca ggaagatgaa tgtgcgttaa tgttgctgga
     1081 acatggcact gatccaaata ttccagatga gtatggaaat accactctgc actacgctat
     1141 ctataatgaa gataaattaa tggccaaagc actgctctta tatggtgctg atatcgaatc
     1201 aaaaaacaag catggcctca caccactgtt acttggtgta catgagcaaa aacagcaagt
     1261 cgtgaaattt ttaattaaga aaaaagcgaa tttaaatgca ctggatagat atggaagaac
     1321 tgctctcata cttgctgtat gttgtggatc agcaagtata gtcagccttc tacttgagca
     1381 aaatattgat gtatcttctc aagatctatc tggacagacg gccagagagt atgctgtttc
     1441 tagtcatcat catgtaattt gccagttact ttctgactac aaagaaaaac agatgctaaa
     1501 aatctcttct gaaaacagca atccagaaca agacttaaag ctgacatcag aggaagagtc
     1561 acaaaggttc aaaggcagtg aaaatagcca gccagagaaa atgtctcaag aaccagaaat
     1621 aaataaggat ggtgatagag aggttgaaga agaaatgaag aagcatgaaa gtaataatgt
     1681 gggattacta gaaaacctga ctaatggtgt cactgctggc aatggtgata atggattaat
     1741 tcctcaaagg aagagcagaa cacctgaaaa tcagcaattt cctgacaacg aaagtgaaga
     1801 gtatcacaga atttgtgaat tactttctga ctacaaagaa aagcagatgc caaaatactc
     1861 ttctgaaaac agcaacccag aacaagactt aaagctgaca tcagaggaag agtcacaaag
     1921 gcttaaaggc agtgaaaatg gccagccaga gaaaagatct caagaaccag aaataaataa
     1981 ggatggtgat agagagctag aaaattttat ggctatcgaa gaaatgaaga agcacagaag
     2041 tactcatgtc ggattcccag aaaacctgac taatggtgcc actgctggca atggtgatga
     2101 tggattaatt cctccaagga agagcagaac acctgaaagc cagcaatttc ctgacactga
     2161 gaatgaagag tatcacagtg acgaacaaaa tgatactcag aagcaatttt gtgaagaaca
     2221 gaacactgga atattacacg atgagattct gattcatgaa gaaaagcaga tagaagtggt
     2281 tgaaaaaatg aattctgagc tttctcttag ttgtaagaaa gaaaaagaca tcttgcatga
     2341 aaatagtacg ttgcgggaag aaattgccat gctaagactg gagctagaca caatgaaaca
     2401 tcagagccag ctaagagaaa agaaatattt ggaggatatt gaaagtgtga aaaaaaggaa
     2461 tgataatctt ttaaaggctc tacaattgaa tgagctcacc atggatgatg ataccgctgt
     2521 gctcgtcatt gacaacggct ctggcatgtg caaggccggc tttgcgggcg acgatgcccc
     2581 ccgggctgtc ttcccttcca tcgtggggcg ccccaggcag cagggcatga tggggggcat
     2641 gcatcagaaa gagtcctatg tgggcaagga ggcccagagc aaaagaggca tcctgaccct
     2701 gaagtacccc atggaacacg gcatcatcac caactgggat gacatggaga agatctggca
     2761 ccacaccttc tacaacgagc tgcgtgtggc tcccgaggag caccccgtcc tgctgaccga
     2821 ggccaccctg aaccctaagg ccaaccgcga gaagatgacc cagatcatgt ttgagacctt
     2881 caacacccca gccatgtacg tggccatcca ggctgtgctg tccctgtaca cctctggccg
     2941 tactactggc atcgtgatgg actctggtga cggggtcacc cacactgtgc ccatctatga
     3001 ggggaatgcc ctcccccatg ccaccctgcg cctagacctg gctgggcggg aactgcctga
     3061 ctacctcatg aagatcctca ccgagcatgg ctataggttc accaccatgg ccgagcggga
     3121 aatcgtgcgt gacatcaaag agaagctgtg ctatgttgcc ctggacttcg agcaggagat
     3181 ggccacggtg gcctccagct cctccctaga gaagagctac gagctgcccg atggccaggt
     3241 catcaccatc ggcaacgagc ggttccgctg ccccgaggcg ctcttccagc cttgcttcct
     3301 gggcatggaa tcctgtggca tccatgaaac taccttcaac tccatcatga agtctgatgt
     3361 ggacatccgc aaagacctgt acaccaacac agtgctgtct ggcggcacca ccatgtaccc
     3421 tggcatggcc cacagaatgc agaaggagat cgctgccctg gcgcctagca tgatgaagat
     3481 caggatcatt gctcctccca agcgcaagta ctccgtgtgg gtcggtggct ccatcctggc
     3541 ctcgctgtcc accttccagc agatgtggat cagcaagcag gagtatgatg agtcaggccc
     3601 ctccattgtc caccgcaaat gcttgtaggt ggactctgac ttagttgcgt tacacccttt
     3661 cttgacaaaa ccaaacttct cagaaaacaa catgagattg gcatggcttt atttgttttc
     3721 ttgtttcatt ttttgttttg ttttttattg gcttgactca ggatttaaaa accggaatgg
     3781 tgaaggtgac agcagtcggt tggaggaagc ttcctccaaa gttctacaat gtggccaagg
     3841 actttgattg taccttgttc ttcttttcaa tagtcattcc aaatattgtg agacgcattg
     3901 tttcaggaag ccccttgccc tgctaaaagc caccccactt ctctctaagg agaatggccc
     3961 agtcctctcc ctagttcaca caggggaggt gatagcattg cttttgtgca aattacataa
     4021 tgcaaaattt tttgaatctt cgccttaata ctttttaatt ttgttttatt ttgaatgatc
     4081 agccttcgtg gcccccctct tttgtacccc aacttggggt gtatgaaggc ttttggtctc
     4141 cctgagagtg gctggaggca gccagggctt acctgtactc tgacttgagg agagttggat
     4201 aaaagtgcac accttaaaac aaattgagga agcacagtat ttcagtacag tggacagctt
     4261 agcatgttga caactgagaa taaaatgctc agttctgaac tggacaatgt aagacacaac
     4321 gaggaaacac tggaaat
//
