LOCUS       NM_174981               6464 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens POTE ankyrin domain family member D (POTED), mRNA.
ACCESSION   NM_174981
VERSION     NM_174981.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6464)
  AUTHORS   Bera,T.K., Walker,D.A., Sherins,R.J. and Pastan,I.
  TITLE     POTE protein, a cancer-testis antigen, is highly expressed in
            spermatids in human testis and is associated with apoptotic cells
  JOURNAL   Biochem Biophys Res Commun 417 (4), 1271-1274 (2012)
   PUBMED   22234308
  REMARK    GeneRIF: This study suggests POTE may have a role in apoptosis in
            the human testis.
REFERENCE   2  (bases 1 to 6464)
  AUTHORS   Ise,T., Das,S., Nagata,S., Maeda,H., Lee,Y., Onda,M., Anver,M.R.,
            Bera,T.K. and Pastan,I.
  TITLE     Expression of POTE protein in human testis detected by novel
            monoclonal antibodies
  JOURNAL   Biochem Biophys Res Commun 365 (4), 603-608 (2008)
   PUBMED   17996727
  REMARK    GeneRIF: By immunohistochemistry we demonstrated that the POTE
            protein is expressed in primary spermatocytes, implying a role in
            spermatogenesis.
REFERENCE   3  (bases 1 to 6464)
  AUTHORS   Hahn,Y., Bera,T.K., Pastan,I.H. and Lee,B.
  TITLE     Duplication and extensive remodeling shaped POTE family genes
            encoding proteins containing ankyrin repeat and coiled coil domains
  JOURNAL   Gene 366 (2), 238-245 (2006)
   PUBMED   16364570
REFERENCE   4  (bases 1 to 6464)
  AUTHORS   Bera,T.K., Huynh,N., Maeda,H., Sathyanarayana,B.K., Lee,B. and
            Pastan,I.
  TITLE     Five POTE paralogs and their splice variants are expressed in human
            prostate and encode proteins of different lengths
  JOURNAL   Gene 337, 45-53 (2004)
   PUBMED   15276201
  REMARK    GeneRIF: POTE protein isoforms were characterized and may have
            important signaling function in the reproductive system.
REFERENCE   5  (bases 1 to 6464)
  AUTHORS   Bera,T.K., Zimonjic,D.B., Popescu,N.C., Sathyanarayana,B.K.,
            Kumar,V., Lee,B. and Pastan,I.
  TITLE     POTE, a highly homologous gene family located on numerous
            chromosomes and expressed in prostate, ovary, testis, placenta, and
            prostate cancer
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16975-16980 (2002)
   PUBMED   12475935
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1462]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001465.1.
            
            On Jan 17, 2020 this sequence version replaced NM_174981.5.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2148093,
                              SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299443.6/ ENSP00000299443.5
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-973               AP001465.1         67526-68498
            974-1088            AP001465.1         72872-72986
            1089-1262           AP001465.1         73146-73319
            1263-1369           AP001465.1         76098-76204
            1370-1507           AP001465.1         77907-78044
            1508-1578           AP001465.1         80554-80624
            1579-1649           AP001465.1         86131-86201
            1650-1694           AP001465.1         87605-87649
            1695-1861           AP001465.1         88690-88856
            1862-1985           AP001465.1         97264-97387
            1986-6464           AP001465.1         99094-103572
FEATURES             Location/Qualifiers
     source          1..6464
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q11.2"
     gene            1..6464
                     /gene="POTED"
                     /gene_synonym="A26B3; ANKRD21; CT104.1; POTE; POTE-21;
                     POTE21"
                     /note="POTE ankyrin domain family member D"
                     /db_xref="GeneID:317754"
                     /db_xref="HGNC:HGNC:23822"
                     /db_xref="MIM:607549"
     exon            1..973
                     /gene="POTED"
                     /gene_synonym="A26B3; ANKRD21; CT104.1; POTE; POTE-21;
                     POTE21"
                     /inference="alignment:Splign:2.1.0"
     CDS             453..2207
                     /gene="POTED"
                     /gene_synonym="A26B3; ANKRD21; CT104.1; POTE; POTE-21;
                     POTE21"
                     /note="Expressed in prostate, ovary, testis, and placenta;
                     ankyrin repeat domain 21; cancer/testis antigen family
                     104, member 1; ANKRD26-like family B member 3; prostate,
                     ovary, testis-expressed protein; ankyrin repeat
                     domain-containing protein 21"
                     /codon_start=1
                     /product="POTE ankyrin domain family member D"
                     /protein_id="NP_778146.2"
                     /db_xref="CCDS:CCDS13562.1"
                     /db_xref="GeneID:317754"
                     /db_xref="HGNC:HGNC:23822"
                     /db_xref="MIM:607549"
                     /translation="MVAEVCSMPTASTVKKPFDLRSKMGKWCHHRFPCCRGSGKSNMG
                     TSGDHDDSFMKMLRSKMGKCCRHCFPCCRGSGTSNVGTSGDHENSFMKMLRSKMGKWC
                     CHCFPCCRGSGKSNVGAWGDYDHSAFMEPRYHIRREDLDKLHRAAWWGKVPRKDLIVM
                     LRDTDMNKRDKEKRTALHLASANGNSEVVQLLLDRRCQLNVLDNKKRTALIKAIQCQE
                     DECVLMLLEHGADRNIPDEYGNTALHYAIYNEDKLMAKALLLYGADIESKNKCGLTPL
                     LLGVHEQKQQVVKFLIKKKANLNVLDRYGRTALILAVCCGSASIVNLLLEQNVDVSSQ
                     DLSGQTAREYAVSSHHHVICELLSDYKEKQMLKISSENSNPEQDLKLTSEEESQRLKV
                     SENSQPEKMSQEPEINKDCDREVEEEIKKHGSNPVGLPENLTNGASAGNGDDGLIPQR
                     RSRKPENQQFPDTENEEYHSDEQNDTRKQLSEEQNTGISQDEILTNKQKQIEVAEQKM
                     NSELSLSHKKEEDLLRENSVLQEEIAMLRLELDETKHQNQLRENKILEEIESVKEKTD
                     KLLRAMQLNEEALTKTNI"
     exon            974..1088
                     /gene="POTED"
                     /gene_synonym="A26B3; ANKRD21; CT104.1; POTE; POTE-21;
                     POTE21"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1262
                     /gene="POTED"
                     /gene_synonym="A26B3; ANKRD21; CT104.1; POTE; POTE-21;
                     POTE21"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1369
                     /gene="POTED"
                     /gene_synonym="A26B3; ANKRD21; CT104.1; POTE; POTE-21;
                     POTE21"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1507
                     /gene="POTED"
                     /gene_synonym="A26B3; ANKRD21; CT104.1; POTE; POTE-21;
                     POTE21"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1578
                     /gene="POTED"
                     /gene_synonym="A26B3; ANKRD21; CT104.1; POTE; POTE-21;
                     POTE21"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1649
                     /gene="POTED"
                     /gene_synonym="A26B3; ANKRD21; CT104.1; POTE; POTE-21;
                     POTE21"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1694
                     /gene="POTED"
                     /gene_synonym="A26B3; ANKRD21; CT104.1; POTE; POTE-21;
                     POTE21"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1861
                     /gene="POTED"
                     /gene_synonym="A26B3; ANKRD21; CT104.1; POTE; POTE-21;
                     POTE21"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..1985
                     /gene="POTED"
                     /gene_synonym="A26B3; ANKRD21; CT104.1; POTE; POTE-21;
                     POTE21"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..6464
                     /gene="POTED"
                     /gene_synonym="A26B3; ANKRD21; CT104.1; POTE; POTE-21;
                     POTE21"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacggcttgg cttacctgta atgggtgcgc ttcgctttgc gttcctcgct tggccttgcg
       61 ttcctagctt ggcttggcgt tagtcgcttt gcctggtgtt tcttgcttgg attggcgttt
      121 tctccctcgc attcctttgc tgggcctgaa tttttctctg ctgggtttgg cattcccttg
      181 actgggctgg gtgtttcctt cggagggggg gcttggcctt tcctggggtg ggcctggggt
      241 ccccctggtg ggcgtgggct ttccccgggt gggtgtgggt tttccctggg tggggtgggc
      301 tgggctccct tgctggggtt ggcaagtttt ggctgggatt gacctttctc ttcaaacaga
      361 ttggaaaccc aaggtttcct gctagttggt gaaactggtt ggtagacgcg atctgttcgc
      421 tactaccggc ctcccctggc tgttaaaagc agatggtggc tgaggtttgt tcaatgccca
      481 ctgcctctac tgtgaagaag ccatttgatc tcaggagcaa gatgggcaag tggtgccacc
      541 accgcttccc ctgctgcagg gggagcggca agagcaacat gggcacttct ggagaccacg
      601 acgactcctt tatgaagatg ctcaggagca agatgggcaa gtgttgccgc cactgcttcc
      661 cctgctgcag ggggagcggc acgagcaacg tgggcacttc tggagaccat gaaaactcct
      721 ttatgaagat gctcaggagc aagatgggca agtggtgctg tcactgcttc ccctgctgca
      781 gggggagcgg caagagcaac gtgggcgctt ggggagacta cgaccacagc gccttcatgg
      841 agccgaggta ccacatccgt cgagaagatc tggacaagct ccacagagct gcctggtggg
      901 gtaaagtccc cagaaaggat ctcatcgtca tgctcaggga cactgacatg aacaagaggg
      961 acaaggaaaa gaggactgct ctacatttgg cctctgccaa tggaaattca gaagtagtac
     1021 aactcctgct ggacagacga tgtcaactta atgtccttga caacaaaaaa aggacagctc
     1081 tgataaaggc catacaatgc caggaagatg aatgtgtgtt aatgttgctg gaacatggcg
     1141 ctgatcgaaa tattccagat gagtatggaa ataccgctct acactatgct atctacaatg
     1201 aagataaatt aatggccaaa gcactgctct tatatggtgc tgatattgaa tcaaaaaaca
     1261 agtgtggcct cacaccactt ttgcttggcg tacatgaaca aaaacagcaa gtggtgaaat
     1321 ttttaatcaa gaaaaaagct aatttaaatg tacttgatag atatggaaga actgccctca
     1381 tacttgctgt atgttgtgga tcagcaagta tagtcaatct tctacttgag caaaatgttg
     1441 atgtatcttc tcaagatcta tctggacaga cggccagaga gtatgctgtt tctagtcatc
     1501 atcatgtaat ttgtgaatta ctttctgact ataaagaaaa acagatgcta aaaatctctt
     1561 ctgaaaacag caatccagaa caagacttaa agctgacatc agaggaagag tcacaaaggc
     1621 ttaaagtcag tgaaaatagc cagccagaga aaatgtctca agaaccagaa ataaataagg
     1681 actgtgatag agaggttgaa gaagaaataa agaagcatgg aagtaatcct gtgggattac
     1741 cagaaaacct gactaatggt gccagtgctg gcaatggtga tgatggatta attccacaaa
     1801 ggaggagcag aaaacctgaa aatcagcaat ttcctgacac tgagaatgaa gagtatcaca
     1861 gtgatgaaca aaatgatacc cggaaacaac tttctgaaga acagaacact ggaatatcac
     1921 aagatgagat tctgactaat aaacaaaagc agatagaagt ggctgaacag aaaatgaatt
     1981 ctgagctttc tcttagtcat aagaaagaag aagatctctt gcgtgaaaac agcgtgttgc
     2041 aggaagaaat tgccatgcta agactggaac tagatgaaac aaaacatcag aaccagctaa
     2101 gggaaaataa aattttggag gaaattgaaa gtgtgaaaga aaagactgat aaacttctaa
     2161 gggctatgca attgaatgaa gaagcattaa cgaaaaccaa tatttaagta cagtggacag
     2221 cttaggattt tgacaactga gaatgctcag ttctgaactg gagagtgtaa gacacagcta
     2281 ggaaacactg gaaatggaaa ttcaatcatg tcattgtaga ctgactactg ctctacatga
     2341 ttgtgatcaa agtcagatag ctgaaaggga cttctttcca gagaacaaac atgaacaggt
     2401 ttatttacag gagaaaatga attctcatat atctcaccta aaagataaca gtgagattct
     2461 ttctgaacaa ctctaacgct gacagtaaaa ttaacaacct aaaaattaag ctccatcaca
     2521 caggataaat tctgagagaa aagatgaggc aggccaccat ctttcctgtt tgggcaactt
     2581 agccattcca gcgtgcgggc tttggagagt acaaacccac caggggcaga agagatcctg
     2641 tggcatagca cagctgcttt accaaatcat ggccagaatg cttctgtaag caggcccctg
     2701 atcctgttcc ttgtcactgg acaggatctc ccacctgagg cctccagcta cacccaccag
     2761 tgttccctgg ccaatggaga tttgaaacct tcctgggaca gagttcccag agagaggggt
     2821 gggccatgac ctttgttgtt tgggcaacta gcccttctgg cctgtgggct ttggagagcc
     2881 caagctgacc aggggtggaa gtggtacctc agcacagaac agccaccctg cgaaaacgtg
     2941 gccagattct tgtttaagcc agtccccaac cacatttcta atcactggct ggagcctttc
     3001 aaccagggtc tccagccacc ttcactgctg ttctctggct gacagaggtt tcaggcctcc
     3061 tgagtgagag ctcccagggg gaggaccaga ctgtcatctt tgctgtttgg atgactcagc
     3121 cagttcagtc ttagagtttc agagtgtctg aggagaccag gggctgaagt gaaccccccg
     3181 cacagcatag ccactctaca aaaacgtggc cagacttctt ttttaaacaa gtccctattc
     3241 ctgttcctcc ttactaggca agacttctca acttgcttcc agtcacatcc tacaggtgtg
     3301 ttcagattgg caacaggttc atacctcaga ggtacagagc tcccagaggg aagggcaggt
     3361 tatcgtcttt gctttttcgc aggcttcact gctgatacct tcagccactg gaaaatacga
     3421 ggcaattggc gactggagtg gacccccagc ataccacggc agccccacag aaaagtggcc
     3481 agactgttat gtgggtgccc atttccatat ctcctcgatg ggcaggtctt cctggcctgg
     3541 gtctccagcc agccccccac ttgagctttc aagccagtag caactcagca actccctgga
     3601 cagagcttcc aggagcaaca gaaatcctct ctgccactgc ctctgcagtg gaactgccct
     3661 tgctaccctc agaatatcaa gggagcaaag accctaagta ccatattgac acctccaaca
     3721 agctgcagtt gacacaagga acaagtcagt ccatcttcca caggtacaac acacccctta
     3781 ctgctcatca ccagacaagg aaccctggct tgggcccaca acacagaccc tccatcctgg
     3841 ggtgattaca ttaagtaact gctaacttac acctctctgg ggtggagccc ccaggagaca
     3901 aggaaagtgg tggagcagca agtcagctga tgtggagccc ggagggcagg gacagctatg
     3961 tctctaggct ccacttgctc ttatgagaca ctttatccca gcactttagg agtgctgagg
     4021 tcagaccagc cccatctcac atgcaggatt gcccagcaca gatcaggtct aagagttctc
     4081 ttcgtaaaaa aggggacttg cttaaaaaag aagtctggcc acgtttgtgt agagcagttg
     4141 tgctgtgctg aggattcact tttgagagag ttctcctctg agacctgatc tgtgctgggc
     4201 agtcttgcac atgagatggg gctggtctga cctcagcacc ccttagtctg cttgcctctc
     4261 ccaggacccc agccaggcca cacctgctta gagggcactt tcgggtgccc acaccatagc
     4321 ttctgtacaa gcggaccatg cctgatcaat ggagagctgc agcaaggtga cctctacagc
     4381 cacgcactag cctgcacatt acctctccat actgcagccc tttatatgga aacttcctac
     4441 atcactttgc tgtgtgtgtt tacacaggtg ggttttgttg tacttgccct aacagcatat
     4501 gggaatgcag cacacacccc aacccacacc aactgccact gaagatgaag ccatggtggg
     4561 cacagaacca aaaaccccac ccctgctagc atctcaccct tgaggtaatg ctgtgcagag
     4621 gaaaagggac cttcttatac cctgagtgac cactgttgct tgggggggat caaagaaggc
     4681 accttcactg gccagccacc caccccaaac cagcactacc tccagtgcaa cagcacacac
     4741 agcaggggcc ccctggccca caccccagct gttttgcctc caccactggg tgaatgccca
     4801 cagggaggca gggacttttg catctggtag cattctgcca cagctgccgc actttggtcc
     4861 cctcagtgca gtggactcca aacctcgagg agccagagaa caaagttgtg gcccaataca
     4921 agttccccag agttaaagca cacagtccaa gaattgggag ctgcatgttg gccccttaaa
     4981 atcctccaaa aacaaaacct gttggctgaa tccaccttac accacaatca aatcctcaag
     5041 gtcatcagat ataataaagg aaaaataccc tgtccaaacg tcagcaacct caaagattga
     5101 agatggataa gcccataaag atgagaaaaa gactctgtgc aagaacacta aaaactcaaa
     5161 aattcagcat gccttctttt ctccaaatga ctgcatcaac tctccagcaa gtgttcagaa
     5221 ctgggctgag gctgagatgt ctgaaatgat acaagcagag ttcaggatat gggtaggaac
     5281 aaagttcatt gcgtgaaaga agtatgttgt aatccaatac aaggaagcta aaaatcattg
     5341 taaaacattg caggaagtaa cagacaaaag agcaagtata aagaagaaaa taactgacct
     5401 gacagagctg taaatcacac tagaagaatt ttcataatgc agtcacatgg tgattgtgtg
     5461 tgattgcatt atgaatatta ttgtatgtgt gggcacctga gagtgccctg taagcaggtg
     5521 tggccaggct ggggtcctgg gagaggcaag cagactaggg agggctgagg tcagaccagc
     5581 tccatctcat gtgcaagacc atccaacaga atagaccaag aagaggaaag aatcccagag
     5641 cttgaaaact ggctttctga aataaaacag gcaaacaaga atgggggaaa aaagaatgaa
     5701 agggaatgaa caaaacatct gagatatatg ggattatata aacgaccaaa tctatgactg
     5761 attaatgtac ctgaaagaga tgagaatgga accaacttgg aaaacacatt tcagaatatc
     5821 attcatgaga atgtccccaa cctagccaga caggccaaca ttcaacttca ggaaatccag
     5881 agaacctcag taagatatgc catgagaaga tcatccccaa gacacataat cgtcagattt
     5941 tctgaggtca aaataaaaga aaaaatgtta aaggcagcta gggagaaagg caacatcacc
     6001 tgcaaaggga attccatcag atttagcaga cctctcaact gaaactgtac aagccagaaa
     6061 agacattcaa catctcaaag aaaagaaatt tcaacccaga atttcatgtc cagcaaaatt
     6121 aagcatcata agtgaaggag aaacaagatc cttttcagac aagcaaatgc tgagggaatt
     6181 cgttatcacc agacctacct tacaagagct cctgaaggaa gcactaaata tggaaagaaa
     6241 agaccaccac cagccactac agaaacacac tgaagtacac agacaagtga tgctaaaaac
     6301 caactacata agtctgcaaa aaagccagct gacagcatga cgacaggatc aaatccacac
     6361 ataccattac taaccttaaa tggaaatggg ctaaatgctc caattgaaag acacaggggg
     6421 caagctggat aaagaaccaa gacccattgg agtatgccgt cttc
//
