LOCUS       NM_006468               3777 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens RNA polymerase III subunit C (POLR3C), transcript
            variant 1, mRNA.
ACCESSION   NM_006468
VERSION     NM_006468.8
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3777)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 3777)
  AUTHORS   Hou,H., Li,Y., Wang,M., Liu,A., Yu,Z., Chen,K., Zhao,D. and Xu,Y.
  TITLE     Structural insights into RNA polymerase III-mediated transcription
            termination through trapping poly-deoxythymidine
  JOURNAL   Nat Commun 12 (1), 6135 (2021)
   PUBMED   34675218
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3777)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3777)
  AUTHORS   Ramsay,E.P., Abascal-Palacios,G., Daiss,J.L., King,H., Gouge,J.,
            Pilsl,M., Beuron,F., Morris,E., Gunkel,P., Engel,C. and Vannini,A.
  TITLE     Structure of human RNA polymerase III
  JOURNAL   Nat Commun 11 (1), 6409 (2020)
   PUBMED   33335104
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3777)
  AUTHORS   Harich,B., van der Voet,M., Klein,M., Cizek,P., Fenckova,M.,
            Schenck,A. and Franke,B.
  TITLE     From Rare Copy Number Variants to Biological Processes in ADHD
  JOURNAL   Am J Psychiatry 177 (9), 855-866 (2020)
   PUBMED   32600152
  REMARK    GeneRIF: From Rare Copy Number Variants to Biological Processes in
            ADHD.
REFERENCE   6  (bases 1 to 3777)
  AUTHORS   Mertens,C., Hofmann,I., Wang,Z., Teichmann,M., Sepehri Chong,S.,
            Schnolzer,M. and Franke,W.W.
  TITLE     Nuclear particles containing RNA polymerase III complexes
            associated with the junctional plaque protein plakophilin 2
  JOURNAL   Proc Natl Acad Sci U S A 98 (14), 7795-7800 (2001)
   PUBMED   11416169
REFERENCE   7  (bases 1 to 3777)
  AUTHORS   Hsieh,Y.J., Kundu,T.K., Wang,Z., Kovelman,R. and Roeder,R.G.
  TITLE     The TFIIIC90 subunit of TFIIIC interacts with multiple components
            of the RNA polymerase III machinery and contains a histone-specific
            acetyltransferase activity
  JOURNAL   Mol Cell Biol 19 (11), 7697-7704 (1999)
   PUBMED   10523658
REFERENCE   8  (bases 1 to 3777)
  AUTHORS   Hsieh,Y.J., Wang,Z., Kovelman,R. and Roeder,R.G.
  TITLE     Cloning and characterization of two evolutionarily conserved
            subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their
            involvement in functional interactions with TFIIIB and RNA
            polymerase III
  JOURNAL   Mol Cell Biol 19 (7), 4944-4952 (1999)
   PUBMED   10373544
REFERENCE   9  (bases 1 to 3777)
  AUTHORS   Wang,Z. and Roeder,R.G.
  TITLE     Three human RNA polymerase III-specific subunits form a subcomplex
            with a selective function in specific transcription initiation
  JOURNAL   Genes Dev 11 (10), 1315-1326 (1997)
   PUBMED   9171375
REFERENCE   10 (bases 1 to 3777)
  AUTHORS   Jang,K.L., Collins,M.K. and Latchman,D.S.
  TITLE     The human immunodeficiency virus tat protein increases the
            transcription of human Alu repeated sequences by increasing the
            activity of the cellular transcription factor TFIIIC
  JOURNAL   J Acquir Immune Defic Syndr (1988) 5 (11), 1142-1147 (1992)
   PUBMED   1403646
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI831011.1, BC002586.1, DA291657.1, BE258456.1, BQ932484.1 and
            BC053590.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006468.7.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the shorter isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.2101243.1, BC002586.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334163.4/ ENSP00000334564.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               BI831011.1         132-265
            135-1880            BC002586.1         115-1860
            1881-1910           DA291657.1         337-366
            1911-2394           BE258456.1         25-508
            2395-2757           BQ932484.1         1-363
            2758-3777           BC053590.1         610-1629
FEATURES             Location/Qualifiers
     source          1..3777
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.1"
     gene            1..3777
                     /gene="POLR3C"
                     /gene_synonym="C82; RPC3; RPC62"
                     /note="RNA polymerase III subunit C"
                     /db_xref="GeneID:10623"
                     /db_xref="HGNC:HGNC:30076"
                     /db_xref="MIM:617454"
     exon            1..170
                     /gene="POLR3C"
                     /gene_synonym="C82; RPC3; RPC62"
                     /inference="alignment:Splign:2.1.0"
     exon            171..337
                     /gene="POLR3C"
                     /gene_synonym="C82; RPC3; RPC62"
                     /inference="alignment:Splign:2.1.0"
     exon            338..593
                     /gene="POLR3C"
                     /gene_synonym="C82; RPC3; RPC62"
                     /inference="alignment:Splign:2.1.0"
     exon            594..779
                     /gene="POLR3C"
                     /gene_synonym="C82; RPC3; RPC62"
                     /inference="alignment:Splign:2.1.0"
     exon            780..868
                     /gene="POLR3C"
                     /gene_synonym="C82; RPC3; RPC62"
                     /inference="alignment:Splign:2.1.0"
     exon            869..973
                     /gene="POLR3C"
                     /gene_synonym="C82; RPC3; RPC62"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1066
                     /gene="POLR3C"
                     /gene_synonym="C82; RPC3; RPC62"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1147
                     /gene="POLR3C"
                     /gene_synonym="C82; RPC3; RPC62"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1199
                     /gene="POLR3C"
                     /gene_synonym="C82; RPC3; RPC62"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1260
                     /gene="POLR3C"
                     /gene_synonym="C82; RPC3; RPC62"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1411
                     /gene="POLR3C"
                     /gene_synonym="C82; RPC3; RPC62"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1513
                     /gene="POLR3C"
                     /gene_synonym="C82; RPC3; RPC62"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1563
                     /gene="POLR3C"
                     /gene_synonym="C82; RPC3; RPC62"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1713
                     /gene="POLR3C"
                     /gene_synonym="C82; RPC3; RPC62"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..3777
                     /gene="POLR3C"
                     /gene_synonym="C82; RPC3; RPC62"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1843..1848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POLR3C"
                     /gene_synonym="C82; RPC3; RPC62"
                     /note="hexamer: AATAAA"
     polyA_site      1880
                     /gene="POLR3C"
                     /gene_synonym="C82; RPC3; RPC62"
                     /note="major polyA site"
     regulatory      3755..3760
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POLR3C"
                     /gene_synonym="C82; RPC3; RPC62"
                     /note="hexamer: AATAAA"
     polyA_site      3777
                     /gene="POLR3C"
                     /gene_synonym="C82; RPC3; RPC62"
                     /note="major polyA site"
ORIGIN      
        1 agagtggcac gcgctttttg cttttccgcg tcttcttcgg tggcgatccg cgtcctagaa
       61 agggcggtgg gctccacctc ggcctagaag gccagcggga gccgtaggaa gccgtcgcgg
      121 gaagctcagc cgaattggag ttggagcccc cggattgcgc tgaccctgag ctctcagact
      181 ccccagtaca atgactcaag cagaaattaa gctctgttct ttgttgctgc aagagcattt
      241 tggagagatt gtagaaaaaa ttggagtcca tctgataaga accggcagcc agccactaag
      301 agtaattgcc catgacacag gaacatcact ggatcaggtg aagaaagccc tgtgtgtcct
      361 cgtccaacat aacctggtga gttatcaagt gcacaaacgt ggtgtggtgg agtatgaagc
      421 ccagtgcagc cgggtattgc gaatgcttag atatccccgg tacatctata ctaccaaaac
      481 tctgtacagt gacactggag agctgattgt tgaggagctt ctgttgaacg gcaaactgac
      541 aatgtcagct gttgtgaaga aagtggcaga ccggctcaca gagaccatgg aggatggcaa
      601 gaccatggac tatgctgaag tatcaaacac atttgtgcga ctggcagaca cacactttgt
      661 acaacgctgc ccttcggtac ctaccactga gaattcagac cctgggccac caccacctgc
      721 ccccacactt gtcattaatg aaaaggacat gtacctggtt cctaaactca gcttgatagg
      781 gaaaggtaaa aggaggagat catctgatga agatgctgct ggggagccca aggccaagag
      841 accaaaatat actacagata acaaggagcc cattccagat gatgggattt attggcaggc
      901 caaccttgac agattccacc aacacttccg tgaccaagcc attgtgagcg cagttgctaa
      961 caggatggac cagacaagca gcgagattgt gcgaaccatg ctccgaatga gtgagattac
     1021 cacttcctct agtgctccct tcacccagcc attgtcttcc aatgagatct tcagatccct
     1081 acctgttggc tataacatct ctaagcaagt tcttgatcag tatctcactc tgctggcaga
     1141 tgatccacta gagtttgttg gaaagtctgg cgacagtggt ggaggaatgt atgtcatcaa
     1201 cctccataag gcattagcat ccctagccac agccactctg gagtccgtcg tacaggagag
     1261 atttgggtct cgctgtgcta gaatattccg tctagttttg cagaagaaac acatagagca
     1321 gaagcaagtg gaagactttg caatgattcc tgcaaaggag gcaaaggata tgctatataa
     1381 gatgctctca gaaaatttca tgtcactcca ggaaattccc aaaacaccag accatgcccc
     1441 atccaggacc ttctatttat atactgtgaa catcctgtca gctgcccgaa tgttgttgca
     1501 caggtgctac aagagcatag ccaacttgat agaaaggagg caatttgaaa ccaaagagaa
     1561 taagcgtcta ctagaaaaat ctcagagggt agaagccatc attgcatcta tgcaggctac
     1621 tggtgcagag gaagcacagt tacaagaaat agaggagatg atcacagctc ctgaacgtca
     1681 gcagctagag accctgaaac gtaatgtcaa caagttggat gccagtgaga tccaggtgga
     1741 cgaaaccatc ttcctgctgg agtcttacat tgagtgcacc atgaagagac agtgatccag
     1801 aagaagcatc ttcctcagaa gatctggggg gatggaaagc aaaataaagg aggtgcctgg
     1861 atgcattatt tgcagtggga taagtcgcag agtcttcaac taaacccccc tctctatccc
     1921 ctgcagccca ggatacacct gaaagaattt ggcatattta gatccattgc tgtagtctcc
     1981 cctcatcaaa tcttggcagt gggaagaacc ttaaatcaac aaggttaatc atctatcaga
     2041 tgcatctgtt cccataaaga agttacccac acctatggtt acctatatcc ctggcaatag
     2101 gaaacttcct aagaagttaa ttttattttc agatgtctat gcctgttctt tattttgttg
     2161 agataggtga tagatagata gatagataga taatttgttg ttgttgagac aggatctcac
     2221 tctgtcactc aggctggggt gtaatagcgc aatcacagct ccctacagcc ttgacctcct
     2281 gagctcaagc agtccttcca cctcagcctc tggagtagct gggactacag gcatgcacca
     2341 cacataccca gctatttttt atttatttat ttattttttt gtagagacag ggcctccctg
     2401 tgttgcccag gctgatgaac tgtaattttt aacacacaca gtgtagggaa tgtgaaagac
     2461 tatcacagag tagaagaaaa aattattttc agggttagca ggtggattgt cccaagcagt
     2521 cacactagaa tctgtggact gaagccacat ttgccagctc caggcttcta acacatctga
     2581 aactgtgtat gtagaacagc tagctcaatg cctggcatat ggtaagcaca cagtaaatta
     2641 gcgccttcct cttctccatg gttccttaaa actggcaacg ctaaattctc tctctcagta
     2701 tcacggatat aatttgtccc agcagcttta attcatttaa agcagttaga tgttttataa
     2761 tatcttcagt tttctctcac caatgtgttt tctaattgtt taaacacttg agtgtcaaac
     2821 aattgccagc caccatacta aacacaacat acaaggatag ataaataaga caccatctct
     2881 gccctcaagc cagtcaccat catttactaa gcacctgttt tgtgctaagt actggggtaa
     2941 gccttgggga tataaagatt aataaatttt gagcatacag tctagtagga ggagacaaat
     3001 aagtacataa gtaccaggaa gtattagggg tgctacagta gaagagtaaa cactatgtac
     3061 agagaggcca gaaagggaaa agggtcaggc agggaaggga acacagagag tgacaatgta
     3121 tagtttgaaa gatgaggatg ctttatttgc aaactatctt aacaagggat tcgtaaccag
     3181 aatatataag gagctcaaac aatagcaaaa agaacaatcc aacttaaaaa tggccaaaag
     3241 atcttaatag gtagttttcg aaagaagata cacaaatggc cgacagatac atcaaaaaat
     3301 gttcaacatc actaatcaga gaaatggaaa tcaaaatcaa tgagataaca tctcacccca
     3361 attcattact tttatcaaga agaaagaatg aatgctagtg aggatgtgga aaaaggagag
     3421 ccctgcctgg tacactgttg ggaatgtaaa ttggtacagc cactgtggaa gactacagag
     3481 gttcctcaaa aaactaaaaa cagaactatg ctccagcagt tccactactg ggtatatata
     3541 tatctccaaa aggaaagaaa tcaatgtatc aaaaagatac ctgcactccc atgtttattg
     3601 cagcagtatt cacgatagcc aaaacatgga atcaacctaa gtgcccatca atagatgaaa
     3661 ggctaaagaa aatgtattat tcagccataa gaatgaatga aatcctgtca ttggcagcaa
     3721 catggatgga attggaggtc attatgttaa gtaaaataaa ccaagcacag aaacaaa
//
