LOCUS       NM_007055               6610 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens RNA polymerase III subunit A (POLR3A), mRNA.
ACCESSION   NM_007055
VERSION     NM_007055.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6610)
  AUTHORS   Kraoua,I., Jamoussi,M., Drissi,C., Kraoua,L., Drunat,S.,
            Benrhouma,H., Ben Younes,T., Nagi,S., Abdelhak,S., Boespflug
            Tanguy,O., Youssef-Turki,I.B., Trabelsi,M. and Dorboz,I.
  TITLE     Tremor Ataxia With Central Hypomyelation Phenotype Related to a
            Recurrent POLR3A Mutation in Six Unrelated Tunisian Families
  JOURNAL   Mol Genet Genomic Med 12 (10), e70007 (2024)
   PUBMED   39436788
  REMARK    GeneRIF: Tremor Ataxia With Central Hypomyelation Phenotype Related
            to a Recurrent POLR3A Mutation in Six Unrelated Tunisian Families.
REFERENCE   2  (bases 1 to 6610)
  AUTHORS   Ruan,D.D., Ruan,X.L., Wang,R.L., Lin,X.F., Zhang,Y.P., Lin,B.,
            Li,S.J., Wu,M., Chen,Q., Zhang,J.H., Cheng,Q., Zhang,Y.W., Lin,F.,
            Luo,J.W., Zheng,Z. and Li,Y.F.
  TITLE     Clinical phenotype and genetic function analysis of a family with
            hypomyelinating leukodystrophy-7 caused by POLR3A mutation
  JOURNAL   Sci Rep 14 (1), 7638 (2024)
   PUBMED   38561452
  REMARK    GeneRIF: Clinical phenotype and genetic function analysis of a
            family with hypomyelinating leukodystrophy-7 caused by POLR3A
            mutation.
            Erratum:[Sci Rep. 2024 Sep 10;14(1):21122. doi:
            10.1038/s41598-024-72293-3.. PMID: 39256586]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6610)
  AUTHORS   Khan,A., Al Shamsi,B., Al Shehhi,M., Kashgari,A.A., Al Balushi,A.,
            Al Dihan,F.A., Alghamdi,M.A., Manal,A., Gonzalez-Alvarez,A.C.,
            Arold,S.T. and Eyaid,W.
  TITLE     Further delineation of Wiedemann-Rautenstrauch syndrome linked with
            POLR3A
  JOURNAL   Mol Genet Genomic Med 12 (3), e2274 (2024)
   PUBMED   38348603
  REMARK    GeneRIF: Further delineation of Wiedemann-Rautenstrauch syndrome
            linked with POLR3A.
REFERENCE   4  (bases 1 to 6610)
  AUTHORS   Van Bortle,K., Marciano,D.P., Liu,Q., Chou,T., Lipchik,A.M.,
            Gollapudi,S., Geller,B.S., Monte,E., Kamakaka,R.T. and Snyder,M.P.
  TITLE     A cancer-associated RNA polymerase III identity drives robust
            transcription and expression of snaR-A noncoding RNA
  JOURNAL   Nat Commun 13 (1), 3007 (2022)
   PUBMED   35637192
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6610)
  AUTHORS   Mertens,C., Hofmann,I., Wang,Z., Teichmann,M., Sepehri Chong,S.,
            Schnolzer,M. and Franke,W.W.
  TITLE     Nuclear particles containing RNA polymerase III complexes
            associated with the junctional plaque protein plakophilin 2
  JOURNAL   Proc Natl Acad Sci U S A 98 (14), 7795-7800 (2001)
   PUBMED   11416169
REFERENCE   6  (bases 1 to 6610)
  AUTHORS   Sepehri,S. and Hernandez,N.
  TITLE     The largest subunit of human RNA polymerase III is closely related
            to the largest subunit of yeast and trypanosome RNA polymerase III
  JOURNAL   Genome Res 7 (10), 1006-1019 (1997)
   PUBMED   9331371
REFERENCE   7  (bases 1 to 6610)
  AUTHORS   Vanderver,A., Tonduti,D., Schiffmann,R., Schmidt,J. and van der
            Knaap,M.S.
  TITLE     Leukodystrophy Overview - RETIRED CHAPTER, FOR HISTORICAL REFERENCE
            ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   24501781
REFERENCE   8  (bases 1 to 6610)
  AUTHORS   Bernard,G. and Vanderver,A.
  TITLE     POLR3-Related Leukodystrophy
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   22855961
REFERENCE   9  (bases 1 to 6610)
  AUTHORS   Perlman,S.
  TITLE     Hereditary Ataxia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301317
REFERENCE   10 (bases 1 to 6610)
  AUTHORS   Jang,K.L., Collins,M.K. and Latchman,D.S.
  TITLE     The human immunodeficiency virus tat protein increases the
            transcription of human Alu repeated sequences by increasing the
            activity of the cellular transcription factor TFIIIC
  JOURNAL   J Acquir Immune Defic Syndr (1988) 5 (11), 1142-1147 (1992)
   PUBMED   1403646
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA103416.1, AY091459.1,
            BC041089.1, AK024744.1, DA353439.1 and CA449326.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_007055.3.
            
            Summary: The protein encoded by this gene is the catalytic
            component of RNA polymerase III, which synthesizes small RNAs. The
            encoded protein also acts as a sensor to detect foreign DNA and
            trigger an innate immune response. [provided by RefSeq, Aug 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.40301.1,
                                           SRR1660809.11944.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372371.8/ ENSP00000361446.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               DA103416.1         26-133
            109-955             AY091459.1         1-847
            956-5332            BC041089.1         942-5318
            5333-5623           AK024744.1         1416-1706
            5624-6025           DA353439.1         162-563
            6026-6610           CA449326.1         18-602              c
FEATURES             Location/Qualifiers
     source          1..6610
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.3"
     gene            1..6610
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /note="RNA polymerase III subunit A"
                     /db_xref="GeneID:11128"
                     /db_xref="HGNC:HGNC:30074"
                     /db_xref="MIM:614258"
     exon            1..152
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..4281
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /EC_number="2.7.7.6"
                     /note="RNA polymerase III subunit RPC155-D; RNA polymerase
                     III subunit C1; RNA polymerase III subunit C160;
                     DNA-directed RNA polymerase III subunit A; DNA-directed
                     RNA polymerase III largest subunit; RNA polymerase III 155
                     kDa subunit; polymerase (RNA) III (DNA directed)
                     polypeptide A, 155kDa; polymerase (RNA) III subunit A"
                     /codon_start=1
                     /product="DNA-directed RNA polymerase III subunit RPC1"
                     /protein_id="NP_008986.2"
                     /db_xref="CCDS:CCDS7354.1"
                     /db_xref="GeneID:11128"
                     /db_xref="HGNC:HGNC:30074"
                     /db_xref="MIM:614258"
                     /translation="MVKEQFRETDVAKKISHICFGMKSPEEMRQQAHIQVVSKNLYSQ
                     DNQHAPLLYGVLDHRMGTSEKDRPCETCGKNLADCLGHYGYIDLELPCFHVGYFRAVI
                     GILQMICKTCCHIMLSQEEKKQFLDYLKRPGLTYLQKRGLKKKISDKCRKKNICHHCG
                     AFNGTVKKCGLLKIIHEKYKTNKKVVDPIVSNFLQSFETAIEHNKEVEPLLGRAQENL
                     NPLVVLNLFKRIPAEDVPLLLMNPEAGKPSDLILTRLLVPPLCIRPSVVSDLKSGTNE
                     DDLTMKLTEIIFLNDVIKKHRISGAKTQMIMEDWDFLQLQCALYINSELSGIPLNMAP
                     KKWTRGFVQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLRIDEVAVPVHVAKILTF
                     PEKVNKANINFLRKLVQNGPEVHPGANFIQQRHTQMKRFLKYGNREKMAQELKYGDIV
                     ERHLIDGDVVLFNRQPSLHKLSIMAHLARVKPHRTFRFNECVCTPYNADFDGDEMNLH
                     LPQTEEAKAEALVLMGTKANLVTPRNGEPLIAAIQDFLTGAYLLTLKDTFFDRAKACQ
                     IIASILVGKDEKIKVRLPPPTILKPVTLWTGKQIFSVILRPSDDNPVRANLRTKGKQY
                     CGKGEDLCANDSYVTIQNSELMSGSMDKGTLGSGSKNNIFYILLRDWGQNEAADAMSR
                     LARLAPVYLSNRGFSIGIGDVTPGQGLLKAKYELLNAGYKKCDEYIEALNTGKLQQQP
                     GCTAEETLEALILKELSVIRDHAGSACLRELDKSNSPLTMALCGSKGSFINISQMIAC
                     VGQQAISGSRVPDGFENRSLPHFEKHSKLPAAKGFVANSFYSGLTPTEFFFHTMAGRE
                     GLVDTAVKTAETGYMQRRLVKSLEDLCSQYDLTVRSSTGDIIQFIYGGDGLDPAAMEG
                     KDEPLEFKRVLDNIKAVFPCPSEPALSKNELILTTESIMKKSEFLCCQDSFLQEIKKF
                     IKGVSEKIKKTRDKYGINDNGTTEPRVLYQLDRITPTQVEKFLETCRDKYMRAQMEPG
                     SAVGALCAQSIGEPGTQMTLKTFHFAGVASMNITLGVPRIKEIINASKAISTPIITAQ
                     LDKDDDADYARLVKGRIEKTLLGEISEYIEEVFLPDDCFILVKLSLERIRLLRLEVNA
                     ETVRYSICTSKLRVKPGDVAVHGEAVVCVTPRENSKSSMYYVLQFLKEDLPKVVVQGI
                     PEVSRAVIHIDEQSGKEKYKLLVEGDNLRAVMATHGVKGTRTTSNNTYEVEKTLGIEA
                     ARTTIINEIQYTMVNHGMSIDRRHVMLLSDLMTYKGEVLGITRFGLAKMKESVLMLAS
                     FEKTADHLFDAAYFGQKDSVCGVSECIIMGIPMNIGTGLFKLLHKADRDPNPPKRPLI
                     FDTNEFHIPLVT"
     exon            153..288
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /inference="alignment:Splign:2.1.0"
     exon            289..426
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /inference="alignment:Splign:2.1.0"
     exon            427..598
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /inference="alignment:Splign:2.1.0"
     exon            599..753
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /inference="alignment:Splign:2.1.0"
     exon            754..993
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1156
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1293
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1397
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1539
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1680
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1750
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1878
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2017
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2182
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..2355
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2467
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..2586
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /inference="alignment:Splign:2.1.0"
     exon            2587..2724
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /inference="alignment:Splign:2.1.0"
     exon            2725..2895
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /inference="alignment:Splign:2.1.0"
     exon            2896..3009
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /inference="alignment:Splign:2.1.0"
     exon            3010..3096
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..3179
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /inference="alignment:Splign:2.1.0"
     exon            3180..3350
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /inference="alignment:Splign:2.1.0"
     exon            3351..3444
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /inference="alignment:Splign:2.1.0"
     exon            3445..3537
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /inference="alignment:Splign:2.1.0"
     exon            3538..3702
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /inference="alignment:Splign:2.1.0"
     exon            3703..3867
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /inference="alignment:Splign:2.1.0"
     exon            3868..3999
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /inference="alignment:Splign:2.1.0"
     exon            4000..4132
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /inference="alignment:Splign:2.1.0"
     exon            4133..6610
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5120..5125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /note="hexamer: ATTATA"
     polyA_site      5140
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /note="major polyA site"
     regulatory      6120..6125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /note="hexamer: AATAAA"
     polyA_site      6148
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /note="major polyA site"
     regulatory      6583..6588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /note="hexamer: AATAAA"
     polyA_site      6610
                     /gene="POLR3A"
                     /gene_synonym="ADDH; C160; HLD7; hRPC155; RPC1; RPC155;
                     WDRTS"
                     /note="major polyA site"
ORIGIN      
        1 gcagatgtgt tagcggcgag tccagaagca gccccaggag gtgctggggg catcgtttct
       61 ctaatctggc ctcccgagtg ccaaggaggc gtcccggcag cggtcatcat ggtgaaggag
      121 cagttccggg agacggatgt ggccaagaaa ataagccaca tctgttttgg aatgaagtca
      181 cctgaggaga tgcgccagca ggcgcacatc caagttgtga gtaagaacct gtacagccag
      241 gacaaccaac atgccccctt gctatatggg gtgctcgacc ataggatggg tacgagtgag
      301 aaggatcgtc catgtgaaac ctgtgggaaa aacttggctg actgtctagg ccactatggg
      361 tatatcgacc tggagttgcc gtgttttcat gtagggtact tcagagcagt cataggcatc
      421 ttacagatga tctgcaaaac ctgctgccac atcatgctgt cccaagagga gaagaagcag
      481 tttctggact atctaaagag gcccggcctg acctaccttc agaagcgagg actgaaaaag
      541 aaaatctctg acaagtgccg gaagaaaaac atctgccatc actgtggcgc ttttaatggt
      601 accgtaaaga agtgtggact gctgaaaata attcatgaga aatacaagac caacaaaaaa
      661 gtggtggatc ccattgtatc aaatttcctt cagtcttttg aaacagccat tgaacataat
      721 aaagaagtgg agcctctgct gggaagggca caggaaaact tgaatccctt agtagttctg
      781 aatttattta aacgaatccc agctgaagat gttcctctac ttctgatgaa cccagaagcc
      841 ggaaagccgt ctgatttgat tctcacacga cttttggtgc ctcctttgtg tatcagaccc
      901 tccgttgtga gtgatttgaa gtctggcacc aatgaagatg atctgacaat gaaactgaca
      961 gaaatcattt tcctaaacga tgttattaaa aagcatcgga tctcaggagc caagacccag
     1021 atgatcatgg aggactggga tttcctgcag ctgcagtgtg ccctctacat taacagtgag
     1081 ctctcgggca ttcccctcaa catggcaccc aagaagtgga ccagaggctt cgtccaacgc
     1141 ctgaagggaa aacagggtcg atttagagga aatctctcag gaaagagagt ggatttttct
     1201 ggcagaacag tcatctcgcc cgaccccaac ctccggattg atgaggtagc tgtgccagtt
     1261 catgtggcca aaattctaac ttttcctgag aaggtaaaca aagcaaacat caatttcttg
     1321 aggaaactgg ttcaaaacgg ccctgaggtt cacccaggag caaacttcat tcagcagaga
     1381 catacgcaga tgaaaaggtt tttgaaatac ggaaatcgag aaaagatggc tcaagagctc
     1441 aagtatggtg acatcgtaga gagacacctc atcgatggag atgtggtgct gttcaatcgg
     1501 cagccctcgc tgcacaaatt gagcattatg gctcatctgg ccagggtcaa gccccaccgg
     1561 accttcagat ttaatgagtg tgtctgtaca ccctataatg ctgactttga tggtgatgaa
     1621 atgaaccttc atcttcctca aacagaagaa gctaaagcag aggcccttgt tctgatgggg
     1681 actaaagcaa atcttgtaac cccgaggaat ggggaaccgc tgattgctgc tattcaggat
     1741 tttctaacag gtgcctatct cctcactctc aaggacactt tctttgatcg agccaaggct
     1801 tgccaaatca ttgcttcaat actggttggc aaggatgaga aaattaaagt tcgcctccca
     1861 ccgcctacaa tcctaaagcc tgtcaccctg tggacgggaa agcagatctt cagtgtcatc
     1921 ctcaggccta gcgatgacaa tccagtgagg gccaacctgc gaaccaaggg caagcagtac
     1981 tgtggcaaag gggaagatct ctgtgccaat gattcctatg ttacaatcca gaacagtgag
     2041 ttgatgagtg gcagcatgga caaaggaacc ctagggtcag gatccaagaa caatattttt
     2101 tacattttgc tgcgagactg gggacagaat gaagctgcag atgccatgtc acggctcgcc
     2161 aggctggctc ctgtctacct gtctaaccgt ggtttctcaa ttgggatcgg tgatgtcaca
     2221 cctggccaag gactgctgaa ggccaagtat gagttgctga atgccggcta caagaaatgt
     2281 gatgagtaca tcgaagccct gaacacgggc aagctgcagc agcagcctgg ctgcactgct
     2341 gaggagaccc tggaggcact gatcctgaag gagctgtctg tgatccgtga ccacgctggc
     2401 agtgcctgcc tccgggagct ggacaagagc aacagccccc tcaccatggc tctgtgcggc
     2461 tccaaaggtt ccttcattaa catatcacag atgattgcct gtgtgggaca gcaggccatc
     2521 agtggctctc gagtgccaga cggctttgaa aacaggtcct tgcctcattt tgaaaaacac
     2581 tcaaagctcc cagctgccaa aggctttgtg gctaatagct tttattccgg tttgacacca
     2641 actgagtttt tcttccacac aatggccggc cgggaaggtc tagtcgacac ggctgtaaag
     2701 acagctgaaa cgggatacat gcagcgaagg cttgtcaaat ctcttgaaga tctttgctcc
     2761 cagtatgatc tgacagtccg aagctctact ggcgatatta tccagttcat ttatggagga
     2821 gatggcttag atcctgcagc tatggaggga aaagatgaac ctttggagtt taaaagggtt
     2881 ctggacaaca tcaaagcagt cttcccgtgt cccagtgagc ctgctctcag caaaaacgag
     2941 ctgatcctga ccacagagtc catcatgaag aagagtgagt tcctctgctg ccaggacagc
     3001 ttcctgcagg aaataaaaaa attcattaag ggggtctctg agaagatcaa gaaaaccaga
     3061 gataaatatg gcatcaatga taacggcaca acagagcccc gtgtgctgta ccagctggac
     3121 cgcatcaccc ccacccaagt agaaaagttt ctggagacct gtagggacaa gtacatgagg
     3181 gcacagatgg agccaggttc tgcagtgggt gctctgtgtg cccagagcat tggtgagcca
     3241 ggcacccaga tgaccctgaa gactttccac tttgcaggtg tggcctccat gaacatcacc
     3301 ctgggcgtgc cccggattaa agagatcatc aacgcttcca aggccatcag cactccaatt
     3361 atcacagcac agctagacaa ggatgacgac gcggattatg ctcgcctcgt gaaagggaga
     3421 attgagaaaa ccctcttggg agagatttcc gagtatattg aagaagtgtt tcttcctgat
     3481 gactgcttta ttctcgtcaa gctctccctg gaacggatta ggcttctgag actggaagtg
     3541 aacgctgaga cagtgagata ttccatctgc acatccaagc tccgtgtgaa gcccggtgat
     3601 gtggctgttc atggtgaggc tgtggtgtgt gtcaccccca gagagaacag caagagctcc
     3661 atgtactacg tgctgcagtt cctgaaagag gatctcccca aggtggtggt gcagggcatt
     3721 ccagaggtgt ccagagctgt catccacatt gacgagcaga gtggaaagga gaagtacaag
     3781 cttctggtgg aaggtgataa cctgcgggca gtcatggcca cacacggtgt gaagggcacc
     3841 cgaaccacct ccaataacac ctatgaggtg gagaaaactc tgggcatcga ggccgcccgg
     3901 acaacgatca tcaatgaaat ccagtacacc atggtgaacc acggcatgag catcgacagg
     3961 aggcacgtga tgctgctctc cgacctcatg acctacaagg gtgaagtcct gggcatcact
     4021 aggtttggcc tggccaagat gaaggagagt gtgctgatgc tggcctcctt tgagaagacg
     4081 gctgaccatc tctttgacgc tgcctacttc gggcagaagg actctgtgtg tggggtgtct
     4141 gagtgcatca tcatgggaat cccaatgaac attggaaccg ggctcttcaa gctgcttcac
     4201 aaggctgaca gggacccgaa ccctcccaag aggcccctga tcttcgacac aaatgaattc
     4261 cacatccccc ttgtcacata gtccaaagaa agaggggacc atgcctgacc ttgactcctt
     4321 gtcctgtctc cagctgatgt ataaagagtt ttgtgctccc tgggacgggg gtcctgaggt
     4381 ccccacctat gccagcaatc agagaagccc tcttggcatc cccaggagca gcttctcctc
     4441 tgatagggtg cagctcacac cagtgaccct gactgtgcca cgctgctcgg gagagctgag
     4501 ggttttattg tttgcttgct tgaaacctaa tctatagacg gccccacagc tcgtgcacac
     4561 actgcttccc tggacttaaa gcccagccag gtgtcatggt ccatcccagc tcactgcata
     4621 catccatcgg ctccccatgg tgtcttcaca cctgacgatg agccaggcct gagccccaca
     4681 caggccaggg cacattcttg gattttccat tccttggtca tgctggaatc tctcaatgtg
     4741 acatacttat gtaaatattg ttactattat ttatttgttc catttgaggg atttggaatt
     4801 tttgttattt tagttttatt tttgaaacca agcatctata gaaaccaaga aagtcagcat
     4861 gtaagcgtca ctggaaaaac tggtttaagc aaatagagcc gtctgggatt tgtaactgag
     4921 gtgcaactgt catgaggccc aggcagctct gtaacatctt ctatagatgc ccctggctac
     4981 cctgttgttt tcatctacct cagaccccta tcatggggct ctaccctgtg acaagagcca
     5041 aacccattct ccatggccta tggaagcctc actggagttt ggggcctgct gcaatgggga
     5101 tgagatggtt ttttgtagaa ttatacttac gttccttgga tgatctctag ttgatttttt
     5161 aagttctgag ttgatgctgt taaggtaccc ggggtagcca ttggttcttg gatctgtgtt
     5221 agaatgagtg ctttcccttc ctactgatgt gattgtggat taggaattcg tgaccgagtg
     5281 atttttggcc agtggttggg tttaaaattc tattaaaatt tgtagtttgg gctgggtgct
     5341 gtggctcata cctataatcc cagcactttg ggaggccgag gggggcagat cacttgagcc
     5401 caggagttcg agagcagcct gggcaacatg acgaaacccc gtctctacag agaatacaaa
     5461 aattagccag gcatggtggc ccatgcctgt agtacctgct attggtaagg ctgaggtgga
     5521 aggttcactt gagcctggga ggtggaggtt gtagtgagcc aagatcgtgc cactacactc
     5581 cagcctgggc aacaaagcaa gaccttgtct caaaaaaaaa aaagaaaaaa attaagcgta
     5641 aaaaaaaatt agtttttata aaaaattata gtttgacctt ttgatttccc tgcatctaca
     5701 aggtagacct attaacttct cttggggtat cagtgatgtg gaaaaaaaat gccatttttc
     5761 ttaatgttta accccccttt atctttgaat tgagctagag cctggtttag gacaaaggat
     5821 taagtttgtt aatgaacact aattcagggc ttctacttga gaccccaccg agatcaccag
     5881 ttctcatgta acctgggaag agccataaag gggtaccccc caccccaact gccttcctgg
     5941 aagcatgcct gggaagtaag ctgtaggcct gatccgagcc aggaccactg ggatccgtgc
     6001 aaaggccagg ggagggtaga attgaatcat aggagtgaac tccggcacct gttgtcttct
     6061 gcgggtgacg cacactttaa atggaagaga ggttgtggct ataacttgtg gctgggaata
     6121 ataaagatgg caccgccaag gagcctcacc ttgcgtgagt gagtactcag ttgggcgctg
     6181 cagggtctgg agtctgtgtg agacgtgtgt gattgtgatg ggtgcgaatc agcgtatagc
     6241 acttgagaac aaggcagacc ttggagcaga atggttatgt gaaggatcac atcacccatg
     6301 ggtagggggg gaagtcatac gtcctggagg tgctggtcct cctcctggaa ctgccagcct
     6361 tgctaggact atcaacatca acagcattgc ctggtaaacc ctactgtttg tgctccccac
     6421 tgtgtcccat gactggtgtt aaaattctcc ctactttgat catctgccct gcccaggcct
     6481 tgggctttat gccagcacag agctcaaagg ccaggtagca gcacatcctc aagcatgaga
     6541 gctcaaaggg ttacatttga gtctctgtac ctgcttggaa gaaataaaaa tacgtgtgaa
     6601 ttccatctca
//
