LOCUS       NM_000305               1610 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens paraoxonase 2 (PON2), transcript variant 1, mRNA.
ACCESSION   NM_000305
VERSION     NM_000305.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1610)
  AUTHORS   Lampitella,E.A., Marone,M., Achanta,N.S.K., Porzio,E.,
            Trepiccione,F. and Manco,G.
  TITLE     The Human Paraoxonase 2: An Optimized Procedure for Refolding and
            Stabilization Facilitates Enzyme Analyses and a Proteomics Approach
  JOURNAL   Molecules 29 (11), 2434 (2024)
   PUBMED   38893310
  REMARK    GeneRIF: The Human Paraoxonase 2: An Optimized Procedure for
            Refolding and Stabilization Facilitates Enzyme Analyses and a
            Proteomics Approach.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1610)
  AUTHORS   Campagna,R., Serritelli,E.N., Salvolini,E., Schiavoni,V.,
            Cecati,M., Sartini,D., Pozzi,V. and Emanuelli,M.
  TITLE     Contribution of the Paraoxonase-2 Enzyme to Cancer Cell Metabolism
            and Phenotypes
  JOURNAL   Biomolecules 14 (2), 208 (2024)
   PUBMED   38397445
  REMARK    GeneRIF: Contribution of the Paraoxonase-2 Enzyme to Cancer Cell
            Metabolism and Phenotypes.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1610)
  AUTHORS   Campagna,R., Pozzi,V., Giorgini,S., Morichetti,D., Goteri,G.,
            Sartini,D., Serritelli,E.N. and Emanuelli,M.
  TITLE     Paraoxonase-2 is upregulated in triple negative breast cancer and
            contributes to tumor progression and chemoresistance
  JOURNAL   Hum Cell 36 (3), 1108-1119 (2023)
   PUBMED   36897549
  REMARK    GeneRIF: Paraoxonase-2 is upregulated in triple negative breast
            cancer and contributes to tumor progression and chemoresistance.
REFERENCE   4  (bases 1 to 1610)
  AUTHORS   Ye,Y., Zhang,J., Guo,Y., Zhu,J., Tang,B. and Fan,P.
  TITLE     PON2 ameliorates Ang II-induced cardiomyocyte injury by targeting
            the CANX/NOX4 signaling pathway
  JOURNAL   Immun Inflamm Dis 11 (2), e765 (2023)
   PUBMED   36840500
  REMARK    GeneRIF: PON2 ameliorates Ang II-induced cardiomyocyte injury by
            targeting the CANX/NOX4 signaling pathway.
REFERENCE   5  (bases 1 to 1610)
  AUTHORS   Karlov,V.D., Pestov,N.B., Shakhparonov,M.I. and Korneenko,T.V.
  TITLE     Interactome of Paraoxonase PON2 Reveals New Pathways for Tumor
            Growth Regulation
  JOURNAL   Dokl Biochem Biophys 508 (1), 31-36 (2023)
   PUBMED   36653584
  REMARK    GeneRIF: Interactome of Paraoxonase PON2 Reveals New Pathways for
            Tumor Growth Regulation.
REFERENCE   6  (bases 1 to 1610)
  AUTHORS   Ng,C.J., Shih,D.M., Hama,S.Y., Villa,N., Navab,M. and Reddy,S.T.
  TITLE     The paraoxonase gene family and atherosclerosis
  JOURNAL   Free Radic Biol Med 38 (2), 153-163 (2005)
   PUBMED   15607899
  REMARK    Review article
REFERENCE   7  (bases 1 to 1610)
  AUTHORS   Mochizuki,H., Scherer,S.W., Xi,T., Nickle,D.C., Majer,M.,
            Huizenga,J.J., Tsui,L.C. and Prochazka,M.
  TITLE     Human PON2 gene at 7q21.3: cloning, multiple mRNA forms, and
            missense polymorphisms in the coding sequence
  JOURNAL   Gene 213 (1-2), 149-157 (1998)
   PUBMED   9714608
REFERENCE   8  (bases 1 to 1610)
  AUTHORS   Sanghera,D.K., Aston,C.E., Saha,N. and Kamboh,M.I.
  TITLE     DNA polymorphisms in two paraoxonase genes (PON1 and PON2) are
            associated with the risk of coronary heart disease
  JOURNAL   Am J Hum Genet 62 (1), 36-44 (1998)
   PUBMED   9443862
REFERENCE   9  (bases 1 to 1610)
  AUTHORS   Hegele,R.A., Connelly,P.W., Scherer,S.W., Hanley,A.J., Harris,S.B.,
            Tsui,L.C. and Zinman,B.
  TITLE     Paraoxonase-2 gene (PON2) G148 variant associated with elevated
            fasting plasma glucose in noninsulin-dependent diabetes mellitus
  JOURNAL   J Clin Endocrinol Metab 82 (10), 3373-3377 (1997)
   PUBMED   9329371
REFERENCE   10 (bases 1 to 1610)
  AUTHORS   Primo-Parmo,S.L., Sorenson,R.C., Teiber,J. and La Du,B.N.
  TITLE     The human serum paraoxonase/arylesterase gene (PON1) is one member
            of a multigene family
  JOURNAL   Genomics 33 (3), 498-507 (1996)
   PUBMED   8661009
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB961097.1, AF001601.1 and
            BC040010.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000305.2.
            
            Summary: This gene encodes a member of the paraoxonase gene family,
            which includes three known members located adjacent to each other
            on the long arm of chromosome 7. The encoded protein is
            ubiquitously expressed in human tissues, membrane-bound, and may
            act as a cellular antioxidant, protecting cells from oxidative
            stress. Hydrolytic activity against acylhomoserine lactones,
            important bacterial quorum-sensing mediators, suggests the encoded
            protein may also play a role in defense responses to pathogenic
            bacteria. Mutations in this gene may be associated with vascular
            disease and a number of quantitative phenotypes related to
            diabetes. Alternatively spliced transcript variants encoding
            different isoforms have been described. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF001601.1, AK301313.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: experimental evidence
                                                (PMID:15607899)
            MANE Ensembl match               :: ENST00000222572.8/
                                                ENSP00000222572.3
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                CB961097.1         74-118
            46-921              AF001601.1         1-876
            922-1307            BC040010.1         869-1254
            1308-1531           AF001601.1         1264-1487
            1532-1610           AF001601.1         1491-1569
FEATURES             Location/Qualifiers
     source          1..1610
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.3"
     gene            1..1610
                     /gene="PON2"
                     /note="paraoxonase 2"
                     /db_xref="GeneID:5445"
                     /db_xref="HGNC:HGNC:9205"
                     /db_xref="MIM:602447"
     exon            1..151
                     /gene="PON2"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1142
                     /gene="PON2"
                     /EC_number="3.1.1.2"
                     /EC_number="3.1.1.81"
                     /note="isoform 1 is encoded by transcript variant 1;
                     paraoxonase nirs; serum paraoxonase/arylesterase 2;
                     aromatic esterase 2; A-esterase 2; serum
                     aryldialkylphosphatase 2; PON 2"
                     /codon_start=1
                     /product="serum paraoxonase/arylesterase 2 isoform 1"
                     /protein_id="NP_000296.2"
                     /db_xref="CCDS:CCDS5640.1"
                     /db_xref="GeneID:5445"
                     /db_xref="HGNC:HGNC:9205"
                     /db_xref="MIM:602447"
                     /translation="MGRLVAVGLLGIALALLGERLLALRNRLKASREVESVDLPHCHL
                     IKGIEAGSEDIDILPNGLAFFSVGLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRI
                     SRGFDLASFNPHGISTFIDNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKH
                     ELLPSVNDITAVGPAHFYATNDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEG
                     FDSANGINISPDDKYIYVADILAHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSS
                     GDIWVGCHPNGQKLFVYDPNNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVAS
                     VYDGKLLIGTLYHRALYCEL"
     exon            152..222
                     /gene="PON2"
                     /inference="alignment:Splign:2.1.0"
     exon            223..278
                     /gene="PON2"
                     /inference="alignment:Splign:2.1.0"
     exon            279..444
                     /gene="PON2"
                     /inference="alignment:Splign:2.1.0"
     exon            445..571
                     /gene="PON2"
                     /inference="alignment:Splign:2.1.0"
     exon            572..772
                     /gene="PON2"
                     /inference="alignment:Splign:2.1.0"
     exon            773..854
                     /gene="PON2"
                     /inference="alignment:Splign:2.1.0"
     exon            855..983
                     /gene="PON2"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1610
                     /gene="PON2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1588..1593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PON2"
                     /note="hexamer: ATTAAA"
     polyA_site      1610
                     /gene="PON2"
                     /note="major polyA site"
ORIGIN      
        1 atcgagccgg gaagatggca ccgcccacgg agctgctggc caggccggag cgaggcagcg
       61 cgcccggctc ccgcgccatg gggcggctgg tggctgtggg cttgctgggg atcgcgctgg
      121 cgctcctggg cgagaggctt ctggcactca gaaatcgact taaagcctcc agagaagtag
      181 aatctgtaga ccttccacac tgccacctga ttaaaggaat tgaagctggc tctgaagata
      241 ttgacatact tcccaatggt ctggcttttt ttagtgtggg tctaaaattc ccaggactcc
      301 acagctttgc accagataag cctggaggaa tactaatgat ggatctaaaa gaagaaaaac
      361 caagggcacg ggaattaaga atcagtcgtg ggtttgattt ggcctcattc aatccacatg
      421 gcatcagcac tttcatagac aacgatgaca cagtttatct ctttgttgta aaccacccag
      481 aattcaagaa tacagtggaa atttttaaat ttgaagaagc agaaaattct ctgttgcatc
      541 tgaaaacagt caaacatgag cttcttccaa gtgtgaatga catcacagct gttggaccgg
      601 cacatttcta tgccacaaat gaccactact tctctgatcc tttcttaaag tatttagaaa
      661 catacttgaa cttacactgg gcaaatgttg tttactacag tccaaatgaa gttaaagtgg
      721 tagcagaagg atttgattca gcaaatggga tcaatatttc acctgatgat aagtatatct
      781 atgttgctga catattggct catgaaattc atgttttgga aaaacacact aatatgaatt
      841 taactcagtt gaaggtactt gagctggata cactggtgga taatttatct attgatcctt
      901 cctcggggga catctgggta ggctgtcatc ctaatggcca gaagctcttc gtgtatgacc
      961 cgaacaatcc tccctcgtca gaggttctcc gcatccagaa cattctatct gagaagccta
     1021 cagtgactac agtttatgcc aacaatgggt ctgttctcca aggaagttct gtagcctcag
     1081 tgtatgatgg gaagctgctc ataggcactt tataccacag agccttgtat tgtgaactct
     1141 aaattgtact tttggcatga aagtgcgata acttaacaat taattttcta tgaattgcta
     1201 attctgaggg aatttaacca gcaacattga cccagaaatg tatggcatgt gtagttaatt
     1261 ttattccagt aaggaacggc ccttttagtt cttagagcac ttttaacaaa aaaggaaaat
     1321 gaacaggttc tttaaaatgc caagcaaggg acagaaaaga aagctgcttt cgaataaagt
     1381 gaatacattt tgcacaaagt aagcctcacc tttgccttcc aactgccaga acatggattc
     1441 cactgaaata gagtgaatta tatttcctta aaatgtgagt gacctcactt ctggcactgt
     1501 gactactatg gctgtttaga actactgata acgtattttg atgttttgta cttacatctt
     1561 tgtttaccat taaaaagttg gagttatatt aaagactaac taaaatccca
//
