LOCUS       NM_012230               1528 bp    mRNA    linear   PRI 16-FEB-2024
DEFINITION  Homo sapiens POM121 and ZP3 fusion (POMZP3), transcript variant 1,
            mRNA.
ACCESSION   NM_012230
VERSION     NM_012230.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1528)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
REFERENCE   2  (bases 1 to 1528)
  AUTHORS   Kipersztok,S., Osawa,G.A., Liang,L.F., Modi,W.S. and Dean,J.
  TITLE     POM-ZP3, a bipartite transcript derived from human ZP3 and a POM121
            homologue
  JOURNAL   Genomics 25 (2), 354-359 (1995)
   PUBMED   7789967
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI084456.1, AC004980.5 and
            BG461659.1.
            
            On Nov 20, 2020 this sequence version replaced NM_012230.4.
            
            Summary: This gene appears to have resulted from a fusion of DNA
            sequences derived from 2 distinct loci, specifically through the
            duplication of two internal exons from the POM121 gene and four 3'
            exons from the ZP3 gene. The 5' end of this gene is similar to the
            5` coding region of the POM121 gene which encodes an integral
            nuclear pore membrane protein. However, the protein encoded by this
            gene lacks the nuclear pore localization motif. The 3' end of this
            gene is similar to the last 4 exons of the zona pellucida
            glycoprotein 3 (ZP3) gene and the encoded protein retains one zona
            pellucida domain. Multiple protein isoforms are encoded by
            transcript variants of this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: U10099.1, SRR14038192.1893553.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310842.9/ ENSP00000309233.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-366               BI084456.1         25-390
            367-572             AC004980.5         112749-112954       c
            573-788             AC004980.5         112041-112256       c
            789-950             AC004980.5         111563-111724       c
            951-1068            AC004980.5         104224-104341       c
            1069-1160           AC004980.5         97763-97854         c
            1161-1298           AC004980.5         97495-97632         c
            1299-1481           AC004980.5         96074-96256         c
            1482-1528           BG461659.1         418-464
FEATURES             Location/Qualifiers
     source          1..1528
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..1528
                     /gene="POMZP3"
                     /gene_synonym="POM-ZP3"
                     /note="POM121 and ZP3 fusion"
                     /db_xref="GeneID:22932"
                     /db_xref="HGNC:HGNC:9203"
                     /db_xref="MIM:600587"
     exon            1..572
                     /gene="POMZP3"
                     /gene_synonym="POM-ZP3"
                     /inference="alignment:Splign:2.1.0"
     exon            573..788
                     /gene="POMZP3"
                     /gene_synonym="POM-ZP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             724..1287
                     /gene="POMZP3"
                     /gene_synonym="POM-ZP3"
                     /note="isoform 1 is encoded by transcript variant 1; POM
                     (POM121 rat homolog) and ZP3 fusion; POM (POM121 homolog,
                     rat) and ZP3 fusion; POM-ZP3 fusion protein; POM121/ZP3
                     fusion protein; POM121 and ZP3 fusion protein"
                     /codon_start=1
                     /product="POM121 and ZP3 fusion protein isoform 1"
                     /protein_id="NP_036362.3"
                     /db_xref="CCDS:CCDS43606.1"
                     /db_xref="GeneID:22932"
                     /db_xref="HGNC:HGNC:9203"
                     /db_xref="MIM:600587"
                     /translation="MVCSPVTLRIAPPDRRFSRSAIPEQIISSTLSSPSSNAPDPCAK
                     ETVLSALKEKKKKRTVEEEDQIFLDGQENKRSCLVDGLTDASSAFKVPRPGPDTLQFT
                     VDVFHFANDSRNMIYITCHLKVTLAEQDPDELNKACSFSKPSNSWFPVEGLADICQCC
                     NKGDCGTPSHSRRQPRVVSQWSTSASL"
     exon            789..950
                     /gene="POMZP3"
                     /gene_synonym="POM-ZP3"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1068
                     /gene="POMZP3"
                     /gene_synonym="POM-ZP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1160
                     /gene="POMZP3"
                     /gene_synonym="POM-ZP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1298
                     /gene="POMZP3"
                     /gene_synonym="POM-ZP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1528
                     /gene="POMZP3"
                     /gene_synonym="POM-ZP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1509..1514
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POMZP3"
                     /gene_synonym="POM-ZP3"
                     /note="hexamer: AATAAA"
     polyA_site      1528
                     /gene="POMZP3"
                     /gene_synonym="POM-ZP3"
                     /note="major polyA site"
ORIGIN      
        1 aagtctcctc cgcggcgcgg agccgcgatg tctccggcgg ctgcggcggc tggagcaggc
       61 gagcggcggc ggccgatagc gagtgtcagg gccggccggg gcggcgcttc tcggcctgtc
      121 gctggtcggc ctcctactgt acctcgtgcc tgctgcggct gcgctggcct ggctggccgt
      181 ggggactacc gcggcctggt ggggactgag ccgcgagccc cgaggttcgc gccccttgtc
      241 ctccttcgtt cagaaggcgc gacatcggcg aacactgttc gcttcgcctc cggccaagtc
      301 gacagccaac ggaaacctcc tagagccgcg gaccctgctc gaaggacctg accctgccga
      361 actgctcctc atgggcagtt acctgggcaa gcccgggccg ccgcagcccg cccccgctcc
      421 ggagggccag gacctgcgga ataggcctgg ccgccgcccg cccgcccggc gccgcgctcc
      481 acaccgccct ccccgccgac ccatcgcgtt caccactttt acccctctct ccccactcct
      541 cttctccgac cctccgggag gccttcccca cgggatcgtg ggactttacc agatcggttt
      601 gtaataacac ctcgaagacg ctatccgatc catcaggccc agtattcctg tccgggggta
      661 cttcccacag tgtgctggaa tggttatcac aagaaggctg tgctgtcccc tcgcaactcc
      721 aggatggtgt gtagcccagt gactctgagg atcgcccctc ctgacagaag attttcgcgt
      781 tctgcgatac cagagcagat aatcagctca acactgtcct caccatcaag taatgcccca
      841 gacccatgtg caaaggagac tgtactgagt gccctcaaag agaagaagaa gaaaaggaca
      901 gtggaggaag aagaccaaat attccttgat ggccaggaaa ataaaagaag ctgtcttgtc
      961 gacggtctca ctgatgcctc ttctgcattc aaagttcctc gacccgggcc agatacactc
     1021 cagttcacag tggatgtctt ccactttgct aatgactcca gaaacatgat atacatcacc
     1081 tgccacctga aggtcaccct agctgagcag gacccagatg aactcaacaa ggcctgttcc
     1141 ttcagcaagc cttccaacag ctggttccca gtggaaggcc tggctgacat ctgtcaatgc
     1201 tgtaacaaag gtgactgtgg cactccaagc cattccagga ggcagcctcg tgtcgtgagc
     1261 cagtggtcca cgtctgcttc cctgtaaccg caggcatgtg acagaagaag cagatgtcac
     1321 cgtggggcca ctgatcttcc tggacaggag gggtgaccat gaagtagagc agtgggcttt
     1381 gccttctgac acctcagtgg tgctgctggg cgtaggcctg gctgtggtgg tgtccctgac
     1441 tctgactgct gttatcctgg ttctcaccag gaggtgtcgc actgcctccc accctgtgtc
     1501 tgcttccgaa taaaagaaga aagcaata
//
