LOCUS       NM_002696                791 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens RNA polymerase II subunit G (POLR2G), mRNA.
ACCESSION   NM_002696
VERSION     NM_002696.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 791)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 791)
  AUTHORS   Zhang,Y., Zhang,T. and Chen,Y.
  TITLE     Comprehensive Analysis of Gene Expression Profiles and DNA
            Methylome reveals Oas1, Ppie, Polr2g as Pathogenic Target Genes of
            Gestational Diabetes Mellitus
  JOURNAL   Sci Rep 8 (1), 16244 (2018)
   PUBMED   30389953
  REMARK    GeneRIF: Study of datasets analyzing the gene expression profiles
            and DNA methylation data of gestational Diabetes Mellitus (GDM) and
            confirmed through real time PCR in placenta tissue of three GDM
            samples and three normal samples identified Oas1, Ppie, Polr2g as
            possible pathogenic target genes of GDM by combining
            protein-protein interaction analysis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 791)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 791)
  AUTHORS   Zhao,Y., Li,K.K., Ng,K.P., Ng,C.H. and Lee,K.A.
  TITLE     The RNA Pol II sub-complex hsRpb4/7 is required for viability of
            multiple human cell lines
  JOURNAL   Protein Cell 3 (11), 846-854 (2012)
   PUBMED   23073835
  REMARK    GeneRIF: The function of Rpb7 interaction with rpb4 in human cells
            indicate that Rpb7 have gene-specific effects but are also more
            generally required for human cell survival.
REFERENCE   5  (bases 1 to 791)
  AUTHORS   Ujvari,A. and Luse,D.S.
  TITLE     RNA emerging from the active site of RNA polymerase II interacts
            with the Rpb7 subunit
  JOURNAL   Nat Struct Mol Biol 13 (1), 49-54 (2006)
   PUBMED   16327806
  REMARK    GeneRIF: the emerging transcript cross-links to the Rpb7 subunit of
            RNA polymerase II in various complexes containing 26- to 32-nt
            transcripts
REFERENCE   6  (bases 1 to 791)
  AUTHORS   Cramer,P., Bushnell,D.A., Fu,J., Gnatt,A.L., Maier-Davis,B.,
            Thompson,N.E., Burgess,R.R., Edwards,A.M., David,P.R. and
            Kornberg,R.D.
  TITLE     Architecture of RNA polymerase II and implications for the
            transcription mechanism
  JOURNAL   Science 288 (5466), 640-649 (2000)
   PUBMED   10784442
REFERENCE   7  (bases 1 to 791)
  AUTHORS   Schoen,T.J., Chandrasekharappa,S.C., Guru,S.C., Mazuruk,K.,
            Chader,G.J. and Rodriguez,I.R.
  TITLE     Human gene for the RNA polymerase II seventh subunit (hsRPB7):
            structure, expression and chromosomal localization
  JOURNAL   Biochim Biophys Acta 1353 (1), 39-49 (1997)
   PUBMED   9256063
REFERENCE   8  (bases 1 to 791)
  AUTHORS   Kato,H., Sumimoto,H., Pognonec,P., Chen,C.H., Rosen,C.A. and
            Roeder,R.G.
  TITLE     HIV-1 Tat acts as a processivity factor in vitro in conjunction
            with cellular elongation factors
  JOURNAL   Genes Dev 6 (4), 655-666 (1992)
   PUBMED   1559613
REFERENCE   9  (bases 1 to 791)
  AUTHORS   Jacob,G.A., Luse,S.W. and Luse,D.S.
  TITLE     Abortive initiation is increased only for the weakest members of a
            set of down mutants of the adenovirus 2 major late promoter
  JOURNAL   J Biol Chem 266 (33), 22537-22544 (1991)
   PUBMED   1939271
REFERENCE   10 (bases 1 to 791)
  AUTHORS   Southgate,C., Zapp,M.L. and Green,M.R.
  TITLE     Activation of transcription by HIV-1 Tat protein tethered to
            nascent RNA through another protein
  JOURNAL   Nature 345 (6276), 640-642 (1990)
   PUBMED   2190099
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG530809.1, BC112162.1 and
            AW016747.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002696.2.
            
            Summary: This gene encodes the seventh largest subunit of RNA
            polymerase II, the polymerase responsible for synthesizing
            messenger RNA in eukaryotes. The protein functions in transcription
            initiation, and is also thought to help stabilize transcribing
            polyermase molecules during elongation. [provided by RefSeq, Jan
            2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.238328.1,
                                           SRR1163655.390074.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301788.12/ ENSP00000301788.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BG530809.1         60-79
            21-610              BC112162.1         1-590
            611-791             AW016747.1         21-201              c
FEATURES             Location/Qualifiers
     source          1..791
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..791
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /note="RNA polymerase II subunit G"
                     /db_xref="GeneID:5436"
                     /db_xref="HGNC:HGNC:9194"
                     /db_xref="MIM:602013"
     exon            1..81
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..588
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /EC_number="2.7.7.6"
                     /note="DNA directed RNA polymerase II 19 kda polypeptide;
                     RNA polymerase II seventh subunit; RNA polymerase II
                     subunit B7; DNA-directed RNA polymerase II subunit G;
                     polymerase (RNA) II subunit G; DNA-directed RNA polymerase
                     II 19 kDa polypeptide; RNA polymerase II 19 kDa subunit;
                     polymerase (RNA) II (DNA directed) polypeptide G"
                     /codon_start=1
                     /product="DNA-directed RNA polymerase II subunit RPB7"
                     /protein_id="NP_002687.1"
                     /db_xref="CCDS:CCDS31585.1"
                     /db_xref="GeneID:5436"
                     /db_xref="HGNC:HGNC:9194"
                     /db_xref="MIM:602013"
                     /translation="MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGF
                     VIAVTTIDNIGAGVIQPGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIG
                     PMSCFISRHSIPSEMEFDPNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAI
                     GSLMDDYLGLVS"
     exon            82..191
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /inference="alignment:Splign:2.1.0"
     exon            192..351
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /inference="alignment:Splign:2.1.0"
     exon            352..402
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /inference="alignment:Splign:2.1.0"
     exon            403..468
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /inference="alignment:Splign:2.1.0"
     exon            469..540
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /inference="alignment:Splign:2.1.0"
     exon            541..574
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /inference="alignment:Splign:2.1.0"
     exon            575..791
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      770..775
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /note="hexamer: TATAAA"
     polyA_site      791
                     /gene="POLR2G"
                     /gene_synonym="hRPB19; hsRPB7; RPB19; RPB7"
                     /note="major polyA site"
ORIGIN      
        1 aagtgtttcc ggtggattcc cagggactgt cggaggtgtg gactctgcct gcctacctgg
       61 tctgggaaga tgttctacca tatctcccta gagcacgaaa tcctgctgca cccgcgctac
      121 ttcggcccca acttgctcaa cacggtgaag cagaagctct tcaccgaggt ggaggggacc
      181 tgcacaggga agtatggctt tgtaattgct gtcaccacca ttgacaatat tggtgctggt
      241 gtgatccagc caggccgagg ctttgtcctt tatccagtta agtacaaggc cattgttttc
      301 cggccattta aaggggaggt cgtggatgct gttgtcactc aggtcaacaa ggttggactc
      361 ttcacagaaa ttgggcccat gtcttgcttc atctctcgac attccatccc ttcagagatg
      421 gagtttgatc ctaactccaa cccaccatgt tacaagacaa tggatgagga tattgtgatt
      481 cagcaggacg atgagatccg cttaaagatt gtggggaccc gtgtggacaa gaatgacatt
      541 tttgctattg gctccctgat ggacgattac ttggggcttg taagctgagc ctggtggcct
      601 cctacccttg gtcctactct aggaagtgtg attgtcacac ttatcatgtt gtccagaggt
      661 ccagtctggc tgctgttgtg gaggcaagga aggcaactca tcccagaagg catctggtgc
      721 ttcttgtagc ttaactactg cctcctcatt tttcagtatg tgttctaagt ataaaaagtc
      781 cttggttctc a
//
