LOCUS       NM_000446               2393 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens paraoxonase 1 (PON1), mRNA.
ACCESSION   NM_000446
VERSION     NM_000446.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2393)
  AUTHORS   Wentworth,K. and Nandakumar,J.
  TITLE     At the end, it is POT1 again: Phosphorylation allows human
            telomeric protein POT1 to recruit the C-rich strand end replication
            machinery
  JOURNAL   Mol Cell 84 (14), 2598-2600 (2024)
   PUBMED   39059369
  REMARK    GeneRIF: At the end, it is POT1 again: Phosphorylation allows human
            telomeric protein POT1 to recruit the C-rich strand end replication
            machinery.
REFERENCE   2  (bases 1 to 2393)
  AUTHORS   Zhang,X., Fan,P., Liu,Q., Liu,X., Bai,H., Wu,Y. and Li,S.
  TITLE     [Association of the -c.108C>T and c.192Q>R polymorphisms of the
            PON1 gene with preeclampsia among Chinese women]
  JOURNAL   Zhonghua Yi Xue Yi Chuan Xue Za Zhi 41 (7), 866-871 (2024)
   PUBMED   38946375
  REMARK    GeneRIF: [Association of the -c.108C>T and c.192Q>R polymorphisms
            of the PON1 gene with preeclampsia among Chinese women].
REFERENCE   3  (bases 1 to 2393)
  AUTHORS   Malinowski,D., Safranow,K. and Pawlik,A.
  TITLE     PON1 rs662, rs854560 and TRIB1 rs17321515, rs2954029 Gene
            Polymorphisms Are Associated with Lipid Parameters in Patients with
            Unstable Angina
  JOURNAL   Genes (Basel) 15 (7), 871 (2024)
   PUBMED   39062650
  REMARK    GeneRIF: PON1 rs662, rs854560 and TRIB1 rs17321515, rs2954029 Gene
            Polymorphisms Are Associated with Lipid Parameters in Patients with
            Unstable Angina.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2393)
  AUTHORS   Ragkousis,A., Kazantzis,D., Georgalas,I., Theodossiadis,P.,
            Kroupis,C. and Chatziralli,I.
  TITLE     PON1, APOE and SDF-1 Gene Polymorphisms and Risk of Retinal Vein
            Occlusion: A Case-Control Study
  JOURNAL   Genes (Basel) 15 (6), 712 (2024)
   PUBMED   38927649
  REMARK    GeneRIF: PON1, APOE and SDF-1 Gene Polymorphisms and Risk of
            Retinal Vein Occlusion: A Case-Control Study.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2393)
  AUTHORS   Adilay,U., Gencer,N., Cikrikci,K., Sari,M.F., Abdallah,E.A. and
            Guclu,B.
  TITLE     Paraoxonase 1 Activity and Phenotype Distribution in Lumbar Disc
            Herniation Patients
  JOURNAL   Turk Neurosurg 34 (4), 655-659 (2024)
   PUBMED   38874244
  REMARK    GeneRIF: Paraoxonase 1 Activity and Phenotype Distribution in
            Lumbar Disc Herniation Patients.
REFERENCE   6  (bases 1 to 2393)
  AUTHORS   Sorenson,R.C., Primo-Parmo,S.L., Kuo,C.L., Adkins,S., Lockridge,O.
            and La Du,B.N.
  TITLE     Reconsideration of the catalytic center and mechanism of mammalian
            paraoxonase/arylesterase
  JOURNAL   Proc Natl Acad Sci U S A 92 (16), 7187-7191 (1995)
   PUBMED   7638166
REFERENCE   7  (bases 1 to 2393)
  AUTHORS   Furlong,C.E., Richter,R.J., Chapline,C. and Crabb,J.W.
  TITLE     Purification of rabbit and human serum paraoxonase
  JOURNAL   Biochemistry 30 (42), 10133-10140 (1991)
   PUBMED   1718413
REFERENCE   8  (bases 1 to 2393)
  AUTHORS   Hassett,C., Richter,R.J., Humbert,R., Chapline,C., Crabb,J.W.,
            Omiecinski,C.J. and Furlong,C.E.
  TITLE     Characterization of cDNA clones encoding rabbit and human serum
            paraoxonase: the mature protein retains its signal sequence
  JOURNAL   Biochemistry 30 (42), 10141-10149 (1991)
   PUBMED   1657140
REFERENCE   9  (bases 1 to 2393)
  AUTHORS   Gan,K.N., Smolen,A., Eckerson,H.W. and La Du,B.N.
  TITLE     Purification of human serum paraoxonase/arylesterase. Evidence for
            one esterase catalyzing both activities
  JOURNAL   Drug Metab Dispos 19 (1), 100-106 (1991)
   PUBMED   1673382
REFERENCE   10 (bases 1 to 2393)
  AUTHORS   Ortigoza-Ferado,J., Richter,R.J., Hornung,S.K., Motulsky,A.G. and
            Furlong,C.E.
  TITLE     Paraoxon hydrolysis in human serum mediated by a genetically
            variable arylesterase and albumin
  JOURNAL   Am J Hum Genet 36 (2), 295-305 (1984)
   PUBMED   6324579
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BJ993711.1, BC074719.2,
            M63014.1, AV652982.1 and AC004022.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_000446.6.
            
            Summary: This gene encodes a member of the paraoxonase family of
            enzymes and exhibits lactonase and ester hydrolase activity.
            Following synthesis in the kidney and liver, the enzyme is secreted
            into the circulation, where it binds to high density lipoprotein
            (HDL) particles and hydrolyzes thiolactones and xenobiotics,
            including paraoxon, a metabolite of the insecticide parathion.
            Polymorphisms in this gene may be associated with coronary artery
            disease and diabetic retinopathy. The gene is found in a cluster of
            three related paraoxonase genes on chromosome 7. [provided by
            RefSeq, Aug 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D84371.1, U53784.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968832 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222381.8/ ENSP00000222381.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                BJ993711.1         41-68
            29-1156             BC074719.2         1-1128
            1157-1456           M63014.1           1014-1313
            1457-1712           AV652982.1         63-318
            1713-2393           AC004022.1         42443-43123         c
FEATURES             Location/Qualifiers
     source          1..2393
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.3"
     gene            1..2393
                     /gene="PON1"
                     /gene_synonym="ESA; MVCD5; PON"
                     /note="paraoxonase 1"
                     /db_xref="GeneID:5444"
                     /db_xref="HGNC:HGNC:9204"
                     /db_xref="MIM:168820"
     exon            1..131
                     /gene="PON1"
                     /gene_synonym="ESA; MVCD5; PON"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1125
                     /gene="PON1"
                     /gene_synonym="ESA; MVCD5; PON"
                     /EC_number="3.1.1.2"
                     /EC_number="3.1.8.1"
                     /EC_number="3.1.1.81"
                     /note="esterase A; serum aryldiakylphosphatase;
                     paraoxonase B-type; arylesterase B-type; K-45; PON 1;
                     A-esterase 1; aromatic esterase 1; serum
                     aryldialkylphosphatase 1; arylesterase 1"
                     /codon_start=1
                     /product="serum paraoxonase/arylesterase 1"
                     /protein_id="NP_000437.3"
                     /db_xref="CCDS:CCDS5638.1"
                     /db_xref="GeneID:5444"
                     /db_xref="HGNC:HGNC:9204"
                     /db_xref="MIM:168820"
                     /translation="MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNL
                     VKGIETGSEDLEILPNGLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGI
                     TGSKFDVSSFNPHGISTFTDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIR
                     HKLLPNLNDIVAVGPEHFYGTNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAE
                     GFDFANGINISPDGKYVYIAELLAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPE
                     TGDLWVGCHPNGMKIFFYDSENPPASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVA
                     SVYKGKLLIGTVFHKALYCEL"
     exon            132..202
                     /gene="PON1"
                     /gene_synonym="ESA; MVCD5; PON"
                     /inference="alignment:Splign:2.1.0"
     exon            203..258
                     /gene="PON1"
                     /gene_synonym="ESA; MVCD5; PON"
                     /inference="alignment:Splign:2.1.0"
     exon            259..427
                     /gene="PON1"
                     /gene_synonym="ESA; MVCD5; PON"
                     /inference="alignment:Splign:2.1.0"
     exon            428..554
                     /gene="PON1"
                     /gene_synonym="ESA; MVCD5; PON"
                     /inference="alignment:Splign:2.1.0"
     exon            555..755
                     /gene="PON1"
                     /gene_synonym="ESA; MVCD5; PON"
                     /inference="alignment:Splign:2.1.0"
     exon            756..837
                     /gene="PON1"
                     /gene_synonym="ESA; MVCD5; PON"
                     /inference="alignment:Splign:2.1.0"
     exon            838..966
                     /gene="PON1"
                     /gene_synonym="ESA; MVCD5; PON"
                     /inference="alignment:Splign:2.1.0"
     exon            967..2393
                     /gene="PON1"
                     /gene_synonym="ESA; MVCD5; PON"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1349..1354
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PON1"
                     /gene_synonym="ESA; MVCD5; PON"
                     /note="hexamer: CATAAA"
     polyA_site      1371
                     /gene="PON1"
                     /gene_synonym="ESA; MVCD5; PON"
                     /note="major polyA site"
     regulatory      1402..1407
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PON1"
                     /gene_synonym="ESA; MVCD5; PON"
                     /note="hexamer: ATTAAA"
     polyA_site      1428
                     /gene="PON1"
                     /gene_synonym="ESA; MVCD5; PON"
                     /note="major polyA site"
     regulatory      1686..1691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PON1"
                     /gene_synonym="ESA; MVCD5; PON"
                     /note="hexamer: AGTAAA"
     polyA_site      1712
                     /gene="PON1"
                     /gene_synonym="ESA; MVCD5; PON"
                     /note="major polyA site"
     regulatory      2056..2061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PON1"
                     /gene_synonym="ESA; MVCD5; PON"
                     /note="hexamer: AATAGA"
     polyA_site      2075
                     /gene="PON1"
                     /gene_synonym="ESA; MVCD5; PON"
ORIGIN      
        1 agagcctcct agcccgtcgg tgtctgcgcc catcgatccc tttgtctatc cccgaccatg
       61 gcgaagctga ttgcgctcac cctcttgggg atgggactgg cactcttcag gaaccaccag
      121 tcttcttacc aaacacgact taatgctctc cgagaggtac aacccgtaga acttcctaac
      181 tgtaatttag ttaaaggaat cgaaactggc tctgaagact tggagatact gcctaatgga
      241 ctggctttca ttagctctgg attaaagtat cctggaataa agagcttcaa ccccaacagt
      301 cctggaaaaa tacttctgat ggacctgaat gaagaagatc caacagtgtt ggaattgggg
      361 atcactggaa gtaaatttga tgtatcttca tttaaccctc atgggattag cacattcaca
      421 gatgaagata atgccatgta cctcctggtg gtgaaccatc cagatgccaa gtccacagtg
      481 gagttgttta aatttcaaga agaagaaaaa tcgcttttgc atctaaaaac catcagacat
      541 aaacttctgc ctaatttgaa tgatattgtt gctgtgggac ctgagcactt ttatggcaca
      601 aatgatcact attttcttga cccctactta caatcctggg agatgtattt gggtttagcg
      661 tggtcgtatg ttgtctacta tagtccaagt gaagttcgag tggtggcaga aggatttgat
      721 tttgctaatg gaatcaacat ttcacccgat ggcaagtatg tctatatagc tgagttgctg
      781 gctcataaga ttcatgtgta tgaaaagcat gctaattgga ctttaactcc attgaagtcc
      841 cttgacttta ataccctcgt ggataacata tctgtggatc ctgagacagg agacctttgg
      901 gttggatgcc atcccaatgg catgaaaatc ttcttctatg actcagagaa tcctcctgca
      961 tcagaggtgc ttcgaatcca gaacattcta acagaagaac ctaaagtgac acaggtttat
     1021 gcagaaaatg gcacagtgtt gcaaggcagt acagttgcct ctgtgtacaa agggaaactg
     1081 ctgattggca cagtgtttca caaagctctt tactgtgagc tctaacagac cgatttgcac
     1141 ccatgccata gaaactgagg ccattatttc aaccgcttgc catattccga ggacccagtg
     1201 ttcttagctg aacaatgaat gctgacccta aatgtggaca tcatgaagca tcaaagcact
     1261 gtttaactgg gagtgatatg atgtgtaggg cttttttttg agaatacact atcaaatcag
     1321 tcttggaata cttgaaaacc tcatttacca taaaaatcct tctcactaaa atggataaat
     1381 cagttatgtc aattgtcaga tattaaataa cagtgtgtga ccccaaaagt acttacccta
     1441 aaacatgtgt tgcctggaag cacatgtgtg tatcgctgcc ttgccatgtc ttgttcagaa
     1501 gacacagggg agcagggtta gctcacgtgt ctttagaact ccagtactca cccagggact
     1561 ccagttcaca ggccagaaaa catatgcatt atgaagttcc cctctactcc atgcacatag
     1621 taagtctgac tatggcagtc agacttactt actcccattt tcccttcgat atatgacttt
     1681 ttctcagtaa atattaacct gaattattcc aactcccctt gtactcttgc tttttcaatt
     1741 ctcctgttgc aatgacacat aggaaaatct taaaattctt gggagtgttg tcacacctga
     1801 aaattatgag tctctatgat cttggcacaa attgtacatt tgagtgtctt tgacttggtt
     1861 aaaggaagtt tgttcacttc gatgactgga tacagaatga atcccataat tgacatgggc
     1921 gaagctaaaa gtgtccccaa agactacact gttgttgagg tggtggtagt gctggtgggt
     1981 ttttgtttaa tatttaaact tcttgttgtg gaggctgaaa agaaaaaaaa taatagaaag
     2041 gtaaacaaac aaataaatag aaaagatcaa caaccccttt ggctatctac tgagacatga
     2101 ctaggaagaa aacatgactt tatcattttg ttatagaaac tgatatataa aggttacaca
     2161 ttttcattta tttgtttttc tgatttgaag gtataacctt catgatgaat tacttcttca
     2221 gggtgttaag gcagtgactt tagaaacaaa tttttttctt gtttttgttt tgtttttgag
     2281 accgaatctc actctgttgc ccaggctgga gtgcagtggt gcgatcttgg ctcactgcaa
     2341 cttctacctc cgaggttcaa gagattcttg tgcctcagcc tcccggatag ctg
//
