LOCUS       NM_033482               3897 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens POM121 transmembrane nucleoporin like 2 (POM121L2),
            mRNA.
ACCESSION   NM_033482 XM_001715475 XM_001717703 XM_001718816
VERSION     NM_033482.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3897)
  AUTHORS   Aberg,K.A., Liu,Y., Bukszar,J., McClay,J.L., Khachane,A.N.,
            Andreassen,O.A., Blackwood,D., Corvin,A., Djurovic,S., Gurling,H.,
            Ophoff,R., Pato,C.N., Pato,M.T., Riley,B., Webb,T., Kendler,K.,
            O'Donovan,M., Craddock,N., Kirov,G., Owen,M., Rujescu,D., St
            Clair,D., Werge,T., Hultman,C.M., Delisi,L.E., Sullivan,P. and van
            den Oord,E.J.
  TITLE     A comprehensive family-based replication study of schizophrenia
            genes
  JOURNAL   JAMA Psychiatry 70 (6), 573-581 (2013)
   PUBMED   23894747
REFERENCE   2  (bases 1 to 3897)
  AUTHORS   Shi,J., Levinson,D.F., Duan,J., Sanders,A.R., Zheng,Y., Pe'er,I.,
            Dudbridge,F., Holmans,P.A., Whittemore,A.S., Mowry,B.J., Olincy,A.,
            Amin,F., Cloninger,C.R., Silverman,J.M., Buccola,N.G.,
            Byerley,W.F., Black,D.W., Crowe,R.R., Oksenberg,J.R., Mirel,D.B.,
            Kendler,K.S., Freedman,R. and Gejman,P.V.
  TITLE     Common variants on chromosome 6p22.1 are associated with
            schizophrenia
  JOURNAL   Nature 460 (7256), 753-757 (2009)
   PUBMED   19571809
  REMARK    GeneRIF: Observational study, meta-analysis, and genome-wide
            association study of gene-disease association. (HuGE Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL021808.2.
            
            On Nov 19, 2020 this sequence version replaced NM_033482.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on partial human and orthologous transcript
            alignments.
            
            CCDS Note: This CCDS representation lacks full-length human
            transcript support and it is therefore inferred, but it is
            supported by several partial human transcripts including
            CR748811.1, HY022779.1, HY202236.1 and HY206240.1.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000444565.2/ ENSP00000392726.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3897              AL021808.2         93605-97501         c
FEATURES             Location/Qualifiers
     source          1..3897
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..3897
                     /gene="POM121L2"
                     /gene_synonym="POM121-L; POM121L"
                     /note="POM121 transmembrane nucleoporin like 2"
                     /db_xref="GeneID:94026"
                     /db_xref="HGNC:HGNC:13973"
     exon            1..3897
                     /gene="POM121L2"
                     /gene_synonym="POM121-L; POM121L"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..3211
                     /gene="POM121L2"
                     /gene_synonym="POM121-L; POM121L"
                     /note="OM121 membrane glycoprotein (rat homolog)-like 2;
                     POM121 membrane glycoprotein (rat homolog)-like 2; POM121
                     membrane glycoprotein-like 2"
                     /codon_start=1
                     /product="POM121-like protein 2"
                     /protein_id="NP_258443.2"
                     /db_xref="CCDS:CCDS59497.1"
                     /db_xref="GeneID:94026"
                     /db_xref="HGNC:HGNC:13973"
                     /translation="MGSFLSKLELSPSSPAQVRTDLPERPTKRRPPQPLHQVHRVQFV
                     HRAHPAPRYRPVRRRPNLDPANPTTWLANEAWRRFPMKKSQNSPLGPLPSDWWESYLK
                     RTIWSLRHPRPIWSPVTIRITPPDQRVPPSTSPEDVIALAGLPPSEELADPCSKETVL
                     RALRECRKGKGRLEEPLFPESLDSKRRSPETRPSAFKPLMKNGTLTSFVPRPGPLKRS
                     LHSWGSDHSLTKRPNCSSMSSLASIYRGGTLSSKRNAIGSSYSSCRNFSDPWKRSVPS
                     VSFETPEWPIKKEKSCHRPSSPVPLVSDFESLGGSESSGQQNQKIPQLPSSPENLVSE
                     IPPPQLGYAVSDENLTLGKKAELQVSNNAGEDTTEVNTDPFPETWLAIQPSLSLALPS
                     SETDLTQGANPQLENLRKMQKSLGPLASPQSTGEATSVAHSPLKTPSLPTPPGCSQSE
                     LLPGTSPDSKPTATFILLTPTSPTLPVTDTTWPPSTSQADRSPMPPDPPAPPTIQSTL
                     LGMVSSPTSHLSASAPPDATSAHLMLKPILGPLHNSEIGSSSYSRISVTAAASSISSL
                     STIQGTLTPTFKPIFGSIDPLKTTPMIAPFSSKQTPPPFTHASTHHFHGLVKATSVVM
                     STTLASTSKDSVFKPPLDFGVVNVTSAVGNTYSVPSTCDTFLLGTAQAFRADFTPATG
                     FIFPPHHHPTIPTVHTVTMFTQVLSSVVQISPRSSTANFRGMGSPLPASALVSTNWLA
                     STPSISNLTPAITSPLGSSSRPPFPLSQGANPQPAFGATNGQKQGPSQPALMPSVSSS
                     FLFGSSAVALPTPMPTPAQPAFISTTQSALGCLTPSASTSQTPASTWSGIGGIPAGFP
                     ISQASTTGFRIVIQTHQSGAFGSVFGSRAPQPFTFGGFVTPMDCDESGIIMTGPDMSP
                     TSGAFSIGALPSGTTNTMIPFGKGWSQNTEGLPSHRTAFSLGRGSISARKTMAPIAQN
                     TPVPGQAKAGSSVGFGMPFPPAQGSVGRGPFRSSASSFSIGAKSKTPKNREKGHSRRH
                     HAYKK"
     regulatory      3764..3769
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POM121L2"
                     /gene_synonym="POM121-L; POM121L"
                     /note="hexamer: ATTAAA"
     polyA_site      3787
                     /gene="POM121L2"
                     /gene_synonym="POM121-L; POM121L"
                     /note="major polyA site"
     regulatory      3869..3874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POM121L2"
                     /gene_synonym="POM121-L; POM121L"
                     /note="hexamer: AATAAA"
     polyA_site      3897
                     /gene="POM121L2"
                     /gene_synonym="POM121-L; POM121L"
                     /note="major polyA site"
ORIGIN      
        1 aaccgaacac tgcgctcttc gactctgtcc gattctgcag acgtccgaaa cctcggaagc
       61 caaaaccgtg cttgaactca ctgcccgcgc ctcatctctc ctcatgggca gtttcctgag
      121 caaactggaa ctttcgccct cgtccccagc ccaggtgcgc accgacttgc ccgagaggcc
      181 cacgaaacgc cggccacctc agccccttca ccaagttcat cgggttcagt tcgtccaccg
      241 cgcccaccct gccccacggt atagacctgt gaggaggcgg ccaaacctgg atcctgccaa
      301 tccaaccacg tggctggcca acgaggcctg gaggcgcttt cccatgaaga agtcccagaa
      361 ttcccccctg gggcctctcc cttcagactg gtgggaaagt tacttaaagc ggactatttg
      421 gtctcttcga catcccaggc caatttggag cccagtgacc atcaggatca ctcctcctga
      481 ccagagagtg cccccttcca cttctcctga agatgtaatt gcccttgcag gactcccgcc
      541 ctctgaggag ctcgcagatc catgttcaaa ggagacagtg ttgagggccc tcagagagtg
      601 cagaaaaggg aaagggaggt tggaagaacc actattccct gagagtctgg acagtaagag
      661 aaggagtcca gagaccagac catcggcatt taagcccctg atgaaaaatg gaaccctcac
      721 ttcttttgtg cccaggcctg ggccgctgaa gagaagtctc cactcctggg gctcagatca
      781 cagcttgact aagaggccca attgctcctc catgagctcc ttggccagca tatacagagg
      841 tggcaccctc agctccaaaa ggaatgctat tggcagctct tacagctctt gcagaaattt
      901 ctcagaccct tggaagagaa gtgttcccag tgtatcattc gagacaccag agtggccaat
      961 aaaaaaggaa aaaagttgtc atcggccttc ctctccagtc ccactggtat cagattttga
     1021 gtccctagga ggatctgaaa gttctgggca gcaaaaccag aagattccac agctgccgtc
     1081 tagccctgag aacctggtgt cagagatccc acctccccag cttggttatg cagtctctga
     1141 tgagaacttg actttgggga agaaagctga gctacaggta agcaacaacg caggagaaga
     1201 tacaactgag gtcaacacag accctttccc tgagacttgg cttgctattc agccttcctt
     1261 gtctcttgct ctgccttctt cagaaacaga tctaacccag ggagcaaatc ctcagttgga
     1321 aaacttaaga aaaatgcaga agtctctagg tccactggcc tctccacagt ccacgggaga
     1381 ggcaaccagt gtggcccatt ctcctttgaa gacacccagc ctaccgaccc cacctgggtg
     1441 ctcacagtca gagctccttc caggcacctc tccagactca aagcccacag ctactttcat
     1501 cctgctgacc cccacctctc ccacattacc agttactgac accacctggc cgccttcaac
     1561 ctctcaggct gacaggtctc ccatgccccc agacccacct gcaccaccca ccatccaaag
     1621 tactttgctt ggaatggtga gtagcccaac atcccatctt tctgcatctg cacctcctga
     1681 tgcaacttct gctcacctca tgttaaaacc gattttgggg cccctgcaca acagcgagat
     1741 tggaagctcc tcatattcca gaatttcagt cacagctgca gcatcttcaa tctcttccct
     1801 ttccacaatt cagggtacct taactcctac cttcaagcct atctttggca gcatagatcc
     1861 acttaaaact acgcccatga tagctccttt ctcctccaag cagacccctc ctccatttac
     1921 tcatgcttct acccatcatt tccatggcct ggtcaaggcc acctctgtgg tcatgtccac
     1981 caccctagcc agcacatcta aagactctgt ttttaagcca cctttggatt ttggtgtagt
     2041 gaatgtcacc agtgccgtag gcaacactta ttctgtccct tccacttgcg acactttcct
     2101 gcttgggact gctcaggcct tcagggccga cttcacccca gccacaggat tcattttccc
     2161 accacaccac catcctacaa ttcctactgt gcatacagtc accatgttta cccaggtcct
     2221 ttccagtgtt gtacagatat cccctagaag cagcactgct aatttcaggg gtatgggcag
     2281 ccctctgcct gcctctgccc tagtatccac aaactggctt gcatcaaccc ccagcatctc
     2341 caacctgact ccagcaatca caagtccctt gggatcaagc tcaaggccac ctttcccact
     2401 atcccaagga gctaatcccc agcctgcatt tggtgccaca aatggacaga aacaagggcc
     2461 ttcccagcca gcccttatgc caagtgtcag tagttctttt ctttttggga gctcagcagt
     2521 ggcattgcca acccccatgc caactccagc tcagccagcc ttcattagta ccacacagtc
     2581 agccttgggg tgtttgacac cctcagcctc cacctctcaa acccctgcca gcacctggtc
     2641 aggcattggc ggcattccag caggttttcc cattagtcaa gctagtacaa ctgggtttag
     2701 aattgtaatt cagacccacc aaagtggggc ttttggctca gtgtttggca gcagagctcc
     2761 acaacctttc acttttgggg gattcgtgac ccctatggac tgtgatgagt ctgggatcat
     2821 aatgactggt ccagacatga gccccacctc tggagctttc agcattggag cattgcctag
     2881 tgggaccact aacaccatga tcccctttgg aaaaggctgg agccagaaca ctgaaggcct
     2941 gcccagccac cgcacagctt tttccttggg gagaggcagc atttctgcaa gaaagactat
     3001 ggcccccatt gctcaaaaca ccccagtccc tggacaagct aaggcaggca gcagtgttgg
     3061 ctttgggatg ccttttccac ctgcccaggg ctctgttggg agaggacctt ttagatcatc
     3121 agcctcttca ttttccattg gcgcaaaatc aaaaacccca aagaatcggg agaaagggca
     3181 ttcccgaagg catcatgcct acaagaagta gcctgtgttc cctgtcactt gcaccctgat
     3241 ttagacctca gtattgtttt tgaaaaacct cagtgtcttc caattttcta aagtaaacat
     3301 actccagatc taaaactgga gctttagatg ttcacactgt gtgtcctaat ctacatcctt
     3361 gacgaaagtg aaggactaaa ccatctagtg ctgattgcag attgaggcca ggtggaacca
     3421 aacccattgg acttgaacag aacctcgcct tccccttcct gtccactctt ctctgtgtca
     3481 ggtgtgcagt gtgcacagca gcaggatcta taatatccag actttccaaa taagttgaat
     3541 gtctatcaat tagaacatct tttcgtacat cctgccatcc ctactgctgg taaacactaa
     3601 catgttctct gttactcact ataggttgtc ttttagagag tgtcacttaa atggaatcaa
     3661 acagtatgta acctttggag actggcttcc ttcactcagc ataatgccac tgagatttat
     3721 ccaagttgtt acttatatca ataatttatt tcttttattg ctgattaaaa atccattttt
     3781 aattgtgttc agttgtatga gtataccaca gttcatttat ccattcacct gttgaagaac
     3841 atttatttcc atttttttct caaaaataaa taaagtcacc agaaacattc atgttca
//
