LOCUS       NM_170783                851 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens RNA polymerase I subunit H (POLR1H), transcript
            variant a, mRNA.
ACCESSION   NM_170783
VERSION     NM_170783.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 851)
  AUTHORS   Ford,B.L., Wei,T., Liu,H., Scull,C.E., Najmi,S.M., Pitts,S.,
            Fan,W., Schneider,D.A. and Laiho,M.
  TITLE     Expression of RNA polymerase I catalytic core is influenced by
            RPA12
  JOURNAL   PLoS One 18 (5), e0285660 (2023)
   PUBMED   37167337
  REMARK    GeneRIF: Expression of RNA polymerase I catalytic core is
            influenced by RPA12.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 851)
  AUTHORS   Daiss,J.L., Pilsl,M., Straub,K., Bleckmann,A., Hocherl,M.,
            Heiss,F.B., Abascal-Palacios,G., Ramsay,E.P., Tluckova,K.,
            Mars,J.C., Furtges,T., Bruckmann,A., Rudack,T., Bernecky,C.,
            Lamour,V., Panov,K., Vannini,A., Moss,T. and Engel,C.
  TITLE     The human RNA polymerase I structure reveals an HMG-like docking
            domain specific to metazoans
  JOURNAL   Life Sci Alliance 5 (11), e202201568 (2022)
   PUBMED   36271492
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 851)
  AUTHORS   Zhao,D., Liu,W., Chen,K., Wu,Z., Yang,H. and Xu,Y.
  TITLE     Structure of the human RNA polymerase I elongation complex
  JOURNAL   Cell Discov 7 (1), 97 (2021)
   PUBMED   34671025
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 851)
  AUTHORS   Yin,X., Zhang,K., Wang,J., Zhou,X., Zhang,C., Song,X., Wu,Z.,
            Du,J., Chen,Q., Zhang,S. and Deng,W.
  TITLE     RNA polymerase I subunit 12 plays opposite roles in cell
            proliferation and migration
  JOURNAL   Biochem Biophys Res Commun 560, 112-118 (2021)
   PUBMED   33984768
  REMARK    GeneRIF: RNA polymerase I subunit 12 plays opposite roles in cell
            proliferation and migration.
REFERENCE   5  (bases 1 to 851)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 851)
  AUTHORS   Hong,L., Zhang,Y., Liu,N., Liu,C., Zhi,M., Pan,Y., Lan,M., Sun,L.
            and Fan,D.
  TITLE     Suppression of the cell proliferation in stomach cancer cells by
            the ZNRD1 gene
  JOURNAL   Biochem Biophys Res Commun 321 (3), 611-616 (2004)
   PUBMED   15358150
  REMARK    GeneRIF: This study clearly demonstrates that ZNRD1 may play an
            important role in the control of human gastric cancer development
            by regulating cell proliferation.
REFERENCE   7  (bases 1 to 851)
  AUTHORS   Shi,Y., Zhang,Y., Zhao,Y., Hong,L., Liu,N., Jin,X., Pan,Y. and
            Fan,D.
  TITLE     Overexpression of ZNRD1 promotes multidrug-resistant phenotype of
            gastric cancer cells through upregulation of P-glycoprotein
  JOURNAL   Cancer Biol Ther 3 (4), 377-381 (2004)
   PUBMED   14726695
  REMARK    GeneRIF: overexpression of ZNRD1 could promote multidrug-resistant
            phenotype of gastric cancer cells through upregulation of
            P-glycoprotein
REFERENCE   8  (bases 1 to 851)
  AUTHORS   Coriton,O., Lepourcelet,M., Hampe,A., Galibert,F. and Mosser,J.
  TITLE     Transcriptional analysis of the 69-kb sequence centromeric to
            HLA-J: a dense and complex structure of five genes
  JOURNAL   Mamm Genome 11 (12), 1127-1131 (2000)
   PUBMED   11130983
REFERENCE   9  (bases 1 to 851)
  AUTHORS   Fan,W., Wang,Z., Kyzysztof,F., Prange,C. and Lennon,G.
  TITLE     A new zinc ribbon gene (ZNRD1) is cloned from the human MHC class I
            region
  JOURNAL   Genomics 63 (1), 139-141 (2000)
   PUBMED   10662553
REFERENCE   10 (bases 1 to 851)
  AUTHORS   Lepourcelet,M., Andrieux,N., Giffon,T., Pichon,L., Hampe,A.,
            Galibert,F. and Mosser,J.
  TITLE     Systematic sequencing of the human HLA-A/HLA-F region:
            establishment of a cosmid contig and identification of a new gene
            cluster within 37 kb of sequence
  JOURNAL   Genomics 37 (3), 316-326 (1996)
   PUBMED   8938444
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY071776.1, BQ690150.1 and
            AF238321.1.
            
            On Nov 24, 2018 this sequence version replaced NM_170783.3.
            
            Summary: This gene encodes a DNA-directed RNA polymerase I subunit.
            The encoded protein contains two potential zinc-binding motifs and
            may play a role in regulation of cell proliferation. The encoded
            protein may be involved in cancer and human immunodeficiency virus
            progression. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (a) represents the longest
            transcript. Variants a, b, c, and d encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF024617.1, SRR1803615.282539.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332435.10/ ENSP00000331111.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                HY071776.1         26-91
            67-706              BQ690150.1         1-640
            707-851             AF238321.1         577-721
FEATURES             Location/Qualifiers
     source          1..851
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..851
                     /gene="POLR1H"
                     /gene_synonym="A12.2; HTEX-6; HTEX6; hZR14; Rpa12;
                     tctex-6; TCTEX6; TEX6; ZNRD1; ZR14"
                     /note="RNA polymerase I subunit H"
                     /db_xref="GeneID:30834"
                     /db_xref="HGNC:HGNC:13182"
                     /db_xref="MIM:607525"
     exon            1..405
                     /gene="POLR1H"
                     /gene_synonym="A12.2; HTEX-6; HTEX6; hZR14; Rpa12;
                     tctex-6; TCTEX6; TEX6; ZNRD1; ZR14"
                     /inference="alignment:Splign:2.1.0"
     CDS             261..641
                     /gene="POLR1H"
                     /gene_synonym="A12.2; HTEX-6; HTEX6; hZR14; Rpa12;
                     tctex-6; TCTEX6; TEX6; ZNRD1; ZR14"
                     /EC_number="2.7.7.6"
                     /note="transcription-associated zinc ribbon protein; RNA
                     polymerase I small specific subunit Rpa12; zinc ribbon
                     domain containing 1; DNA-directed RNA polymerase I subunit
                     H"
                     /codon_start=1
                     /product="DNA-directed RNA polymerase I subunit RPA12"
                     /protein_id="NP_740753.1"
                     /db_xref="CCDS:CCDS4670.1"
                     /db_xref="GeneID:30834"
                     /db_xref="HGNC:HGNC:13182"
                     /db_xref="MIM:607525"
                     /translation="MSVMDLANTCSSFQSDLDFCSDCGSVLPLPGAQDTVTCIRCGFN
                     INVRDFEGKVVKTSVVFHQLGTAMPMSVEEGPECQGPVVDRRCPRCGHEGMAYHTRQM
                     RSADEGQTVFYTCTNCKFQEKEDS"
     exon            406..506
                     /gene="POLR1H"
                     /gene_synonym="A12.2; HTEX-6; HTEX6; hZR14; Rpa12;
                     tctex-6; TCTEX6; TEX6; ZNRD1; ZR14"
                     /inference="alignment:Splign:2.1.0"
     exon            507..616
                     /gene="POLR1H"
                     /gene_synonym="A12.2; HTEX-6; HTEX6; hZR14; Rpa12;
                     tctex-6; TCTEX6; TEX6; ZNRD1; ZR14"
                     /inference="alignment:Splign:2.1.0"
     exon            617..851
                     /gene="POLR1H"
                     /gene_synonym="A12.2; HTEX-6; HTEX6; hZR14; Rpa12;
                     tctex-6; TCTEX6; TEX6; ZNRD1; ZR14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      821..826
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POLR1H"
                     /gene_synonym="A12.2; HTEX-6; HTEX6; hZR14; Rpa12;
                     tctex-6; TCTEX6; TEX6; ZNRD1; ZR14"
                     /note="hexamer: ATTAAA"
     polyA_site      851
                     /gene="POLR1H"
                     /gene_synonym="A12.2; HTEX-6; HTEX6; hZR14; Rpa12;
                     tctex-6; TCTEX6; TEX6; ZNRD1; ZR14"
                     /note="major polyA site"
ORIGIN      
        1 agagctggcg ctctagccca cggagttggt taactcctct caccggcccc tggaaagggt
       61 tccaagtcct ttagtacccg acgctgtctg ggaattccgg gcgtttcggc tccttggtcg
      121 cagaggcagg aggcgtgcgt ggcaggaggg ttcgggttat atactcctag gtcctgggac
      181 agaatagtta cgacctctgg gacaggaact cttctctctt ttgttaataa acttccaact
      241 ccctcctcag acccgaccgc atgtctgtca tggacctcgc caatacttgc tccagctttc
      301 agtcggacct ggatttctgt tcagattgcg gctcggtcct gcctctgccc ggggctcagg
      361 atacggtcac ctgtattcgc tgtggcttca acatcaacgt tcgggacttt gaggggaagg
      421 ttgtgaagac ttcggttgtg ttccaccaac tggggacagc catgcctatg tcggtggagg
      481 aagggcctga gtgccaggga cctgtggttg acaggcgctg ccctcgatgt ggtcatgaag
      541 gaatggcata ccacaccaga cagatgcgtt cagccgatga agggcaaact gtcttctaca
      601 cctgtaccaa ctgcaagttc caggagaagg aagactcttg acctttttcc tgggcaactc
      661 tacagtccct ccctcctttc ggaaggtgaa ggatactggg tttttagatg ccttgtccat
      721 cctgtctggt tgcaatgttt tgctcccaga agagaatcag atcatcatgt ggggattacc
      781 attgttcctg gagtactcct acccttagtt gaatttcctt attaaagtta tatttttcta
      841 taagaccctg a
//
