LOCUS       NM_006475               3301 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens periostin (POSTN), transcript variant 1, mRNA.
ACCESSION   NM_006475
VERSION     NM_006475.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3301)
  AUTHORS   Li,W., Li,Z., Zou,Z., Liu,X. and Li,X.
  TITLE     Integrated single-cell and bulk RNA sequencing identifies POSTN as
            a potential biomarker and therapeutic target for rheumatoid
            arthritis
  JOURNAL   Gene 928, 148798 (2024)
   PUBMED   39067546
  REMARK    GeneRIF: Integrated single-cell and bulk RNA sequencing identifies
            POSTN as a potential biomarker and therapeutic target for
            rheumatoid arthritis.
REFERENCE   2  (bases 1 to 3301)
  AUTHORS   Zhu,D., Chen,S., Sheng,P., Wang,Z., Li,Y. and Kang,X.
  TITLE     POSTN promotes nucleus pulposus cell senescence and extracellular
            matrix metabolism via activing Wnt/beta-catenin and NF-kappaB
            signal pathway in intervertebral disc degeneration
  JOURNAL   Cell Signal 121, 111277 (2024)
   PUBMED   38944256
  REMARK    GeneRIF: POSTN promotes nucleus pulposus cell senescence and
            extracellular matrix metabolism via activing Wnt/beta-catenin and
            NF-kappaB signal pathway in intervertebral disc degeneration.
REFERENCE   3  (bases 1 to 3301)
  AUTHORS   She,Z., Chen,H., Lin,X., Li,C. and Su,J.
  TITLE     POSTN Regulates Fibroblast Proliferation and Migration in
            Laryngotracheal Stenosis Through the TGF-beta/RHOA Pathway
  JOURNAL   Laryngoscope 134 (9), 4078-4087 (2024)
   PUBMED   38771155
  REMARK    GeneRIF: POSTN Regulates Fibroblast Proliferation and Migration in
            Laryngotracheal Stenosis Through the TGF-beta/RHOA Pathway.
REFERENCE   4  (bases 1 to 3301)
  AUTHORS   Jin,X., Deng,Q., Ye,S., Liu,S., Fu,Y., Liu,Y., Wu,G., Ouyang,G. and
            Wu,T.
  TITLE     Cancer-associated fibroblast-derived periostin promotes papillary
            thyroid tumor growth through integrin-FAK-STAT3 signaling
  JOURNAL   Theranostics 14 (7), 3014-3028 (2024)
   PUBMED   38773979
  REMARK    GeneRIF: Cancer-associated fibroblast-derived periostin promotes
            papillary thyroid tumor growth through integrin-FAK-STAT3
            signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3301)
  AUTHORS   Yuan,C. and Li,J.
  TITLE     Research progress of periostin and osteoporosis
  JOURNAL   Front Endocrinol (Lausanne) 15, 1356297 (2024)
   PUBMED   38487345
  REMARK    GeneRIF: Research progress of periostin and osteoporosis.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3301)
  AUTHORS   Shao,R., Bao,S., Bai,X., Blanchette,C., Anderson,R.M., Dang,T.,
            Gishizky,M.L., Marks,J.R. and Wang,X.F.
  TITLE     Acquired expression of periostin by human breast cancers promotes
            tumor angiogenesis through up-regulation of vascular endothelial
            growth factor receptor 2 expression
  JOURNAL   Mol Cell Biol 24 (9), 3992-4003 (2004)
   PUBMED   15082792
  REMARK    GeneRIF: Data suggest that periostin-mediated angiogenesis derives
            in part from the up-regulation of the vascular endothelial growth
            factor receptor Flk-1/KDR by endothelial cells through an integrin
            alpha(v)beta(3)-focal adhesion kinase signaling pathway.
REFERENCE   7  (bases 1 to 3301)
  AUTHORS   Bao,S., Ouyang,G., Bai,X., Huang,Z., Ma,C., Liu,M., Shao,R.,
            Anderson,R.M., Rich,J.N. and Wang,X.F.
  TITLE     Periostin potently promotes metastatic growth of colon cancer by
            augmenting cell survival via the Akt/PKB pathway
  JOURNAL   Cancer Cell 5 (4), 329-339 (2004)
   PUBMED   15093540
  REMARK    GeneRIF: Over expression of Periostin promotes metastatic growth of
            colon cancer by augmenting cell survival via the Akt/PKB pathway
REFERENCE   8  (bases 1 to 3301)
  AUTHORS   Gillan,L., Matei,D., Fishman,D.A., Gerbin,C.S., Karlan,B.Y. and
            Chang,D.D.
  TITLE     Periostin secreted by epithelial ovarian carcinoma is a ligand for
            alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell
            motility
  JOURNAL   Cancer Res 62 (18), 5358-5364 (2002)
   PUBMED   12235007
  REMARK    GeneRIF: Periostin secreted by epithelial ovarian carcinoma is a
            ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and
            promotes cell motility.
REFERENCE   9  (bases 1 to 3301)
  AUTHORS   Sasaki,H., Dai,M., Auclair,D., Fukai,I., Kiriyama,M., Yamakawa,Y.,
            Fujii,Y. and Chen,L.B.
  TITLE     Serum level of the periostin, a homologue of an insect cell
            adhesion molecule, as a prognostic marker in nonsmall cell lung
            carcinomas
  JOURNAL   Cancer 92 (4), 843-848 (2001)
   PUBMED   11550156
  REMARK    Erratum:[Cancer 2002 Dec 15;95(12):2580]
REFERENCE   10 (bases 1 to 3301)
  AUTHORS   Takeshita,S., Kikuno,R., Tezuka,K. and Amann,E.
  TITLE     Osteoblast-specific factor 2: cloning of a putative bone adhesion
            protein with homology with the insect protein fasciclin I
  JOURNAL   Biochem J 294 (Pt 1) (Pt 1), 271-278 (1993)
   PUBMED   8363580
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC403736.1, BC106709.1,
            D13666.1, BQ575951.1 and AI580215.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006475.2.
            
            Summary: This gene encodes a secreted extracellular matrix protein
            that functions in tissue development and regeneration, including
            wound healing, and ventricular remodeling following myocardial
            infarction. The encoded protein binds to integrins to support
            adhesion and migration of epithelial cells. This protein plays a
            role in cancer stem cell maintenance and metastasis. Mice lacking
            this gene exhibit cardiac valve disease, and skeletal and dental
            defects. Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Sep
            2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D13666.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379747.9/ ENSP00000369071.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-468               DC403736.1         77-544
            469-2050            BC106709.1         438-2019
            2051-2515           D13666.1           2020-2484
            2516-3173           BQ575951.1         16-673              c
            3174-3301           AI580215.1         14-141              c
FEATURES             Location/Qualifiers
     source          1..3301
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q13.3"
     gene            1..3301
                     /gene="POSTN"
                     /gene_synonym="OSF-2; OSF2; PDLPOSTN; PN"
                     /note="periostin"
                     /db_xref="GeneID:10631"
                     /db_xref="HGNC:HGNC:16953"
                     /db_xref="MIM:608777"
     exon            1..161
                     /gene="POSTN"
                     /gene_synonym="OSF-2; OSF2; PDLPOSTN; PN"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..2553
                     /gene="POSTN"
                     /gene_synonym="OSF-2; OSF2; PDLPOSTN; PN"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; osteoblast specific factor 2 (fasciclin
                     I-like); periodontal ligament-specific periostin;
                     periostin, osteoblast specific factor"
                     /codon_start=1
                     /product="periostin isoform 1 precursor"
                     /protein_id="NP_006466.2"
                     /db_xref="CCDS:CCDS9364.1"
                     /db_xref="GeneID:10631"
                     /db_xref="HGNC:HGNC:16953"
                     /db_xref="MIM:608777"
                     /translation="MIPFLPMFSLLLLLIVNPINANNHYDKILAHSRIRGRDQGPNVC
                     ALQQILGTKKKYFSTCKNWYKKSICGQKTTVLYECCPGYMRMEGMKGCPAVLPIDHVY
                     GTLGIVGATTTQRYSDASKLREEIEGKGSFTYFAPSNEAWDNLDSDIRRGLESNVNVE
                     LLNALHSHMINKRMLTKDLKNGMIIPSMYNNLGLFINHYPNGVVTVNCARIIHGNQIA
                     TNGVVHVIDRVLTQIGTSIQDFIEAEDDLSSFRAAAITSDILEALGRDGHFTLFAPTN
                     EAFEKLPRGVLERIMGDKVASEALMKYHILNTLQCSESIMGGAVFETLEGNTIEIGCD
                     GDSITVNGIKMVNKKDIVTNNGVIHLIDQVLIPDSAKQVIELAGKQQTTFTDLVAQLG
                     LASALRPDGEYTLLAPVNNAFSDDTLSMDQRLLKLILQNHILKVKVGLNELYNGQILE
                     TIGGKQLRVFVYRTAVCIENSCMEKGSKQGRNGAIHIFREIIKPAEKSLHEKLKQDKR
                     FSTFLSLLEAADLKELLTQPGDWTLFVPTNDAFKGMTSEEKEILIRDKNALQNIILYH
                     LTPGVFIGKGFEPGVTNILKTTQGSKIFLKEVNDTLLVNELKSKESDIMTTNGVIHVV
                     DKLLYPADTPVGNDQLLEILNKLIKYIQIKFVRGSTFKEIPVTVYTTKIITKVVEPKI
                     KVIEGSLQPIIKTEGPTLTKVKIEGEPEFRLIKEGETITEVIHGEPIIKKYTKIIDGV
                     PVEITEKETREERIITGPEIKYTRISTGGGETEETLKKLLQEEVTKVTKFIEGGDGHL
                     FEDEEIKRLLQGDTPVRKLQANKKVQGSRRRLREGRSQ"
     exon            162..260
                     /gene="POSTN"
                     /gene_synonym="OSF-2; OSF2; PDLPOSTN; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            261..325
                     /gene="POSTN"
                     /gene_synonym="OSF-2; OSF2; PDLPOSTN; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            326..483
                     /gene="POSTN"
                     /gene_synonym="OSF-2; OSF2; PDLPOSTN; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            484..648
                     /gene="POSTN"
                     /gene_synonym="OSF-2; OSF2; PDLPOSTN; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            649..795
                     /gene="POSTN"
                     /gene_synonym="OSF-2; OSF2; PDLPOSTN; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            796..937
                     /gene="POSTN"
                     /gene_synonym="OSF-2; OSF2; PDLPOSTN; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1150
                     /gene="POSTN"
                     /gene_synonym="OSF-2; OSF2; PDLPOSTN; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1285
                     /gene="POSTN"
                     /gene_synonym="OSF-2; OSF2; PDLPOSTN; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1434
                     /gene="POSTN"
                     /gene_synonym="OSF-2; OSF2; PDLPOSTN; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1571
                     /gene="POSTN"
                     /gene_synonym="OSF-2; OSF2; PDLPOSTN; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1702
                     /gene="POSTN"
                     /gene_synonym="OSF-2; OSF2; PDLPOSTN; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1833
                     /gene="POSTN"
                     /gene_synonym="OSF-2; OSF2; PDLPOSTN; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1936
                     /gene="POSTN"
                     /gene_synonym="OSF-2; OSF2; PDLPOSTN; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2004
                     /gene="POSTN"
                     /gene_synonym="OSF-2; OSF2; PDLPOSTN; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2050
                     /gene="POSTN"
                     /gene_synonym="OSF-2; OSF2; PDLPOSTN; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2131
                     /gene="POSTN"
                     /gene_synonym="OSF-2; OSF2; PDLPOSTN; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2221
                     /gene="POSTN"
                     /gene_synonym="OSF-2; OSF2; PDLPOSTN; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2311
                     /gene="POSTN"
                     /gene_synonym="OSF-2; OSF2; PDLPOSTN; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2389
                     /gene="POSTN"
                     /gene_synonym="OSF-2; OSF2; PDLPOSTN; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2473
                     /gene="POSTN"
                     /gene_synonym="OSF-2; OSF2; PDLPOSTN; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            2474..2515
                     /gene="POSTN"
                     /gene_synonym="OSF-2; OSF2; PDLPOSTN; PN"
                     /inference="alignment:Splign:2.1.0"
     exon            2516..3301
                     /gene="POSTN"
                     /gene_synonym="OSF-2; OSF2; PDLPOSTN; PN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3281..3286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POSTN"
                     /gene_synonym="OSF-2; OSF2; PDLPOSTN; PN"
                     /note="hexamer: ATTAAA"
     polyA_site      3301
                     /gene="POSTN"
                     /gene_synonym="OSF-2; OSF2; PDLPOSTN; PN"
                     /note="major polyA site"
ORIGIN      
        1 gccagttctc ttcggggact aactgcaacg gagagactca agatgattcc ctttttaccc
       61 atgttttctc tactattgct gcttattgtt aaccctataa acgccaacaa tcattatgac
      121 aagatcttgg ctcatagtcg tatcaggggt cgggaccaag gcccaaatgt ctgtgccctt
      181 caacagattt tgggcaccaa aaagaaatac ttcagcactt gtaagaactg gtataaaaag
      241 tccatctgtg gacagaaaac gactgtgtta tatgaatgtt gccctggtta tatgagaatg
      301 gaaggaatga aaggctgccc agcagttttg cccattgacc atgtttatgg cactctgggc
      361 atcgtgggag ccaccacaac gcagcgctat tctgacgcct caaaactgag ggaggagatc
      421 gagggaaagg gatccttcac ttactttgca ccgagtaatg aggcttggga caacttggat
      481 tctgatatcc gtagaggttt ggagagcaac gtgaatgttg aattactgaa tgctttacat
      541 agtcacatga ttaataagag aatgttgacc aaggacttaa aaaatggcat gattattcct
      601 tcaatgtata acaatttggg gcttttcatt aaccattatc ctaatggggt tgtcactgtt
      661 aattgtgctc gaatcatcca tgggaaccag attgcaacaa atggtgttgt ccatgtcatt
      721 gaccgtgtgc ttacacaaat tggtacctca attcaagact tcattgaagc agaagatgac
      781 ctttcatctt ttagagcagc tgccatcaca tcggacatat tggaggccct tggaagagac
      841 ggtcacttca cactctttgc tcccaccaat gaggcttttg agaaacttcc acgaggtgtc
      901 ctagaaagga tcatgggaga caaagtggct tccgaagctc ttatgaagta ccacatctta
      961 aatactctcc agtgttctga gtctattatg ggaggagcag tctttgagac gctggaagga
     1021 aatacaattg agataggatg tgacggtgac agtataacag taaatggaat caaaatggtg
     1081 aacaaaaagg atattgtgac aaataatggt gtgatccatt tgattgatca ggtcctaatt
     1141 cctgattctg ccaaacaagt tattgagctg gctggaaaac agcaaaccac cttcacggat
     1201 cttgtggccc aattaggctt ggcatctgct ctgaggccag atggagaata cactttgctg
     1261 gcacctgtga ataatgcatt ttctgatgat actctcagca tggatcagcg cctccttaaa
     1321 ttaattctgc agaatcacat attgaaagta aaagttggcc ttaatgagct ttacaacggg
     1381 caaatactgg aaaccatcgg aggcaaacag ctcagagtct tcgtatatcg tacagctgtc
     1441 tgcattgaaa attcatgcat ggagaaaggg agtaagcaag ggagaaacgg tgcgattcac
     1501 atattccgcg agatcatcaa gccagcagag aaatccctcc atgaaaagtt aaaacaagat
     1561 aagcgcttta gcaccttcct cagcctactt gaagctgcag acttgaaaga gctcctgaca
     1621 caacctggag actggacatt atttgtgcca accaatgatg cttttaaggg aatgactagt
     1681 gaagaaaaag aaattctgat acgggacaaa aatgctcttc aaaacatcat tctttatcac
     1741 ctgacaccag gagttttcat tggaaaagga tttgaacctg gtgttactaa cattttaaag
     1801 accacacaag gaagcaaaat ctttctgaaa gaagtaaatg atacacttct ggtgaatgaa
     1861 ttgaaatcaa aagaatctga catcatgaca acaaatggtg taattcatgt tgtagataaa
     1921 ctcctctatc cagcagacac acctgttgga aatgatcaac tgctggaaat acttaataaa
     1981 ttaatcaaat acatccaaat taagtttgtt cgtggtagca ccttcaaaga aatccccgtg
     2041 actgtctata caactaaaat tataaccaaa gttgtggaac caaaaattaa agtgattgaa
     2101 ggcagtcttc agcctattat caaaactgaa ggacccacac taacaaaagt caaaattgaa
     2161 ggtgaacctg aattcagact gattaaagaa ggtgaaacaa taactgaagt gatccatgga
     2221 gagccaatta ttaaaaaata caccaaaatc attgatggag tgcctgtgga aataactgaa
     2281 aaagagacac gagaagaacg aatcattaca ggtcctgaaa taaaatacac taggatttct
     2341 actggaggtg gagaaacaga agaaactctg aagaaattgt tacaagaaga ggtcaccaag
     2401 gtcaccaaat tcattgaagg tggtgatggt catttatttg aagatgaaga aattaaaaga
     2461 ctgcttcagg gagacacacc cgtgaggaag ttgcaagcca acaaaaaagt tcaaggatct
     2521 agaagacgat taagggaagg tcgttctcag tgaaaatcca aaaaccagaa aaaaatgttt
     2581 atacaaccct aagtcaataa cctgacctta gaaaattgtg agagccaagt tgacttcagg
     2641 aactgaaaca tcagcacaaa gaagcaatca tcaaataatt ctgaacacaa atttaatatt
     2701 tttttttctg aatgagaaac atgagggaaa ttgtggagtt agcctcctgt ggtaaaggaa
     2761 ttgaagaaaa tataacacct tacacccttt ttcatcttga cattaaaagt tctggctaac
     2821 tttggaatcc attagagaaa aatccttgtc accagattca ttacaattca aatcgaagag
     2881 ttgtgaactg ttatcccatt gaaaagaccg agccttgtat gtatgttatg gatacataaa
     2941 atgcacgcaa gccattatct ctccatggga agctaagtta taaaaatagg tgcttggtgt
     3001 acaaaacttt ttatatcaaa aggctttgca catttctata tgagtgggtt tactggtaaa
     3061 ttatgttatt ttttacaact aattttgtac tctcagaatg tttgtcatat gcttcttgca
     3121 atgcatattt tttaatctca aacgtttcaa taaaaccatt tttcagatat aaagagaatt
     3181 acttcaaatt gagtaattca gaaaaactca agatttaagt taaaaagtgg tttggacttg
     3241 ggaacaggac tttatacctc ttttactgta acaagtactc attaaaggaa attgaatgaa
     3301 a
//
