LOCUS       NM_001005365            1976 bp    mRNA    linear   PRI 26-SEP-2024
DEFINITION  Homo sapiens POTE ankyrin domain family member A (gene/pseudogene)
            (POTEA), transcript variant 2, mRNA.
ACCESSION   NM_001005365
VERSION     NM_001005365.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1976)
  AUTHORS   Chen,Z., Kapus,A., Khatri,I., Kos,O., Zhu,F. and Gorczynski,R.M.
  TITLE     Cell membrane-bound CD200 signals both via an extracellular domain
            and following nuclear translocation of a cytoplasmic fragment
  JOURNAL   Leuk Res 69, 72-80 (2018)
   PUBMED   29698858
REFERENCE   2  (bases 1 to 1976)
  AUTHORS   Jiao,X., Liu,W., Mahdessian,H., Bryant,P., Ringdahl,J.,
            Timofeeva,M., Farrington,S.M., Dunlop,M. and Lindblom,A.
  TITLE     Recurrent, low-frequency coding variants contributing to colorectal
            cancer in the Swedish population
  JOURNAL   PLoS One 13 (3), e0193547 (2018)
   PUBMED   29547645
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1976)
  AUTHORS   Hahn,Y., Bera,T.K., Pastan,I.H. and Lee,B.
  TITLE     Duplication and extensive remodeling shaped POTE family genes
            encoding proteins containing ankyrin repeat and coiled coil domains
  JOURNAL   Gene 366 (2), 238-245 (2006)
   PUBMED   16364570
REFERENCE   4  (bases 1 to 1976)
  AUTHORS   Bera,T.K., Huynh,N., Maeda,H., Sathyanarayana,B.K., Lee,B. and
            Pastan,I.
  TITLE     Five POTE paralogs and their splice variants are expressed in human
            prostate and encode proteins of different lengths
  JOURNAL   Gene 337, 45-53 (2004)
   PUBMED   15276201
REFERENCE   5  (bases 1 to 1976)
  AUTHORS   Bera,T.K., Zimonjic,D.B., Popescu,N.C., Sathyanarayana,B.K.,
            Kumar,V., Lee,B. and Pastan,I.
  TITLE     POTE, a highly homologous gene family located on numerous
            chromosomes and expressed in prostate, ovary, testis, placenta, and
            prostate cancer
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16975-16980 (2002)
   PUBMED   12475935
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1462]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY462869.1.
            
            On Oct 6, 2004 this sequence version replaced NM_001005365.1.
            
            Transcript Variant: This variant (2) includes an additional
            in-frame exon in the central coding region, compared to variant 1,
            resulting in an isoform (2) that is longer than isoform 1. It
            should be noted that this variant may possibly undergo
            nonsense-mediated mRNA decay (NMD); this RefSeq is currently being
            retained because this gene is considered to be protein-coding in
            the literature, including PMID:15276201.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY462869.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2151119
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate          :: translation inferred
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1976
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.1"
     gene            1..1976
                     /gene="POTEA"
                     /gene_synonym="A26A1; CT104.3; POTE-8; POTE8"
                     /note="POTE ankyrin domain family member A
                     (gene/pseudogene)"
                     /db_xref="GeneID:340441"
                     /db_xref="HGNC:HGNC:33893"
                     /db_xref="MIM:608915"
     exon            1..342
                     /gene="POTEA"
                     /gene_synonym="A26A1; CT104.3; POTE-8; POTE8"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1540
                     /gene="POTEA"
                     /gene_synonym="A26A1; CT104.3; POTE-8; POTE8"
                     /note="isoform 2 is encoded by transcript variant 2;
                     cancer/testis antigen family 104, member 3; ANKRD26-like
                     family A, member 1; protein expressed in prostate, ovary,
                     testis, and placenta 8; prostate, ovary, testis-expressed
                     protein on chromosome 8; POTE ankyrin domain family,
                     member A"
                     /codon_start=1
                     /product="POTE ankyrin domain family member A isoform 2"
                     /protein_id="NP_001005365.2"
                     /db_xref="GeneID:340441"
                     /db_xref="HGNC:HGNC:33893"
                     /db_xref="MIM:608915"
                     /translation="MVAEVSPKLAASPMKKPFGFRGKMGKWCCCCFPCCRGSGKNNMG
                     AWRDHDDSAFTEPRYHVRREDLGKLHRAAWWGEVPRADLIVMLRGPGINKRDKKKRTA
                     LHLACANGNSEVVSLLLDRQCQLHVFDSKKRTALIKAVQCQEDECALMLLQHGTDPNL
                     PDMYGNTALHYAVYNEDKLMAKTLLLYGADIESKNKGGLTPLLLAVHGQKQRMVKFLI
                     KKKANLNALDRFGRTALILAVRCGSASIVSLLLQQNIDVFSQDVFGQTAEDYAVSSHH
                     SIICQLLSDYKENQMPNNSSGNSNPEQDLKLTSEEEPQRLKGSENSQHEKVTQEPDIN
                     KDCDREVEEEMQKHGSNNVGLSENLTDGAAAGNGDGGLVPQRKSRKHENQQFPNTEIE
                     EYHRPEKKSNEKNKVKSQIHSVDNLDDITWPSEIASEDYDLLFSNYETFTLLIEQLKM
                     DFNDSASLSKIQDAVISEEHLLELKNSHYEQLTVEVEQMENMVHVLQK"
     exon            343..457
                     /gene="POTEA"
                     /gene_synonym="A26A1; CT104.3; POTE-8; POTE8"
                     /inference="alignment:Splign:2.1.0"
     exon            458..631
                     /gene="POTEA"
                     /gene_synonym="A26A1; CT104.3; POTE-8; POTE8"
                     /inference="alignment:Splign:2.1.0"
     exon            632..738
                     /gene="POTEA"
                     /gene_synonym="A26A1; CT104.3; POTE-8; POTE8"
                     /inference="alignment:Splign:2.1.0"
     exon            739..876
                     /gene="POTEA"
                     /gene_synonym="A26A1; CT104.3; POTE-8; POTE8"
                     /inference="alignment:Splign:2.1.0"
     exon            877..947
                     /gene="POTEA"
                     /gene_synonym="A26A1; CT104.3; POTE-8; POTE8"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1018
                     /gene="POTEA"
                     /gene_synonym="A26A1; CT104.3; POTE-8; POTE8"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1063
                     /gene="POTEA"
                     /gene_synonym="A26A1; CT104.3; POTE-8; POTE8"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1230
                     /gene="POTEA"
                     /gene_synonym="A26A1; CT104.3; POTE-8; POTE8"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1261
                     /gene="POTEA"
                     /gene_synonym="A26A1; CT104.3; POTE-8; POTE8"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1403
                     /gene="POTEA"
                     /gene_synonym="A26A1; CT104.3; POTE-8; POTE8"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1617
                     /gene="POTEA"
                     /gene_synonym="A26A1; CT104.3; POTE-8; POTE8"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1741
                     /gene="POTEA"
                     /gene_synonym="A26A1; CT104.3; POTE-8; POTE8"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1976
                     /gene="POTEA"
                     /gene_synonym="A26A1; CT104.3; POTE-8; POTE8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacagacacc atctgctcgc tactaccagg ctgttgaaag cagatggtgg ctgaggtttc
       61 tccaaagctg gctgcctccc ctatgaagaa gccctttggc ttcaggggca agatgggcaa
      121 gtggtgctgc tgctgcttcc cctgctgcag gggaagcggc aagaacaaca tgggtgcttg
      181 gagagaccac gacgacagcg ccttcacgga gccaaggtat cacgtccgtc gagaagatct
      241 gggcaagctc cacagagctg cctggtgggg tgaagtcccc agagcggatc tcatcgtcat
      301 gctcaggggc cctggcatta acaaaaggga caagaagaag aggactgctc tacacttggc
      361 ctgtgccaat ggcaattcag aagtagtaag tcttctgctg gacagacaat gtcaacttca
      421 tgtctttgac agcaaaaaga ggacagctct gataaaggcc gtacaatgcc aggaggatga
      481 atgtgcgtta atgttgctac aacatggcac tgatccaaat cttccagata tgtatgggaa
      541 tactgctcta cactatgcag tctacaatga agataaatta atggccaaaa cactgctttt
      601 atacggtgct gacattgaat caaaaaacaa gggtggcctc acaccacttt tgcttgctgt
      661 acatggacaa aaacagcgaa tggtgaaatt tttaatcaag aaaaaagcta atttaaatgc
      721 acttgatagg tttggaagaa ctgccctcat acttgctgta cgttgtggat cagcaagtat
      781 agttagtctt ctacttcagc aaaatattga tgtattttct caagatgtat ttggacaaac
      841 tgctgaagat tatgcagttt ctagtcatca tagtataatt tgccaattac tttctgacta
      901 caaagaaaac cagatgccaa acaactcttc tggaaatagc aatccagaac aagacttaaa
      961 gctgacatca gaggaagagc cacaaaggct taaaggaagt gaaaatagtc agcatgagaa
     1021 agtgactcaa gaaccagaca taaataagga ttgcgataga gaggttgaag aagaaatgca
     1081 gaagcatgga agtaataatg tgggattatc agaaaacctg actgatggtg ctgctgctgg
     1141 caatggtgat ggtggattag ttccacaaag aaagagcaga aagcatgaaa atcagcaatt
     1201 tcctaacaca gagattgaag agtatcacag gcctgaaaag aaatctaatg aaaagaacaa
     1261 ggtcaaaagc caaatacatt cagtggataa ccttgatgac ataacatggc catcagaaat
     1321 agcgtcagag gattatgatt tgcttttctc taattatgag acttttacat tgctcattga
     1381 acaactcaaa atggatttta acgattctgc tagcctatca aaaatccagg atgcagttat
     1441 ttcagaagaa cacttactag aactcaaaaa tagccactat gagcaactta cagtagaagt
     1501 tgaacaaatg gaaaatatgg ttcatgtact acaaaaatag ctatctgagg caaaagaaac
     1561 acaattacag ttagctcctc agaaaggtga atgtgagcaa gaacgctaca gttcgagtga
     1621 agaacaaaat gatacccgga agcaactttc caaggaacag aatgctagaa tattacaaga
     1681 tgagattctg actactaaac agaagcagat agaagtggcc gaaaaaaaaa tgaattttga
     1741 gatttctctt agccataagg aagaaaaaga actcttgcat gaaaatagca tgatgcagga
     1801 agaaattgcc atgctaagaa tagaactaga cacaataaaa catcagaacc agctaaggga
     1861 aaagaaatat ctggagtaca ttaaaagtgt gaaagaaaag aatgataatc ttctaaaggc
     1921 tatacaattg aatgaggaag cactaacaaa agcagtagtt cagtacagtg gacagc
//
