LOCUS       NM_005837                850 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens POP7 homolog, ribonuclease P/MRP subunit (POP7), mRNA.
ACCESSION   NM_005837
VERSION     NM_005837.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 850)
  AUTHORS   Huang,Y., Zheng,Y., Yao,L., Qiao,F., Hou,Y., Hu,X., Li,D. and
            Shao,Z.
  TITLE     RNA binding protein POP7 regulates ILF3 mRNA stability and
            expression to promote breast cancer progression
  JOURNAL   Cancer Sci 113 (11), 3801-3813 (2022)
   PUBMED   35579257
  REMARK    GeneRIF: RNA binding protein POP7 regulates ILF3 mRNA stability and
            expression to promote breast cancer progression.
REFERENCE   2  (bases 1 to 850)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 850)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 850)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 850)
  AUTHORS   Wu,J., Niu,S., Tan,M., Huang,C., Li,M., Song,Y., Wang,Q., Chen,J.,
            Shi,S., Lan,P. and Lei,M.
  TITLE     Cryo-EM Structure of the Human Ribonuclease P Holoenzyme
  JOURNAL   Cell 175 (5), 1393-1404 (2018)
   PUBMED   30454648
REFERENCE   6  (bases 1 to 850)
  AUTHORS   Welting,T.J., van Venrooij,W.J. and Pruijn,G.J.
  TITLE     Mutual interactions between subunits of the human RNase MRP
            ribonucleoprotein complex
  JOURNAL   Nucleic Acids Res 32 (7), 2138-2146 (2004)
   PUBMED   15096576
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 850)
  AUTHORS   Hua,Y. and Zhou,J.
  TITLE     Rpp20 interacts with SMN and is re-distributed into SMN granules in
            response to stress
  JOURNAL   Biochem Biophys Res Commun 314 (1), 268-276 (2004)
   PUBMED   14715275
REFERENCE   8  (bases 1 to 850)
  AUTHORS   Jiang,T. and Altman,S.
  TITLE     Protein-protein interactions with subunits of human nuclear RNase P
  JOURNAL   Proc Natl Acad Sci U S A 98 (3), 920-925 (2001)
   PUBMED   11158571
REFERENCE   9  (bases 1 to 850)
  AUTHORS   Stolc,V., Katz,A. and Altman,S.
  TITLE     Rpp2, an essential protein subunit of nuclear RNase P, is required
            for processing of precursor tRNAs and 35S precursor rRNA in
            Saccharomyces cerevisiae
  JOURNAL   Proc Natl Acad Sci U S A 95 (12), 6716-6721 (1998)
   PUBMED   9618478
REFERENCE   10 (bases 1 to 850)
  AUTHORS   Jarrous,N., Eder,P.S., Guerrier-Takada,C., Hoog,C. and Altman,S.
  TITLE     Autoantigenic properties of some protein subunits of catalytically
            active complexes of human ribonuclease P
  JOURNAL   RNA 4 (4), 407-417 (1998)
   PUBMED   9630247
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI666854.1 and BC001430.2.
            
            On Nov 22, 2018 this sequence version replaced NM_005837.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.137178.1, CD048511.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303151.5/ ENSP00000304353.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                BI666854.1         72-93
            23-850              BC001430.2         1-828
FEATURES             Location/Qualifiers
     source          1..850
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..850
                     /gene="POP7"
                     /gene_synonym="0610037N12Rik; RPP2; RPP20"
                     /note="POP7 homolog, ribonuclease P/MRP subunit"
                     /db_xref="GeneID:10248"
                     /db_xref="HGNC:HGNC:19949"
                     /db_xref="MIM:606113"
     exon            1..184
                     /gene="POP7"
                     /gene_synonym="0610037N12Rik; RPP2; RPP20"
                     /inference="alignment:Splign:2.1.0"
     exon            185..850
                     /gene="POP7"
                     /gene_synonym="0610037N12Rik; RPP2; RPP20"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..617
                     /gene="POP7"
                     /gene_synonym="0610037N12Rik; RPP2; RPP20"
                     /EC_number="3.1.26.5"
                     /note="POP7 (processing of precursor, S. cerevisiae)
                     homolog; hPOP7; RNaseP protein p20; ribonucleases P/MRP
                     protein subunit POP7 homolog; processing of precursor 7,
                     ribonuclease P subunit; processing of precursor 7,
                     ribonuclease P/MRP subunit"
                     /codon_start=1
                     /product="ribonuclease P protein subunit p20"
                     /protein_id="NP_005828.2"
                     /db_xref="CCDS:CCDS5704.1"
                     /db_xref="GeneID:10248"
                     /db_xref="HGNC:HGNC:19949"
                     /db_xref="MIM:606113"
                     /translation="MAENREPRGAVEAELDPVEYTLRKRLPSRLPRRPNDIYVNMKTD
                     FKAQLARCQKLLDGGARGQNACSEIYIHGLGLAINRAINIALQLQAGSFGSLQVAANT
                     STVELVDELEPETDTREPLTRIRNNSAIHIRVFRVTPK"
     regulatory      827..832
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POP7"
                     /gene_synonym="0610037N12Rik; RPP2; RPP20"
                     /note="hexamer: AATAAA"
     polyA_site      850
                     /gene="POP7"
                     /gene_synonym="0610037N12Rik; RPP2; RPP20"
                     /note="major polyA site"
ORIGIN      
        1 actccgcagc ccgttcagga ccccggcgcg ggcagggcgc ccacgagctg gctggctgct
       61 tgcacccaca tccttctttc tctgggacct ggggtcgcgg ttacttgggc tggccggcga
      121 acccttgagt ggcctggcgg ggagcgggcc tcgcgcgcct ggagggccct gtggaacgaa
      181 gagaggcaca cagcatggca gaaaaccgag agccccgcgg tgctgtggag gctgaactgg
      241 atccagtgga atacaccctt aggaaaaggc ttcccagccg cctgccccgg agacccaatg
      301 acatttatgt caacatgaag acggacttta aggcccagct ggcccgctgc cagaagctgc
      361 tggacggagg ggcccggggt cagaacgcgt gctctgagat ctacattcac ggcttgggcc
      421 tggccatcaa ccgcgccatc aacatcgcgc tgcagctgca ggcgggcagc ttcgggtcct
      481 tgcaggtggc tgccaatacc tccaccgtgg agcttgttga tgagctggag ccagagaccg
      541 acacacggga gccactgact cggatccgca acaactcagc catccacatc cgagtcttca
      601 gggtcacacc caagtaattg aaaagacact cctccactta tcccctccgt gatatggctc
      661 ttcgcatgct gagtactgga cctcggacca gagccatgta agaaaaggcc tgttccctgg
      721 aagcccaaag gactctgcat tgagggtggg ggtaattgtc tcttggtggg cccagttagt
      781 gggccttcct gagtgtgtgt atgcggtctg taactattgc catataaata aaaaatcctg
      841 ttgcactagt
//
