LOCUS       NM_015918               1086 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens POP5 homolog, ribonuclease P/MRP subunit (POP5),
            transcript variant 1, mRNA.
ACCESSION   NM_015918
VERSION     NM_015918.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1086)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1086)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1086)
  AUTHORS   Wu,J., Niu,S., Tan,M., Huang,C., Li,M., Song,Y., Wang,Q., Chen,J.,
            Shi,S., Lan,P. and Lei,M.
  TITLE     Cryo-EM Structure of the Human Ribonuclease P Holoenzyme
  JOURNAL   Cell 175 (5), 1393-1404 (2018)
   PUBMED   30454648
REFERENCE   4  (bases 1 to 1086)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1086)
  AUTHORS   Suematsu,K., Ueda,T., Nakashima,T., Kakuta,Y. and Kimura,M.
  TITLE     On archaeal homologs of the human RNase P proteins Pop5 and Rpp30
            in the hyperthermophilic archaeon Thermococcus kodakarensis
  JOURNAL   Biosci Biotechnol Biochem 79 (6), 952-959 (2015)
   PUBMED   25704799
  REMARK    GeneRIF: archaeal homologs of the human RNase P proteins Pop5 and
            Rpp30
REFERENCE   6  (bases 1 to 1086)
  AUTHORS   Welting,T.J., Kikkert,B.J., van Venrooij,W.J. and Pruijn,G.J.
  TITLE     Differential association of protein subunits with the human RNase
            MRP and RNase P complexes
  JOURNAL   RNA 12 (7), 1373-1382 (2006)
   PUBMED   16723659
REFERENCE   7  (bases 1 to 1086)
  AUTHORS   Welting,T.J., van Venrooij,W.J. and Pruijn,G.J.
  TITLE     Mutual interactions between subunits of the human RNase MRP
            ribonucleoprotein complex
  JOURNAL   Nucleic Acids Res 32 (7), 2138-2146 (2004)
   PUBMED   15096576
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1086)
  AUTHORS   van Eenennaam,H., Lugtenberg,D., Vogelzangs,J.H., van Venrooij,W.J.
            and Pruijn,G.J.
  TITLE     hPop5, a protein subunit of the human RNase MRP and RNase P
            endoribonucleases
  JOURNAL   J Biol Chem 276 (34), 31635-31641 (2001)
   PUBMED   11413139
REFERENCE   9  (bases 1 to 1086)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
REFERENCE   10 (bases 1 to 1086)
  AUTHORS   van Eenennaam,H., Pruijn,G.J. and van Venrooij,W.J.
  TITLE     hPop4: a new protein subunit of the human RNase MRP and RNase P
            ribonucleoprotein complexes
  JOURNAL   Nucleic Acids Res 27 (12), 2465-2472 (1999)
   PUBMED   10352175
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC063943.23, BI668578.1 and AJ306296.1.
            
            On May 17, 2019 this sequence version replaced NM_015918.3.
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.45866.1,
                                           SRR5189667.341060.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2151358
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357500.5/ ENSP00000350098.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC063943.23        105941-105948       c
            9-155               BI668578.1         9-155
            156-805             AJ306296.1         135-784
            806-1086            AC063943.23        103310-103590       c
FEATURES             Location/Qualifiers
     source          1..1086
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..1086
                     /gene="POP5"
                     /gene_synonym="hPop5; HSPC004; RPP2; RPP20"
                     /note="POP5 homolog, ribonuclease P/MRP subunit"
                     /db_xref="GeneID:51367"
                     /db_xref="HGNC:HGNC:17689"
                     /db_xref="MIM:609992"
     exon            1..60
                     /gene="POP5"
                     /gene_synonym="hPop5; HSPC004; RPP2; RPP20"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..532
                     /gene="POP5"
                     /gene_synonym="hPop5; HSPC004; RPP2; RPP20"
                     /EC_number="3.1.26.5"
                     /note="isoform a is encoded by transcript variant 1;
                     ribonuclease P/MRP protein subunit POP5; processing of
                     precursor 5, ribonuclease P/MRP subunit"
                     /codon_start=1
                     /product="ribonuclease P/MRP protein subunit POP5 isoform
                     a"
                     /protein_id="NP_057002.2"
                     /db_xref="CCDS:CCDS9202.1"
                     /db_xref="GeneID:51367"
                     /db_xref="HGNC:HGNC:17689"
                     /db_xref="MIM:609992"
                     /translation="MVRFKHRYLLCELVSDDPRCRLSLDDRVLSSLVRDTIARVHGTF
                     GAAACSIGFAVRYLNAYTGIVLLRCRKEFYQLVWSALPFITYLENKGHRYPCFFNTLH
                     VGGTIRTCQKFLIQYNRRQLLILLQNCTDEGEREAIQKSVTRSCLLEEEEESGEEAAE
                     AME"
     exon            61..203
                     /gene="POP5"
                     /gene_synonym="hPop5; HSPC004; RPP2; RPP20"
                     /inference="alignment:Splign:2.1.0"
     exon            204..353
                     /gene="POP5"
                     /gene_synonym="hPop5; HSPC004; RPP2; RPP20"
                     /inference="alignment:Splign:2.1.0"
     exon            354..437
                     /gene="POP5"
                     /gene_synonym="hPop5; HSPC004; RPP2; RPP20"
                     /inference="alignment:Splign:2.1.0"
     exon            438..1086
                     /gene="POP5"
                     /gene_synonym="hPop5; HSPC004; RPP2; RPP20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      780..785
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POP5"
                     /gene_synonym="hPop5; HSPC004; RPP2; RPP20"
                     /note="hexamer: AATAAA"
     polyA_site      805
                     /gene="POP5"
                     /gene_synonym="hPop5; HSPC004; RPP2; RPP20"
                     /note="major polyA site"
     regulatory      820..825
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POP5"
                     /gene_synonym="hPop5; HSPC004; RPP2; RPP20"
                     /note="hexamer: ATTACA"
     polyA_site      829
                     /gene="POP5"
                     /gene_synonym="hPop5; HSPC004; RPP2; RPP20"
     polyA_site      845
                     /gene="POP5"
                     /gene_synonym="hPop5; HSPC004; RPP2; RPP20"
ORIGIN      
        1 atccggtttg cacgccggac cggagagcgc ggaggcagcc atggtgcggt tcaagcacag
       61 gtacctgctc tgcgaactgg tgtctgacga cccccgctgc cgcctaagcc tcgatgaccg
      121 agttctgagc agcctcgtac gggacacgat cgccagggtg cacggaactt tcggcgcagc
      181 cgcctgctcc atcggcttcg cggttcgata tctcaatgcc tatactggaa tagtgctact
      241 tcgatgcaga aaagaattct atcagcttgt gtggtcagct cttcccttca tcacatactt
      301 ggagaacaaa ggacaccgtt acccatgctt tttcaacaca ttacatgtgg gaggtacaat
      361 aagaacatgt cagaagttcc taattcagta caacaggaga cagctgttga tcttgttgca
      421 gaactgcact gatgaaggag agcgggaagc tatccagaag tctgtgacaa gaagctgctt
      481 attagaggag gaggaggagt caggtgagga ggctgcagaa gcaatggagt gaacctctgc
      541 tccccacaca gctggctaca ctgctcaggc ttcaggccca cttgttgaac agaacaatct
      601 gggtagcaac agcatcttcc acagttttcc aaactggata gctgccaacc agcagacatt
      661 acccacttga aatggagtac tcagttaaac tgaagttgcc tttacctagc attccctggt
      721 gaagtgttgc aggttgtgaa ctctgtagac atctttattg cttggctaag agtagattta
      781 ataaatgtat ctggtttccg tggcatttag catacttata ttacagaaag ggcttatgga
      841 gtccatgctt ggccaagtct ctgttctctc tctatcccta gccttggtgg gaagactgac
      901 tccctatgtg gtactagtta aacttttttt tttgagacag tctcagtcta tcacccaggc
      961 tggagtgtag tggcccagta tcggctcact gcaacctccg cctcctgggt tcaagcaatt
     1021 ctcccacctc agccttccaa gtaactggga ttacagacgt gcaccaccac gtctggctaa
     1081 tttttg
//
