LOCUS       NM_001077365            3057 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens protein O-mannosyltransferase 1 (POMT1), transcript
            variant 2, mRNA.
ACCESSION   NM_001077365
VERSION     NM_001077365.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3057)
  AUTHORS   Gan,S., Yang,H., Xiao,T., Pan,Z. and Wu,L.
  TITLE     POMT1 and POMT2 gene mutations result in 2 cases of
            alpha-dystroglycanopathy
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 46 (8), 915-919 (2021)
   PUBMED   34565739
  REMARK    GeneRIF: POMT1 and POMT2 gene mutations result in 2 cases of
            alpha-dystroglycanopathy.', trans 'POMT1POMT22alpha-.
REFERENCE   2  (bases 1 to 3057)
  AUTHORS   Vuorela,A., Freitag,T.L., Leskinen,K., Pessa,H., Harkonen,T.,
            Stracenski,I., Kirjavainen,T., Olsen,P., Saarenpaa-Heikkila,O.,
            Ilonen,J., Knip,M., Vaheri,A., Partinen,M., Saavalainen,P., Meri,S.
            and Vaarala,O.
  TITLE     Enhanced influenza A H1N1 T cell epitope recognition and
            cross-reactivity to protein-O-mannosyltransferase 1 in
            Pandemrix-associated narcolepsy type 1
  JOURNAL   Nat Commun 12 (1), 2283 (2021)
   PUBMED   33863907
  REMARK    GeneRIF: Enhanced influenza A H1N1 T cell epitope recognition and
            cross-reactivity to protein-O-mannosyltransferase 1 in
            Pandemrix-associated narcolepsy type 1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3057)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3057)
  AUTHORS   Hu,P., Yuan,L. and Deng,H.
  TITLE     Molecular genetics of the POMT1-related muscular
            dystrophy-dystroglycanopathies
  JOURNAL   Mutat Res Rev Mutat Res 778, 45-50 (2018)
   PUBMED   30454682
  REMARK    GeneRIF: In this review, we highlight the present knowledge of the
            identified disease-associated POMT1 gene mutations and genetic
            animal models related to the POMT1 gene.
            Review article
REFERENCE   5  (bases 1 to 3057)
  AUTHORS   Sabatelli,P., Columbaro,M., Mura,I., Capanni,C., Lattanzi,G.,
            Maraldi,N.M., Beltran-Valero de Barnabe,D., van Bokoven,H.,
            Squarzoni,S. and Merlini,L.
  TITLE     Extracellular matrix and nuclear abnormalities in skeletal muscle
            of a patient with Walker-Warburg syndrome caused by POMT1 mutation
  JOURNAL   Biochim Biophys Acta 1638 (1), 57-62 (2003)
   PUBMED   12757935
  REMARK    GeneRIF: Extracellular matrix and nuclear abnormalities in skeletal
            muscle of a patient with Walker-Warburg syndrome caused by POMT1
            mutation.
REFERENCE   6  (bases 1 to 3057)
  AUTHORS   Beltran-Valero de Bernabe,D., Currier,S., Steinbrecher,A.,
            Celli,J., van Beusekom,E., van der Zwaag,B., Kayserili,H.,
            Merlini,L., Chitayat,D., Dobyns,W.B., Cormand,B., Lehesjoki,A.E.,
            Cruces,J., Voit,T., Walsh,C.A., van Bokhoven,H. and Brunner,H.G.
  TITLE     Mutations in the O-mannosyltransferase gene POMT1 give rise to the
            severe neuronal migration disorder Walker-Warburg syndrome
  JOURNAL   Am J Hum Genet 71 (5), 1033-1043 (2002)
   PUBMED   12369018
  REMARK    GeneRIF: Mutations in the O-mannosyltransferase gene POMT1 give
            rise to the severe neuronal migration disorder Walker-Warburg
            syndrome
REFERENCE   7  (bases 1 to 3057)
  AUTHORS   Jurado,L.A., Coloma,A. and Cruces,J.
  TITLE     Identification of a human homolog of the Drosophila rotated abdomen
            gene (POMT1) encoding a putative protein O-mannosyl-transferase,
            and assignment to human chromosome 9q34.1
  JOURNAL   Genomics 58 (2), 171-180 (1999)
   PUBMED   10366449
REFERENCE   8  (bases 1 to 3057)
  AUTHORS   Pegoraro,E. and Hoffman,E.P.
  TITLE     Limb-Girdle Muscular Dystrophy Overview - RETIRED CHAPTER, FOR
            HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301582
REFERENCE   9  (bases 1 to 3057)
  AUTHORS   Bardakjian,T., Weiss,A. and Schneider,A.
  TITLE     Microphthalmia/Anophthalmia/Coloboma Spectrum - RETIRED CHAPTER,
            FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301552
REFERENCE   10 (bases 1 to 3057)
  AUTHORS   Sparks,S.E., Quijano-Roy,S., Harper,A., Rutkowski,A., Gordon,E.,
            Hoffman,E.P. and Pegoraro,E.
  TITLE     Congenital Muscular Dystrophy Overview - RETIRED CHAPTER, FOR
            HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301468
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL358781.19.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001077365.1.
            
            Summary: The protein encoded by this gene is an
            O-mannosyltransferase that requires interaction with the product of
            the POMT2 gene for enzymatic function. The encoded protein is found
            in the membrane of the endoplasmic reticulum. Defects in this gene
            are a cause of Walker-Warburg syndrome (WWS) and limb-girdle
            muscular dystrophy type 2K (LGMD2K). Several transcript variants
            encoding different isoforms have been found for this gene.[provided
            by RefSeq, Oct 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.43787.1, HM005680.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000402686.8/ ENSP00000385797.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AL358781.19        107184-107339
            157-308             AL358781.19        108455-108606
            309-415             AL358781.19        110380-110486
            416-466             AL358781.19        110669-110719
            467-613             AL358781.19        111634-111780
            614-725             AL358781.19        113177-113288
            726-791             AL358781.19        114009-114074
            792-885             AL358781.19        114169-114262
            886-1041            AL358781.19        114526-114681
            1042-1172           AL358781.19        115603-115733
            1173-1268           AL358781.19        116307-116402
            1269-1361           AL358781.19        117505-117597
            1362-1458           AL358781.19        119692-119788
            1459-1551           AL358781.19        122711-122803
            1552-1672           AL358781.19        123103-123223
            1673-1770           AL358781.19        123655-123752
            1771-1884           AL358781.19        124346-124459
            1885-2011           AL358781.19        125612-125738
            2012-2189           AL358781.19        126313-126490
            2190-3057           AL358781.19        127198-128065
FEATURES             Location/Qualifiers
     source          1..3057
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.13"
     gene            1..3057
                     /gene="POMT1"
                     /gene_synonym="LGMD2K; LGMDR11; MDDGA1; MDDGB1; MDDGC1;
                     RT"
                     /note="protein O-mannosyltransferase 1"
                     /db_xref="GeneID:10585"
                     /db_xref="HGNC:HGNC:9202"
                     /db_xref="MIM:607423"
     exon            1..156
                     /gene="POMT1"
                     /gene_synonym="LGMD2K; LGMDR11; MDDGA1; MDDGB1; MDDGC1;
                     RT"
                     /inference="alignment:Splign:2.1.0"
     exon            157..308
                     /gene="POMT1"
                     /gene_synonym="LGMD2K; LGMDR11; MDDGA1; MDDGB1; MDDGC1;
                     RT"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..2364
                     /gene="POMT1"
                     /gene_synonym="LGMD2K; LGMDR11; MDDGA1; MDDGB1; MDDGC1;
                     RT"
                     /EC_number="2.4.1.109"
                     /note="isoform b is encoded by transcript variant 2;
                     protein O-mannosyl-transferase 1;
                     dolichyl-phosphate-mannose--protein mannosyltransferase 1;
                     testis tissue sperm-binding protein Li 57p"
                     /codon_start=1
                     /product="protein O-mannosyl-transferase 1 isoform b"
                     /protein_id="NP_001070833.1"
                     /db_xref="CCDS:CCDS43894.1"
                     /db_xref="GeneID:10585"
                     /db_xref="HGNC:HGNC:9202"
                     /db_xref="MIM:607423"
                     /translation="MWGFLKRPVVVTADINLSLVALTGMGLLSRLWRLTYPRAVVFDE
                     VYYGQYISFYMKQIFFLDDSGPPFGHMVLALGGYLGGFDGNFLWNRIGAEYSSNVPVW
                     SLRLLPALAGALSVPMAYQIVLELHFSHCAAMGAALLMLIENALITQSRLMLLESVLI
                     FFNLLAVLSYLKFFNCQKHSPFSLSWWFWLTLTGVACSCAVGIKYMGVFTYVLVLGVA
                     AVHAWHLLGDQTLSNVCVFCHLLARAVALLVIPVVLYLLFFYVHLILVFRSGPHDQIM
                     SSAFQASLEGGLARITQGQPLEVAFGSQVTLRNVFGKPVPCWLHSHQDTYPMIYENGR
                     GSSHQQQVTCYPFKDVNNWWIVKDPRRHQLVVSSPPRPVRHGDMVQLVHGMTTRSLNT
                     HDVAAPLSPHSQEVSCYIDYNISMPAQNLWRLEIVNRGSDTDVWKTILSEVRFVHVNT
                     SAVLKLSGAHLPDWGYRQLEIVGEKLSRGYHGSTVWNVEEHRYGASQEQRERERELHS
                     PAQVDVSRNLSFMARFSELQWRMLALRSDDSEHKYSSSPLEWVTLDTNIAYWLHPRTS
                     AQIHLLGNIVIWVSGSLALAIYALLSLWYLLRRRRNVHDLPQDAWLRWVLAGALCAGG
                     WAVNYLPFFLMEKTLFLYHYLPALTFQILLLPVVLQHISDHLCRSQLQRSIFSALVVA
                     WYSSACHVSNTLRPLTYGDKSLSPHELKALRWKDSWDILIRKH"
     exon            309..415
                     /gene="POMT1"
                     /gene_synonym="LGMD2K; LGMDR11; MDDGA1; MDDGB1; MDDGC1;
                     RT"
                     /inference="alignment:Splign:2.1.0"
     exon            416..466
                     /gene="POMT1"
                     /gene_synonym="LGMD2K; LGMDR11; MDDGA1; MDDGB1; MDDGC1;
                     RT"
                     /inference="alignment:Splign:2.1.0"
     exon            467..613
                     /gene="POMT1"
                     /gene_synonym="LGMD2K; LGMDR11; MDDGA1; MDDGB1; MDDGC1;
                     RT"
                     /inference="alignment:Splign:2.1.0"
     exon            614..725
                     /gene="POMT1"
                     /gene_synonym="LGMD2K; LGMDR11; MDDGA1; MDDGB1; MDDGC1;
                     RT"
                     /inference="alignment:Splign:2.1.0"
     exon            726..791
                     /gene="POMT1"
                     /gene_synonym="LGMD2K; LGMDR11; MDDGA1; MDDGB1; MDDGC1;
                     RT"
                     /inference="alignment:Splign:2.1.0"
     exon            792..885
                     /gene="POMT1"
                     /gene_synonym="LGMD2K; LGMDR11; MDDGA1; MDDGB1; MDDGC1;
                     RT"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1041
                     /gene="POMT1"
                     /gene_synonym="LGMD2K; LGMDR11; MDDGA1; MDDGB1; MDDGC1;
                     RT"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1172
                     /gene="POMT1"
                     /gene_synonym="LGMD2K; LGMDR11; MDDGA1; MDDGB1; MDDGC1;
                     RT"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1268
                     /gene="POMT1"
                     /gene_synonym="LGMD2K; LGMDR11; MDDGA1; MDDGB1; MDDGC1;
                     RT"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1361
                     /gene="POMT1"
                     /gene_synonym="LGMD2K; LGMDR11; MDDGA1; MDDGB1; MDDGC1;
                     RT"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1458
                     /gene="POMT1"
                     /gene_synonym="LGMD2K; LGMDR11; MDDGA1; MDDGB1; MDDGC1;
                     RT"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1551
                     /gene="POMT1"
                     /gene_synonym="LGMD2K; LGMDR11; MDDGA1; MDDGB1; MDDGC1;
                     RT"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1672
                     /gene="POMT1"
                     /gene_synonym="LGMD2K; LGMDR11; MDDGA1; MDDGB1; MDDGC1;
                     RT"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1770
                     /gene="POMT1"
                     /gene_synonym="LGMD2K; LGMDR11; MDDGA1; MDDGB1; MDDGC1;
                     RT"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1884
                     /gene="POMT1"
                     /gene_synonym="LGMD2K; LGMDR11; MDDGA1; MDDGB1; MDDGC1;
                     RT"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2011
                     /gene="POMT1"
                     /gene_synonym="LGMD2K; LGMDR11; MDDGA1; MDDGB1; MDDGC1;
                     RT"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2189
                     /gene="POMT1"
                     /gene_synonym="LGMD2K; LGMDR11; MDDGA1; MDDGB1; MDDGC1;
                     RT"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..3057
                     /gene="POMT1"
                     /gene_synonym="LGMD2K; LGMDR11; MDDGA1; MDDGB1; MDDGC1;
                     RT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3036..3041
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POMT1"
                     /gene_synonym="LGMD2K; LGMDR11; MDDGA1; MDDGB1; MDDGC1;
                     RT"
                     /note="hexamer: ATTAAA"
     polyA_site      3057
                     /gene="POMT1"
                     /gene_synonym="LGMD2K; LGMDR11; MDDGA1; MDDGB1; MDDGC1;
                     RT"
                     /note="major polyA site"
ORIGIN      
        1 gtctggcccc gcaggctcgg tgaatcgaac gttgagcagg gcggtgggtg gtgcggagtg
       61 ccgagcggcc tcacccccaa ccgtcggccc agtcggacgg ttccgaggcg ttgccgggag
      121 ccgggcgcgg ctctgtgtgg actcggagaa acgcggggcg tctgcctgag cccgcttttc
      181 tacaagatgt ggggattttt gaagcgccct gtagtggtga cggctgacat caacttgagc
      241 cttgtggccc tgactgggat ggggttactg agccggctgt ggcgactcac ctacccgcgg
      301 gctgtggttt ttgacgaagt atattatggg cagtacatct ctttttacat gaaacaaatc
      361 ttcttcttgg atgacagtgg gccgccattt ggccacatgg tgctggcctt gggaggttat
      421 ttaggaggat tcgatggcaa ttttttgtgg aacagaattg gagcagaata cagtagcaac
      481 gtgcctgtgt ggtccctgcg cctgctgcca gcactcgcgg gggccttgtc ggtccccatg
      541 gcctaccaga tagtgttgga gctccacttt tctcattgtg ccgccatggg agctgctctg
      601 ttgatgctta tcgagaatgc tctcatcact cagtcaaggc taatgctttt ggaatcagtg
      661 ttaatatttt tcaatctatt ggccgtgttg tcctacctga agttcttcaa ctgccaaaag
      721 cacagccctt tttctctgag ctggtggttc tggctaacac tgacaggggt cgcttgttcc
      781 tgtgcagtgg gcatcaagta catgggtgtg ttcacgtacg tgctcgtgct gggtgttgca
      841 gctgtccatg cctggcacct gcttggagac cagactttgt ccaatgtctg tgtgttctgt
      901 cacttgctcg cccgagcagt ggctttgctg gtcatcccgg tcgtcctgta cttactgttc
      961 ttctacgtcc acttgattct agtcttccgc tctgggcccc acgaccaaat catgtccagt
     1021 gccttccagg ccagcttaga gggaggacta gctcggatca ctcagggtca gccactggag
     1081 gtggcctttg ggtcccaggt cactctgagg aacgtctttg ggaaacctgt gccctgctgg
     1141 cttcattccc accaggacac ctaccccatg atatatgaga acggccgagg cagctcccac
     1201 cagcaacagg tgacctgtta ccccttcaaa gatgtcaata actggtggat tgtaaaggat
     1261 cccaggaggc accagctggt ggtgagcagc cctccgagac ctgtgaggca cggggacatg
     1321 gtgcagctgg tccacggcat gaccacccgc tccctgaaca cgcatgatgt tgcagccccc
     1381 ctgagccccc attcacagga ggtctcctgc tacattgact ataacatctc catgcccgcc
     1441 cagaacctct ggagactgga aattgtgaac agaggatctg acacagacgt ctggaagacc
     1501 atcctctcag aggtccgctt tgtgcacgtg aacacttccg ctgtcttaaa gctgagcggg
     1561 gctcacctcc ctgactgggg gtatcggcaa ctggagatcg tcggggagaa gctgtcccgg
     1621 ggctaccacg ggagcacggt gtggaacgtg gaggagcacc gatacggcgc gagccaggag
     1681 cagagggagc gggaacggga gctgcactca cctgcgcagg tggacgtcag caggaacctc
     1741 agcttcatgg cgagattctc ggagctgcag tggaggatgc tggcgctgag aagtgatgac
     1801 tcggaacaca agtacagctc cagcccactg gagtgggtca ccctggacac caatattgcc
     1861 tactggctgc accccaggac cagcgctcag atccacctac ttggaaacat agtgatctgg
     1921 gtttcgggca gcctcgctct ggccatctac gccctgctgt ccttgtggta cctgctccga
     1981 cggcgaagaa atgtccatga cctccctcag gatgcctggc tgcgctgggt gctggctggg
     2041 gcgctgtgtg ccggtggctg ggcagtgaac tacctcccgt tcttcctgat ggagaagaca
     2101 ctcttcctct accactacct gcccgcactc accttccaaa tccttctgct ccctgtggtc
     2161 ctgcagcaca tcagcgacca cctgtgcagg tcccagctcc agaggagcat cttcagcgcc
     2221 ctggtggtgg cctggtactc ctccgcgtgc cacgtgtcca acacgctgcg cccactcacc
     2281 tacggggaca agtcactctc gccacatgaa ctcaaggccc ttcgctggaa agacagctgg
     2341 gacatcttga tccgaaaaca ctagaacaag agtgtggcaa agaacacccg tgctggggtc
     2401 gggatgaggt tgaagggtct tggtcaatgt acgtaatgag cagggtgggc cccacgctgg
     2461 gaggacacgg gctgggctga gcagggcctc tagtggaaca catgggggtc tcattgaaaa
     2521 gctctctgat gagcacctcc ttttgtgcaa agttaatttt ttctcgacaa taaagatatt
     2581 ccgtgtcttt acccctgaac taagacacag ggagtatttc agaggccagc gtaggagtca
     2641 ttgacaacaa aaagccgaga acccagggcc agcagtggag cctcagcaga ccagggcctg
     2701 gtccttgcta actgctgcag ggtggagttt gatctggcag acccgatcct ccttcatgaa
     2761 cacccagcaa cctgagcaag tcccggccct gccctcagcg agcccggcag gcgtcctggg
     2821 acagctcagt gttggagggc cacctgaacc acgagccagg gctggggctt gcatgtcatt
     2881 gtctatgaca gcgtcaagac tggcccttgg caccgtgctg tgtggaaacc ctcccctctg
     2941 agactccact gagacgtggc tgagtgaaat cttcctcgtc agtggtcaag gtgtgtcatc
     3001 catacagctc catgcctttg tcttttttaa atgtaattaa aaaaggaacc aactggc
//
