LOCUS       NM_021128                876 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens RNA polymerase II, I and III subunit L (POLR2L), mRNA.
ACCESSION   NM_021128
VERSION     NM_021128.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 876)
  AUTHORS   Daiss,J.L., Pilsl,M., Straub,K., Bleckmann,A., Hocherl,M.,
            Heiss,F.B., Abascal-Palacios,G., Ramsay,E.P., Tluckova,K.,
            Mars,J.C., Furtges,T., Bruckmann,A., Rudack,T., Bernecky,C.,
            Lamour,V., Panov,K., Vannini,A., Moss,T. and Engel,C.
  TITLE     The human RNA polymerase I structure reveals an HMG-like docking
            domain specific to metazoans
  JOURNAL   Life Sci Alliance 5 (11), e202201568 (2022)
   PUBMED   36271492
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 876)
  AUTHORS   Hou,H., Li,Y., Wang,M., Liu,A., Yu,Z., Chen,K., Zhao,D. and Xu,Y.
  TITLE     Structural insights into RNA polymerase III-mediated transcription
            termination through trapping poly-deoxythymidine
  JOURNAL   Nat Commun 12 (1), 6135 (2021)
   PUBMED   34675218
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 876)
  AUTHORS   Zhao,D., Liu,W., Chen,K., Wu,Z., Yang,H. and Xu,Y.
  TITLE     Structure of the human RNA polymerase I elongation complex
  JOURNAL   Cell Discov 7 (1), 97 (2021)
   PUBMED   34671025
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 876)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 876)
  AUTHORS   Acker,J., Murroni,O., Mattei,M.G., Kedinger,C. and Vigneron,M.
  TITLE     The gene (POLR2L) encoding the hRPB7.6 subunit of human RNA
            polymerase
  JOURNAL   Genomics 32 (1), 86-90 (1996)
   PUBMED   8786124
REFERENCE   6  (bases 1 to 876)
  AUTHORS   McKune,K., Moore,P.A., Hull,M.W. and Woychik,N.A.
  TITLE     Six human RNA polymerase subunits functionally substitute for their
            yeast counterparts
  JOURNAL   Mol Cell Biol 15 (12), 6895-6900 (1995)
   PUBMED   8524256
REFERENCE   7  (bases 1 to 876)
  AUTHORS   Shpakovski,G.V., Acker,J., Wintzerith,M., Lacroix,J.F., Thuriaux,P.
            and Vigneron,M.
  TITLE     Four subunits that are shared by the three classes of RNA
            polymerase are functionally interchangeable between Homo sapiens
            and Saccharomyces cerevisiae
  JOURNAL   Mol Cell Biol 15 (9), 4702-4710 (1995)
   PUBMED   7651387
REFERENCE   8  (bases 1 to 876)
  AUTHORS   Kato,H., Sumimoto,H., Pognonec,P., Chen,C.H., Rosen,C.A. and
            Roeder,R.G.
  TITLE     HIV-1 Tat acts as a processivity factor in vitro in conjunction
            with cellular elongation factors
  JOURNAL   Genes Dev 6 (4), 655-666 (1992)
   PUBMED   1559613
REFERENCE   9  (bases 1 to 876)
  AUTHORS   Jang,K.L., Collins,M.K. and Latchman,D.S.
  TITLE     The human immunodeficiency virus tat protein increases the
            transcription of human Alu repeated sequences by increasing the
            activity of the cellular transcription factor TFIIIC
  JOURNAL   J Acquir Immune Defic Syndr (1988) 5 (11), 1142-1147 (1992)
   PUBMED   1403646
REFERENCE   10 (bases 1 to 876)
  AUTHORS   Jacob,G.A., Luse,S.W. and Luse,D.S.
  TITLE     Abortive initiation is increased only for the weakest members of a
            set of down mutants of the adenovirus 2 major late promoter
  JOURNAL   J Biol Chem 266 (33), 22537-22544 (1991)
   PUBMED   1939271
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC005903.1, BC018649.2,
            BQ435190.1 and BU679804.1.
            
            On Nov 23, 2018 this sequence version replaced NM_021128.4.
            
            Summary: This gene encodes a subunit of RNA polymerase II, the
            polymerase responsible for synthesizing messenger RNA in
            eukaryotes. The product of this gene contains four conserved
            cysteines characteristic of an atypical zinc-binding domain. Like
            its counterpart in yeast, this subunit may be shared by the other
            two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.295353.1,
                                           SRR5189667.157673.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322028.5/ ENSP00000324124.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BC005903.1         2-20
            20-119              BC018649.2         1-100
            120-392             BQ435190.1         106-378
            393-829             BU679804.1         68-504              c
            830-876             BC018649.2         813-859
FEATURES             Location/Qualifiers
     source          1..876
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..876
                     /gene="POLR2L"
                     /gene_synonym="hRPB7.6; RBP10; RPABC5; RPB10; RPB10beta;
                     RPB7.6"
                     /note="RNA polymerase II, I and III subunit L"
                     /db_xref="GeneID:5441"
                     /db_xref="HGNC:HGNC:9199"
                     /db_xref="MIM:601189"
     exon            1..116
                     /gene="POLR2L"
                     /gene_synonym="hRPB7.6; RBP10; RPABC5; RPB10; RPB10beta;
                     RPB7.6"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..225
                     /gene="POLR2L"
                     /gene_synonym="hRPB7.6; RBP10; RPABC5; RPB10; RPB10beta;
                     RPB7.6"
                     /EC_number="2.7.7.6"
                     /note="RPB10 homolog; RNA polymerase II 7.6 kDa subunit;
                     RNA polymerase II subunit L; polymerase (RNA) II subunit
                     L; DNA-directed RNA polymerase III subunit L; RNA
                     polymerases I, II, and III subunit ABC5; polymerase (RNA)
                     II (DNA directed) polypeptide L, 7.6kDa"
                     /codon_start=1
                     /product="DNA-directed RNA polymerases I, II, and III
                     subunit RPABC5"
                     /protein_id="NP_066951.1"
                     /db_xref="CCDS:CCDS7720.1"
                     /db_xref="GeneID:5441"
                     /db_xref="HGNC:HGNC:9199"
                     /db_xref="MIM:601189"
                     /translation="MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYC
                     CRRMLLAHVDLIEKLLNYAPLEK"
     exon            117..876
                     /gene="POLR2L"
                     /gene_synonym="hRPB7.6; RBP10; RPABC5; RPB10; RPB10beta;
                     RPB7.6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      373..378
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POLR2L"
                     /gene_synonym="hRPB7.6; RBP10; RPABC5; RPB10; RPB10beta;
                     RPB7.6"
                     /note="hexamer: AGTAAA"
     polyA_site      393
                     /gene="POLR2L"
                     /gene_synonym="hRPB7.6; RBP10; RPABC5; RPB10; RPB10beta;
                     RPB7.6"
                     /note="major polyA site"
     regulatory      783..788
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POLR2L"
                     /gene_synonym="hRPB7.6; RBP10; RPABC5; RPB10; RPB10beta;
                     RPB7.6"
                     /note="hexamer: AATAAA"
     polyA_site      808
                     /gene="POLR2L"
                     /gene_synonym="hRPB7.6; RBP10; RPABC5; RPB10; RPB10beta;
                     RPB7.6"
     polyA_site      876
                     /gene="POLR2L"
                     /gene_synonym="hRPB7.6; RBP10; RPABC5; RPB10; RPB10beta;
                     RPB7.6"
ORIGIN      
        1 agtctgggac gcgccgccgc catgatcatc cctgtacgct gcttcacttg tggcaagatc
       61 gtcggcaaca agtgggaggc ttacctgggg ctgctgcagg ccgagtacac cgagggggat
      121 gcgctggatg ccctgggcct gaagcgctac tgctgccgcc ggatgctgct ggcccacgtg
      181 gacctgatcg agaagctgct caattatgca cccctggaga agtgaccacg ctggaaccca
      241 cccacccgct gtgctgacca tgggccctga gcgtcctgcc ccgaattcac gaggctgagg
      301 catccgggag ctggcgtaat gcctggccgc agtgtgtgtg tatccgatac cccactctgg
      361 aaggaaccat ccagtaaagg tctttcagaa ccactaaggt cccagccctc actaggatgt
      421 caggagccag gtctaggccc agctttcaca ctgtggcagc ccagtgaagc agactgggcc
      481 atgaactctc ctagccctgg ggccagcctg ttccacaggc acccctgcag gaggcgctgc
      541 caggagagcc ttccatctcg gggctctttg aggttccctc cttctgggtg ttcttcaggc
      601 tgagcagaga ggctcctgta ccctctctct cggaatctga agagccagat ttaggccggg
      661 caaaggggct cacccctata atcccaggac tttgggaggc caaggcagga ggatcacttg
      721 agtccagaaa ttcaagaccc gcctgggcat cataatgaga ccccatctct acaacaaaat
      781 ttaataaatt agctgggcac agtgttcaca cctgtagtcc cggccactcg gggctgaggc
      841 aggaggatca ctggaacctg ggaggttgcc actgca
//
