LOCUS       NM_015532               4114 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens RNA polymerase II subunit M (POLR2M), transcript
            variant 1, mRNA.
ACCESSION   NM_015532
VERSION     NM_015532.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4114)
  AUTHORS   Stavast,C.J., van Zuijen,I., Karkoulia,E., Ozcelik,A., van
            Hoven-Beijen,A., Leon,L.G., Voerman,J.S.A., Janssen,G.M.C., van
            Veelen,P.A., Burocziova,M., Brouwer,R.W.W., van IJcken,W.F.J.,
            Maas,A., Bindels,E.M., van der Velden,V.H.J., Schliehe,C.,
            Katsikis,P.D., Alberich-Jorda,M. and Erkeland,S.J.
  TITLE     The tumor suppressor MIR139 is silenced by POLR2M to promote AML
            oncogenesis
  JOURNAL   Leukemia 36 (3), 687-700 (2022)
   PUBMED   34741119
  REMARK    GeneRIF: The tumor suppressor MIR139 is silenced by POLR2M to
            promote AML oncogenesis.
REFERENCE   2  (bases 1 to 4114)
  AUTHORS   Ball,C.B., Parida,M., Santana,J.F., Spector,B.M., Suarez,G.A. and
            Price,D.H.
  TITLE     Nuclear export restricts Gdown1 to a mitotic function
  JOURNAL   Nucleic Acids Res 50 (4), 1908-1926 (2022)
   PUBMED   35048979
  REMARK    GeneRIF: Nuclear export restricts Gdown1 to a mitotic function.
REFERENCE   3  (bases 1 to 4114)
  AUTHORS   Jishage,M., Yu,X., Shi,Y., Ganesan,S.J., Chen,W.Y., Sali,A.,
            Chait,B.T., Asturias,F.J. and Roeder,R.G.
  TITLE     Architecture of Pol II(G) and molecular mechanism of transcription
            regulation by Gdown1
  JOURNAL   Nat Struct Mol Biol 25 (9), 859-867 (2018)
   PUBMED   30190596
REFERENCE   4  (bases 1 to 4114)
  AUTHORS   DeLaney,E. and Luse,D.S.
  TITLE     Gdown1 Associates Efficiently with RNA Polymerase II after Promoter
            Clearance and Displaces TFIIF during Transcript Elongation
  JOURNAL   PLoS One 11 (10), e0163649 (2016)
   PUBMED   27716820
  REMARK    GeneRIF: The relatively slow functional loading of Gdown1 in the
            presence of TFIIF.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4114)
  AUTHORS   Jacob,C.P., Koutsilieri,E., Bartl,J., Neuen-Jacob,E., Arzberger,T.,
            Zander,N., Ravid,R., Roggendorf,W., Riederer,P. and Grunblatt,E.
  TITLE     Alterations in expression of glutamatergic transporters and
            receptors in sporadic Alzheimer's disease
  JOURNAL   J Alzheimers Dis 11 (1), 97-116 (2007)
   PUBMED   17361039
REFERENCE   6  (bases 1 to 4114)
  AUTHORS   Hu,X., Malik,S., Negroiu,C.C., Hubbard,K., Velalar,C.N.,
            Hampton,B., Grosu,D., Catalano,J., Roeder,R.G. and Gnatt,A.
  TITLE     A Mediator-responsive form of metazoan RNA polymerase II
  JOURNAL   Proc Natl Acad Sci U S A 103 (25), 9506-9511 (2006)
   PUBMED   16769904
REFERENCE   7  (bases 1 to 4114)
  AUTHORS   Guinn,B.A., Bland,E.A., Lodi,U., Liggins,A.P., Tobal,K.,
            Petters,S., Wells,J.W., Banham,A.H. and Mufti,G.J.
  TITLE     Humoral detection of leukaemia-associated antigens in presentation
            acute myeloid leukaemia
  JOURNAL   Biochem Biophys Res Commun 335 (4), 1293-1304 (2005)
   PUBMED   16112646
REFERENCE   8  (bases 1 to 4114)
  AUTHORS   Roginski,R.S., Mohan Raj,B.K., Birditt,B. and Rowen,L.
  TITLE     The human GRINL1A gene defines a complex transcription unit, an
            unusual form of gene organization in eukaryotes
  JOURNAL   Genomics 84 (2), 265-276 (2004)
   PUBMED   15233991
REFERENCE   9  (bases 1 to 4114)
  AUTHORS   Sato,S., Tomomori-Sato,C., Parmely,T.J., Florens,L., Zybailov,B.,
            Swanson,S.K., Banks,C.A., Jin,J., Cai,Y., Washburn,M.P.,
            Conaway,J.W. and Conaway,R.C.
  TITLE     A set of consensus mammalian mediator subunits identified by
            multidimensional protein identification technology
  JOURNAL   Mol Cell 14 (5), 685-691 (2004)
   PUBMED   15175163
REFERENCE   10 (bases 1 to 4114)
  AUTHORS   Roginski,R.S., Mohan Raj,B.K., Finkernagel,S.W. and Sciorra,L.J.
  TITLE     Assignment of an ionotropic glutamate receptor-like gene (GRINL1A)
            to human chromosome 15q22.1 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 93 (1-2), 143-144 (2001)
   PUBMED   11474202
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY339380.1, AK074955.1,
            AL050091.1 and BF939412.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_015532.4.
            
            Summary: This gene encodes a subunit of a specific form of RNA
            polymerase II termed Pol II(G). The encoded protein may act as a
            negative regulator of transcriptional activation by the Mediator
            complex. Alternative splicing results in multiple transcript
            variants. There is a pseudogene for this gene on chromosome 4.
            Readthrough transcription between this gene and the neighboring
            upstream gene MYZAP (myocardial zonula adherens protein) is
            represented with GeneID 145781. [provided by RefSeq, Oct 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.8888.1,
                                           SRR1660805.235853.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299638.8/ ENSP00000299638.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-312               AY339380.1         12-323
            313-1362            AK074955.1         310-1359
            1363-4112           AL050091.1         724-3473
            4113-4114           BF939412.1         14-15               c
FEATURES             Location/Qualifiers
     source          1..4114
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.3"
     gene            1..4114
                     /gene="POLR2M"
                     /gene_synonym="GCOM1; Gdown; Gdown1; GRINL1A"
                     /note="RNA polymerase II subunit M"
                     /db_xref="GeneID:81488"
                     /db_xref="HGNC:HGNC:14862"
                     /db_xref="MIM:606485"
     exon            1..242
                     /gene="POLR2M"
                     /gene_synonym="GCOM1; Gdown; Gdown1; GRINL1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1236
                     /gene="POLR2M"
                     /gene_synonym="GCOM1; Gdown; Gdown1; GRINL1A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     GRINL1A downstream protein Gdown4; polymerase (RNA) II
                     (DNA directed) polypeptide M; glutamate receptor,
                     ionotropic, N-methyl D-aspartate-like 1A; polymerase (RNA)
                     II subunit M"
                     /codon_start=1
                     /product="protein GRINL1A isoform 1"
                     /protein_id="NP_056347.1"
                     /db_xref="CCDS:CCDS32252.1"
                     /db_xref="GeneID:81488"
                     /db_xref="HGNC:HGNC:14862"
                     /db_xref="MIM:606485"
                     /translation="MCSLPRGFEPQAPEDLAQRSLVELREMLKRQERLLRNEKFICKL
                     PDKGKKIFDSFAKLKAAIAECEEVRRKSELFNPVSLDCKLRQKAIAEVDVGTDKAQNS
                     DPILDTSSLVPGCSSVDNIKSSQTSQNQGLGRPTLEGDEETSEVEYTVNKGPASSNRD
                     RVPPSSEASEHHPRHRVSSQAEDTSSSFDNLFIDRLQRITIADQGEQQSEENASTKNL
                     TGLSSGTEKKPHYMEVLEMRAKNPVPQLRKFKTNVLPFRQNDSSSHCQKSGSPISSEE
                     RRRRDKQHLDDITAARLLPLHHMPTQLLSIEESLALQKQQKQNYEEMQAKLAAQKLAE
                     RLNIKMRSYNPEGESSGRYREVRDEDDDWSSDEF"
     exon            243..887
                     /gene="POLR2M"
                     /gene_synonym="GCOM1; Gdown; Gdown1; GRINL1A"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1092
                     /gene="POLR2M"
                     /gene_synonym="GCOM1; Gdown; Gdown1; GRINL1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..4114
                     /gene="POLR2M"
                     /gene_synonym="GCOM1; Gdown; Gdown1; GRINL1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1449..1454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POLR2M"
                     /gene_synonym="GCOM1; Gdown; Gdown1; GRINL1A"
                     /note="hexamer: ATTAAA"
     polyA_site      1467
                     /gene="POLR2M"
                     /gene_synonym="GCOM1; Gdown; Gdown1; GRINL1A"
                     /note="major polyA site"
     regulatory      2789..2794
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POLR2M"
                     /gene_synonym="GCOM1; Gdown; Gdown1; GRINL1A"
                     /note="hexamer: ATTAAA"
     polyA_site      2808
                     /gene="POLR2M"
                     /gene_synonym="GCOM1; Gdown; Gdown1; GRINL1A"
                     /note="major polyA site"
     regulatory      4103..4108
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POLR2M"
                     /gene_synonym="GCOM1; Gdown; Gdown1; GRINL1A"
                     /note="hexamer: AATAAT"
     polyA_site      4114
                     /gene="POLR2M"
                     /gene_synonym="GCOM1; Gdown; Gdown1; GRINL1A"
                     /note="major polyA site"
ORIGIN      
        1 gttcttccgg gaaaatggcg actcccgctc gtgccccgga gtcaccgccg tccgcggatc
       61 cggcgctagt agcggggcct gccgaggaag ccgagtgccc gccgccgcgc cagcctcagc
      121 ccgcgcagaa tgtgctcgct gccccgcggc ttcgagcccc aagctcccga ggacttggcg
      181 cagcggagtt tggtggagct gcgggaaatg ttgaagcgcc aggagagact tttgcgcaac
      241 gaaaaattca tttgcaaatt gcccgacaaa ggtaaaaaga tctttgactc ttttgccaaa
      301 ctgaaagctg ccattgcaga atgtgaagaa gttagaagaa aaagtgaact gtttaaccct
      361 gttagtttag actgtaagct aaggcaaaaa gcaattgcag aagttgatgt gggtacagat
      421 aaggcccaga attctgaccc gatacttgat acttcatcac tagttcctgg atgttcctct
      481 gtagataaca tcaagtcatc tcaaacctca caaaaccagg gacttggacg tcctactctt
      541 gaaggtgatg aagagacttc agaggttgag tacacagtga ataagggccc agcttccagc
      601 aatagagaca gggtaccacc ttcatctgaa gctagtgagc atcacccgcg gcatcgtgtt
      661 tcaagtcaag cggaagatac ttccagcagc tttgacaacc tgtttattga caggttacag
      721 aggatcacca ttgcggacca aggtgaacaa cagtcagaag aaaacgcaag tactaagaac
      781 ttgacaggcc tttccagtgg gactgagaag aaacctcatt acatggaagt gctagaaatg
      841 cgagccaaaa acccagtgcc ccagctgcgt aaatttaaaa ccaatgtgtt accttttcga
      901 caaaatgatt catctagtca ttgccagaag agtgggtctc ctatttcctc agaagagcgg
      961 cggcgcaggg ataagcagca tcttgatgac atcacagcag ctcggcttct accacttcac
     1021 catatgccca cgcagctgct ctccatagaa gaatccttgg cacttcagaa acagcagaaa
     1081 cagaattatg aggagatgca agcaaagctc gcagcgcaaa aattagctga aagactgaat
     1141 attaaaatgc ggagttataa tccagaaggg gagtcttcag ggagataccg agaagtaagg
     1201 gatgaagatg acgattggtc ctctgatgaa ttctgaagat aatctcctaa atcactgacg
     1261 ttgagatgtc atcatcttac atcagacttt ctaactagta tcaagatcag tgtcagatat
     1321 tgttgaggga agtaatttta taaagttaca caaaggtagt tataaaaaaa gcccagtttg
     1381 tctttcagaa ggtgactttc atgtgcttga aaagtttaat atttgaatat tgtgtttaac
     1441 cacatggtat taaaattttg caatatattg tgtattggtc tgatatttta gtatatagta
     1501 gaacatactt tttttttctt taagccaaat gaaaagaggt aactttgctt ttttcctttt
     1561 tcttacctat caaatagcat ttattacatg tctttcagtg aaatacttag ttgttccagg
     1621 cacctaaaat caattaggaa gacatagttc ccttcttttt tgggtaatga agggagcagt
     1681 ctaaagaatt gtatgcatgt ttgcatgggg ttattgagac attggatgtg aaatacctag
     1741 gaagacatgt atggagaatg cttaacaaat gctcttctcc tttttctgtc ttcccttagg
     1801 aagaacgtta tctctcttct gattaggaag gacttccctt ttgagtagat gctggaaagt
     1861 ggaggttttt tttgttggtt tgtttgtttg gttttgtgtt tttttttgag atggggtctt
     1921 gctctgtcgc ccaggctgga gtgcagtggc aggatctcgg ctcactgcaa tctaggtgga
     1981 ggtcttttta aataacctca tgttacttca ggcaaatctg gtacaggaga agcccaagct
     2041 aactgagctg ggtgaaggct tgtgcatcac ctggcttgag ttccttgctg tcacagatga
     2101 taggttcatg tacacaacat taatgtttga taaggaaagc attttttttt tgttaaaatt
     2161 gaattgtcag tactttactt ttttcccccc aaataggtat atatagactg cagaagcttc
     2221 agtcccatat ataaacgttc atgtcatttt agaggattat atggttgtct ccagagaaat
     2281 taacttacat tatcaaaaaa ttctttgtct aatatattgg agtctttaaa agtgttgaag
     2341 aataaaatat taattagaac aacttcaaat gctaaggtga tgttttaccg ggacttaatt
     2401 aaatacaact ttttcctttc gaaaaagact gttcacattt gcttccaggt gtaattattg
     2461 ctttcattcc ttacccccct caagcaaatg tgaaaagtat actgacctaa gattctcatt
     2521 agttttagtt cttaaaacga atagtaaatg atttcacagc gtaaaatttg atgttatttc
     2581 tggaagctgg atgatatgga agagttcatg tgcctggaca cacagttccc tgtaatcctg
     2641 ccatctaggg agataaactc tgttaacatt ttgatgttgt gtttttgctt atttttctat
     2701 gcatagttat gcatttatat tctcaaaaat gaaatcataa tgtacattgc tttgtagtct
     2761 gctctatata ttgtcaatat gttcccatat taaatatttt gctttttaga cagctgtagg
     2821 atattttatt tcatgggtat accataactt taagatttat ttcctattca gcaatttgat
     2881 tatgtattat aatgtaatct gtaaatagtg atatgattaa catcttaatc acatccatag
     2941 aaaatgactt atttccagaa gataccgctc taaaaatgaa attgttaggt gaaagtgttt
     3001 ttgagaattt ttatatatat tactcactgc agagatcatg ttcatttaca ttcccattag
     3061 caatatatcc aatgctcaga attgaaaatt actacttaaa atctttgcaa attgaataat
     3121 tacagaaaag ggctacattt aaaatttgta tttgtttttc ttacttagtg aaggttgtgt
     3181 tttttttcat attcattggc catgctatat tcattctttt gagaattgct cattcatatt
     3241 ttttctgttg cttgcttgga gaatttgctc tttttttggc atataagttc ttaagaatgt
     3301 ccgtcctttg tcatatattg taactttttt tagccttatt tgtcatttaa catagtttgt
     3361 ggtatttcag tatagaagtt gttttcttta ggagtctacc tttgtgtatg tgcttgaaag
     3421 tatttttgta atccaagaat ggataaatgt ccttattttc ttctagtatt ttcttatttc
     3481 acttttacac ctatctttaa aaggaattta aattttgttt atatacatta actaaatcag
     3541 tacaagtttg gggtgaaaag gaaattttta atccatctca aatgtatttg gttatattat
     3601 ataaggtagg gatttgattt tatttcgaag aatttaccaa ttggttcagt atgtgaaacc
     3661 accatttccc ctctgattag taatgctatt tttatagaat attaaattct tatgtgtctt
     3721 ttgtgtctta ggccaatttc tgggccttct gggttttttc tacactgtca ataattatcg
     3781 ctttaattgg tgttaatatt tggtagtaca caggttctcc cttgttcttt taaattttgt
     3841 gaaatataac ttacaaataa gtacttaaaa cagagcttaa tgggtaaagc aacagctgtg
     3901 taatcacaaa ctagatgcag aggaggtctt gccagcactc caaaatctct gtgtgtcccc
     3961 tcttgacact cactgtttcc cccagagcta actatcctga cgtatggtaa ttctccctct
     4021 gtccttttaa gaattatttt accagttatg tgtataacaa tatggtttac attttgctca
     4081 cttttgactt atataaaaat agaataatac tata
//
