LOCUS       NM_001145861            4679 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens POP1 homolog, ribonuclease P/MRP subunit (POP1),
            transcript variant 2, mRNA.
ACCESSION   NM_001145861
VERSION     NM_001145861.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4679)
  AUTHORS   Liang,F. and Huang,S.
  TITLE     PGC-1alpha inhibits NLRP3 signaling through transcriptional
            activation of POP1 to alleviate inflammation and strengthen
            osteogenic differentiation of lipopolysaccharide-induced human
            periodontal stem cells
  JOURNAL   Prostaglandins Other Lipid Mediat 174, 106853 (2024)
   PUBMED   38763227
  REMARK    GeneRIF: PGC-1alpha inhibits NLRP3 signaling through
            transcriptional activation of POP1 to alleviate inflammation and
            strengthen osteogenic differentiation of lipopolysaccharide-induced
            human periodontal stem cells.
REFERENCE   2  (bases 1 to 4679)
  AUTHORS   Zhu,M., Wu,C., Wu,X., Song,G., Li,M. and Wang,Q.
  TITLE     POP1 promotes the progression of breast cancer through maintaining
            telomere integrity
  JOURNAL   Carcinogenesis 44 (3), 252-262 (2023)
   PUBMED   37010429
  REMARK    GeneRIF: POP1 promotes the progression of breast cancer through
            maintaining telomere integrity.
REFERENCE   3  (bases 1 to 4679)
  AUTHORS   de Almeida,L., Devi,S., Indramohan,M., Huang,Q.Q.,
            Ratsimandresy,R.A., Pope,R.M., Dorfleutner,A. and Stehlik,C.
  TITLE     POP1 inhibits MSU-induced inflammasome activation and ameliorates
            gout
  JOURNAL   Front Immunol 13, 912069 (2022)
   PUBMED   36225929
  REMARK    GeneRIF: POP1 inhibits MSU-induced inflammasome activation and
            ameliorates gout.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4679)
  AUTHORS   He,X., Wang,J., Yu,H., Lv,W., Wang,Y., Zhang,Q., Liu,Z. and Wu,Y.
  TITLE     Clinical significance for diagnosis and prognosis of POP1 and its
            potential role in breast cancer: a comprehensive analysis based on
            multiple databases
  JOURNAL   Aging (Albany NY) 14 (17), 6936-6956 (2022)
   PUBMED   36084948
  REMARK    GeneRIF: Clinical significance for diagnosis and prognosis of POP1
            and its potential role in breast cancer: a comprehensive analysis
            based on multiple databases.
REFERENCE   5  (bases 1 to 4679)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 4679)
  AUTHORS   Jiang,T., Guerrier-Takada,C. and Altman,S.
  TITLE     Protein-RNA interactions in the subunits of human nuclear RNase P
  JOURNAL   RNA 7 (7), 937-941 (2001)
   PUBMED   11455963
REFERENCE   7  (bases 1 to 4679)
  AUTHORS   Pluk,H., van Eenennaam,H., Rutjes,S.A., Pruijn,G.J. and van
            Venrooij,W.J.
  TITLE     RNA-protein interactions in the human RNase MRP ribonucleoprotein
            complex
  JOURNAL   RNA 5 (4), 512-524 (1999)
   PUBMED   10199568
REFERENCE   8  (bases 1 to 4679)
  AUTHORS   Dundr,M. and Olson,M.O.
  TITLE     Partially processed pre-rRNA is preserved in association with
            processing components in nucleolus-derived foci during mitosis
  JOURNAL   Mol Biol Cell 9 (9), 2407-2422 (1998)
   PUBMED   9725903
REFERENCE   9  (bases 1 to 4679)
  AUTHORS   Schmiedeknecht,G., Buchler,C. and Schmitz,G.
  TITLE     A bidirectional promoter connects the p14.5 gene to the gene for
            RNase P and RNase MRP protein subunit hPOP1
  JOURNAL   Biochem Biophys Res Commun 241 (1), 59-67 (1997)
   PUBMED   9405234
REFERENCE   10 (bases 1 to 4679)
  AUTHORS   Lygerou,Z., Pluk,H., van Venrooij,W.J. and Seraphin,B.
  TITLE     hPop1: an autoantigenic protein subunit shared by the human RNase P
            and RNase MRP ribonucleoproteins
  JOURNAL   EMBO J 15 (21), 5936-5948 (1996)
   PUBMED   8918471
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP280616.1, BP249298.1,
            AK291434.1, D31765.1, AP003439.2 and BF511088.1.
            
            On May 31, 2019 this sequence version replaced NM_001145861.1.
            
            Summary: This gene encodes the protein subunit of two different
            small nucleolar ribonucleoprotein complexes: the endoribonuclease
            for mitochondrial RNA processing complex and the ribonuclease P
            complex. The encoded protein is a ribonuclease that localizes to
            the nucleus and functions in pre-RNA processing. This protein is
            also an autoantigen in patients suffering from connective tissue
            diseases. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Mar 2009].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968540,
                              SAMEA1968968 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                BP280616.1         1-14
            15-527              BP249298.1         1-513
            528-3258            AK291434.1         585-3315
            3259-4399           D31765.1           2858-3998
            4400-4484           AP003439.2         79432-79516
            4485-4679           BF511088.1         23-217              c
FEATURES             Location/Qualifiers
     source          1..4679
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.2"
     gene            1..4679
                     /gene="POP1"
                     /gene_synonym="ANXD2"
                     /note="POP1 homolog, ribonuclease P/MRP subunit"
                     /db_xref="GeneID:10940"
                     /db_xref="HGNC:HGNC:30129"
                     /db_xref="MIM:602486"
     exon            1..38
                     /gene="POP1"
                     /gene_synonym="ANXD2"
                     /inference="alignment:Splign:2.1.0"
     exon            39..182
                     /gene="POP1"
                     /gene_synonym="ANXD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..3115
                     /gene="POP1"
                     /gene_synonym="ANXD2"
                     /EC_number="3.1.26.5"
                     /note="processing of precursors 1; hPOP1; processing of
                     precursor 1, ribonuclease P/MRP subunit"
                     /codon_start=1
                     /product="ribonucleases P/MRP protein subunit POP1"
                     /protein_id="NP_001139333.1"
                     /db_xref="CCDS:CCDS6277.1"
                     /db_xref="GeneID:10940"
                     /db_xref="HGNC:HGNC:30129"
                     /db_xref="MIM:602486"
                     /translation="MSNAKERKHAKKMRNQPTNVTLSSGFVADRGVKHHSGGEKPFQA
                     QKQEPHPGTSRQRQTRVNPHSLPDPEVNEQSSSKGMFRKKGGWKAGPEGTSQEIPKYI
                     TASTFAQARAAEISAMLKAVTQKSSNSLVFQTLPRHMRRRAMSHNVKRLPRRLQEIAQ
                     KEAEKAVHQKKEHSKNKCHKARRCHMNRTLEFNRRQKKNIWLETHIWHAKRFHMVKKW
                     GYCLGERPTVKSHRACYRAMTNRCLLQDLSYYCCLELKGKEEEILKALSGMCNIDTGL
                     TFAAVHCLSGKRQGSLVLYRVNKYPREMLGPVTFIWKSQRTPGDPSESRQLWIWLHPT
                     LKQDILEEIKAACQCVEPIKSAVCIADPLPTPSQEKSQTELPDEKIGKKRKRKDDGEN
                     AKPIKKIIGDGTRDPCLPYSWISPTTGIIISDLTMEMNRFRLIGPLSHSILTEAIKAA
                     SVHTVGEDTEETPHRWWIETCKKPDSVSLHCRQEAIFELLGGITSPAEIPAGTILGLT
                     VGDPRINLPQKKSKALPNPEKCQDNEKVRQLLLEGVPVECTHSFIWNQDICKSVTENK
                     ISDQDLNRMRSELLVPGSQLILGPHESKIPILLIQQPGKVTGEDRLGWGSGWDVLLPK
                     GWGMAFWIPFIYRGVRVGGLKESAVHSQYKRSPNVPGDFPDCPAGMLFAEEQAKNLLE
                     KYKRRPPAKRPNYVKLGTLAPFCCPWEQLTQDWESRVQAYEEPSVASSPNGKESDLRR
                     SEVPCAPMPKKTHQPSDEVGTSIEHPREAEEVMDAGCQESAGPERITDQEASENHVAA
                     TGSHLCVLRSRKLLKQLSAWCGPSSEDSRGGRRAPGRGQQGLTREACLSILGHFPRAL
                     VWVSLSLLSKGSPEPHTMICVPAKEDFLQLHEDWHYCGPQESKHSDPFRSKILKQKEK
                     KKREKRQKPGRASSDGPAGEEPVAGQEALTLGLWSGPLPRVTLHCSRTLLGFVTQGDF
                     SMAVGCGEALGFVSLTGLLDMLSSQPAAQRGLVLLRPPASLQYRFARIAIEV"
     exon            183..350
                     /gene="POP1"
                     /gene_synonym="ANXD2"
                     /inference="alignment:Splign:2.1.0"
     exon            351..526
                     /gene="POP1"
                     /gene_synonym="ANXD2"
                     /inference="alignment:Splign:2.1.0"
     exon            527..775
                     /gene="POP1"
                     /gene_synonym="ANXD2"
                     /inference="alignment:Splign:2.1.0"
     exon            776..863
                     /gene="POP1"
                     /gene_synonym="ANXD2"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1051
                     /gene="POP1"
                     /gene_synonym="ANXD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1308
                     /gene="POP1"
                     /gene_synonym="ANXD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1402
                     /gene="POP1"
                     /gene_synonym="ANXD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1514
                     /gene="POP1"
                     /gene_synonym="ANXD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1634
                     /gene="POP1"
                     /gene_synonym="ANXD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1750
                     /gene="POP1"
                     /gene_synonym="ANXD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1942
                     /gene="POP1"
                     /gene_synonym="ANXD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2097
                     /gene="POP1"
                     /gene_synonym="ANXD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2460
                     /gene="POP1"
                     /gene_synonym="ANXD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..4679
                     /gene="POP1"
                     /gene_synonym="ANXD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3232..3237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POP1"
                     /gene_synonym="ANXD2"
                     /note="hexamer: AATAAA"
     polyA_site      3259
                     /gene="POP1"
                     /gene_synonym="ANXD2"
     regulatory      4658..4663
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POP1"
                     /gene_synonym="ANXD2"
                     /note="hexamer: AATAAA"
     polyA_site      4679
                     /gene="POP1"
                     /gene_synonym="ANXD2"
                     /note="major polyA site"
ORIGIN      
        1 atgcgctctc cagcgcgctc tccaggagct ttggctcgaa atgtcaaatg caaaagaaag
       61 aaaacacgcc aagaaaatga gaaaccagcc taccaatgtg actctgtcct ctggctttgt
      121 ggctgacaga ggtgtaaagc accacagtgg aggtgaaaaa cctttccaag ctcaaaaaca
      181 agagcctcat cctggaactt cacgacagcg gcaaaccaga gtcaaccccc attctctgcc
      241 tgaccctgaa gtgaatgagc agtcttcctc caaagggatg tttagaaaaa agggaggatg
      301 gaaagcaggt cccgagggca cgtctcagga gatccccaag tatataactg cttctacttt
      361 tgctcaagca cgagctgctg aaatcagtgc tatgttaaaa gctgtgaccc agaagtcttc
      421 gaattcactg gtttttcaga ctctgccacg gcacatgcga cgaagagcca tgagccacaa
      481 cgtcaaacgc cttcccagac ggttacagga gattgcccag aaagaggcgg agaaagccgt
      541 acatcagaaa aaagaacatt caaaaaataa atgccataaa gctcgaagat gtcacatgaa
      601 ccggacgcta gaatttaacc gtagacaaaa gaagaacatt tggttagaaa ctcacatctg
      661 gcacgccaag cggtttcata tggtcaagaa gtggggctac tgccttgggg agaggccaac
      721 agtcaagagc cacagagcct gctatcgagc catgacgaac cggtgcctcc tgcaggattt
      781 atcctattac tgttgtttgg agttgaaagg caaagaggaa gaaatactaa aggcgctttc
      841 tggaatgtgt aacatagaca cagggctgac gtttgcagca gttcactgct tgtctggaaa
      901 gcgccaaggg agccttgtgc tttatcgggt gaataaatat cccagagaaa tgcttgggcc
      961 tgttacgttt atctggaagt cccagaggac cccgggtgac ccttctgaga gcaggcagct
     1021 gtggatctgg ctgcatccaa cccttaaaca ggatatctta gaggaaataa aagcagcgtg
     1081 ccagtgtgtg gaacccatca aatcagctgt ctgcatcgct gacccacttc caacaccatc
     1141 ccaagaaaaa agccaaactg aattgcctga cgagaaaatt ggcaagaaaa gaaaaaggaa
     1201 agatgatgga gaaaatgcta aaccaattaa aaaaattatc ggtgatggaa ctagagatcc
     1261 atgtctacca tactcttgga tctctccaac cacaggcatt ataatcagcg atttgacgat
     1321 ggagatgaac agattccggc tgattgggcc actttcccac tccatcctaa ctgaagcaat
     1381 aaaagctgct tctgtccaca ctgtgggaga ggacacagag gagacacctc accgctggtg
     1441 gatagaaacc tgtaagaaac ctgacagcgt ttcccttcat tgcagacaag aagccatttt
     1501 cgagttgttg ggaggaataa catcaccagc agaaattccg gcaggtacta ttctgggact
     1561 gacagttggg gatcctcgaa taaatttgcc ccaaaagaag tccaaagctt tgcccaatcc
     1621 agaaaaatgc caagataatg agaaagttag acagctgctt ctggagggtg tgcctgtgga
     1681 atgtacgcat agctttatct ggaaccaaga tatctgtaag agtgtcacag agaataaaat
     1741 ctcggatcag gatttaaacc ggatgaggag tgaattgctg gtgcctgggt cacagcttat
     1801 tttaggtccc catgaatcca agatacctat acttttgatt cagcagccag gaaaagtgac
     1861 tggtgaagat cgactaggct ggggaagtgg ctgggatgtc ctactcccaa agggctgggg
     1921 catggctttc tggattccat ttatttatcg aggtgtgaga gtcggagggt tgaaagagtc
     1981 tgcagtgcat tctcagtata agaggtcgcc taatgtccca ggcgattttc cagactgccc
     2041 tgccgggatg ctgtttgcgg aagagcaagc taagaatctt cttgaaaagt acaaaagacg
     2101 ccctcctgca aaacggccca actacgttaa gcttggcact ctggcacctt tctgctgtcc
     2161 ctgggagcag ttaactcaag actgggagtc aagagtccag gcttacgaag aaccttctgt
     2221 agcttcatct ccaaatggta aggagagtga cctaagaaga tctgaggtgc cttgtgctcc
     2281 catgcctaaa aaaactcatc agccatctga tgaagtgggc acatccatag agcaccccag
     2341 ggaggcagag gaggtaatgg atgcagggtg tcaagaatcg gcagggcctg agaggatcac
     2401 agaccaggag gccagtgaaa accatgttgc tgccacaggg agtcacctct gcgttctcag
     2461 gagtagaaaa ttactgaagc aactgtcagc ctggtgtggg cccagttctg aggatagtcg
     2521 gggaggccgg cgagctcccg gcagaggcca gcaaggattg accagagagg cttgcctgtc
     2581 catcttgggc cacttcccca gggccctggt ttgggtcagc ctgtccctgc tcagcaaggg
     2641 cagccccgag cctcacacca tgatctgtgt cccagccaag gaggacttcc tccagctcca
     2701 tgaggactgg cattactgtg ggccccagga atccaaacac agtgacccat tcaggagcaa
     2761 gatcctgaaa cagaaagaga agaagaaaag ggagaagagg cagaagccag gacgtgcctc
     2821 ttctgatggc ccggcggggg aagagcccgt ggctgggcag gaagctctga ctctagggct
     2881 gtggtcaggc cctctgccgc gtgtgacgtt gcactgctcc agaactctcc taggctttgt
     2941 gactcaggga gatttttcca tggctgttgg ctgtggagaa gccctggggt ttgttagctt
     3001 gacaggcttg ctggatatgc tgtccagcca gcctgcagcg cagaggggct tagtgctact
     3061 gaggcctccc gcctctctgc agtatcgatt tgcgaggatt gctattgagg tgtgaatgcg
     3121 tgcttgtatc ccagcagggc atagataata cgttattatt gtctgccaag ttctacatgt
     3181 ggagaatctg cttctgcttt aaaatatcat gtgaaactcc ctggaaacaa gaataaaaaa
     3241 ttatgtatta tgcagatgat gaaatgttta catcattcca gtaatgtcat tgattttcat
     3301 ctttccctgt ccttgctgta atacttttaa attatttggc caaaagcttt gtattatgat
     3361 ctcttggtct gtgtagttgt ggctgaaaat aatgagaagc tctacgagtt atcatcccct
     3421 ttttttgtta gaaacaaagg gcttgtcagg tctatttgaa aaacctcata gtcatgtgat
     3481 aagcaacaat agatgtttaa tgatttcact gttatagcag aagacaagag aagacgcttg
     3541 gcctctgtac atgaaatatg ggctcctgat ggacctcatt caattctgta ctgtgatttc
     3601 catgccgaac aactcaagcc ttaaagagag aaatcatgga caactgattt ctgcctgttt
     3661 tcaggcaggc acagtttatg gcgtcagtgc taggctggaa ttagaaagtg ggggtctatg
     3721 acgtggactt cctgactctt tgatctcttt gttgttgacc aacacttgat cctactagtt
     3781 acttaatttt tttaagtaaa aaattattat tattttgttt ctgcaaagat tttctcaaag
     3841 ccatagagga gcatttctca gaatatgttc tatgatatgt gtcacctaaa aaagtaagag
     3901 attccaaggt caggttgata tggaaactct aggttaaata aagttaagca tttctttatg
     3961 aaagaacttc tggaaacttc catgtgataa tgtgcattgc ggatctctag gaaggaaatg
     4021 atagtgtata gtattttcta aatacttgtg attcctaaag ttctcttaca aggagccctt
     4081 tgtaggacca gtgttcttag tagcgcgctt tgggcagtgt ggctgtgtag tgcatagcta
     4141 cctctgcaag gtgataacta agccggcaag ctgcctttca acactcatgc agtcacgttg
     4201 tccacctgag attctcaaca gggtataaaa ggaaggtctc atcttgcctc acaggaagag
     4261 tgggctcagt gtggcttttt tccaactatg gagaaactca gtgctcatct actttaagtt
     4321 tccacatatg gcttgctcat agccttggtc cttacctttc ctgccataac tttctagaag
     4381 agcttaatgg gatttttttt ctaaaaaatg taaatatgca gttaggcatt attttatgta
     4441 aatgcattgg gtttttactg tagcatttgg cactaaatgg ctttgggggt gatgaggtgg
     4501 ggaaggatac agcaggtggt acagtagtca ggaagtacct gccaccaatg agatgtctga
     4561 tgctttgcct cttaccatgc ctctgaatgt ctttggatcc aacccagatg agactgaaaa
     4621 aaaaaaaaca gtgtaactaa gtggcatctg taaacagaat aaatgaaaat gtcacctga
//
