LOCUS       NM_005035               3771 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens RNA polymerase mitochondrial (POLRMT), transcript
            variant 5, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_005035
VERSION     NM_005035.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3771)
  AUTHORS   Yan,W., Xie,C., Sun,S., Zheng,Q., Wang,J., Wang,Z., Man,C.H.,
            Wang,H., Yang,Y., Wang,T., Shi,L., Zhang,S., Huang,C., Xu,S. and
            Wang,Y.P.
  TITLE     SUCLG1 restricts POLRMT succinylation to enhance mitochondrial
            biogenesis and leukemia progression
  JOURNAL   EMBO J 43 (12), 2337-2367 (2024)
   PUBMED   38649537
  REMARK    GeneRIF: SUCLG1 restricts POLRMT succinylation to enhance
            mitochondrial biogenesis and leukemia progression.
REFERENCE   2  (bases 1 to 3771)
  AUTHORS   Liu,Y., Chen,Z., Wang,Z.H., Delaney,K.M., Tang,J., Pirooznia,M.,
            Lee,D.Y., Tunc,I., Li,Y. and Xu,H.
  TITLE     The PPR domain of mitochondrial RNA polymerase is an
            exoribonuclease required for mtDNA replication in Drosophila
            melanogaster
  JOURNAL   Nat Cell Biol 24 (5), 757-765 (2022)
   PUBMED   35449456
REFERENCE   3  (bases 1 to 3771)
  AUTHORS   Inatomi,T., Matsuda,S., Ishiuchi,T., Do,Y., Nakayama,M., Abe,S.,
            Kasho,K., Wanrooij,S., Nakada,K., Ichiyanagi,K., Sasaki,H.,
            Yasukawa,T. and Kang,D.
  TITLE     TFB2M and POLRMT are essential for mammalian mitochondrial DNA
            replication
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1869 (1), 119167 (2022)
   PUBMED   34744028
  REMARK    GeneRIF: TFB2M and POLRMT are essential for mammalian mitochondrial
            DNA replication.
REFERENCE   4  (bases 1 to 3771)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   5  (bases 1 to 3771)
  AUTHORS   Zhou,T., Sang,Y.H., Cai,S., Xu,C. and Shi,M.H.
  TITLE     The requirement of mitochondrial RNA polymerase for non-small cell
            lung cancer cell growth
  JOURNAL   Cell Death Dis 12 (8), 751 (2021)
   PUBMED   34326320
  REMARK    GeneRIF: The requirement of mitochondrial RNA polymerase for
            non-small cell lung cancer cell growth.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3771)
  AUTHORS   Gaspari,M., Falkenberg,M., Larsson,N.G. and Gustafsson,C.M.
  TITLE     The mitochondrial RNA polymerase contributes critically to promoter
            specificity in mammalian cells
  JOURNAL   EMBO J 23 (23), 4606-4614 (2004)
   PUBMED   15526033
  REMARK    GeneRIF: POLRMT recognizes promoter elements in a sequence specific
            manner; TFAM induces a structural change of the promoter that is
            required for POLRMT-dependent promoter recognition
REFERENCE   7  (bases 1 to 3771)
  AUTHORS   Graziewicz,M.A., Longley,M.J., Bienstock,R.J., Zeviani,M. and
            Copeland,W.C.
  TITLE     Structure-function defects of human mitochondrial DNA polymerase in
            autosomal dominant progressive external ophthalmoplegia
  JOURNAL   Nat Struct Mol Biol 11 (8), 770-776 (2004)
   PUBMED   15258572
  REMARK    GeneRIF: human mitochondrial DNA polymerase has a role in autosomal
            dominant progressive external ophthalmoplegia
REFERENCE   8  (bases 1 to 3771)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   9  (bases 1 to 3771)
  AUTHORS   Falkenberg,M., Gaspari,M., Rantanen,A., Trifunovic,A., Larsson,N.G.
            and Gustafsson,C.M.
  TITLE     Mitochondrial transcription factors B1 and B2 activate
            transcription of human mtDNA
  JOURNAL   Nat Genet 31 (3), 289-294 (2002)
   PUBMED   12068295
REFERENCE   10 (bases 1 to 3771)
  AUTHORS   Tiranti,V., Savoia,A., Forti,F., D'Apolito,M.F., Centra,M.,
            Rocchi,M. and Zeviani,M.
  TITLE     Identification of the gene encoding the human mitochondrial RNA
            polymerase (h-mtRPOL) by cyberscreening of the Expressed Sequence
            Tags database
  JOURNAL   Hum Mol Genet 6 (4), 615-625 (1997)
   PUBMED   9097968
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC070057.1, BC030829.1,
            BC098387.1 and AC004449.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_005035.3.
            
            Summary: This gene encodes a mitochondrial DNA-directed RNA
            polymerase. The gene product is responsible for mitochondrial gene
            expression as well as for providing RNA primers for initiation of
            replication of the mitochondrial genome. Although this polypeptide
            has the same function as the three nuclear DNA-directed RNA
            polymerases, it is more closely related to RNA polymerases of phage
            and mitochondrial polymerases of lower eukaryotes. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098387.1, U75370.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000588649.7/
                                                  ENSP00000465759.2
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3089              BC070057.1         32-3120
            3090-3432           BC030829.1         3073-3415
            3433-3769           BC098387.1         3445-3781
            3770-3771           AC004449.1         6285-6286           c
FEATURES             Location/Qualifiers
     source          1..3771
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..3771
                     /gene="POLRMT"
                     /gene_synonym="APOLMT; COXPD55; h-mtRPOL; MTRNAP; MTRPOL"
                     /note="RNA polymerase mitochondrial"
                     /db_xref="GeneID:5442"
                     /db_xref="HGNC:HGNC:9200"
                     /db_xref="MIM:601778"
     exon            1..113
                     /gene="POLRMT"
                     /gene_synonym="APOLMT; COXPD55; h-mtRPOL; MTRNAP; MTRPOL"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..3718
                     /gene="POLRMT"
                     /gene_synonym="APOLMT; COXPD55; h-mtRPOL; MTRNAP; MTRPOL"
                     /EC_number="2.7.7.6"
                     /note="isoform 5 precursor is encoded by transcript
                     variant 5; polymerase (RNA) mitochondrial (DNA directed)"
                     /codon_start=1
                     /product="DNA-directed RNA polymerase, mitochondrial
                     isoform 5 precursor"
                     /protein_id="NP_005026.3"
                     /db_xref="CCDS:CCDS12036.1"
                     /db_xref="GeneID:5442"
                     /db_xref="HGNC:HGNC:9200"
                     /db_xref="MIM:601778"
                     /translation="MSALCWGRGAAGLKRALRPCGRPGLPGKEGTAGGVCGPRRSSSA
                     SPQEQDQDRRKDWGHVELLEVLQARVRQLQAESVSEVVVNRVDVARLPECGSGDGSLQ
                     PPRKVQMGAKDATPVPCGRWAKILEKDKRTQQMRMQRLKAKLQMPFQSGEFKALTRRL
                     QVEPRLLSKQMAGCLEDCTRQAPESPWEEQLARLLQEAPGKLSLDVEQAPSGQHSQAQ
                     LSGQQQRLLAFFKCCLLTDQLPLAHHLLVVHHGQRQKRKLLTLDMYNAVMLGWARQGA
                     FKELVYVLFMVKDAGLTPDLLSYAAALQCMGRQDQDAGTIERCLEQMSQEGLKLQALF
                     TAVLLSEEDRATVLKAVHKVKPTFSLPPQLPPPVNTSKLLRDVYAKDGRVSYPKLHLP
                     LKTLQCLFEKQLHMELASRVCVVSVEKPTLPSKEVKHARKTLKTLRDQWEKALCRALR
                     ETKNRLEREVYEGRFSLYPFLCLLDEREVVRMLLQVLQALPAQGESFTTLARELSART
                     FSRHVVQRQRVSGQVQALQNHYRKYLCLLASDAEVPEPCLPRQYWEELGAPEALREQP
                     WPLPVQMELGKLLAEMLVQATQMPCSLDKPHRSSRLVPVLYHVYSFRNVQQIGILKPH
                     PAYVQLLEKAAEPTLTFEAVDVPMLCPPLPWTSPHSGAFLLSPTKLMRTVEGATQHQE
                     LLETCPPTALHGALDALTQLGNCAWRVNGRVLDLVLQLFQAKGCPQLGVPAPPSEAPQ
                     PPEAHLPHSAAPARKAELRRELAHCQKVAREMHSLRAEALYRLSLAQHLRDRVFWLPH
                     NMDFRGRTYPCPPHFNHLGSDVARALLEFAQGRPLGPHGLDWLKIHLVNLTGLKKREP
                     LRKRLAFAEEVMDDILDSADQPLTGRKWWMGAEEPWQTLACCMEVANAVRASDPAAYV
                     SHLPVHQDGSCNGLQHYAALGRDSVGAASVNLEPSDVPQDVYSGVAAQVEVFRRQDAQ
                     RGMRVAQVLEGFITRKVVKQTVMTVVYGVTRYGGRLQIEKRLRELSDFPQEFVWEASH
                     YLVRQVFKSLQEMFSGTRAIQHWLTESARLISHMGSVVEWVTPLGVPVIQPYRLDSKV
                     KQIGGGIQSITYTHNGDISRKPNTRKQKNGFPPNFIHSLDSSHMMLTALHCYRKGLTF
                     VSVHDCYWTHAADVSVMNQVCREQFVRLHSEPILQDLSRFLVKRFCSEPQKILEASQL
                     KETLQAVPKPGAFDLEQVKRSTYFFS"
     exon            114..218
                     /gene="POLRMT"
                     /gene_synonym="APOLMT; COXPD55; h-mtRPOL; MTRNAP; MTRPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            219..847
                     /gene="POLRMT"
                     /gene_synonym="APOLMT; COXPD55; h-mtRPOL; MTRNAP; MTRPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            848..978
                     /gene="POLRMT"
                     /gene_synonym="APOLMT; COXPD55; h-mtRPOL; MTRNAP; MTRPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1165
                     /gene="POLRMT"
                     /gene_synonym="APOLMT; COXPD55; h-mtRPOL; MTRNAP; MTRPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1315
                     /gene="POLRMT"
                     /gene_synonym="APOLMT; COXPD55; h-mtRPOL; MTRNAP; MTRPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1480
                     /gene="POLRMT"
                     /gene_synonym="APOLMT; COXPD55; h-mtRPOL; MTRNAP; MTRPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1651
                     /gene="POLRMT"
                     /gene_synonym="APOLMT; COXPD55; h-mtRPOL; MTRNAP; MTRPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1876
                     /gene="POLRMT"
                     /gene_synonym="APOLMT; COXPD55; h-mtRPOL; MTRNAP; MTRPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..2665
                     /gene="POLRMT"
                     /gene_synonym="APOLMT; COXPD55; h-mtRPOL; MTRNAP; MTRPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            2666..2788
                     /gene="POLRMT"
                     /gene_synonym="APOLMT; COXPD55; h-mtRPOL; MTRNAP; MTRPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..2911
                     /gene="POLRMT"
                     /gene_synonym="APOLMT; COXPD55; h-mtRPOL; MTRNAP; MTRPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..3091
                     /gene="POLRMT"
                     /gene_synonym="APOLMT; COXPD55; h-mtRPOL; MTRNAP; MTRPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            3092..3178
                     /gene="POLRMT"
                     /gene_synonym="APOLMT; COXPD55; h-mtRPOL; MTRNAP; MTRPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            3179..3292
                     /gene="POLRMT"
                     /gene_synonym="APOLMT; COXPD55; h-mtRPOL; MTRNAP; MTRPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            3293..3348
                     /gene="POLRMT"
                     /gene_synonym="APOLMT; COXPD55; h-mtRPOL; MTRNAP; MTRPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            3349..3447
                     /gene="POLRMT"
                     /gene_synonym="APOLMT; COXPD55; h-mtRPOL; MTRNAP; MTRPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            3448..3520
                     /gene="POLRMT"
                     /gene_synonym="APOLMT; COXPD55; h-mtRPOL; MTRNAP; MTRPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            3521..3606
                     /gene="POLRMT"
                     /gene_synonym="APOLMT; COXPD55; h-mtRPOL; MTRNAP; MTRPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            3607..3668
                     /gene="POLRMT"
                     /gene_synonym="APOLMT; COXPD55; h-mtRPOL; MTRNAP; MTRPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            3669..3771
                     /gene="POLRMT"
                     /gene_synonym="APOLMT; COXPD55; h-mtRPOL; MTRNAP; MTRPOL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3745..3750
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POLRMT"
                     /gene_synonym="APOLMT; COXPD55; h-mtRPOL; MTRNAP; MTRPOL"
                     /note="hexamer: AATAAA"
     polyA_site      3771
                     /gene="POLRMT"
                     /gene_synonym="APOLMT; COXPD55; h-mtRPOL; MTRNAP; MTRPOL"
                     /note="major polyA site"
ORIGIN      
        1 ggggtggcct ggagcggcgt gcgtaatgtc ggcactttgc tggggccgcg gagcggcggg
       61 gctcaaacga gccctacggc cttgcggccg cccgggactc cccggcaaag aagggaccgc
      121 cggtggcgtc tgcggcccca ggaggagctc gtccgccagc ccccaggagc aagaccaaga
      181 ccgcaggaag gactggggcc acgtggagct gctggaggtg ctccaggcgc gggtgcggca
      241 gctgcaggct gagagcgtgt cggaggtggt ggtgaacagg gtggatgtgg cgcggctccc
      301 agaatgtggc agtggagatg gtagcctcca gccacccagg aaggtccaga tgggggccaa
      361 ggatgccacc ccggtgccct gtggccgctg ggcaaagata ctggagaagg ataagcggac
      421 ccagcagatg cgtatgcagc ggttgaaggc gaagctgcag atgccattcc agagcgggga
      481 gttcaaggcg ctgaccaggc gcctgcaggt ggagccccgg ctcctgagca agcagatggc
      541 cgggtgcctg gaggactgca cgcgccaggc ccccgagagc ccctgggagg agcagctggc
      601 ccggctgctg caggaggccc ctgggaagct gagcctcgat gtggagcagg ccccgtcggg
      661 gcagcactcg caggcccagc tctcaggtca gcagcagagg ctcctggcct tcttcaagtg
      721 ctgcctgctc actgaccagc tgcccctcgc ccaccacctg ctggtcgtcc accacggcca
      781 gcggcagaag cggaagctgc tcacgctgga catgtacaac gccgtgatgc ttggctgggc
      841 gcggcagggt gccttcaagg agctggtata tgtgttattc atggtgaagg atgccggctt
      901 gactccggac ctgctgtcct atgcggctgc cctccagtgc atggggaggc aggaccagga
      961 cgccgggacc atcgaaaggt gtctggaaca gatgagccag gaggggctga agctgcaggc
     1021 actcttcacc gccgttctgc tgtctgagga ggatcgggcc actgttctga aggccgtgca
     1081 caaggtgaag cccaccttca gcctcccgcc gcagctgccg cccccggtca acacctccaa
     1141 gctgctcagg gacgtgtatg ccaaggatgg gcgtgtgtcc tacccgaagc tgcacctgcc
     1201 cttgaagacc ctgcagtgcc tctttgagaa gcagctccac atggagctgg ccagcagggt
     1261 gtgcgtggtg tccgtggaga agcccacgtt gccaagcaag gaggtcaagc acgcgcggaa
     1321 gaccctgaag accctgcggg accaatggga gaaagcactg tgccgggcgc tgcgggagac
     1381 caagaaccgc ctagagcgcg aggtgtacga gggccggttc tcactttacc ccttcctgtg
     1441 cctgctggac gagcgcgagg tggtgcggat gctcctgcag gtcctgcagg cgctgcccgc
     1501 ccaaggtgag tccttcacca ccctggcccg ggagctgagt gcgcgcactt tcagccggca
     1561 cgtggtgcag aggcagcggg tcagtggcca ggtgcaggcg ctgcagaacc actacaggaa
     1621 gtacctctgc ttgctggcct ccgacgccga ggtgcccgag ccctgcctgc cgcggcagta
     1681 ctgggaggag ctgggggcgc ccgaggccct gcgggagcag ccctggcccc tgccagtgca
     1741 gatggagctg ggcaagctgc tggcggagat gctggtgcag gctacgcaga tgccatgcag
     1801 cctggacaag ccgcatcgtt cctctcggct tgtccccgtg ctctaccacg tgtattcctt
     1861 ccgcaacgtc cagcagatcg gcatcctgaa gccgcacccg gcctacgtgc agctgctgga
     1921 gaaggccgcg gagcccacgc tgaccttcga ggcggtggat gtacccatgc tttgcccccc
     1981 gctgccctgg acatcgccgc actctggtgc tttcctgctc agccccacca agctgatgcg
     2041 cacggtggaa ggcgccacgc agcaccagga gctgctggaa acctgcccgc ccaccgcgct
     2101 gcatggcgca ctggacgccc tcacccaact gggcaactgc gcctggcgcg tcaacgggcg
     2161 cgtgctggac ctggtgctgc agctcttcca ggccaagggc tgcccccagc taggcgtgcc
     2221 ggccccgccc tccgaggcgc cccagccgcc cgaggcccac ctgccgcaca gcgccgcgcc
     2281 cgcccgcaag gccgagctgc gccgtgagct ggcgcactgc cagaaggtgg cccgggagat
     2341 gcacagcctg cgggcggagg cgctgtaccg cctctcgctg gcgcagcacc tgcgggaccg
     2401 cgtcttctgg ctgccgcaca acatggactt ccgcggccgc acctacccct gcccgccgca
     2461 cttcaaccac ctgggcagcg acgtggcgcg ggccctgctg gagttcgccc agggccgccc
     2521 gctcggcccg cacggcctgg attggctcaa gatccacctg gtcaatctca cggggttgaa
     2581 gaagcgggag ccgctgcgga agcgcctggc ctttgcggag gaggtgatgg atgacatcct
     2641 ggactccgcg gaccaaccct tgacgggccg aaagtggtgg atgggcgcgg aggaaccctg
     2701 gcagacgctg gcctgctgta tggaggtggc gaacgctgtg cgcgcctccg accctgccgc
     2761 ctatgtctcc cacctccccg tccatcagga cggctcttgc aacggcctgc agcattatgc
     2821 tgctctgggc cgcgacagcg tgggcgccgc ctccgtcaac ctggagccct cggatgtgcc
     2881 gcaggacgtg tacagcggcg tggccgcgca ggtggaggtg ttccgtaggc aggacgccca
     2941 gcggggcatg cgggtggcac aggtgctgga aggtttcatc acccgcaagg tggtgaagca
     3001 gacggtgatg acggtggtgt acggggtcac gcgctatggc gggcgcctgc agattgagaa
     3061 gcgcctccgg gagctgagcg actttcccca ggagttcgtg tgggaggcct ctcactatct
     3121 cgtacgccag gtcttcaaga gtctacagga gatgttctcg gggacccggg ccatccagca
     3181 ctggctgacc gagagtgccc gcctcatctc ccacatgggc tctgtggtgg agtgggtcac
     3241 acccctgggc gtccccgtca tccagcccta tcgcctggac tccaaggtca agcaaatagg
     3301 aggtggaatt cagagcatca cctacaccca caacggagac atcagccgaa agcccaacac
     3361 acgtaagcag aagaacggct tcccgcccaa cttcatccac tcgctggact cctcccacat
     3421 gatgctcacc gccctgcact gctacaggaa gggcctgacc ttcgtctctg tgcacgactg
     3481 ttactggact cacgcagctg atgtctccgt catgaaccag gtgtgccggg agcagtttgt
     3541 ccgcttgcac agcgagccca tcctgcagga cctgtccaga ttcctggtca agcggttctg
     3601 ctctgagccc cagaagatct tggaggccag ccagctgaag gagacactgc aggcggtgcc
     3661 caagccaggg gccttcgacc tggagcaggt gaagcgttcc acctacttct tcagctgaca
     3721 ccccgtgagc cttgtcagtg tgtaaataaa gctcttttgc cacccccagg a
//
