LOCUS       NM_000937               6749 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens RNA polymerase II subunit A (POLR2A), mRNA.
ACCESSION   NM_000937
VERSION     NM_000937.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6749)
  AUTHORS   Okano,A., Miyawaki,S., Teranishi,Y., Hongo,H., Dofuku,S., Ohara,K.,
            Sakai,Y., Shin,M., Nakatomi,H. and Saito,N.
  TITLE     POLR2A Mutation is a Poor Prognostic Marker of Cerebellopontine
            Angle Meningioma
  JOURNAL   Neurosurgery 95 (2), 275-283 (2024)
   PUBMED   38380947
  REMARK    GeneRIF: POLR2A Mutation is a Poor Prognostic Marker of
            Cerebellopontine Angle Meningioma.
REFERENCE   2  (bases 1 to 6749)
  AUTHORS   Anastasopoulou,S., Georgakopoulos,T. and Mouzaki,A.
  TITLE     HIV-1 Transcriptional Activator Tat Inhibits IL2 Expression by
            Preventing the Presence of Pol II on the IL2 Promoter
  JOURNAL   Biomolecules 13 (6), 881 (2023)
   PUBMED   37371461
  REMARK    GeneRIF: HIV-1 Transcriptional Activator Tat Inhibits IL2
            Expression by Preventing the Presence of Pol II on the IL2
            Promoter.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6749)
  AUTHORS   Ohe,S., Kubota,Y., Yamaguchi,K., Takagi,Y., Nashimoto,J.,
            Kozuka-Hata,H., Oyama,M., Furukawa,Y. and Takekawa,M.
  TITLE     ERK-mediated NELF-A phosphorylation promotes transcription
            elongation of immediate-early genes by releasing promoter-proximal
            pausing of RNA polymerase II
  JOURNAL   Nat Commun 13 (1), 7476 (2022)
   PUBMED   36463234
  REMARK    GeneRIF: ERK-mediated NELF-A phosphorylation promotes transcription
            elongation of immediate-early genes by releasing promoter-proximal
            pausing of RNA polymerase II.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6749)
  AUTHORS   Munoz,J.C., Beckerman,I., Choudhary,R., Bouvier,L.A. and Munoz,M.J.
  TITLE     DNA Damage-Induced RNAPII Degradation and Its Consequences in Gene
            Expression
  JOURNAL   Genes (Basel) 13 (11), 1951 (2022)
   PUBMED   36360188
  REMARK    GeneRIF: DNA Damage-Induced RNAPII Degradation and Its Consequences
            in Gene Expression.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6749)
  AUTHORS   Acker,J., Mattei,M.G., Wintzerith,M., Roeckel,N., Depetris,D.,
            Vigneron,M. and Kedinger,C.
  TITLE     Chromosomal localization of human RNA polymerase II subunit genes
  JOURNAL   Genomics 20 (3), 496-499 (1994)
   PUBMED   8034326
REFERENCE   6  (bases 1 to 6749)
  AUTHORS   Barron-Casella,E. and Corden,J.L.
  TITLE     Conservation of the mammalian RNA polymerase II largest-subunit
            C-terminal domain
  JOURNAL   J Mol Evol 35 (5), 405-410 (1992)
   PUBMED   1487824
REFERENCE   7  (bases 1 to 6749)
  AUTHORS   Kato,H., Sumimoto,H., Pognonec,P., Chen,C.H., Rosen,C.A. and
            Roeder,R.G.
  TITLE     HIV-1 Tat acts as a processivity factor in vitro in conjunction
            with cellular elongation factors
  JOURNAL   Genes Dev 6 (4), 655-666 (1992)
   PUBMED   1559613
REFERENCE   8  (bases 1 to 6749)
  AUTHORS   Wintzerith,M., Acker,J., Vicaire,S., Vigneron,M. and Kedinger,C.
  TITLE     Complete sequence of the human RNA polymerase II largest subunit
  JOURNAL   Nucleic Acids Res 20 (4), 910 (1992)
   PUBMED   1542581
REFERENCE   9  (bases 1 to 6749)
  AUTHORS   Jacob,G.A., Luse,S.W. and Luse,D.S.
  TITLE     Abortive initiation is increased only for the weakest members of a
            set of down mutants of the adenovirus 2 major late promoter
  JOURNAL   J Biol Chem 266 (33), 22537-22544 (1991)
   PUBMED   1939271
REFERENCE   10 (bases 1 to 6749)
  AUTHORS   Smith,S.S., Kelly,K.H. and Jockusch,B.M.
  TITLE     Actin co-purifies with RNA polymerase II
  JOURNAL   Biochem Biophys Res Commun 86 (1), 161-166 (1979)
   PUBMED   435297
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC113189.11, X63564.1,
            BC137231.1, BQ353795.1, BU730469.1 and AW589665.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 1, 2018 this sequence version replaced NM_000937.4.
            
            Summary: This gene encodes the largest subunit of RNA polymerase
            II, the polymerase responsible for synthesizing messenger RNA in
            eukaryotes. The product of this gene contains a carboxy terminal
            domain composed of heptapeptide repeats that are essential for
            polymerase activity. These repeats contain serine and threonine
            residues that are phosphorylated in actively transcribing RNA
            polymerase. In addition, this subunit, in combination with several
            other polymerase subunits, forms the DNA binding domain of the
            polymerase, a groove in which the DNA template is transcribed into
            RNA. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X63564.1, BC137231.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000643490.2/ ENSP00000494840.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC113189.11        134449-134461
            14-53               X63564.1           1-40
            54-197              X63564.1           42-185
            198-1859            BC137231.1         1-1662
            1860-1860           BQ353795.1         57-57
            1861-2690           BC137231.1         1664-2493
            2691-2691           AC113189.11        151755-151755
            2692-6366           BC137231.1         2495-6169
            6367-6367           BU730469.1         397-397             c
            6368-6463           BC137231.1         6171-6266
            6464-6749           AW589665.1         3-288               c
FEATURES             Location/Qualifiers
     source          1..6749
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..6749
                     /gene="POLR2A"
                     /gene_synonym="hRPB220; hsRPB1; NEDHIB; POLR2; POLRA;
                     RPB1; RPBh1; RpIILS; RPO2; RPOL2"
                     /note="RNA polymerase II subunit A"
                     /db_xref="GeneID:5430"
                     /db_xref="HGNC:HGNC:9187"
                     /db_xref="MIM:180660"
     exon            1..492
                     /gene="POLR2A"
                     /gene_synonym="hRPB220; hsRPB1; NEDHIB; POLR2; POLRA;
                     RPB1; RPBh1; RpIILS; RPO2; RPOL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             400..6312
                     /gene="POLR2A"
                     /gene_synonym="hRPB220; hsRPB1; NEDHIB; POLR2; POLRA;
                     RPB1; RPBh1; RpIILS; RPO2; RPOL2"
                     /EC_number="2.7.7.6"
                     /EC_number="2.7.7.48"
                     /note="3'-5' exoribonuclease; RNA-directed RNA polymerase
                     II subunit RPB1; DNA-directed RNA polymerase II subunit A;
                     DNA-directed RNA polymerase II largest subunit, RNA
                     polymerase II 220 kd subunit; RNA polymerase II subunit
                     B1; DNA-directed RNA polymerase III largest subunit;
                     polymerase (RNA) II (DNA directed) polypeptide A, 220kDa;
                     polymerase (RNA) II subunit A"
                     /codon_start=1
                     /product="DNA-directed RNA polymerase II subunit RPB1"
                     /protein_id="NP_000928.1"
                     /db_xref="GeneID:5430"
                     /db_xref="HGNC:HGNC:9187"
                     /db_xref="MIM:180660"
                     /translation="MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYP
                     ETTEGGRPKLGGLMDPRQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVK
                     TMKVLRCVCFFCSKLLVDSNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEM
                     DNKFGVEQPEGDEDLTKEKGHGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSP
                     ERVHEIFKRISDEECFVLGMEPRYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDL
                     THKLADIVKINNQLRRNEQNGAAAHVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGR
                     PLKSLKQRLKGKEGRVRGNLMGKRVDFSARTVITPDPNLSIDQVGVPRSIAANMTFAE
                     IVTPFNIDRLQELVRRGNSQYPGAKYIIRDNGDRIDLRFHPKPSDLHLQTGYKVERHM
                     CDGDIVIFNRQPTLHKMSMMGHRVRILPWSTFRLNLSVTTPYNADFDGDEMNLHLPQS
                     LETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTAVRKFTKRDVFLERGEVMNLLMF
                     LSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHINCIRTHSTHPDDEDSGPYKHISPG
                     DTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEMGHDITRLFYSNIQTVINNWLLI
                     EGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQTFENQ
                     VNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKINISQVIAVVGQQNVEGKRI
                     PFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHAMGGREGLIDTAVKTAE
                     TGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGESVEFQNLATLKPSNK
                     AFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMREDREVLRVIFPT
                     GDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKLVIVNGDDPLS
                     RQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVG
                     ALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLTVFLLGQ
                     SARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMPDFDV
                     ARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIRIM
                     NSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
                     IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKAL
                     ERELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETV
                     DVLMEAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLG
                     AAGPTGMFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAAS
                     DASGFSPGYSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTP
                     QSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTS
                     PSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS
                     YSPTSPSYSPTSPSYSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYS
                     PTSPSYSPTSPSYSPTSPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPT
                     SPSYSPSSPEYTPTSPKYSPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSP
                     VYTPTSPKYSPTSPTYSPTSPKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTS
                     PAISPDDSDEEN"
     exon            493..625
                     /gene="POLR2A"
                     /gene_synonym="hRPB220; hsRPB1; NEDHIB; POLR2; POLRA;
                     RPB1; RPBh1; RpIILS; RPO2; RPOL2"
                     /inference="alignment:Splign:2.1.0"
     exon            626..762
                     /gene="POLR2A"
                     /gene_synonym="hRPB220; hsRPB1; NEDHIB; POLR2; POLRA;
                     RPB1; RPBh1; RpIILS; RPO2; RPOL2"
                     /inference="alignment:Splign:2.1.0"
     exon            763..936
                     /gene="POLR2A"
                     /gene_synonym="hRPB220; hsRPB1; NEDHIB; POLR2; POLRA;
                     RPB1; RPBh1; RpIILS; RPO2; RPOL2"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1218
                     /gene="POLR2A"
                     /gene_synonym="hRPB220; hsRPB1; NEDHIB; POLR2; POLRA;
                     RPB1; RPBh1; RpIILS; RPO2; RPOL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1380
                     /gene="POLR2A"
                     /gene_synonym="hRPB220; hsRPB1; NEDHIB; POLR2; POLRA;
                     RPB1; RPBh1; RpIILS; RPO2; RPOL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1601
                     /gene="POLR2A"
                     /gene_synonym="hRPB220; hsRPB1; NEDHIB; POLR2; POLRA;
                     RPB1; RPBh1; RpIILS; RPO2; RPOL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1734
                     /gene="POLR2A"
                     /gene_synonym="hRPB220; hsRPB1; NEDHIB; POLR2; POLRA;
                     RPB1; RPBh1; RpIILS; RPO2; RPOL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1859
                     /gene="POLR2A"
                     /gene_synonym="hRPB220; hsRPB1; NEDHIB; POLR2; POLRA;
                     RPB1; RPBh1; RpIILS; RPO2; RPOL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..2070
                     /gene="POLR2A"
                     /gene_synonym="hRPB220; hsRPB1; NEDHIB; POLR2; POLRA;
                     RPB1; RPBh1; RpIILS; RPO2; RPOL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2280
                     /gene="POLR2A"
                     /gene_synonym="hRPB220; hsRPB1; NEDHIB; POLR2; POLRA;
                     RPB1; RPBh1; RpIILS; RPO2; RPOL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2449
                     /gene="POLR2A"
                     /gene_synonym="hRPB220; hsRPB1; NEDHIB; POLR2; POLRA;
                     RPB1; RPBh1; RpIILS; RPO2; RPOL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2544
                     /gene="POLR2A"
                     /gene_synonym="hRPB220; hsRPB1; NEDHIB; POLR2; POLRA;
                     RPB1; RPBh1; RpIILS; RPO2; RPOL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2545..2748
                     /gene="POLR2A"
                     /gene_synonym="hRPB220; hsRPB1; NEDHIB; POLR2; POLRA;
                     RPB1; RPBh1; RpIILS; RPO2; RPOL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2749..2971
                     /gene="POLR2A"
                     /gene_synonym="hRPB220; hsRPB1; NEDHIB; POLR2; POLRA;
                     RPB1; RPBh1; RpIILS; RPO2; RPOL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2972..3155
                     /gene="POLR2A"
                     /gene_synonym="hRPB220; hsRPB1; NEDHIB; POLR2; POLRA;
                     RPB1; RPBh1; RpIILS; RPO2; RPOL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3156..3327
                     /gene="POLR2A"
                     /gene_synonym="hRPB220; hsRPB1; NEDHIB; POLR2; POLRA;
                     RPB1; RPBh1; RpIILS; RPO2; RPOL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3328..3433
                     /gene="POLR2A"
                     /gene_synonym="hRPB220; hsRPB1; NEDHIB; POLR2; POLRA;
                     RPB1; RPBh1; RpIILS; RPO2; RPOL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3434..3639
                     /gene="POLR2A"
                     /gene_synonym="hRPB220; hsRPB1; NEDHIB; POLR2; POLRA;
                     RPB1; RPBh1; RpIILS; RPO2; RPOL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3640..3864
                     /gene="POLR2A"
                     /gene_synonym="hRPB220; hsRPB1; NEDHIB; POLR2; POLRA;
                     RPB1; RPBh1; RpIILS; RPO2; RPOL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3865..4111
                     /gene="POLR2A"
                     /gene_synonym="hRPB220; hsRPB1; NEDHIB; POLR2; POLRA;
                     RPB1; RPBh1; RpIILS; RPO2; RPOL2"
                     /inference="alignment:Splign:2.1.0"
     exon            4112..4212
                     /gene="POLR2A"
                     /gene_synonym="hRPB220; hsRPB1; NEDHIB; POLR2; POLRA;
                     RPB1; RPBh1; RpIILS; RPO2; RPOL2"
                     /inference="alignment:Splign:2.1.0"
     exon            4213..4317
                     /gene="POLR2A"
                     /gene_synonym="hRPB220; hsRPB1; NEDHIB; POLR2; POLRA;
                     RPB1; RPBh1; RpIILS; RPO2; RPOL2"
                     /inference="alignment:Splign:2.1.0"
     exon            4318..4500
                     /gene="POLR2A"
                     /gene_synonym="hRPB220; hsRPB1; NEDHIB; POLR2; POLRA;
                     RPB1; RPBh1; RpIILS; RPO2; RPOL2"
                     /inference="alignment:Splign:2.1.0"
     exon            4501..4704
                     /gene="POLR2A"
                     /gene_synonym="hRPB220; hsRPB1; NEDHIB; POLR2; POLRA;
                     RPB1; RPBh1; RpIILS; RPO2; RPOL2"
                     /inference="alignment:Splign:2.1.0"
     exon            4705..4891
                     /gene="POLR2A"
                     /gene_synonym="hRPB220; hsRPB1; NEDHIB; POLR2; POLRA;
                     RPB1; RPBh1; RpIILS; RPO2; RPOL2"
                     /inference="alignment:Splign:2.1.0"
     exon            4892..5005
                     /gene="POLR2A"
                     /gene_synonym="hRPB220; hsRPB1; NEDHIB; POLR2; POLRA;
                     RPB1; RPBh1; RpIILS; RPO2; RPOL2"
                     /inference="alignment:Splign:2.1.0"
     exon            5006..5155
                     /gene="POLR2A"
                     /gene_synonym="hRPB220; hsRPB1; NEDHIB; POLR2; POLRA;
                     RPB1; RPBh1; RpIILS; RPO2; RPOL2"
                     /inference="alignment:Splign:2.1.0"
     exon            5156..6749
                     /gene="POLR2A"
                     /gene_synonym="hRPB220; hsRPB1; NEDHIB; POLR2; POLRA;
                     RPB1; RPBh1; RpIILS; RPO2; RPOL2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcagaagc gccgagagcg cggccgggac ggttggagaa gaaggcggct cccggaaggg
       61 ggagagacaa actgccgtaa cctctgccgt tcaggaaccc ggttacttat ttattcgtta
      121 ccctttttct tcttcctccc ccaaaaacct tttccttttc ccttcttttt ttttcctttt
      181 tgggagctga aaaatttccg gtaagggaaa gaagggctcc tttcgctcct tatttccccg
      241 cctccttccc tcccccacct tcccctcctc cggctttttc ctcccaactc ggggaggtcc
      301 ttcccggtgg ccgccctgac gaggtctgag cacctaggcg gaggcggcgc aggctttttg
      361 tagtgaggtt tgcgcctgcg cagcgcgcct gcctccgcca tgcacggggg tggccccccc
      421 tcgggggaca gcgcatgccc gctgcgcacc atcaagagag tccagttcgg agtcctgagt
      481 ccggatgaac tgaagcgaat gtctgtgacg gagggtggca tcaaataccc agagacgact
      541 gagggaggcc gccccaagct tggggggctg atggacccga ggcagggggt gattgagcgg
      601 actggccgct gccaaacatg tgcaggaaac atgacagagt gtcctggcca ctttggccac
      661 attgaactgg ccaagcctgt gtttcacgtg ggcttcctgg tgaagacaat gaaagttttg
      721 cgctgtgtct gcttcttctg ctccaaactg cttgtggact ctaacaaccc aaagatcaag
      781 gatatcctgg ctaagtccaa gggacagccc aagaagcggc tcacacatgt ctacgacctt
      841 tgcaagggca aaaacatatg cgagggtggg gaggagatgg acaacaagtt cggtgtggaa
      901 caacctgagg gtgacgagga tctgaccaaa gaaaagggcc atggtggctg tgggcggtac
      961 cagcccagga tccggcgttc tggcctagag ctgtatgcgg aatggaagca cgttaatgag
     1021 gactctcagg agaagaagat cctgctgagt ccagagcgag tgcatgagat cttcaaacgc
     1081 atctcagatg aggagtgttt tgtgctgggc atggagcccc gctatgcacg gccagagtgg
     1141 atgattgtca cagtgctgcc tgtgcccccg ctctccgtgc ggcctgctgt tgtgatgcag
     1201 ggctctgccc gtaaccagga tgacctgact cacaaactgg ctgacatcgt gaagatcaac
     1261 aatcagctgc ggcgcaatga gcagaacggc gcagcggccc atgtcattgc agaggatgtg
     1321 aagctcctcc agttccatgt ggccaccatg gtggacaatg agctgcctgg cttgccccgt
     1381 gccatgcaga agtctgggcg tcccctcaag tccctgaagc agcggttgaa gggcaaggaa
     1441 ggccgggtgc gagggaacct gatgggcaaa agagtggact tctcggcccg tactgtcatc
     1501 acccccgacc ccaacctctc cattgaccag gttggcgtgc cccgctccat tgctgccaac
     1561 atgacctttg cggagattgt cacccccttc aacattgaca gacttcaaga actagtgcgc
     1621 agggggaaca gccagtaccc aggcgccaag tacatcatcc gagacaatgg tgatcgcatt
     1681 gacttgcgtt tccaccccaa gcccagtgac cttcacctgc agaccggcta taaggtggaa
     1741 cggcacatgt gtgatgggga cattgttatc ttcaaccggc agccaactct gcacaaaatg
     1801 tccatgatgg ggcatcgggt ccgcattctc ccatggtcta cctttcgctt gaatcttagt
     1861 gtgacaactc cgtacaatgc agactttgac ggggatgaga tgaacttgca cctgccacag
     1921 tctctggaga cgcgagcaga gatccaggag ctggccatgg ttcctcgcat gattgtcacc
     1981 ccccagagca atcggcctgt catgggtatt gtgcaggaca cactcacagc agtgcgcaaa
     2041 ttcaccaaga gagacgtctt cctggagcgg ggtgaagtga tgaacctcct gatgttcctg
     2101 tcgacgtggg atgggaaggt cccacagccg gccatcctaa agccccggcc cctgtggaca
     2161 ggcaagcaaa tcttctccct catcatacct ggtcacatca attgtatccg tacccacagc
     2221 acccatcccg atgatgaaga cagtggccct tacaagcaca tctctcctgg ggacaccaag
     2281 gtggtggtgg agaatgggga gctgatcatg ggcatcctgt gtaagaagtc tctgggcacg
     2341 tcagctggct ccctggtcca catctcctac ctagagatgg gtcatgacat cactcgcctc
     2401 ttctactcca acattcagac tgtcattaac aactggctcc tcatcgaggg tcatactatt
     2461 ggcattgggg actccattgc tgattctaag acttaccagg acattcagaa cactattaag
     2521 aaggccaagc aggacgtaat agaggtcatc gagaaggcac acaacaatga gctggagccc
     2581 accccaggga acactctgcg gcagacgttt gagaatcagg tgaaccgcat tcttaacgat
     2641 gcccgagaca agactggctc ctctgctcag aaatccctgt ctgaatacaa taacttcaag
     2701 tctatggtcg tgtccggagc taaaggttcc aagattaaca tctcccaggt cattgctgtc
     2761 gttggacagc agaacgtcga gggcaagcgg attccatttg gcttcaagca ccggactctg
     2821 cctcacttca tcaaggatga ctacgggcct gagagccgtg gctttgtgga gaactcctac
     2881 ctagccggcc tcacacccac tgagttcttt ttccacgcca tggggggtcg tgaggggctc
     2941 attgacacgg ctgtcaagac tgctgagact ggatacatcc agcggcggct gatcaagtcc
     3001 atggagtcag tgatggtgaa gtacgacgcg actgtgcgga actccatcaa ccaggtggtg
     3061 cagctgcgct acggcgaaga cggcctggca ggcgagagcg ttgagttcca gaacctggct
     3121 acgcttaagc cttccaacaa ggcttttgag aagaagttcc gctttgatta taccaatgag
     3181 agggccctgc ggcgcactct gcaggaggac ctggtgaagg acgtgctgag caacgcacac
     3241 atccagaacg agttggagcg ggaatttgag cggatgcggg aggatcggga ggtgctcagg
     3301 gtcatcttcc caactggaga cagcaaggtc gtcctcccct gtaacctgct gcggatgatc
     3361 tggaatgctc agaaaatctt ccacatcaac ccacgccttc cctccgacct gcaccccatc
     3421 aaagtggtgg agggagtcaa ggaattgagc aagaagctgg tgattgtgaa tggggatgac
     3481 ccactaagtc gacaggccca ggaaaatgcc acgctgctct tcaacatcca cctgcggtcc
     3541 acgttgtgtt cccgccgcat ggcagaggag tttcggctca gtggggaggc cttcgactgg
     3601 ctgcttgggg agattgagtc caagttcaac caagccattg cgcatcccgg ggaaatggtg
     3661 ggggctctgg ctgcgcagtc ccttggagaa cctgccaccc agatgacctt gaataccttc
     3721 cactatgctg gtgtgtctgc caagaatgtg acgctgggtg tgccccgact taaggagctc
     3781 atcaacattt ccaagaagcc aaagactcct tcgcttactg tcttcctgtt gggccagtcc
     3841 gctcgagatg ctgagagagc caaggatatt ctgtgccgtc tggagcatac aacgttgagg
     3901 aaggtgactg ccaacacagc catctactat gaccccaacc cccagagcac ggtggtggca
     3961 gaggatcagg aatgggtgaa tgtctactat gaaatgcctg actttgatgt ggcccgaatc
     4021 tccccctggc tgttgcgggt ggagctggat cggaagcaca tgactgaccg gaagctcacc
     4081 atggagcaga ttgctgaaaa gatcaatgct ggttttggtg acgacttgaa ctgcatcttt
     4141 aatgatgaca atgcagagaa gctggtgctc cgtattcgca tcatgaacag cgatgagaac
     4201 aagatgcaag aggaggaaga ggtggtggac aagatggatg atgatgtctt cctgcgctgc
     4261 atcgagtcca acatgctgac agatatgacc ctgcagggca tcgagcagat cagcaaggtg
     4321 tacatgcact tgccacagac agacaacaag aagaagatca tcatcacgga ggatggggaa
     4381 ttcaaggccc tgcaggagtg gatcctggag acggacggcg tgagcttgat gcgggtgctg
     4441 agtgagaagg acgtggaccc cgtacgcacc acgtccaatg acattgtgga gatcttcacg
     4501 gtgctgggca ttgaagccgt gcggaaggcc ctggagcggg agctgtacca cgtcatctcc
     4561 tttgatggct cctatgtcaa ttaccgacac ttggctctct tgtgtgatac catgacctgt
     4621 cgtggccact tgatggccat cacccgacac ggagtcaacc gccaggacac aggaccactc
     4681 atgaagtgtt cctttgagga aacggtggac gtgcttatgg aagcagccgc acacggtgag
     4741 agtgacccca tgaagggggt ctctgagaat atcatgctgg gccagctggc tccggccggc
     4801 actggctgct ttgacctcct gcttgatgca gagaagtgca agtatggcat ggagatcccc
     4861 accaatatcc ccggcctggg ggctgctgga cccaccggca tgttctttgg ttcagcaccc
     4921 agtcccatgg gtggaatctc tcctgccatg acaccttgga accagggtgc aacccctgcc
     4981 tatggcgcct ggtcccccag tgttgggagt ggaatgaccc caggggcagc cggcttctct
     5041 cccagtgctg cgtcagatgc cagcggcttc agcccaggtt actcccctgc ctggtctccc
     5101 acaccgggct ccccggggtc cccaggtccc tcaagcccct acatcccttc accaggtggt
     5161 gccatgtctc ccagctactc gccaacgtca cctgcctacg agccccgctc tcctgggggc
     5221 tacacacccc agagtccctc ttattccccc acttcaccct cctactcccc tacctctcca
     5281 tcctattctc caaccagtcc caactatagt cccacatcac ccagctattc gccaacgtca
     5341 cccagctact caccgacctc tcccagctac tcacccacct ctcccagcta ctcgcccacc
     5401 tctcccagct actcgcccac ctctcccagc tactcaccca cttcccctag ctactcgccc
     5461 acttccccta gctactcgcc aacgtctccc agctactcgc cgacatctcc cagctactcg
     5521 ccaacttcac ccagctattc tcccacttct cccagctact cacctacctc tccaagctat
     5581 tcacccacct cccccagcta ctcacccact tccccaagtt actcacccac cagcccgaac
     5641 tattctccaa ccagtcccaa ttacacccca acatcaccca gctacagccc gacatcaccc
     5701 agctattcac ctactagtcc caactacaca cctaccagcc ctaactacag cccaacctct
     5761 ccaagctact ctccaacatc acccagctat tccccgacct caccaagtta ctccccttcc
     5821 agcccacgat acacaccaca gtctccaacc tataccccaa gctcacccag ctacagcccc
     5881 agctcgccca gctacagccc aacctcaccc aagtacaccc caaccagtcc ttcttacagt
     5941 cccagctccc cagagtatac cccaacctct cccaagtact cacctaccag tcccaaatat
     6001 tcacccacct ctcccaagta ctcgcctacc agtcccacct attcacccac caccccaaaa
     6061 tactccccaa catctcctac ttattcccca acctctccag tctacacccc aacctctccc
     6121 aagtactcac ctactagccc cacttactcg cccacttccc ccaagtactc gcccaccagc
     6181 cccacctact cgcccacctc ccccaaaggc tcaacctact ctcccacttc ccctggttac
     6241 tcgcccacca gccccaccta cagtctcaca agcccggcta tcagcccgga tgacagtgac
     6301 gaggagaact gagggcacgt ggggtgcggc agcgggctag ggcccagggc agcttgcccg
     6361 tgctgctgtg cagttcttgc ctccctcacg gggcgtcacc cccagcccag ctccgttgta
     6421 cataaatgcc ttgtggcaga gctcccggtg aacttctgga tcccgtttct gatgcagact
     6481 cttgtcttgt tctccacttg tgctgttaga actcactggc ccagtggtgt tctcactcct
     6541 accccaccca ccccctgcct gtccccaaat tgaagatcct tccttgcctg tggcttgatg
     6601 cggggcgggt aaagggtatt ttaacttagg ggtagttcct gctgtgagtg gttacagctg
     6661 atcctcggga agaacaaagc taaagctgcc ttttgtctgt tattttattt ttttgaagtt
     6721 taaataaagt ttactaattt tgaccaaaa
//
