LOCUS       NM_006627               2556 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens POP4 homolog, ribonuclease P/MRP subunit (POP4),
            transcript variant 1, mRNA.
ACCESSION   NM_006627
VERSION     NM_006627.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2556)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2556)
  AUTHORS   Wu,J., Niu,S., Tan,M., Huang,C., Li,M., Song,Y., Wang,Q., Chen,J.,
            Shi,S., Lan,P. and Lei,M.
  TITLE     Cryo-EM Structure of the Human Ribonuclease P Holoenzyme
  JOURNAL   Cell 175 (5), 1393-1404 (2018)
   PUBMED   30454648
REFERENCE   3  (bases 1 to 2556)
  AUTHORS   Shastrula,P.K., Lund,P.J., Garcia,B.A. and Janicki,S.M.
  TITLE     Rpp29 regulates histone H3.3 chromatin assembly through
            transcriptional mechanisms
  JOURNAL   J Biol Chem 293 (32), 12360-12377 (2018)
   PUBMED   29921582
  REMARK    GeneRIF: Rpp29 regulates H3.3-mediated epigenetic mechanisms by
            processing a transcribed signal that recruits H3.3 to its
            incorporation sites
REFERENCE   4  (bases 1 to 2556)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 2556)
  AUTHORS   Abu-Zhayia,E.R., Khoury-Haddad,H., Guttmann-Raviv,N., Serruya,R.,
            Jarrous,N. and Ayoub,N.
  TITLE     A role of human RNase P subunits, Rpp29 and Rpp21, in homology
            directed-repair of double-strand breaks
  JOURNAL   Sci Rep 7 (1), 1002 (2017)
   PUBMED   28432356
  REMARK    GeneRIF: Results demonstrate that Rpp29 promotes homology-directed
            repair of double-strand breaks. It is rapidly and transiently
            recruited to laser-microirradiated DNA sites.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2556)
  AUTHORS   Mann,H., Ben-Asouli,Y., Schein,A., Moussa,S. and Jarrous,N.
  TITLE     Eukaryotic RNase P: role of RNA and protein subunits of a
            primordial catalytic ribonucleoprotein in RNA-based catalysis
  JOURNAL   Mol Cell 12 (4), 925-935 (2003)
   PUBMED   14580343
REFERENCE   7  (bases 1 to 2556)
  AUTHORS   Jiang,T., Guerrier-Takada,C. and Altman,S.
  TITLE     Protein-RNA interactions in the subunits of human nuclear RNase P
  JOURNAL   RNA 7 (7), 937-941 (2001)
   PUBMED   11455963
REFERENCE   8  (bases 1 to 2556)
  AUTHORS   Jarrous,N., Wolenski,J.S., Wesolowski,D., Lee,C. and Altman,S.
  TITLE     Localization in the nucleolus and coiled bodies of protein subunits
            of the ribonucleoprotein ribonuclease P
  JOURNAL   J Cell Biol 146 (3), 559-572 (1999)
   PUBMED   10444065
REFERENCE   9  (bases 1 to 2556)
  AUTHORS   van Eenennaam,H., Pruijn,G.J. and van Venrooij,W.J.
  TITLE     hPop4: a new protein subunit of the human RNase MRP and RNase P
            ribonucleoprotein complexes
  JOURNAL   Nucleic Acids Res 27 (12), 2465-2472 (1999)
   PUBMED   10352175
REFERENCE   10 (bases 1 to 2556)
  AUTHORS   Jarrous,N., Eder,P.S., Wesolowski,D. and Altman,S.
  TITLE     Rpp14 and Rpp29, two protein subunits of human ribonuclease P
  JOURNAL   RNA 5 (2), 153-157 (1999)
   PUBMED   10024167
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010505.6, Y18863.1 and
            BU727144.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006627.2.
            
            Summary: This gene encodes one of the protein subunits of the small
            nucleolar ribonucleoprotein complexes: the endoribonuclease for
            mitochondrial RNA processing complex and the ribonuclease P
            complex. The encoded protein is localized to the nucleus and
            associates directly with the RNA component of these complexes. This
            protein is involved in processing of precursor RNAs. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Mar 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes processing of precursor 4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.220549.1,
                                           SRR1803617.25698.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000585603.6/ ENSP00000465213.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC010505.6         14850-14860
            12-1070             Y18863.1           1-1059
            1071-2276           AC010505.6         24319-25524
            2277-2556           BU727144.1         37-316              c
FEATURES             Location/Qualifiers
     source          1..2556
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q12"
     gene            1..2556
                     /gene="POP4"
                     /gene_synonym="RPP29"
                     /note="POP4 homolog, ribonuclease P/MRP subunit"
                     /db_xref="GeneID:10775"
                     /db_xref="HGNC:HGNC:30081"
                     /db_xref="MIM:606114"
     exon            1..43
                     /gene="POP4"
                     /gene_synonym="RPP29"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..699
                     /gene="POP4"
                     /gene_synonym="RPP29"
                     /EC_number="3.1.26.5"
                     /note="hPOP4"
                     /codon_start=1
                     /product="ribonuclease P protein subunit p29"
                     /protein_id="NP_006618.1"
                     /db_xref="CCDS:CCDS12416.1"
                     /db_xref="GeneID:10775"
                     /db_xref="HGNC:HGNC:30081"
                     /db_xref="MIM:606114"
                     /translation="MKSVIYHALSQKEANDSDVQPSGAQRAEAFVRAFLKRSTPRMSP
                     QAREDQLQRKAVVLEYFTRHKRKEKKKKAKGLSARQRRELRLFDIKPEQQRYSLFLPL
                     HELWKQYIRDLCSGLKPDTQPQMIQAKLLKADLHGAIISVTKSKCPSYVGITGILLQE
                     TKHIFKIITKEDRLKVIPKLNCVFTVETDGFISYIYGSKFQLRSSERSAKKFKAKGTI
                     DL"
     exon            44..96
                     /gene="POP4"
                     /gene_synonym="RPP29"
                     /inference="alignment:Splign:2.1.0"
     exon            97..320
                     /gene="POP4"
                     /gene_synonym="RPP29"
                     /inference="alignment:Splign:2.1.0"
     exon            321..398
                     /gene="POP4"
                     /gene_synonym="RPP29"
                     /inference="alignment:Splign:2.1.0"
     exon            399..460
                     /gene="POP4"
                     /gene_synonym="RPP29"
                     /inference="alignment:Splign:2.1.0"
     exon            461..562
                     /gene="POP4"
                     /gene_synonym="RPP29"
                     /inference="alignment:Splign:2.1.0"
     exon            563..2556
                     /gene="POP4"
                     /gene_synonym="RPP29"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1014
                     /gene="POP4"
                     /gene_synonym="RPP29"
                     /note="major polyA site"
     regulatory      1099..1104
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POP4"
                     /gene_synonym="RPP29"
                     /note="hexamer: AATAAA"
     polyA_site      1119
                     /gene="POP4"
                     /gene_synonym="RPP29"
                     /note="major polyA site"
     regulatory      2533..2538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POP4"
                     /gene_synonym="RPP29"
                     /note="hexamer: AATACA"
     polyA_site      2556
                     /gene="POP4"
                     /gene_synonym="RPP29"
ORIGIN      
        1 agtgcgtcat cagagagcgc cggaagcggt ccgagaatga agagtgtgat ctaccatgca
       61 ttgtctcaga aagaggcgaa tgactccgat gtccagcctt caggagcaca gcgggccgag
      121 gccttcgtga gggccttcct gaagcgcagc acgccccgca tgagcccgca ggcccgcgag
      181 gaccagctgc agcgcaaggc ggtggtcctg gagtacttca cccgccacaa gcgcaaggag
      241 aagaagaaga aagccaaagg cctctctgcc aggcaaagga gggagctgcg gctctttgac
      301 attaaaccag agcagcagag atacagcctt ttcctccctc tccatgaact ctggaaacag
      361 tacatcaggg acctgtgcag tgggctcaag ccagacacgc agccacagat gattcaggcc
      421 aagctcttaa aggcagatct tcacggggct attatttcag tgacaaaatc caaatgcccc
      481 tcttatgtgg gtattacagg aatccttcta caggaaacaa agcacatttt caaaattatc
      541 accaaagaag accgcctgaa agttatcccc aagctaaact gcgtgttcac tgtggaaacc
      601 gatggcttta tttcctacat ttacgggagc aaattccagc ttcggtcaag tgaacggtct
      661 gcgaagaagt tcaaagcgaa gggaacgatt gacctgtgaa ttctttgccg tctaaggcag
      721 ttgtttatga cagctgaaaa ctggacactc cctaaatgtc cacctttcag tgaagagata
      781 gttaagccaa ttccatttat agaccacctc cagccagtga cgctccgagt tgaggatgtt
      841 gaacaacatg ggaaggtcgc agcgtactaa gtgaagaagt cagaggacag aggaatttct
      901 ctttctagga gattttcatt ttgtgtgact cccatgggga ggaacagact ggcaggaagc
      961 acaccggggt taacactggt tgacttgaat aggattattc gatttttaaa aatacttttc
     1021 catgttttct gagtgctcta tgataaatca gttgcatctg tgataataca gtacatatgt
     1081 ggacataaac agggatcaaa taaaggaggt attgctgcag tccagccagg ttgaaaggga
     1141 aggggggtcc ccaaaggtcc attggatggc aggtgtctac agaggctcgc ctttgggtgg
     1201 aactctgacc cacctaaggt ttactttgct atttcaggaa ggttgaagag gattgaaggg
     1261 tgagttgcta agtgacttag ggtttattca cttcaggaat catagctggg gtggacccca
     1321 ggagcagagt actgcatgca gctgtgccca tgcatggttg ccccagcgta gtgagatggg
     1381 acctgccgca gcatgcccac tcctgagctg ccaggctgag ccatggagga ctgaaaggag
     1441 gtcgcccggc atcacctccc gaggtgagac ctgctgcaaa agccaagcca gcagcattga
     1501 cgccctttga tatcttcgcc atttttgctg ctgaaagact tggcttttca gtctgaccct
     1561 ggccctctgt gaccatgtgt ctgtaaagcc agtgggtcag gcccttccat gcagggccag
     1621 aggaaaagcg ggcccagggc tgcagtgaga gcggggcagg ggaccagcct accagatggg
     1681 ttggaaacat ggctcagaag gaccaactac cccttccctt tgaggagcaa gtctctgccg
     1741 atcagcaagg caaggccagg agccctcctg gcgaaaggca ggccacaaat ctgttctccc
     1801 ccaggagaag tagcagtgcc agggctttgc gtttctggta acttccaccc aaaccacacc
     1861 agagagaaac accgtagtgg agaagggaag tgggagcgct gactgctgtg tgccaggaga
     1921 gtagaaaggc ccaggtctgt gccaccaccc ctccccaaag ctcagtgcac ccagagtctc
     1981 acagggacca acacggtgcc tcggtcctgc ttccatccat gcaagtgtcc tccgctcacc
     2041 agggtgttct gaggcagctc aagtgctctc ccccaagcag cacgcagtca ccgctgccag
     2101 tgatgaacac acgcacgggc taggcacatg gagcccaagc acactgccac ctcggacacg
     2161 ggccccggcc cagcgactgc cttgtggtgt ggccgtcctc atctgccaca ggaagacaga
     2221 cttcgaggga cctcttgcct aaggcctcgc tgactcaagg gtagattgag atttggacct
     2281 aataggctcc agaactgtgc tttgagctac agggtggctg caggatgaga cggatgcagt
     2341 tcaaagtgca ggatgtgctg cctttattac ctgctttccc gctgagcaaa tccctgtctt
     2401 gagtgggaag tggcatctat tcccccagcc atctgaaaat gctgtgttca taaccaaata
     2461 ggtgctgtag cttcctagcc atcccgctct tacccgcccc tctgcaatgt aaaaggcgtc
     2521 cactgttgtg taaatacaca gttgctttcc agaaaa
//
