LOCUS       NM_001722               5336 bp    mRNA    linear   PRI 13-APR-2024
DEFINITION  Homo sapiens RNA polymerase III subunit D (POLR3D), mRNA.
ACCESSION   NM_001722
VERSION     NM_001722.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5336)
  AUTHORS   Hou,H., Li,Y., Wang,M., Liu,A., Yu,Z., Chen,K., Zhao,D. and Xu,Y.
  TITLE     Structural insights into RNA polymerase III-mediated transcription
            termination through trapping poly-deoxythymidine
  JOURNAL   Nat Commun 12 (1), 6135 (2021)
   PUBMED   34675218
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5336)
  AUTHORS   Ramsay,E.P., Abascal-Palacios,G., Daiss,J.L., King,H., Gouge,J.,
            Pilsl,M., Beuron,F., Morris,E., Gunkel,P., Engel,C. and Vannini,A.
  TITLE     Structure of human RNA polymerase III
  JOURNAL   Nat Commun 11 (1), 6409 (2020)
   PUBMED   33335104
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5336)
  AUTHORS   Renaud,M., Praz,V., Vieu,E., Florens,L., Washburn,M.P., l'Hote,P.
            and Hernandez,N.
  TITLE     Gene duplication and neofunctionalization: POLR3G and POLR3GL
  JOURNAL   Genome Res 24 (1), 37-51 (2014)
   PUBMED   24107381
REFERENCE   4  (bases 1 to 5336)
  AUTHORS   Weissglas-Volkov,D., Aguilar-Salinas,C.A., Nikkola,E., Deere,K.A.,
            Cruz-Bautista,I., Arellano-Campos,O., Munoz-Hernandez,L.L.,
            Gomez-Munguia,L., Ordonez-Sanchez,M.L., Reddy,P.M., Lusis,A.J.,
            Matikainen,N., Taskinen,M.R., Riba,L., Cantor,R.M.,
            Sinsheimer,J.S., Tusie-Luna,T. and Pajukanta,P.
  TITLE     Genomic study in Mexicans identifies a new locus for triglycerides
            and refines European lipid loci
  JOURNAL   J Med Genet 50 (5), 298-308 (2013)
   PUBMED   23505323
REFERENCE   5  (bases 1 to 5336)
  AUTHORS   Nikpour,M., Hissaria,P., Byron,J., Sahhar,J., Micallef,M.,
            Paspaliaris,W., Roddy,J., Nash,P., Sturgess,A., Proudman,S. and
            Stevens,W.
  TITLE     Prevalence, correlates and clinical usefulness of antibodies to RNA
            polymerase III in systemic sclerosis: a cross-sectional analysis of
            data from an Australian cohort
  JOURNAL   Arthritis Res Ther 13 (6), R211 (2011)
   PUBMED   22189167
  REMARK    GeneRIF: Studies indicate that aatients with anti-RNAP have an
            increased risk of malignancy within a 5-year timeframe before or
            after onset of systemic sclerosis (SSc) skin changes.
REFERENCE   6  (bases 1 to 5336)
  AUTHORS   Jackson,A.J., Ittmann,M. and Pugh,B.F.
  TITLE     The BN51 protein is a polymerase (Pol)-specific subunit of RNA Pol
            III which reveals a link between Pol III transcription and pre-rRNA
            processing
  JOURNAL   Mol Cell Biol 15 (1), 94-101 (1995)
   PUBMED   7799973
REFERENCE   7  (bases 1 to 5336)
  AUTHORS   Ittmann,M.M.
  TITLE     Cell cycle control of the BN51 cell cycle gene which encodes a
            subunit of RNA polymerase III
  JOURNAL   Cell Growth Differ 5 (7), 783-788 (1994)
   PUBMED   7947392
REFERENCE   8  (bases 1 to 5336)
  AUTHORS   Jang,K.L., Collins,M.K. and Latchman,D.S.
  TITLE     The human immunodeficiency virus tat protein increases the
            transcription of human Alu repeated sequences by increasing the
            activity of the cellular transcription factor TFIIIC
  JOURNAL   J Acquir Immune Defic Syndr (1988) 5 (11), 1142-1147 (1992)
   PUBMED   1403646
REFERENCE   9  (bases 1 to 5336)
  AUTHORS   Greco,A., Ittmann,M., Barletta,C., Basilico,C., Croce,C.M.,
            Cannizzaro,L.A. and Huebner,K.
  TITLE     Chromosomal localization of human genes required for G1 progression
            in mammalian cells
  JOURNAL   Genomics 4 (3), 240-245 (1989)
   PUBMED   2714790
REFERENCE   10 (bases 1 to 5336)
  AUTHORS   Ittmann,M., Greco,A. and Basilico,C.
  TITLE     Isolation of the human gene that complements a
            temperature-sensitive cell cycle mutation in BHK cells
  JOURNAL   Mol Cell Biol 7 (10), 3386-3393 (1987)
   PUBMED   3683386
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK026588.1, AY092086.1,
            BQ006609.1 and AC105206.8.
            
            On Nov 22, 2018 this sequence version replaced NM_001722.2.
            
            Summary: This gene complements a temperature-sensitive mutant
            isolated from the BHK-21 Syrian hamster cell line. It leads to a
            block in progression through the G1 phase of the cell cycle at
            nonpermissive temperatures. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.95896.1,
                                           SRR1803615.94370.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306433.9/ ENSP00000303088.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-394               AK026588.1         90-483
            395-402             AY092086.1         339-346
            403-1310            AK026588.1         492-1399
            1311-1902           BQ006609.1         18-609              c
            1903-5336           AC105206.8         33247-36680         c
FEATURES             Location/Qualifiers
     source          1..5336
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.3"
     gene            1..5336
                     /gene="POLR3D"
                     /gene_synonym="BN51T; C53; RPC4; RPC53; TSBN51"
                     /note="RNA polymerase III subunit D"
                     /db_xref="GeneID:661"
                     /db_xref="HGNC:HGNC:1080"
                     /db_xref="MIM:187280"
     exon            1..51
                     /gene="POLR3D"
                     /gene_synonym="BN51T; C53; RPC4; RPC53; TSBN51"
                     /inference="alignment:Splign:2.1.0"
     exon            52..221
                     /gene="POLR3D"
                     /gene_synonym="BN51T; C53; RPC4; RPC53; TSBN51"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1253
                     /gene="POLR3D"
                     /gene_synonym="BN51T; C53; RPC4; RPC53; TSBN51"
                     /EC_number="2.7.7.6"
                     /note="BN51 (BHK21) temperature sensitivity complementing;
                     polymerase (RNA) III (DNA directed) polypeptide D, 44kDa;
                     temperature sensitive complementation, cell cycle
                     specific, tsBN51; RNA polymerase III subunit C4;
                     DNA-directed RNA polymerase III subunit D; DNA-directed
                     RNA polymerase III 47 kDa polypeptide; RPC53 homolog; RNA
                     polymerase III 47 kDa subunit; polymerase (RNA) III
                     subunit D"
                     /codon_start=1
                     /product="DNA-directed RNA polymerase III subunit RPC4"
                     /protein_id="NP_001713.2"
                     /db_xref="CCDS:CCDS34858.1"
                     /db_xref="GeneID:661"
                     /db_xref="HGNC:HGNC:1080"
                     /db_xref="MIM:187280"
                     /translation="MSEGNAAGEPSTPGGPRPLLTGARGLIGRRPAPPLTPGRLPSIR
                     SRDLTLGGVKKKTFTPNIISRKIKEEPKEEVTVKKEKRERDRDRQREGHGRGRGRPEV
                     IQSHSIFEQGPAEMMKKKGNWDKTVDVSDMGPSHIINIKKEKRETDEETKQILRMLEK
                     DDFLDDPGLRNDTRNMPVQLPLAHSGWLFKEENDEPDVKPWLAGPKEEDMEVDIPAVK
                     VKEEPRDEEEEAKMKAPPKAARKTPGLPKDVSVAELLRELSLTKEEELLFLQLPDTLP
                     GQPPTQDIKPIKTEVQGEDGQVVLIKQEKDREAKLAENACTLADLTEGQVGKLLIRKS
                     GRVQLLLGKVTLDVTMGTACSFLQELVSVGLGDSRTGEMTVLGHVKHKLVCSPDFESL
                     LDHKHR"
     exon            222..265
                     /gene="POLR3D"
                     /gene_synonym="BN51T; C53; RPC4; RPC53; TSBN51"
                     /inference="alignment:Splign:2.1.0"
     exon            266..417
                     /gene="POLR3D"
                     /gene_synonym="BN51T; C53; RPC4; RPC53; TSBN51"
                     /inference="alignment:Splign:2.1.0"
     exon            418..542
                     /gene="POLR3D"
                     /gene_synonym="BN51T; C53; RPC4; RPC53; TSBN51"
                     /inference="alignment:Splign:2.1.0"
     exon            543..711
                     /gene="POLR3D"
                     /gene_synonym="BN51T; C53; RPC4; RPC53; TSBN51"
                     /inference="alignment:Splign:2.1.0"
     exon            712..977
                     /gene="POLR3D"
                     /gene_synonym="BN51T; C53; RPC4; RPC53; TSBN51"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1130
                     /gene="POLR3D"
                     /gene_synonym="BN51T; C53; RPC4; RPC53; TSBN51"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..5336
                     /gene="POLR3D"
                     /gene_synonym="BN51T; C53; RPC4; RPC53; TSBN51"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1876..1881
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POLR3D"
                     /gene_synonym="BN51T; C53; RPC4; RPC53; TSBN51"
                     /note="hexamer: AATAAA"
     polyA_site      1902
                     /gene="POLR3D"
                     /gene_synonym="BN51T; C53; RPC4; RPC53; TSBN51"
                     /note="major polyA site"
     regulatory      5065..5070
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POLR3D"
                     /gene_synonym="BN51T; C53; RPC4; RPC53; TSBN51"
                     /note="hexamer: TATAAA"
     polyA_site      5090
                     /gene="POLR3D"
                     /gene_synonym="BN51T; C53; RPC4; RPC53; TSBN51"
     regulatory      5310..5315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POLR3D"
                     /gene_synonym="BN51T; C53; RPC4; RPC53; TSBN51"
                     /note="hexamer: ATTAAA"
     polyA_site      5336
                     /gene="POLR3D"
                     /gene_synonym="BN51T; C53; RPC4; RPC53; TSBN51"
ORIGIN      
        1 agacttccgc ccggcgcgga gaccgaaggc tggcggctgg tcgcgttgca ggcaacatgt
       61 cggaaggaaa cgccgccggc gagcccagca cgccgggagg gccccgacct ctcctgactg
      121 gggcccgggg gctcatcggg cggcggccgg cgcctcccct cacccccggc cgccttccct
      181 ccatccgttc cagggacctc accctcgggg gagtcaagaa gaaaaccttc accccaaata
      241 tcatcagtcg gaagatcaag gaagagccca aggaagaagt aactgtcaag aaggagaagc
      301 gtgaaaggga cagagaccga caacgagagg ggcatggacg agggcgaggc cgtccagaag
      361 tgatccagtc tcactccatc tttgagcagg gcccagctga aatgatgaag aaaaaaggga
      421 actgggataa gacagtggat gtgtcagaca tgggaccttc tcatatcatc aacatcaaaa
      481 aagagaagag agagacagac gaagaaacta aacagatctt gcgtatgctg gagaaggacg
      541 atttcctcga tgaccccggc ctgaggaacg acactcgaaa tatgcctgtg cagctgccgc
      601 tggctcactc aggatggctt tttaaggaag aaaatgacga accagatgtt aaaccttggc
      661 tggctggccc caaggaagag gacatggagg tggacatacc tgctgtgaaa gtgaaagagg
      721 agccacgaga tgaggaggaa gaggccaaga tgaaggctcc tcccaaagca gccaggaaga
      781 ctccaggcct cccgaaggat gtatctgtgg cagagctgct gagggagctg agcctcacca
      841 aggaagagga actgctgttt ctgcagctgc cagacaccct ccctggccag ccacccaccc
      901 aggacatcaa gcctatcaag acagaggtgc agggcgagga cggacaggtg gtgctcatca
      961 agcaggagaa agaccgagaa gccaaattgg cagagaatgc ttgtaccctg gctgacctga
     1021 cagagggtca ggttggcaag ctactcatcc gcaagtctgg aagggtgcaa ctcctcttgg
     1081 gcaaggtgac tctggacgtg accatgggaa ctgcctgctc cttcctgcag gagctggtgt
     1141 ccgtgggcct tggagacagt aggacagggg agatgacagt cctgggacac gtgaagcaca
     1201 aacttgtatg ttcccctgat tttgaatccc tcttggatca caaacaccgg taaaatgagc
     1261 aggtggagga ggacggcgcc tgtgcccacg gctgctgcct gctccagaca ttttgttctt
     1321 gaatctgtga gacccagaag gggcccactg agcccactca ctccagcctt tggcaaccat
     1381 tgttccaggt cccccagggc ttcctcccac agcagctgtg aatggcacag tgaccttcct
     1441 gcagcgtgga gatggcacat ccttgctgct ggggacttgg ccctgctatt tatttttgta
     1501 tttatgtctt aatctcttcc actgatgcat cctccaaggg tagatgggga gggtctgtgt
     1561 gaaggggccg gcttctcttg gtgcctgctg ggttgcaggg gcaggaagcg tgtggactgc
     1621 agcttctgct ggtgctcccc ccgtcctcct ggaggcagta taggagagag agcaaggatt
     1681 gagtctgaga cttaagcact cggtcccagc ttgccagttc ctggttctgt gtccttggac
     1741 aaactaccta acctttctga gcctcctata cctcatccga cacaaatggg gatgatacct
     1801 acctccaggg ttggcgtgag gattcatggg ctattataga tgaaaactgc acaaggccag
     1861 aaccagcagg cactcaataa acgttcatgt cctttttctc tacctgagtc tattttcaaa
     1921 caaaatagag attctaaatc tcccagaagc agcgactaga gctgctcccg tccccactct
     1981 tgccccttcc tgctttatat cccgtcctca ccctgggcct gatgccctaa atttatggtg
     2041 tcagattgtt ctatgccttt ttctcctggc tcctgttagc caggtgcctc ctgtgtgagt
     2101 tactgtaata gctgcaggta atagaaagga agaagtcaga gacccctccc agcaccctac
     2161 aaaagccttt gggggacatg ttgggcccag gacatgttcc ctgcactctt tcctttgcag
     2221 ttagtactca tgtatgagcc gaagtcatat attgctaaca aaaaaactaa atccttcata
     2281 agagaagtta gggatgtatt gaataatggc ctctttgaca cttggccgat gatgcccact
     2341 tcaaaaactt tgggtttcag aggcctgccc gtctcctgtc ctagcactgc cagagccacc
     2401 tactcagtgt tacttttttg ggtctgtgat cctgttccct ttaccaggtc attgtactgt
     2461 gttgtccctg gaggaacagc ttctcctctt gtcttgacag tagggctggg gttttccctg
     2521 gttcagctgg ggagacgttt gcaggttaga aaaaggtctc atgcggcagc gtgtgtggct
     2581 gttagacgct gatggcacaa cttccctttg ctggcgtcgt ggcacctggc ctctgggaca
     2641 gtatgaacca taggggctca ggaagaaccg cttcccctcc acccccatcc ctgattccta
     2701 gtggcccctt agattttggg tacatcttcc ttcaggctca ccttccttct tttcaaagtt
     2761 cctcaagcct gttactcatt tgtcaaggct gggcttctcc tacaaagccc tcaacctgcc
     2821 cagccagcag ctgtgaggct gactgaatat ttggtgacca tatcaccctt tctggtgctg
     2881 aagctcatgt cagctccatt ggacagtgtt attctgggct cttctcactg tagaggactg
     2941 gagcagaaag ggttccttgg aaacctgtgc tgggaagccc tgtttggtct aaggctaagc
     3001 tttggttaac tctgggctcc agccctttct tcctttaaat agctgatgca cggccagcag
     3061 gtctccattc tcatcctctc tttctattct gtttctttgg ttcagaaata ctcttctgct
     3121 ttttttggac gaactcaatg gcccgatgtt agatattggg tatttttcaa tcttctgttt
     3181 tctgaccctt ccaagaaagt ttgaggaaga acatgtactg ctttcacgtt catttcgccc
     3241 attcagatgt cttggcttga accttatgac tccgtatcaa agtcctcaca acctgtctca
     3301 gatccctgat gcacaaatta ggtcttatta ataagtgtgg gaaaagagag gagagtccac
     3361 cttcttggtc aggcccctga ggcatgcatt tctaccaagg aatatggaca gatgacagag
     3421 gagaagagcc caaagccaaa tttatacatg agtgcaagtg gatgcaaatt tgttgctccc
     3481 tgcatctgtg tatatgcttt ctgttaaata cagaaagaag gaacaatagg cttgcacact
     3541 tttctaacta catgtttaag tggcagagtc caggctgtcg agtcacggtt gggtttgaat
     3601 ctgactccac cagtaacttt ggttggaaaa aatcacttat cctctttaag cttgatttta
     3661 tttattttat tttatgtaag agtgagacag tagtagctta atagggttgc ttttaaatta
     3721 gagtgaacat gaggcattta ttcggtgcca gacagataac tgcctataac aggatgtgat
     3781 cagcacaagt aacagaaaat tagcctgacg gtggcttaag caatgggaat gtttatctca
     3841 catagcaaaa agtctgtaaa tagatggttc tagagttggg tggaagccaa aatgtcatca
     3901 ggatttcctt ggaaccgtct gctttgccat cctcagtatt gcagaatggc tgctcctgcg
     3961 ccaagcatca ttctgcaaat gatggtgtcc acagccagag tggacagtag tacaggagcc
     4021 ttctcattct gcccttatcc gggaataacc gtcagcagct ccagcaacct cccccctgtc
     4081 tctttataga gtggggccac gtgcccactc ttggaccagg ccctggcaaa gggggatggg
     4141 tcgactagtg tatcccctgg cactgagcac acttgccctt gagctggggt tttgttagta
     4201 gggaggaagc tggagtggca gttggataga caattcatag tagctgctgc catgttcaaa
     4261 aaatgctgca atgtaaaatc ataaagtatt catctaggca taacttttta aaatattcag
     4321 tcacctttta ttctactaaa atcaatttta acattttagt gtatattatt ttattttaga
     4381 ttcagcaggt acatgagcat gttagttttg ttttgttttg ttttgttctg ttttgttttt
     4441 tgagatggag tctcactctg tcgcccagtg gtgtgatctt ggcttactgc aactctgtct
     4501 cccaggttca agtgatcctc ccgcctcagc cccccagata gctgggatta caggcacatg
     4561 ccaccacacc tggctaattt ttgtattttt agtagagacg ggagtttcac catgttggcc
     4621 aggctggtct caaactcctc acctcaagtg atctacctgc ctcagcctcc caagtgctgg
     4681 gattacaggc gtgagccact gcgcccagcc acatgtgcgt gtttgtgtat attgcgtact
     4741 ggtggggatt gggcttctgt catacctatc acccaaatag tgaacattgt actcaggtag
     4801 catttcaacc cttgcccccc ctcccactca cccccttttg gagtgcccag tgtttgctat
     4861 ttccatcttt atgtccatag gtacccatta tttagctccc acttataagt gagaacatgt
     4921 gctatttgat tttctgtttc cgaggttagg ataattacct caagctccat ccatgtggct
     4981 gcaaagcaca tgatttcatt gtattttatg actgctcatg tatattattt cagcctccaa
     5041 aattttgtat gttatttata atgatataaa ttatgtggtt ttatcgtgta ctctatctca
     5101 ctcagaaata catacaattc ttcgttccca gctactctgg agctgaggtg ggaggatcac
     5161 ttgagcccag gagttcaaga ccagcctggg caacatggtg aaaccttgtc tctgaaaaat
     5221 aaataataca cacccacatg cacacacatc cagttcttcc atgttaatga gtatgttgtg
     5281 tttcacatac ttctgaatta gccgaaggaa ttaaaggtag catcttttaa tcctca
//
