LOCUS       NM_004805               5038 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens RNA polymerase II subunit D (POLR2D), mRNA.
ACCESSION   NM_004805
VERSION     NM_004805.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5038)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5038)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 5038)
  AUTHORS   Marcon,E., Ni,Z., Pu,S., Turinsky,A.L., Trimble,S.S., Olsen,J.B.,
            Silverman-Gavrila,R., Silverman-Gavrila,L., Phanse,S., Guo,H.,
            Zhong,G., Guo,X., Young,P., Bailey,S., Roudeva,D., Zhao,D.,
            Hewel,J., Li,J., Graslund,S., Paduch,M., Kossiakoff,A.A.,
            Lupien,M., Emili,A., Wodak,S.J. and Greenblatt,J.
  TITLE     Human-chromatin-related protein interactions identify a demethylase
            complex required for chromosome segregation
  JOURNAL   Cell Rep 8 (1), 297-310 (2014)
   PUBMED   24981860
REFERENCE   4  (bases 1 to 5038)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
            10.15252/msb.20178107.. PMID: 29254952]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5038)
  AUTHORS   Michiels,S., Laplanche,A., Boulet,T., Dessen,P., Guillonneau,B.,
            Mejean,A., Desgrandchamps,F., Lathrop,M., Sarasin,A. and
            Benhamou,S.
  TITLE     Genetic polymorphisms in 85 DNA repair genes and bladder cancer
            risk
  JOURNAL   Carcinogenesis 30 (5), 763-768 (2009)
   PUBMED   19237606
  REMARK    GeneRIF: Observational study of gene-disease association, gene-gene
            interaction, and gene-environment interaction. (HuGE Navigator)
REFERENCE   6  (bases 1 to 5038)
  AUTHORS   Wu-Baer,F., Sigman,D. and Gaynor,R.B.
  TITLE     Specific binding of RNA polymerase II to the human immunodeficiency
            virus trans-activating region RNA is regulated by cellular
            cofactors and Tat
  JOURNAL   Proc Natl Acad Sci U S A 92 (16), 7153-7157 (1995)
   PUBMED   7638159
REFERENCE   7  (bases 1 to 5038)
  AUTHORS   Kato,H., Sumimoto,H., Pognonec,P., Chen,C.H., Rosen,C.A. and
            Roeder,R.G.
  TITLE     HIV-1 Tat acts as a processivity factor in vitro in conjunction
            with cellular elongation factors
  JOURNAL   Genes Dev 6 (4), 655-666 (1992)
   PUBMED   1559613
REFERENCE   8  (bases 1 to 5038)
  AUTHORS   Jacob,G.A., Luse,S.W. and Luse,D.S.
  TITLE     Abortive initiation is increased only for the weakest members of a
            set of down mutants of the adenovirus 2 major late promoter
  JOURNAL   J Biol Chem 266 (33), 22537-22544 (1991)
   PUBMED   1939271
REFERENCE   9  (bases 1 to 5038)
  AUTHORS   Southgate,C., Zapp,M.L. and Green,M.R.
  TITLE     Activation of transcription by HIV-1 Tat protein tethered to
            nascent RNA through another protein
  JOURNAL   Nature 345 (6276), 640-642 (1990)
   PUBMED   2190099
REFERENCE   10 (bases 1 to 5038)
  AUTHORS   Conaway,R.C. and Conaway,J.W.
  TITLE     ATP activates transcription initiation from promoters by RNA
            polymerase II in a reversible step prior to RNA synthesis
  JOURNAL   J Biol Chem 263 (6), 2962-2968 (1988)
   PUBMED   2449431
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC093795.1, AC006011.2 and
            AA775787.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004805.3.
            
            Summary: This gene encodes the fourth largest subunit of RNA
            polymerase II, the polymerase responsible for synthesizing
            messenger RNA in eukaryotes. In yeast, this polymerase subunit is
            associated with the polymerase under suboptimal growth conditions
            and may have a stress protective role. A sequence for a ribosomal
            pseudogene is contained within the 3' untranslated region of the
            transcript from this gene. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC093795.1, SRR1163655.112702.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2150385 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000272645.9/ ENSP00000272645.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-526               BC093795.1         1-526
            527-2014            AC006011.2         146258-147745       c
            2015-2325           AA775787.1         14-324              c
            2326-5038           AC006011.2         143234-145946       c
FEATURES             Location/Qualifiers
     source          1..5038
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.3"
     gene            1..5038
                     /gene="POLR2D"
                     /gene_synonym="HSRBP4; HSRPB4; RBP4; RPB16; RPB4"
                     /note="RNA polymerase II subunit D"
                     /db_xref="GeneID:5433"
                     /db_xref="HGNC:HGNC:9191"
                     /db_xref="MIM:606017"
     exon            1..128
                     /gene="POLR2D"
                     /gene_synonym="HSRBP4; HSRPB4; RBP4; RPB16; RPB4"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..484
                     /gene="POLR2D"
                     /gene_synonym="HSRBP4; HSRPB4; RBP4; RPB16; RPB4"
                     /EC_number="2.7.7.6"
                     /note="RNA polymerase II subunit hsRBP4; RNA polymerase II
                     subunit B4; DNA-directed RNA polymerase II subunit D;
                     DNA-directed RNA polymerase II 16 kDa polypeptide; RNA
                     polymerase II 16 kDa subunit; polymerase (RNA) II (DNA
                     directed) polypeptide D; polymerase (RNA) II subunit D;
                     RNA polymerase II subunit hsRPB4"
                     /codon_start=1
                     /product="DNA-directed RNA polymerase II subunit RPB4"
                     /protein_id="NP_004796.1"
                     /db_xref="CCDS:CCDS2151.1"
                     /db_xref="GeneID:5433"
                     /db_xref="HGNC:HGNC:9191"
                     /db_xref="MIM:606017"
                     /translation="MAAGGSDPRAGDVEEDASQLIFPKEFETAETLLNSEVHMLLEHR
                     KQQNESAEDEQELSEVFMKTLNYTARFSRFKNRETIASVRSLLLQKKLHKFELACLAN
                     LCPETAEESKALIPSLEGRFEDEELQQILDDIQTKRSFQY"
     exon            129..309
                     /gene="POLR2D"
                     /gene_synonym="HSRBP4; HSRPB4; RBP4; RPB16; RPB4"
                     /inference="alignment:Splign:2.1.0"
     exon            310..405
                     /gene="POLR2D"
                     /gene_synonym="HSRBP4; HSRPB4; RBP4; RPB16; RPB4"
                     /inference="alignment:Splign:2.1.0"
     exon            406..5038
                     /gene="POLR2D"
                     /gene_synonym="HSRBP4; HSRPB4; RBP4; RPB16; RPB4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1905..1910
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POLR2D"
                     /gene_synonym="HSRBP4; HSRPB4; RBP4; RPB16; RPB4"
                     /note="hexamer: AATAAA"
     polyA_site      1932
                     /gene="POLR2D"
                     /gene_synonym="HSRBP4; HSRPB4; RBP4; RPB16; RPB4"
                     /note="major polyA site"
     regulatory      2305..2310
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POLR2D"
                     /gene_synonym="HSRBP4; HSRPB4; RBP4; RPB16; RPB4"
                     /note="hexamer: AATAAA"
     polyA_site      2325
                     /gene="POLR2D"
                     /gene_synonym="HSRBP4; HSRPB4; RBP4; RPB16; RPB4"
     regulatory      5018..5023
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POLR2D"
                     /gene_synonym="HSRBP4; HSRPB4; RBP4; RPB16; RPB4"
                     /note="hexamer: AATAAA"
     polyA_site      5038
                     /gene="POLR2D"
                     /gene_synonym="HSRBP4; HSRPB4; RBP4; RPB16; RPB4"
ORIGIN      
        1 gctccgcgct tctgcttccg gcggcgctgg tggtggcgcg cggcgcggcg cggcgatggc
       61 ggcgggtggc agcgatccgc gggctggcga cgtagaggag gacgcctcac agctcatctt
      121 tcctaaagag tttgaaacag ctgagacact tctaaattca gaagttcata tgcttctgga
      181 acatcgaaag cagcagaatg agagtgcaga ggacgaacag gagctctcag aagtcttcat
      241 gaaaacatta aactacacag cccgtttcag tcgtttcaaa aacagagaga ccattgccag
      301 tgttcgtagc ttgctactcc agaaaaagct tcataagttt gagttggcct gtttggccaa
      361 cctttgccca gagactgctg aggagtccaa ggctctaatc ccaagcttgg agggacggtt
      421 tgaagatgag gagctgcagc agattcttga tgatatccag acaaagcgca gctttcagta
      481 ttaatctcca aacatcactg ctgctcggag aaaccacatc cccaggcata acaccacctt
      541 cccactgtct ggggctgact tgcacagaaa ttctgttgaa gacagttgag aattcctttg
      601 gagaaaacag cccagcttgg cgtggggtta ggttgctgtt tcaaataact cacaggccca
      661 ggtgacatgg aatcttggag cagccttgtg cagtggcagc cagtggcttc ctgaacgtgc
      721 ctctgcgaag tgtgagatga ggggtcacat aaccacactg ttgactacct cattcctggt
      781 ttttggcctc cacatcatct tttttcttaa tatttcatgt tttaatttca gggtgtttat
      841 actttttgaa actagaccag aagatagtag actttataga gaaagaccag ttttacctag
      901 atactaaagg aagaattaaa ccgctgttag tttgaaatgc tttttttttt tttttttaaa
      961 tggagatagg gtcttaactc ttgtccaggc tggaggagtg cagtcgtaca gtcatggctc
     1021 actgaagtct tgaccccgct gcctcagcct cccaaataac tggggccaca ggtgtgcacc
     1081 acaactctca gctaattttt aaaatttttt atagaggtgg ggttttacta tgctgtccag
     1141 actggtctta aactcctggg ctcaagtgat ccccctgcct tggcctccca aactggtgag
     1201 attacaggca tgagccacca caactggcct gaaattctta aaggatggga gtgtcgatga
     1261 cagcaccttg gcatcgttgt gcctaacctg ggagacggaa gaagcacgcc atgggaagtg
     1321 tttacacttg gggacaagtg ctaagtattg tggagcccat agccccttga gatagatggc
     1381 tactttgcct ttcttcttga actgtcttgc agaatgtgga tttggggtaa gtggtcttga
     1441 aggattcatt tagtcaccct caaattaaga tttttacttc atctttcttg ggcctgcacc
     1501 tccaagataa caaagaagaa gcaatggtcg tgccaaagag gtccacaacc aggtgtgcac
     1561 tgttcactgc agcccatttg ctgtatgaac tgtggttgtt gtgtgcccaa tgacaaggct
     1621 actaagaaat tcatcatttg aaacgtagag gccgcagcag tcagcgatgt ttctgaaatg
     1681 agcatccttg acgcctgtgt acttcccagg ctggatgtga agctacatta ccatgtgagt
     1741 tgtgccattc acagcacagt ggtgaggaat tgagctcatg aagcaggcaa ggaccgaaca
     1801 cctccacccc aacgtagacc tgcaggtgct gccccatgac ctccaccaaa gcccatataa
     1861 ggagcggagt tgttaaggac tgaagaaaaa cttctctgga gaaaaataaa attgcaattc
     1921 tacttaaaaa aatttttttt tttttttact tcataggcca ggcttgaagt tctgaacact
     1981 ttgaagtctc caattatgag agatccagtc taagcctctg gcctgctaat tagcaataag
     2041 tgctttattt ggaaggaggg agtcatccac tcttgagcca ctgcagtgaa gtcacttgat
     2101 ctcagtctgg gggaaaacac ttcaatagct aaacattcta gctttgattt ttctgaaggg
     2161 aatacacttg ttttcaattt tggggttttt ctttggggca cttgcttgac tctgtatgaa
     2221 cttgtgatcc aaggaaaaag gagaaagaac agtgttggct tttaaaatca ggatggtttt
     2281 atgtttgcta cgaaataagg caagaataaa aaattcttat ttttatttat ttatttattt
     2341 tttgagatag agtctggctg tgttgcccag gatgcaatgg cgcaatcttg gctcactgca
     2401 acctctgcct tctgggttca agtgattctc ctgcctcagc ctcccaagta gctgggatta
     2461 caggtacctg ccaccacgcc tggctaattt tttgtgtttt tagtagagac agggtttcac
     2521 cacgttcgcc aggctagtct tgaactgacc tcaagtgatc ctcccacctc ggcttcccaa
     2581 agtgctggga ttacaggcgt gagccaccgg ccaatctttt tatccttgag caacttcgct
     2641 tctttgagcc tcattggtgt tctcaattgt gaaatatgga taatagtatc tgccccatgg
     2701 gtattttgag aaggttgaat gaacaggaaa ttattacaaa gagcctagag gtgtctgata
     2761 tatagtatgt tccagtaaat gttcactatt cttagcatct caggcagatg agctagtata
     2821 gatagatgat taagtcagct tgcttcatag aaattagtgc aagaatttgt tagcctacca
     2881 actgatagta tcagacttgg aaaataaatg aaattgggcc aggcgtggtg gctcaccctt
     2941 gtaatcccag cgctttcaga ggccgaggca ggcggatcac ctgaggttgg gagtttgaga
     3001 ccatcctgac caacatggag aaaccccgtc tctacttaaa atacaaaatt agcggggcgt
     3061 ggtggcgcat gcctgtaatc tcagctactc tggaggctga ggcaggagaa ttgcttgaac
     3121 ctgggaggca gagggggtgg cgagccaaga ttgcaccatt gtactccagc ctaggcaaca
     3181 agagcgaaac tgtctcaaaa aaaaaaaaaa aaaaaaagtg aaattgctta cccaaatcta
     3241 cagttaactt tcgtttttta atgcttgatg aatttgcatg tcattcttgg gcagtggcca
     3301 tgctgtcttc tctgtattgt tccaatttgg gtatatgtgc tgccaaagtg agtactgcag
     3361 aattatttct tgagagaggc acttacatgt gctgattggc actaaagcag tggaatggga
     3421 agaagagact tggaaggcag cccagacgat ccaggcgtgt gctagatggc aactgaggag
     3481 cacggtgcta ccatctttac tggtgtttcc acctatgtgc caggggttct gtgagctacc
     3541 tgagaatact gaagtatata atgctctggc acatagttag gcactaatca gtggtattta
     3601 tcaaggtgat taaaagcaga tttaaaaagc agctcacagt tgggcgcggt ggctcacacc
     3661 tgtaatccca gcactttggg aggccgaggc gggtggatca ccagaggtca gaagttcgag
     3721 accagcctgg ccaacgttgt gaaaccctgt ctctactaaa aatacaaaaa ttggccacgt
     3781 gtggtggcgg gcacctgtaa tcctagctac ttgggaagct gagacaggag aattgcttga
     3841 acccgggagg tggaggttgc agtgagccaa gatcatgcca ttgcactcca gcctgggcaa
     3901 caagagcgag actccatctt gaaaaaaaat aaaataataa aaagcagctc atactaggga
     3961 acttggtaaa gcaacctcat gctgttgtag gttgaaagcc tggtcagcta ttctgcaaga
     4021 cagtcaaaaa ttgtttacag ggctggacag catattgcta ttgaaaaata gctattagga
     4081 gaccttgcac aatttgtgaa acattgttag gctcattgta ctgtgtaaaa tcaggaaaga
     4141 atttgggaac atactgatac aacaaaaaga taggttgtca aaccctcact tcaccagaaa
     4201 gctaaattaa ccagataagt ctttctgaaa gttttagtgt cttagtttgt tcctgcgctg
     4261 taacagaata ccttagactg ggtaacctat aaataatagg aatttatttc tcacagtttt
     4321 ggaggctggc aaatgcaaga tccaggtgct ggtacgttca gtgtctggca agggcggctt
     4381 tctggtccaa gatggtgcct ttttttctgc atcttccata gggaatgaac actccttatg
     4441 gtagaaggga tggaaggacc aggctttttt tttttttttt tttggataca gcaggatctt
     4501 gctctgtcgc ccaggctgga gtgcagtggc atgattaagg ttcactgcag cctcaatctc
     4561 ccactctcca gcgatcatcc cacctcagcc tcttggatag ctgggaccac aggcacgagc
     4621 taccatgcct ggctaattta ttttttgtag agacggggtt tcgccatgtt gcccaggctg
     4681 gtctggaatt tctgacctct agcagtccac ctgtttccgc ctcccaaatg ctgagattag
     4741 aggcatgagt cactgcaccc agcccgcagc ctcttttata agggcattaa tccccttcat
     4801 gagggatatt ctctcatgac ttaatcacct gccaaagacc ccacctctta atactacatc
     4861 agtgatgggt tcaatgtatc aattgggtgg gagggggcac attcagacca tagcatctag
     4921 tcattctggt tttattaaga tttattagac ctgaggcatg aaaaatagca tactggatgg
     4981 gacttcagca tcgatgagtt gccttagtaa tactgttaat aaaaagcact aaatatgc
//
