LOCUS       NM_006467               3290 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens RNA polymerase III subunit G (POLR3G), transcript
            variant 1, mRNA.
ACCESSION   NM_006467
VERSION     NM_006467.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3290)
  AUTHORS   Chen,H., Ma,L., Yang,W., Li,Y. and Ji,Z.
  TITLE     POLR3G promotes EMT via PI3K/AKT signaling pathway in bladder
            cancer
  JOURNAL   FASEB J 37 (12), e23260 (2023)
   PUBMED   37933949
  REMARK    GeneRIF: POLR3G promotes EMT via PI3K/AKT signaling pathway in
            bladder cancer.
REFERENCE   2  (bases 1 to 3290)
  AUTHORS   Van Bortle,K., Marciano,D.P., Liu,Q., Chou,T., Lipchik,A.M.,
            Gollapudi,S., Geller,B.S., Monte,E., Kamakaka,R.T. and Snyder,M.P.
  TITLE     A cancer-associated RNA polymerase III identity drives robust
            transcription and expression of snaR-A noncoding RNA
  JOURNAL   Nat Commun 13 (1), 3007 (2022)
   PUBMED   35637192
  REMARK    GeneRIF: A cancer-associated RNA polymerase III identity drives
            robust transcription and expression of snaR-A noncoding RNA.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3290)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 3290)
  AUTHORS   Hou,H., Li,Y., Wang,M., Liu,A., Yu,Z., Chen,K., Zhao,D. and Xu,Y.
  TITLE     Structural insights into RNA polymerase III-mediated transcription
            termination through trapping poly-deoxythymidine
  JOURNAL   Nat Commun 12 (1), 6135 (2021)
   PUBMED   34675218
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3290)
  AUTHORS   Liu,S., Hua,Y., Wang,J., Li,L., Yuan,J., Zhang,B., Wang,Z., Ji,J.
            and Kong,D.
  TITLE     RNA polymerase III is required for the repair of DNA double-strand
            breaks by homologous recombination
  JOURNAL   Cell 184 (5), 1314-1329 (2021)
   PUBMED   33626331
  REMARK    GeneRIF: RNA polymerase III is required for the repair of DNA
            double-strand breaks by homologous recombination.
REFERENCE   6  (bases 1 to 3290)
  AUTHORS   Ablasser,A., Bauernfeind,F., Hartmann,G., Latz,E., Fitzgerald,K.A.
            and Hornung,V.
  TITLE     RIG-I-dependent sensing of poly(dA:dT) through the induction of an
            RNA polymerase III-transcribed RNA intermediate
  JOURNAL   Nat Immunol 10 (10), 1065-1072 (2009)
   PUBMED   19609254
REFERENCE   7  (bases 1 to 3290)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   8  (bases 1 to 3290)
  AUTHORS   Hu,P., Wu,S., Sun,Y., Yuan,C.C., Kobayashi,R., Myers,M.P. and
            Hernandez,N.
  TITLE     Characterization of human RNA polymerase III identifies orthologues
            for Saccharomyces cerevisiae RNA polymerase III subunits
  JOURNAL   Mol Cell Biol 22 (22), 8044-8055 (2002)
   PUBMED   12391170
REFERENCE   9  (bases 1 to 3290)
  AUTHORS   Wang,Z. and Roeder,R.G.
  TITLE     Three human RNA polymerase III-specific subunits form a subcomplex
            with a selective function in specific transcription initiation
  JOURNAL   Genes Dev 11 (10), 1315-1326 (1997)
   PUBMED   9171375
REFERENCE   10 (bases 1 to 3290)
  AUTHORS   Jang,K.L., Collins,M.K. and Latchman,D.S.
  TITLE     The human immunodeficiency virus tat protein increases the
            transcription of human Alu repeated sequences by increasing the
            activity of the cellular transcription factor TFIIIC
  JOURNAL   J Acquir Immune Defic Syndr (1988) 5 (11), 1142-1147 (1992)
   PUBMED   1403646
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP348952.1, BM788728.1, CD657312.1 and AC027323.5.
            
            On Nov 23, 2018 this sequence version replaced NM_006467.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.35551.1,
                                           SRR1163655.527721.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000651687.1/ ENSP00000498469.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               BP348952.1         1-113
            114-644             BM788728.1         89-619
            645-1185            CD657312.1         206-746
            1186-3285           AC027323.5         104558-106657       c
            3286-3290           AC027323.5         104553-104557       c
FEATURES             Location/Qualifiers
     source          1..3290
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q14.3"
     gene            1..3290
                     /gene="POLR3G"
                     /gene_synonym="C31; RPC32; RPC7"
                     /note="RNA polymerase III subunit G"
                     /db_xref="GeneID:10622"
                     /db_xref="HGNC:HGNC:30075"
                     /db_xref="MIM:617456"
     exon            1..157
                     /gene="POLR3G"
                     /gene_synonym="C31; RPC32; RPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            158..317
                     /gene="POLR3G"
                     /gene_synonym="C31; RPC32; RPC7"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..872
                     /gene="POLR3G"
                     /gene_synonym="C31; RPC32; RPC7"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DNA-directed RNA polymerase III subunit RPC7; polymerase
                     (RNA) III (DNA directed) polypeptide G (32kD); RNA
                     polymerase III subunit C7; DNA-directed RNA polymerase III
                     subunit G; DNA-directed RNA polymerase III 32 kDa
                     polypeptide; RNA polymerase III 32 kDa subunit;
                     RPC32-alpha; polymerase (RNA) III subunit G; RNA
                     polymerase III 32 kDa apha subunit"
                     /codon_start=1
                     /product="DNA-directed RNA polymerase III subunit RPC7
                     isoform 1"
                     /protein_id="NP_006458.2"
                     /db_xref="CCDS:CCDS43337.1"
                     /db_xref="GeneID:10622"
                     /db_xref="HGNC:HGNC:30075"
                     /db_xref="MIM:617456"
                     /translation="MAGNKGRGRAAYTFNIEAVGFSKGEKLPDVVLKPPPLFPDTDYK
                     PVPLKTGEGEEYMLALKQELRETMKRMPYFIETPEERQDIERYSKRYMKVYKEEWIPD
                     WRRLPREMMPRNKCKKAGPKPKKAKDAGKGTPLTNTEDVLKKMEELEKRGDGEKSDEE
                     NEEKEGSKEKSKEGDDDDDDDAAEQEEYDEEEQEEENDYINSYFEDGDDFGADSDDNM
                     DEATY"
     exon            318..447
                     /gene="POLR3G"
                     /gene_synonym="C31; RPC32; RPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            448..504
                     /gene="POLR3G"
                     /gene_synonym="C31; RPC32; RPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            505..555
                     /gene="POLR3G"
                     /gene_synonym="C31; RPC32; RPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            556..638
                     /gene="POLR3G"
                     /gene_synonym="C31; RPC32; RPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            639..785
                     /gene="POLR3G"
                     /gene_synonym="C31; RPC32; RPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            786..3290
                     /gene="POLR3G"
                     /gene_synonym="C31; RPC32; RPC7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3107..3112
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POLR3G"
                     /gene_synonym="C31; RPC32; RPC7"
                     /note="hexamer: ATTAAA"
     polyA_site      3128
                     /gene="POLR3G"
                     /gene_synonym="C31; RPC32; RPC7"
                     /note="major polyA site"
     regulatory      3264..3269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POLR3G"
                     /gene_synonym="C31; RPC32; RPC7"
                     /note="hexamer: AATAAA"
     polyA_site      3290
                     /gene="POLR3G"
                     /gene_synonym="C31; RPC32; RPC7"
ORIGIN      
        1 actccgcggt cctggtgccg cgtgcaggtc ggtgcgcgct tctcccgagg tggaacgggc
       61 ggcagtcaag cgccggcgtt ctctgccgtc accctttcct tgccggccgg cacttcggct
      121 gcagagtttt gcccacgctt cgagacttag ggagcagtgc ctttcagaat ttgcccactc
      181 atctggtata actggttctg atggctggga ataaaggaag aggacgtgct gcttatacct
      241 ttaatattga ggctgttgga tttagcaaag gtgaaaagtt acctgatgta gtgttgaaac
      301 cacccccact atttcctgat acagattata aaccagtgcc actgaaaaca ggagaaggtg
      361 aagaatatat gctggctttg aaacaggagt tgagagaaac aatgaaaaga atgccttatt
      421 ttattgaaac acctgaagaa agacaagata ttgaaaggta tagtaaaaga tacatgaagg
      481 tatacaagga agaatggata ccagattgga gaagacttcc aagagagatg atgccaagaa
      541 ataaatgtaa aaaagcaggc ccaaaaccca aaaaggcaaa agacgcaggc aaaggcacac
      601 cactcactaa tactgaagat gtgttgaaaa aaatggagga attggaaaaa agaggtgatg
      661 gtgaaaaatc agatgaggaa aatgaagaga aagaaggaag caaagagaaa agtaaagaag
      721 gtgatgatga cgatgacgat gatgccgcag aacaggagga atatgatgaa gaagagcaag
      781 aagaggaaaa tgactacatt aattcatact ttgaagatgg agatgatttt ggcgcagaca
      841 gtgatgacaa catggatgag gcaacctatt aggcatgaaa tttttcaaaa aatattttta
      901 tgatgcagct tctgaacatt tggacagact tgatttgtat tttatttctg ataaggaata
      961 agtacttgtt tctgttgttt tggacaaata gttgttacca aaatattcaa aaccactttg
     1021 agtttacata ctagttacct taaaaattat tccctgacac tctgacattc cttctaaaca
     1081 cctctgccat ctctcttatg tactctcatg ggtttttttg tatgatttga atatgaatgt
     1141 gcctaaagaa tttttgctct cttaatctat gtatacatac ttgaacaaat cattcttgct
     1201 taactgctga tcttttgtaa aactattgct agtcataatg gatttctata acctgaaagt
     1261 tgatataata cagcacgtgg agcactttaa aaacaaagaa acttgaaaat aattttattt
     1321 tttaccttta catggtgtgt tctagactac tgcattatga ctacataaac ctacctgagc
     1381 tcttacaagt acagaattgt gagacagagg ttttgtgatg gaaaacatac acatagggaa
     1441 aaataccaaa ctgagcaata taaatttcac agctcacatc ttagccagta caaagaaact
     1501 ttcacatggg gtgaatatta taatacttga atttgagact taatactgta tatgaattaa
     1561 tcatcccact gtaataactg acatcttcaa atagttgggc ttatgaaaaa tttgactaag
     1621 acattttatt ttatacttta tgtaaatgtg aaataagttc tggtcatata aatatgtaga
     1681 atgcatgtgt gtgaactcta tgaagtgaag tgtggtggcc ttttatgttt cagagtactc
     1741 aagtgtacaa ttgatttata taaaaatgca aaatgaactc aggtcatttt gaaattaata
     1801 ttaatatttt tgttgtttaa ctttaaagct agctccccta actttatata ttttttggga
     1861 aaaaatacct aaaaacctca gcctacaaag actctcagaa atgccaaaga ttttcaagga
     1921 aattcatatt atatatttca aaaatgattt atcaatgtta tctaccaaaa gaaataattt
     1981 tatttttccc ctttggggag atattatcct ctaatatgag aatcagatcc ctagattcta
     2041 tttctaccta tactattaaa ctcaaccttg aacctgagct tggttgtttc tgtgccttag
     2101 tttctccact cgtaaacaat ttcctataaa aattgtttaa acaccaacca aaatttacca
     2161 tatgtattca ttctcttgcc ttaaagatca cttcttaact tacatttggc tctcaccctc
     2221 taaaaatttg tagtttggag agtaactgaa agcacaattt taagaaacat gttttcctca
     2281 caaaatatat tgtaatctga ttttcctatc ttgtattcat gcagaaaatt ggagaaaatg
     2341 tgtattgtct tgtgccattc tgcaatatga atttctcagg aaaaagatgt ttcaatggca
     2401 atactttctt aaataattca agatgggtgt gaggacctat cttattagtt tagtgctgtg
     2461 ttaaccattt gtgaattact tcttgtttaa aggaagttgt caaaaaattt taagattcta
     2521 aatggaatac acgaataaag taagccttag aatagaaacc tcacaaaaag ttgtcatttg
     2581 cggttgataa ttaacatagg tgttttattc tctcaactcc ttagtaccag agccaaatac
     2641 aatttagttt tcagaaatct tatcaatatt gttctattta cctacttata aatctgcaga
     2701 taaccacttg aaccaggcaa atacactgaa gataaaggtt atttcttttt ttagctttga
     2761 atttgtcatg accattttag tcttgcagat agcagggcag ccccttgggg caaggattta
     2821 ctctgggagg taccgttaag agccttcttt ccccctttga aagatccttt tacaatgtta
     2881 aagtatacta gttgcaagaa caagcaggat ttgcaggttg ctttaccagc atgagtctca
     2941 tttttctggc ttaaaatctg ggactgtgaa attattccat aggaaagtga atgttatttt
     3001 gcagaattag cctcttacat aaaagtattt gttgaagtgt ctttaaaatt gctatcatga
     3061 gcaaaactgg ttgctgtaat gcttgttttt ctgtatttat ttacacatta aattcttaca
     3121 aaacaaaatg tgttcgtttg ttttatagta agatgtttta ttttgaactt atttaaatgt
     3181 ttatttgtta gagaaaacta atttgttaat atagatctta actagtaact attaagcagg
     3241 gatgtttgtt ccaaatattc ttgaataaac aatcaccaca aacaacaaaa
//
