LOCUS       NM_000940               1191 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens paraoxonase 3 (PON3), mRNA.
ACCESSION   NM_000940
VERSION     NM_000940.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1191)
  AUTHORS   Bjerre,K.P., Clemmensen,T.S., Poulsen,S.H., Hvas,A.M., Holm,N.R.,
            Grove,E.L., Bouchelouche,K., Kristensen,S.D. and Eiskjaer,H.
  TITLE     Micro- and macrovascular cardiac allograft vasculopathy in relation
            to 91 cardiovascular biomarkers in heart transplant recipients-An
            exploratory study
  JOURNAL   Clin Transplant 35 (1), e14133 (2021)
   PUBMED   33128247
  REMARK    GeneRIF: Micro- and macrovascular cardiac allograft vasculopathy in
            relation to 91 cardiovascular biomarkers in heart transplant
            recipients-An exploratory study.
REFERENCE   2  (bases 1 to 1191)
  AUTHORS   Shao,B., Mathew,A.V., Thornock,C. and Pennathur,S.
  CONSRTM   Michigan Kidney Translational Core CPROBE Investigator Group
  TITLE     Altered HDL proteome predicts incident CVD in chronic kidney
            disease patients
  JOURNAL   J Lipid Res 62, 100135 (2021)
   PUBMED   34634315
  REMARK    GeneRIF: Altered HDL proteome predicts incident CVD in chronic
            kidney disease patients.
REFERENCE   3  (bases 1 to 1191)
  AUTHORS   Bedir,F., Kocaturk,H., Altay,M.S., Sebin,E. and Bedir,B.
  TITLE     Serum paraoxonase 1 and 3 activities in benign and malignant
            diseases of the prostate and changes in levels following
            robotic-assisted laparoscopic radical prostatectomy
  JOURNAL   Turk J Med Sci 50 (8), 1872-1878 (2020)
   PUBMED   32549522
  REMARK    GeneRIF: Serum paraoxonase 1 and 3 activities in benign and
            malignant diseases of the prostate and changes in levels following
            robotic-assisted laparoscopic radical prostatectomy
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1191)
  AUTHORS   Zhou,H., Zhou,J., Li,H., Hui,C. and Bi,J.
  TITLE     Paraoxonase 3 gene polymorphisms are associated with occupational
            noise-induced deafness: A matched case-control study from China
  JOURNAL   PLoS One 15 (10), e0240615 (2020)
   PUBMED   33057386
  REMARK    GeneRIF: Paraoxonase 3 gene polymorphisms are associated with
            occupational noise-induced deafness: A matched case-control study
            from China.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1191)
  AUTHORS   Priyanka,K., Singh,S. and Gill,K.
  TITLE     Paraoxonase 3: Structure and Its Role in Pathophysiology of
            Coronary Artery Disease
  JOURNAL   Biomolecules 9 (12), 817 (2019)
   PUBMED   31816846
  REMARK    GeneRIF: Paraoxonase 3: Structure and Its Role in Pathophysiology
            of Coronary Artery Disease.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1191)
  AUTHORS   Wang,X., Fan,Z., Huang,J., Su,S., Yu,Q., Zhao,J., Hui,R., Yao,Z.,
            Shen,Y., Qiang,B. and Gu,D.
  TITLE     Extensive association analysis between polymorphisms of PON gene
            cluster with coronary heart disease in Chinese Han population
  JOURNAL   Arterioscler Thromb Vasc Biol 23 (2), 328-334 (2003)
   PUBMED   12588779
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   7  (bases 1 to 1191)
  AUTHORS   Mackness,B., Durrington,P.N. and Mackness,M.I.
  TITLE     The paraoxonase gene family and coronary heart disease
  JOURNAL   Curr Opin Lipidol 13 (4), 357-362 (2002)
   PUBMED   12151850
  REMARK    GeneRIF: Decreased coronary heart disease risk associated with
            polymorphisms of paraoxonase 1.
            Review article
REFERENCE   8  (bases 1 to 1191)
  AUTHORS   Reddy,S.T., Wadleigh,D.J., Grijalva,V., Ng,C., Hama,S.,
            Gangopadhyay,A., Shih,D.M., Lusis,A.J., Navab,M. and Fogelman,A.M.
  TITLE     Human paraoxonase-3 is an HDL-associated enzyme with biological
            activity similar to paraoxonase-1 protein but is not regulated by
            oxidized lipids
  JOURNAL   Arterioscler Thromb Vasc Biol 21 (4), 542-547 (2001)
   PUBMED   11304470
REFERENCE   9  (bases 1 to 1191)
  AUTHORS   La Du,B.N.
  TITLE     Is paraoxonase-3 another hdl-associated protein protective against
            atherosclerosis?
  JOURNAL   Arterioscler Thromb Vasc Biol 21 (4), 467-468 (2001)
   PUBMED   11304457
REFERENCE   10 (bases 1 to 1191)
  AUTHORS   Primo-Parmo,S.L., Sorenson,R.C., Teiber,J. and La Du,B.N.
  TITLE     The human serum paraoxonase/arylesterase gene (PON1) is one member
            of a multigene family
  JOURNAL   Genomics 33 (3), 498-507 (1996)
   PUBMED   8661009
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AV655538.1, BC020908.1,
            BC070374.1, CD014095.1 and AA860930.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000940.2.
            
            Summary: This gene is a member of the paraoxonase family and lies
            in a cluster on chromosome 7 with the other two family members. The
            encoded protein is secreted into the bloodstream and associates
            with high-density lipoprotein (HDL). The protein also rapidly
            hydrolyzes lactones and can inhibit the oxidation of low-density
            lipoprotein (LDL), a function that is believed to slow the
            initiation and progression of atherosclerosis. Alternatively
            spliced variants which encode different protein isoforms have been
            described; however, only one has been fully characterized.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070374.1, AF329433.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265627.10/ ENSP00000265627.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               AV655538.1         1-173
            174-287             BC020908.1         4-117
            288-321             BC070374.1         274-307
            322-1117            CD014095.1         454-1249
            1118-1191           AA860930.1         23-96               c
FEATURES             Location/Qualifiers
     source          1..1191
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.3"
     gene            1..1191
                     /gene="PON3"
                     /note="paraoxonase 3"
                     /db_xref="GeneID:5446"
                     /db_xref="HGNC:HGNC:9206"
                     /db_xref="MIM:602720"
     exon            1..99
                     /gene="PON3"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1090
                     /gene="PON3"
                     /EC_number="3.1.1.2"
                     /EC_number="3.1.8.1"
                     /EC_number="3.1.1.81"
                     /note="paraoxanase-3; arylesterase 3"
                     /codon_start=1
                     /product="serum paraoxonase/lactonase 3"
                     /protein_id="NP_000931.1"
                     /db_xref="CCDS:CCDS5639.1"
                     /db_xref="GeneID:5446"
                     /db_xref="HGNC:HGNC:9206"
                     /db_xref="MIM:602720"
                     /translation="MGKLVALVLLGVGLSLVGEMFLAFRERVNASREVEPVEPENCHL
                     IEELESGSEDIDILPSGLAFISSGLKYPGMPNFAPDEPGKIFLMDLNEQNPRAQALEI
                     SGGFDKELFNPHGISIFIDKDNTVYLYVVNHPHMKSTVEIFKFEEQQRSLVYLKTIKH
                     ELLKSVNDIVVLGPEQFYATRDHYFTNSLLSFFEMILDLRWTYVLFYSPREVKVVAKG
                     FCSANGITVSADQKYVYVADVAAKNIHIMEKHDNWDLTQLKVIQLGTLVDNLTVDPAT
                     GDILAGCHPNPMKLLNYNPEDPPGSEVLRIQNVLSEKPRVSTVYANNGSVLQGTSVAS
                     VYHGKILIGTVFHKTLYCEL"
     exon            100..170
                     /gene="PON3"
                     /inference="alignment:Splign:2.1.0"
     exon            171..226
                     /gene="PON3"
                     /inference="alignment:Splign:2.1.0"
     exon            227..392
                     /gene="PON3"
                     /inference="alignment:Splign:2.1.0"
     exon            393..519
                     /gene="PON3"
                     /inference="alignment:Splign:2.1.0"
     exon            520..720
                     /gene="PON3"
                     /inference="alignment:Splign:2.1.0"
     exon            721..802
                     /gene="PON3"
                     /inference="alignment:Splign:2.1.0"
     exon            803..931
                     /gene="PON3"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1191
                     /gene="PON3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1173..1178
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PON3"
                     /note="hexamer: AGTAAA"
     polyA_site      1191
                     /gene="PON3"
                     /note="major polyA site"
ORIGIN      
        1 agtcgccgct gggcaccccg agaccatggg gaagctcgtg gcgctggtcc tgctgggggt
       61 cggcctgtcc ttagtcgggg agatgttcct ggcgtttaga gaaagggtga atgcctctcg
      121 agaagtggag ccagtagaac ctgaaaactg ccaccttatt gaggaacttg aaagtggctc
      181 tgaagatatt gatatacttc ctagtgggct ggcttttatc tccagtggat taaaatatcc
      241 aggcatgcca aactttgcgc cagatgaacc aggaaaaatc ttcttgatgg atctgaatga
      301 acaaaaccca agggcacaag cgctagaaat cagtggtgga tttgacaaag aattatttaa
      361 tccacatggg atcagtattt tcatcgacaa agacaatact gtgtatcttt atgttgtgaa
      421 tcatccccac atgaagtcca ctgtggagat atttaaattt gaggaacaac aacgttctct
      481 ggtatacctg aaaactataa aacatgaact tctcaaaagt gtgaatgaca ttgtggttct
      541 tggaccagaa cagttctatg ccaccagaga ccactatttt accaactccc tcctgtcatt
      601 ttttgagatg atcttggatc ttcgctggac ttatgttctt ttctacagcc caagggaggt
      661 taaagtggtg gccaaaggat tttgtagtgc caatgggatc acagtctcag cagaccagaa
      721 gtatgtctat gtagctgatg tagcagctaa gaacattcac ataatggaaa aacatgataa
      781 ctgggattta actcaactga aggtgataca gttgggcacc ttagtggata acctgactgt
      841 cgatcctgcc acaggagaca ttttggcagg atgccatcct aatcctatga agctactgaa
      901 ctataaccct gaggaccctc caggatcaga agtacttcgc atccagaatg ttttgtctga
      961 gaagcccagg gtgagcaccg tgtatgccaa caatggctct gtgcttcagg gcacctctgt
     1021 ggcttctgtg taccatggga aaattctcat aggcaccgta tttcacaaaa ctctgtactg
     1081 tgagctctag actctagata gtaaaaaaaa aaaaaaaaag tctacatatt ttgtaaaagt
     1141 aaactgataa ttgtatgata agtggcactg taagtaaata gcaaacacca a
//
