LOCUS       NM_001083538            4451 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens POTE ankyrin domain family member E (POTEE), mRNA.
ACCESSION   NM_001083538
VERSION     NM_001083538.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4451)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4451)
  AUTHORS   Hao,Q., Gao,L., Niu,W., Chen,L., Zhang,P. and Chen,Z.
  TITLE     POTEE stimulates the proliferation of pancreatic cancer by
            activating the PI3K/Akt/GSK-3beta/beta-catenin signaling
  JOURNAL   Biofactors 46 (4), 685-692 (2020)
   PUBMED   32589786
  REMARK    GeneRIF: POTEE stimulates the proliferation of pancreatic cancer by
            activating the PI3K/Akt/GSK-3beta/beta-catenin signaling.
REFERENCE   3  (bases 1 to 4451)
  AUTHORS   Xu,Q., Chen,J., Peng,M., Duan,S., Hu,Y., Guo,D., Geng,J. and
            Zhou,J.
  TITLE     POTEE promotes colorectal carcinoma progression via activating the
            Rac1/Cdc42 pathway
  JOURNAL   Exp Cell Res 390 (1), 111933 (2020)
   PUBMED   32142855
  REMARK    GeneRIF: POTEE promotes colorectal carcinoma progression via
            activating the Rac1/Cdc42 pathway.
            Erratum:[Exp Cell Res. 2021 Oct 15;407(2):112836. doi:
            10.1016/j.yexcr.2021.112836.. PMID: 34565520]
REFERENCE   4  (bases 1 to 4451)
  AUTHORS   Shen,Z., Feng,X., Fang,Y., Li,Y., Li,Z., Zhan,Y., Lin,M., Li,G.,
            Ding,Y. and Deng,H.
  TITLE     POTEE drives colorectal cancer development via regulating SPHK1/p65
            signaling
  JOURNAL   Cell Death Dis 10 (11), 863 (2019)
   PUBMED   31723122
  REMARK    GeneRIF: POTEE drives colorectal cancer development via regulating
            SPHK1/p65 signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4451)
  AUTHORS   Vekariya,U., Rawat,K., Saxena,R. and Tripathi,R.K.
  TITLE     Identification of MPhi specific POTEE expression: Its role in
            mTORC2 activation via protein-protein interaction in TAMs
  JOURNAL   Cell Immunol 335, 30-40 (2019)
   PUBMED   30420269
  REMARK    GeneRIF: In TAMs, POTEE was involved differential protein-protein
            interaction with mTOR, RICTOR, and Rad51 indicating its biological
            role in cell invasion through mTORC2 activation.
REFERENCE   6  (bases 1 to 4451)
  AUTHORS   Bera,T.K., Saint Fleur,A., Ha,D., Yamada,M., Lee,Y., Lee,B.,
            Hahn,Y., Kaufman,D.S., Pera,M. and Pastan,I.
  TITLE     Selective POTE paralogs on chromosome 2 are expressed in human
            embryonic stem cells
  JOURNAL   Stem Cells Dev 17 (2), 325-332 (2008)
   PUBMED   18447647
  REMARK    GeneRIF: The POTE paralogs that are expressed in ES cells may have
            a specific function during lineage-specific differentiation of ES
            cells.
REFERENCE   7  (bases 1 to 4451)
  AUTHORS   Lee,Y., Ise,T., Ha,D., Saint Fleur,A., Hahn,Y., Liu,X.F.,
            Nagata,S., Lee,B., Bera,T.K. and Pastan,I.
  TITLE     Evolution and expression of chimeric POTE-actin genes in the human
            genome
  JOURNAL   Proc Natl Acad Sci U S A 103 (47), 17885-17890 (2006)
   PUBMED   17101985
REFERENCE   8  (bases 1 to 4451)
  AUTHORS   Chang,K.W., Yang,P.Y., Lai,H.Y., Yeh,T.S., Chen,T.C. and Yeh,C.T.
  TITLE     Identification of a novel actin isoform in hepatocellular carcinoma
  JOURNAL   Hepatol Res 36 (1), 33-39 (2006)
   PUBMED   16824795
REFERENCE   9  (bases 1 to 4451)
  AUTHORS   Hahn,Y., Bera,T.K., Pastan,I.H. and Lee,B.
  TITLE     Duplication and extensive remodeling shaped POTE family genes
            encoding proteins containing ankyrin repeat and coiled coil domains
  JOURNAL   Gene 366 (2), 238-245 (2006)
   PUBMED   16364570
REFERENCE   10 (bases 1 to 4451)
  AUTHORS   Bera,T.K., Huynh,N., Maeda,H., Sathyanarayana,B.K., Lee,B. and
            Pastan,I.
  TITLE     Five POTE paralogs and their splice variants are expressed in human
            prostate and encode proteins of different lengths
  JOURNAL   Gene 337, 45-53 (2004)
   PUBMED   15276201
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131180.3.
            
            On May 21, 2020 this sequence version replaced NM_001083538.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.635019.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2142853 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683005.1/ ENSP00000507284.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               AC131180.3         14556-14839
            285-440             AC131180.3         16048-16203
            441-535             AC131180.3         22609-22703
            536-1149            AC131180.3         23330-23943
            1150-1264           AC131180.3         28616-28730
            1265-1438           AC131180.3         28890-29063
            1439-1545           AC131180.3         31843-31949
            1546-1683           AC131180.3         33264-33401
            1684-1754           AC131180.3         35856-35926
            1755-1825           AC131180.3         41752-41822
            1826-1870           AC131180.3         43214-43258
            1871-2037           AC131180.3         44298-44464
            2038-2108           AC131180.3         50427-50497
            2109-2179           AC131180.3         55798-55868
            2180-2224           AC131180.3         57546-57590
            2225-2406           AC131180.3         57938-58119
            2407-2527           AC131180.3         66746-66866
            2528-4451           AC131180.3         68375-70298
FEATURES             Location/Qualifiers
     source          1..4451
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q21.1"
     gene            1..4451
                     /gene="POTEE"
                     /gene_synonym="A26C1; A26C1A; CT104.2; POTE-2; POTE2;
                     POTE2gamma"
                     /note="POTE ankyrin domain family member E"
                     /db_xref="GeneID:445582"
                     /db_xref="HGNC:HGNC:33895"
                     /db_xref="MIM:608914"
     exon            1..284
                     /gene="POTEE"
                     /gene_synonym="A26C1; A26C1A; CT104.2; POTE-2; POTE2;
                     POTE2gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            285..440
                     /gene="POTEE"
                     /gene_synonym="A26C1; A26C1A; CT104.2; POTE-2; POTE2;
                     POTE2gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            441..535
                     /gene="POTEE"
                     /gene_synonym="A26C1; A26C1A; CT104.2; POTE-2; POTE2;
                     POTE2gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            536..1149
                     /gene="POTEE"
                     /gene_synonym="A26C1; A26C1A; CT104.2; POTE-2; POTE2;
                     POTE2gamma"
                     /inference="alignment:Splign:2.1.0"
     CDS             629..3856
                     /gene="POTEE"
                     /gene_synonym="A26C1; A26C1A; CT104.2; POTE-2; POTE2;
                     POTE2gamma"
                     /note="protein expressed in prostate, ovary, testis, and
                     placenta 2; cancer/testis antigen family 104, member 2;
                     ANKRD26-like family C member 1A; prostate, ovary,
                     testis-expressed protein on chromosome 2"
                     /codon_start=1
                     /product="POTE ankyrin domain family member E"
                     /protein_id="NP_001077007.1"
                     /db_xref="CCDS:CCDS46414.1"
                     /db_xref="GeneID:445582"
                     /db_xref="HGNC:HGNC:33895"
                     /db_xref="MIM:608914"
                     /translation="MVVEVDSMPAASSVKKPFGLRSKMGKWCCRCFPCYRESGKSNVG
                     TSGDHDDSAMKTLRSKMGKWCHHCFPCCRGSGKSNVGASGDHDDSAMKTLRNKMGKWC
                     CHCFPCCRGSGKSKVGAWGDYDDSAFMEPRYHVRGEDLDKLHRAAWWGKVPRKDLIVM
                     LRDTDVNKKDKQKRTALHLASANGNSEVVKLLLDRRCQLNVLDNKKRTALIKAVQCQE
                     DECALMLLEHGTDPNIPDEYGNTTLHYAIYNEDKLMAKALLLYGADIESKNKHGLTPL
                     LLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVSLLLEQNIDVSSQ
                     DLSGQTAREYAVSSHHHVICQLLSDYKEKQMLKISSENSNPEQELKLTSEEESQRFKG
                     SENSQPEKMSQELEINKDGDREVEEEMKKHESNNVGLLENLTNGVTAGNGDNGLIPQR
                     KSRTPENQQFPDNESEEYHRICELLSDYKEKQMPKYSSENSNPEQDLKLTSEEESQRL
                     KGSENGQPEKRSQEPEINKDGDRELENFMAIEEMKKHGSTHVGFPENLTNGATAGNGD
                     DGLIPPRKSRTPESQQFPDTENEEYHSDEQNDTQKQFCEEQNTGILHDEILIHEEKQI
                     EVVEKMNSELSLSCKKEKDVLHENSTLREEIAMLRLELDTMKHQSQLREKKYLEDIES
                     VKKKNDNLLKALQLNELTMDDDTAVLVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRQ
                     QGMMGGMHQKESYVGKEAQSKRGILTLKYPMEHGIITNWDDMEKIWHHTFYNELRVAP
                     EEHPILLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVPSLYTSGRTTGIVMDSG
                     DGVTHTVPIYEGNALPHATLRLDLAGRELPDYLMKILTERGYRFTTMAEREIVRDIKE
                     KLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPCFLGMESC
                     GIHETTFNSIMKSDVDIRKDLYTNTVLSGGTTMYPGMAHRMQKEIAALAPSMMKIRII
                     APPKRKYSVWVGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF"
     exon            1150..1264
                     /gene="POTEE"
                     /gene_synonym="A26C1; A26C1A; CT104.2; POTE-2; POTE2;
                     POTE2gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1438
                     /gene="POTEE"
                     /gene_synonym="A26C1; A26C1A; CT104.2; POTE-2; POTE2;
                     POTE2gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1545
                     /gene="POTEE"
                     /gene_synonym="A26C1; A26C1A; CT104.2; POTE-2; POTE2;
                     POTE2gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1683
                     /gene="POTEE"
                     /gene_synonym="A26C1; A26C1A; CT104.2; POTE-2; POTE2;
                     POTE2gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1754
                     /gene="POTEE"
                     /gene_synonym="A26C1; A26C1A; CT104.2; POTE-2; POTE2;
                     POTE2gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1825
                     /gene="POTEE"
                     /gene_synonym="A26C1; A26C1A; CT104.2; POTE-2; POTE2;
                     POTE2gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1870
                     /gene="POTEE"
                     /gene_synonym="A26C1; A26C1A; CT104.2; POTE-2; POTE2;
                     POTE2gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..2037
                     /gene="POTEE"
                     /gene_synonym="A26C1; A26C1A; CT104.2; POTE-2; POTE2;
                     POTE2gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2108
                     /gene="POTEE"
                     /gene_synonym="A26C1; A26C1A; CT104.2; POTE-2; POTE2;
                     POTE2gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2179
                     /gene="POTEE"
                     /gene_synonym="A26C1; A26C1A; CT104.2; POTE-2; POTE2;
                     POTE2gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2224
                     /gene="POTEE"
                     /gene_synonym="A26C1; A26C1A; CT104.2; POTE-2; POTE2;
                     POTE2gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2406
                     /gene="POTEE"
                     /gene_synonym="A26C1; A26C1A; CT104.2; POTE-2; POTE2;
                     POTE2gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2527
                     /gene="POTEE"
                     /gene_synonym="A26C1; A26C1A; CT104.2; POTE-2; POTE2;
                     POTE2gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..4451
                     /gene="POTEE"
                     /gene_synonym="A26C1; A26C1A; CT104.2; POTE-2; POTE2;
                     POTE2gamma"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atttcaggct cttaagtgtg ggcgtttggt aaccggcatg gctgctacct gtttctggct
       61 ggagcctcgg acactggctc actgcagttg gtggtgtcca cagagcggta ggagggcaac
      121 tagtagcggg agcttctcct gccaggcagg aagacgagta gaagggagca gcaccgacgc
      181 atgctggagg ctggagcctg agcccctggg gctcgccttg ctgtgtttgg tggtgacgtg
      241 ggacactgca gctcggccag agtggtagaa atgtcctggt gtaggctttt ctggctttgc
      301 cggtctagct gctccaagcc aggctggagg aggaggagaa ggaatcacct gtggtacgct
      361 ggagcctgca tgtggcgtga ctctgcagct cgcctcgtgt gactgatggc agccacggag
      421 actgcagctc gacaggagtg aggcttctca gtggcttgaa agctcagctg actcccacga
      481 agtttgccgg aactcaaggc tgtcagtgac attcgtggcg ccaagactta agcagattgg
      541 aaacccggag ttacctgcta gttggtgaaa ctggttggta gacgcgatct gttggctact
      601 actggcttct cctggctgtt aaaagcagat ggtggttgag gttgattcca tgccggctgc
      661 ctcttctgtg aagaagccat ttggtctcag gagcaagatg ggcaagtggt gctgccgttg
      721 cttcccctgc tacagggaga gcggcaagag caacgtgggc acttctggag accacgacga
      781 ctctgctatg aagacactca ggagcaagat gggcaagtgg tgccaccact gcttcccctg
      841 ctgcaggggg agtggcaaga gcaacgtggg cgcttctgga gaccacgacg actctgctat
      901 gaagacactc aggaacaaga tggggaagtg gtgctgccac tgcttcccct gctgcagggg
      961 gagcggcaag agcaaggtgg gcgcttgggg agactacgat gacagcgcct tcatggagcc
     1021 caggtaccac gtccgtggag aagatctgga caagctccac agagctgcct ggtggggtaa
     1081 agtccccaga aaggatctca tcgtcatgct cagggacact gacgtgaaca agaaggacaa
     1141 gcaaaagagg actgctctac atctggcctc tgccaatggg aattcagaag tagtaaaact
     1201 cctgctggac agacgatgtc aacttaatgt ccttgacaac aaaaagagga cagctctgat
     1261 aaaggccgta caatgccagg aagatgaatg tgcgttaatg ttgctggaac atggcactga
     1321 tccaaatatt ccagatgagt atggaaatac cactctgcac tacgctatct ataatgaaga
     1381 taaattaatg gccaaagcac tgctcttata tggtgctgat atcgaatcaa aaaacaagca
     1441 tggcctcaca ccactgttac ttggtgtaca tgagcaaaaa cagcaagtcg tgaaattttt
     1501 aatcaagaaa aaagcgaatt taaatgcact ggatagatat ggaaggactg ctctcatact
     1561 tgctgtatgt tgtggatcag caagtatagt cagccttcta cttgagcaaa atattgatgt
     1621 atcttctcaa gatctatctg gacagacggc cagagagtat gctgtttcta gtcatcatca
     1681 tgtaatttgc cagttacttt ctgactacaa agaaaaacag atgctaaaaa tctcttctga
     1741 aaacagcaat ccagaacaag agttaaagct gacatcagag gaagagtcac aaaggttcaa
     1801 aggcagtgaa aatagccagc cagagaaaat gtctcaagaa ctagaaataa ataaggatgg
     1861 tgatagagag gttgaagaag aaatgaagaa gcatgaaagt aataatgtgg gattactaga
     1921 aaacctgact aatggtgtca ctgctggcaa tggtgataat ggattaattc ctcaaaggaa
     1981 gagcagaaca cctgaaaatc agcaatttcc tgacaacgaa agtgaagagt atcacagaat
     2041 ttgtgaatta ctttctgact acaaagaaaa gcagatgcca aaatactctt ctgaaaacag
     2101 caacccagaa caagacttaa agctgacatc agaggaagag tcacaaaggc ttaaaggcag
     2161 tgaaaatggc cagccagaga aaagatctca agaaccagaa ataaataagg atggtgatag
     2221 agagctagaa aattttatgg ctatcgaaga aatgaagaag cacggaagta ctcatgtcgg
     2281 attcccagaa aacctgacta atggtgccac tgctggcaat ggtgatgatg gattaattcc
     2341 tccaaggaag agcagaacac ctgaaagcca gcaatttcct gacactgaga atgaagagta
     2401 tcacagtgac gaacaaaatg atactcagaa gcaattttgt gaagaacaga acactggaat
     2461 attacacgat gagattctga ttcatgaaga aaagcagata gaagtggttg aaaaaatgaa
     2521 ttctgagctt tctcttagtt gtaagaaaga aaaagacgtc ttgcatgaaa atagtacgtt
     2581 gcgggaagaa attgccatgc taagactgga gctagacaca atgaaacatc agagccagct
     2641 aagagaaaag aaatatttgg aggatattga aagtgtgaaa aaaaagaatg ataatctttt
     2701 aaaggctcta caattgaatg agctcaccat ggatgatgat accgccgtgc tcgtcattga
     2761 caacggctct ggcatgtgca aggccggctt tgcgggcgac gatgcccccc gggctgtctt
     2821 cccttccatc gtggggcgcc ccaggcagca gggcatgatg gggggcatgc atcagaaaga
     2881 gtcctatgtg ggcaaggagg cccagagcaa gagaggcatc ctgaccctga agtaccccat
     2941 ggaacacggc atcatcacca actgggatga catggagaag atctggcacc acaccttcta
     3001 caacgagctg cgtgtggctc ccgaggagca ccccatcctg ctgaccgagg cccccctgaa
     3061 ccccaaggcc aaccgcgaga agatgaccca gatcatgttt gagaccttca acaccccagc
     3121 catgtacgtg gccatccagg ccgtgccgtc cctgtacacc tctggccgta ctactggcat
     3181 cgtgatggac tctggtgacg gggtcaccca cactgtgccc atctatgagg ggaatgccct
     3241 cccccatgcc accctgcgcc tagacctggc tgggcgggaa ctgcctgact acctcatgaa
     3301 gatcctcacc gagcgtggct ataggttcac caccatggcc gagcgggaaa tcgtgcgtga
     3361 catcaaagag aagctgtgct atgttgccct ggacttcgag caggagatgg ccacggcggc
     3421 ctccagctcc tccctagaga agagctacga gctgcccgat ggccaggtca tcaccatcgg
     3481 caacgagcgg ttccgctgcc ccgaggcgct cttccagcct tgcttcctgg gcatggaatc
     3541 ctgtggcatc catgaaacta ccttcaactc catcatgaag tctgatgtgg acatccgcaa
     3601 agacctgtac accaacacag tgctgtctgg cggcaccacc atgtaccctg gcatggccca
     3661 cagaatgcag aaggagatcg ctgccctggc gcctagcatg atgaagatca ggatcattgc
     3721 tcctcccaag cgcaagtact ccgtgtgggt cggtggctcc atcctggcct cgctgtccac
     3781 cttccagcag atgtggatca gcaagcagga gtatgatgag tcaggcccct ccattgtcca
     3841 ccgcaaatgc ttctaggtgg actctgactt agttgcgtta caccctttct tgacaaaacc
     3901 aaacttctca gaaaacaaca tgagattggc atggctttat ttgttttctt gtttcatttt
     3961 ttgttttgtt ttttattggc ttgactcagg atttaaaaac cggaatggtg aaggtgacag
     4021 cagtcggttg gaggaagctt cctccaaagt tctacaatgt tgccaaggac tttgattgta
     4081 cattgttctt cttttcaata gtcattccaa atattgtgag acgcattgtt tcaggaagcc
     4141 ccttgccctg ctaaaagcca tcccacttct ctctaaggag aatggcccag tcctctccct
     4201 agttcacaca ggggaggtga tagcattgct tttgtgcaaa ttacataatg caaaattttt
     4261 tgaatcttcg ccttaatact ttttaatttt gttttatttt gaatgatcag ccttcgtggc
     4321 ccccctcttt tgtaccccaa cttggggtgt atgaaggctt ttggtctccc tgagagtggc
     4381 tggaggcagc cagggcttac ctgtactctg acttgaggag agttggataa aagtgcacac
     4441 cttaaaaaaa a
//
