LOCUS       NM_013382               4875 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens protein O-mannosyltransferase 2 (POMT2), mRNA.
ACCESSION   NM_013382
VERSION     NM_013382.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4875)
  AUTHORS   Zhao,X., Gao,C., Li,L., Jiang,L., Wei,Y., Che,F. and Liu,Q.
  TITLE     Clinical exome sequencing identifies novel compound heterozygous
            mutations of the POMT2 gene in patients with limb-girdle muscular
            dystrophy
  JOURNAL   Int J Dev Neurosci 83 (1), 23-30 (2023)
   PUBMED   36217604
  REMARK    GeneRIF: Clinical exome sequencing identifies novel compound
            heterozygous mutations of the POMT2 gene in patients with
            limb-girdle muscular dystrophy.
REFERENCE   2  (bases 1 to 4875)
  AUTHORS   Gan,S., Yang,H., Xiao,T., Pan,Z. and Wu,L.
  TITLE     POMT1 and POMT2 gene mutations result in 2 cases of
            alpha-dystroglycanopathy
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 46 (8), 915-919 (2021)
   PUBMED   34565739
  REMARK    GeneRIF: POMT1 and POMT2 gene mutations result in 2 cases of
            alpha-dystroglycanopathy.', trans 'POMT1POMT22alpha-.
REFERENCE   3  (bases 1 to 4875)
  AUTHORS   Ostergaard,S.T., Johnson,K., Stojkovic,T., Krag,T., De Ridder,W.,
            De Jonghe,P., Baets,J., Claeys,K.G., Fernandez-Torron,R.,
            Phillips,L., Topf,A., Colomer,J., Nafissi,S., Jamal-Omidi,S.,
            Bouchet-Seraphin,C., Leturcq,F., MacArthur,D.G., Lek,M., Xu,L.,
            Nelson,I., Straub,V. and Vissing,J.
  TITLE     Limb girdle muscular dystrophy due to mutations in POMT2
  JOURNAL   J Neurol Neurosurg Psychiatry 89 (5), 506-512 (2018)
   PUBMED   29175898
  REMARK    GeneRIF: The study expands the mutational spectrum for Limb-girdle
            Muscular Dystrophy type2N, with the description of 11 novel POMT2
            mutations in the association with LGMD2N.
REFERENCE   4  (bases 1 to 4875)
  AUTHORS   Abdullah,S., Hawkins,C., Wilson,G., Yoon,G., Mertens,L.,
            Carter,M.T. and Guerin,A.
  TITLE     Noncompaction cardiomyopathy in an infant with Walker-Warburg
            syndrome
  JOURNAL   Am J Med Genet A 173 (11), 3082-3086 (2017)
   PUBMED   28980384
  REMARK    GeneRIF: Muscle biopsy revealed absent alpha-dystroglycan on
            immunostaining and genetic testing confirmed the diagnosis with two
            previously described POMT2 mutations. This is the first reported
            case of WWS syndrome associated with noncompaction cardiomyopathy
REFERENCE   5  (bases 1 to 4875)
  AUTHORS   Manya,H., Chiba,A., Yoshida,A., Wang,X., Chiba,Y., Jigami,Y.,
            Margolis,R.U. and Endo,T.
  TITLE     Demonstration of mammalian protein O-mannosyltransferase activity:
            coexpression of POMT1 and POMT2 required for enzymatic activity
  JOURNAL   Proc Natl Acad Sci U S A 101 (2), 500-505 (2004)
   PUBMED   14699049
  REMARK    GeneRIF: active enzyme complex of POMT1 and POMT2 suggests that the
            regulation of protein O-mannosylation is complex and appears to be
            required for normal structure and function of alpha-dystroglycan in
            muscle and brain
REFERENCE   6  (bases 1 to 4875)
  AUTHORS   Heilig,R., Eckenberg,R., Petit,J.L., Fonknechten,N., Da Silva,C.,
            Cattolico,L., Levy,M., Barbe,V., de Berardinis,V., Ureta-Vidal,A.,
            Pelletier,E., Vico,V., Anthouard,V., Rowen,L., Madan,A., Qin,S.,
            Sun,H., Du,H., Pepin,K., Artiguenave,F., Robert,C., Cruaud,C.,
            Bruls,T., Jaillon,O., Friedlander,L., Samson,G., Brottier,P.,
            Cure,S., Segurens,B., Aniere,F., Samain,S., Crespeau,H., Abbasi,N.,
            Aiach,N., Boscus,D., Dickhoff,R., Dors,M., Dubois,I., Friedman,C.,
            Gouyvenoux,M., James,R., Madan,A., Mairey-Estrada,B., Mangenot,S.,
            Martins,N., Menard,M., Oztas,S., Ratcliffe,A., Shaffer,T.,
            Trask,B., Vacherie,B., Bellemere,C., Belser,C., Besnard-Gonnet,M.,
            Bartol-Mavel,D., Boutard,M., Briez-Silla,S., Combette,S.,
            Dufosse-Laurent,V., Ferron,C., Lechaplais,C., Louesse,C.,
            Muselet,D., Magdelenat,G., Pateau,E., Petit,E.,
            Sirvain-Trukniewicz,P., Trybou,A., Vega-Czarny,N., Bataille,E.,
            Bluet,E., Bordelais,I., Dubois,M., Dumont,C., Guerin,T.,
            Haffray,S., Hammadi,R., Muanga,J., Pellouin,V., Robert,D.,
            Wunderle,E., Gauguet,G., Roy,A., Sainte-Marthe,L., Verdier,J.,
            Verdier-Discala,C., Hillier,L., Fulton,L., McPherson,J.,
            Matsuda,F., Wilson,R., Scarpelli,C., Gyapay,G., Wincker,P.,
            Saurin,W., Quetier,F., Waterston,R., Hood,L. and Weissenbach,J.
  TITLE     The DNA sequence and analysis of human chromosome 14
  JOURNAL   Nature 421 (6923), 601-607 (2003)
   PUBMED   12508121
  REMARK    Erratum:[Nature. 2023 Aug;620(7973):E17. doi:
            10.1038/s41586-023-06403-y.. PMID: 37491470]
REFERENCE   7  (bases 1 to 4875)
  AUTHORS   Willer,T., Amselgruber,W., Deutzmann,R. and Strahl,S.
  TITLE     Characterization of POMT2, a novel member of the PMT protein
            O-mannosyltransferase family specifically localized to the acrosome
            of mammalian spermatids
  JOURNAL   Glycobiology 12 (11), 771-783 (2002)
   PUBMED   12460945
  REMARK    GeneRIF: molecular cloning and characterization
REFERENCE   8  (bases 1 to 4875)
  AUTHORS   Fukuda,S., Sumii,M., Masuda,Y., Takahashi,M., Koike,N.,
            Teishima,J., Yasumoto,H., Itamoto,T., Asahara,T., Dohi,K. and
            Kamiya,K.
  TITLE     Murine and human SDF2L1 is an endoplasmic reticulum
            stress-inducible gene and encodes a new member of the Pmt/rt
            protein family
  JOURNAL   Biochem Biophys Res Commun 280 (1), 407-414 (2001)
   PUBMED   11162531
REFERENCE   9  (bases 1 to 4875)
  AUTHORS   Pegoraro,E. and Hoffman,E.P.
  TITLE     Limb-Girdle Muscular Dystrophy Overview - RETIRED CHAPTER, FOR
            HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301582
REFERENCE   10 (bases 1 to 4875)
  AUTHORS   Sparks,S.E., Quijano-Roy,S., Harper,A., Rutkowski,A., Gordon,E.,
            Hoffman,E.P. and Pegoraro,E.
  TITLE     Congenital Muscular Dystrophy Overview - RETIRED CHAPTER, FOR
            HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301468
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007954.7 and AC007375.6.
            
            On Feb 27, 2020 this sequence version replaced NM_013382.6.
            
            Summary: The protein encoded by this gene is an
            O-mannosyltransferase that requires interaction with the product of
            the POMT1 gene for enzymatic function. The encoded protein is found
            in the membrane of the endoplasmic reticulum. Defects in this gene
            are a cause of Walker-Warburg syndrome (WWS).[provided by RefSeq,
            Oct 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY090480.1, SRR14038197.1211203.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261534.9/ ENSP00000261534.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-450               AC007954.7         107413-107862       c
            451-535             AC007954.7         98928-99012         c
            536-640             AC007954.7         93316-93420         c
            641-749             AC007954.7         91671-91779         c
            750-858             AC007954.7         89814-89922         c
            859-1018            AC007954.7         88069-88228         c
            1019-1125           AC007954.7         86434-86540         c
            1126-1208           AC007954.7         85668-85750         c
            1209-1318           AC007954.7         83143-83252         c
            1319-1385           AC007375.6         174111-174177       c
            1386-1455           AC007375.6         171559-171628       c
            1456-1534           AC007375.6         169541-169619       c
            1535-1686           AC007375.6         168278-168429       c
            1687-1778           AC007375.6         167747-167838       c
            1779-1855           AC007375.6         166594-166670       c
            1856-1927           AC007375.6         163189-163260       c
            1928-1987           AC007375.6         162818-162877       c
            1988-2093           AC007375.6         162620-162725       c
            2094-2234           AC007375.6         161526-161666       c
            2235-2349           AC007375.6         161191-161305       c
            2350-4875           AC007375.6         157753-160278       c
FEATURES             Location/Qualifiers
     source          1..4875
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..4875
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /note="protein O-mannosyltransferase 2"
                     /db_xref="GeneID:29954"
                     /db_xref="HGNC:HGNC:19743"
                     /db_xref="MIM:607439"
     exon            1..450
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..2455
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /EC_number="2.4.1.109"
                     /note="dolichyl-phosphate-mannose--protein
                     mannosyltransferase 2"
                     /codon_start=1
                     /product="protein O-mannosyl-transferase 2"
                     /protein_id="NP_037514.2"
                     /db_xref="CCDS:CCDS9857.1"
                     /db_xref="GeneID:29954"
                     /db_xref="HGNC:HGNC:19743"
                     /db_xref="MIM:607439"
                     /translation="MPPATGGGLAESELRPRRGRCGPQAARAAGRDVAAEAVARSPKR
                     PAWGSRRFEAVGWWALLALVTLLSFATRFHRLDEPPHICWDETHFGKMGSYYINRTFF
                     FDVHPPLGKMLIGLAGYLSGYDGTFLFQKPGDKYEHHSYMGMRGFCAFLGSWLVPFAY
                     LTVLDLSKSLSAALLTAALLTFDTGCLTLSQYILLDPILMFFIMAAMLSMVKYNSCAD
                     RPFSAPWWFWLSLTGVSLAGALGVKFVGLFIILQVGLNTIADLWYLFGDLSLSLVTVG
                     KHLTARVLCLIVLPLALYTATFAVHFMVLSKSGPGDGFFSSAFQARLSGNNLHNASIP
                     EHLAYGSVITVKNLRMAIGYLHSHRHLYPEGIGARQQQVTTYLHKDYNNLWIIKKHNT
                     NSDPLDPSFPVEFVRHGDIIRLEHKETSRNLHSHYHEAPMTRKHYQVTGYGINGTGDS
                     NDFWRIEVVNRKFGNRIKVLRSRIRFIHLVTGCVLGSSGKVLPKWGWEQLEVTCTPYL
                     KETLNSIWNVEDHINPKLPNISLDVLQPSFPEILLESHMVMIRGNSGLKPKDNEFTSK
                     PWHWPINYQGLRFSGVNDTDFRVYLLGNPVVWWLNLLSIALYLLSGSIIAVAMQRGAR
                     LPAEVAGLSQVLLRGGGQVLLGWTLHYFPFFLMGRVLYFHHYFPAMLFSSMLTGILWD
                     TLLRLCAWGLASWPLARGIHVAGILSLLLGTAYSFYLFHPLAYGMVGPLAQDPQSPMA
                     GLRWLDSWDF"
     exon            451..535
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /inference="alignment:Splign:2.1.0"
     exon            536..640
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /inference="alignment:Splign:2.1.0"
     exon            641..749
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /inference="alignment:Splign:2.1.0"
     exon            750..858
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1018
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1125
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1208
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1318
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1385
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1455
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1534
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1686
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1778
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1855
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..1927
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..1987
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2093
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2234
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2349
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..4875
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2785..2790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /note="hexamer: AATACA"
     regulatory      2817..2822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /note="hexamer: CATAAA"
     polyA_site      2840
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /note="major polyA site"
     polyA_site      2848
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /note="major polyA site"
     regulatory      4854..4859
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /note="hexamer: AATAAA"
     polyA_site      4875
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /note="major polyA site"
ORIGIN      
        1 gcgcctcctg ccgcctccta gcggcccggg ccgcgaccac gctgcccgcc ccgccccgag
       61 cccggggccc cgcgctccgc tgcagtgaag ggcgttgcat ttcccggggt accccgagct
      121 gccctcttgt gactccttgg cggggcggct ggtcagacaa agtgtgcctc cgggccggag
      181 ggcgacccag aggaggggga agatgccgcc ggccacgggc ggaggcctgg cagagtccga
      241 gctgcgtccc cggaggggcc gctgtggccc ccaggctgct agggccgcag gccgggacgt
      301 ggccgctgag gctgtggcgc gaagccccaa acggcctgct tggggctcac ggcgcttcga
      361 ggcggtcggc tggtgggccc tgctggcctt ggtgacgctg ctgtccttcg ccacccgctt
      421 ccaccgcttg gacgagccgc cgcacatctg ttgggatgag actcactttg gaaaaatggg
      481 aagttactat atcaaccgta catttttctt tgatgtgcac ccgcccctgg gaaagatgct
      541 gataggtctt gctggctacc tgagtggata tgatggtacc tttttgttcc agaagcctgg
      601 ggataaatat gagcatcaca gctacatggg aatgagagga ttctgtgcat tccttggctc
      661 ctggctggtc ccctttgcct acctcactgt actggatctg tccaagtccc tctcggcagc
      721 actgctcaca gctgccctcc tcacctttga cacgggatgc ctcactctgt cccagtacat
      781 cctccttgac cccatcctga tgttcttcat catggctgcc atgctgagca tggtcaagta
      841 caactcttgc gccgacaggc ccttctctgc cccctggtgg ttctggctca gcctgactgg
      901 cgttagtctt gctggtgctt taggggtcaa gtttgttggc ctctttatca tccttcaagt
      961 ggggctgaac accattgcag acctttggta cctgttcgga gacctcagtc tttcattggt
     1021 gactgtggga aaacacctga ctgctcgtgt cctgtgcctc atagtgctgc ccctggctct
     1081 ctatacagcc acctttgctg ttcacttcat ggtgctgagt aaaagtggcc ctggtgacgg
     1141 tttcttcagt tctgccttcc aggcccggct ttcagggaac aacctgcaca atgcttccat
     1201 ccctgaacac ctggcctacg gctctgtgat cactgtgaag aacctccgga tggccatcgg
     1261 ctatctgcac tcccacaggc acctctaccc cgagggcatt ggtgcccgtc agcagcaggt
     1321 caccacctat ttgcacaagg actacaacaa cctgtggatt atcaagaaac ataacacaaa
     1381 ctcagatccc ctagaccctt ccttcccagt ggagtttgta agacatggag acattattcg
     1441 actagaacac aaagaaactt cccggaactt gcacagtcac tatcatgagg cccccatgac
     1501 ccggaagcac tatcaggtca ccggctatgg cataaatgga acaggggact caaatgattt
     1561 ctggcggatt gaggtcgtaa acaggaaatt tggaaaccgg atcaaagtgc tgagaagtcg
     1621 aattcgcttc atccatttgg tcacaggttg tgtcctgggc tcctcgggaa aggttctgcc
     1681 caagtggggc tgggagcagt tggaagttac ttgcacccca tacctgaaag aaaccctcaa
     1741 ctccatctgg aatgtggagg accatatcaa tcccaagttg ccaaacatca gcctggatgt
     1801 gctacagccc agttttcctg agatcttgct ggaatcccac atggtcatga tccgggggaa
     1861 cagtggcctc aaacccaagg acaatgagtt cacgtccaaa ccctggcact ggcctatcaa
     1921 ctatcagggc ctacgcttct caggggtcaa tgacacagat ttccgagtct atctgcttgg
     1981 caacccggtg gtttggtggc tgaatctgtt gagcatcgcc ctctacctcc tctcagggag
     2041 catcattgct gtagccatgc agagaggggc acggctgcca gcggaggttg cagggttgtc
     2101 ccaggtcctg cttcgaggag gcggccaggt cctgctcggc tggacactcc attacttccc
     2161 gtttttcctg atgggccggg tcctctactt ccaccactac ttcccagcca tgctcttctc
     2221 aagcatgttg acaggcattc tgtgggacac cctcctgcgg ctctgtgcct ggggcttggc
     2281 ctcatggccc ctggcgaggg gcatacatgt ggcgggaatc ctgagcctgc tcctgggaac
     2341 tgcctacagc ttctacctct tccaccctct ggcttacggg atggttggtc ccctggccca
     2401 ggacccccaa agtccaatgg caggactaag gtggctggac tcatgggact tttgaggcca
     2461 ctgcaaagat tccagcctgg gtccaggaac ttcccaggag agccagctgg gaagcagtac
     2521 tggaccatcc ggccatgagg aagctgccta aggagcccga agaattctgc tgctcaccag
     2581 gacccagctc tgggagtgca gctggaatgg aacccagcat tggagagagc cgggagagag
     2641 ccgcagctcc gtccacagca ccacggagag gacagcgcct cttgggctgc tccctcgtgc
     2701 acagcgcagg ggaggatggg tgccagaggg tgggagtggg tgcgcgtgtg tgtatgtgag
     2761 ggcatgttgt ccatatccct gtggaataca gaccgtgtaa ctggacagct gagtgtcata
     2821 aactctaaaa tagtccaggc tatagtaata ttttctggta tttttttctg ttggatttct
     2881 ttggttttgg tttgtaagat ccatcaaaaa ttctcagacc tctgagaggg ccttgagggc
     2941 agagaatact gacctcacct tgggatgtca ccaaaggcag agcagatggg actgtcaaag
     3001 ttgtgctgcc ctccctccca caaacaaatg aatccagcgt ggaggaaggc gcgccgcccc
     3061 gagctggagg gcctggctcc caccatgccc cccagtggct gcaggtagct ggacttcctg
     3121 cctgtgacgc acagagagca gcggactccg gagcgtcagc ctgccttagc ccttggttcc
     3181 tcgttttttg ggattgtcac actgtgacac tcgggaggaa cgatgtccta tcctgggctg
     3241 ctcagtgttc ccaggccctg tgtgccagag gccaggtctc tccaagtgca tctagcctgg
     3301 cctggagggc aaggcagatg cattctcctg gctgctggga gagcccatgg gaaccttgct
     3361 tagcgcccaa ggtagatgag agacagggca gggaatctgc gtggtgctgg gatgtgggga
     3421 ctctggcctc tccagactaa tgttcctgtc acctgctgag ctttcccagt gtcacttctg
     3481 cagtcctcct ctgctcaccc ctccctcact ccgtgggcaa ttccctttct ctctgtcact
     3541 gcttcagcag tgaagaccca tggcacctag aaatgcatgc cagcttcctg cgtctaccac
     3601 tctgcagctc aaacaagaag ctcagagctg ccccttccac ttcctcccca aaagggatga
     3661 agaaaaccct gtggtagaac caaaccaccc aaggccagcc cttaagcctg cctccacctt
     3721 cctggtgcat gacaaaatat ttcttttgtc tcagaggact ttgatgcttc aatatttaat
     3781 gatgaatccg ccacactcca ttttccctcc tctgaagctc ccaacaactc tgacagggtc
     3841 agatctcttt aaagcatctt caggaggcgg ttgccacgga gactggatat tggtcccagg
     3901 gacaggctgt gctacctact gggtggtggg gagggaagct tctggccatg cttgggcatt
     3961 cagaccaacc atcattaatg ttaatagagg aaatgcagca acgtcaaaag caaggcaggt
     4021 tggttaatta gatctggggc ccgatgacct ccctttccca ctgctacagc ccttttgact
     4081 tcccccagca ggaagcgctg tctgtgcggc tgagtctggg ccacttgctt aattgcattt
     4141 ctggcaggga aggagaggag ggatggagaa gctctgctcg ctgcttccac ctcaccgtgt
     4201 gtcctcccct cccctccctt cctctcctcc ccacaggcgg aattgctttc ttctgagccg
     4261 ggtgggctct cctgcaggga gaatgcaggg gtctgtgctt ggctcttagc aaagcaggtg
     4321 gcccacagtg acctccagga ggtggctgat tttcctttgt gccttcttat ttctcagtag
     4381 gaacttggaa gggaagagct ctgaaggagc cagaggggca gccaccttgc atgagggtga
     4441 ggaaggagaa gcccagccag cctctaccca tccctccctc ccaattaggc tgcactgggg
     4501 ccgaacgctt ccctgggctc ccactgcctt ctaaggagcc aaggagaatt ccctgcccac
     4561 tttctgttcc tccatgccca aactggcaga tgcttctctg ggagcaaggc cacatgggct
     4621 gatgcagctt tgagtgctca ggttctgttt tctggaagtt gctggagaag ggctgtcagg
     4681 gtgcttctat gaatatgggc ttcagctgta gcacttggca gaaacgtgat gtgtcccaca
     4741 aactgctggt ggaggaagaa gatgttcgtc agccaattca acctccagcc agcttcttga
     4801 gcctatttgg tttaaaaaaa aaaagtcttc taatcagaag ccactgattt tataataaat
     4861 aacacttgtt ttgaa
//
