LOCUS       NM_012099               2822 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens RNA polymerase I subunit G (POLR1G), transcript
            variant 2, mRNA.
ACCESSION   NM_012099
VERSION     NM_012099.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2822)
  AUTHORS   McNamar,R., Freeman,E., Baylor,K.N., Fakhouri,A.M., Huang,S.,
            Knutson,B.A. and Rothblum,L.I.
  TITLE     PAF49: An RNA Polymerase I subunit essential for rDNA transcription
            and stabilization of PAF53
  JOURNAL   J Biol Chem 299 (8), 104951 (2023)
   PUBMED   37356716
  REMARK    GeneRIF: PAF49: An RNA Polymerase I subunit essential for rDNA
            transcription and stabilization of PAF53.
REFERENCE   2  (bases 1 to 2822)
  AUTHORS   Yin,J., Wang,C., Vogel,U., Ma,Y., Zhang,Y., Wang,H., Sun,Z. and
            Du,S.
  TITLE     Common variants of pro-inflammatory gene IL1B and interactions with
            PPP1R13L and POLR1G in relation to lung cancer among Northeast
            Chinese
  JOURNAL   Sci Rep 13 (1), 7352 (2023)
   PUBMED   37147350
  REMARK    GeneRIF: Common variants of pro-inflammatory gene IL1B and
            interactions with PPP1R13L and POLR1G in relation to lung cancer
            among Northeast Chinese.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2822)
  AUTHORS   Zhang,C., Wang,J., Song,X., Yu,D., Guo,B., Pang,Y., Yin,X.,
            Zhao,S., Deng,H., Zhang,S. and Deng,W.
  TITLE     STAT3 potentiates RNA polymerase I-directed transcription and tumor
            growth by activating RPA34 expression
  JOURNAL   Br J Cancer 128 (5), 766-782 (2023)
   PUBMED   36526675
  REMARK    GeneRIF: STAT3 potentiates RNA polymerase I-directed transcription
            and tumor growth by activating RPA34 expression.
REFERENCE   4  (bases 1 to 2822)
  AUTHORS   Daiss,J.L., Pilsl,M., Straub,K., Bleckmann,A., Hocherl,M.,
            Heiss,F.B., Abascal-Palacios,G., Ramsay,E.P., Tluckova,K.,
            Mars,J.C., Furtges,T., Bruckmann,A., Rudack,T., Bernecky,C.,
            Lamour,V., Panov,K., Vannini,A., Moss,T. and Engel,C.
  TITLE     The human RNA polymerase I structure reveals an HMG-like docking
            domain specific to metazoans
  JOURNAL   Life Sci Alliance 5 (11), e202201568 (2022)
   PUBMED   36271492
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2822)
  AUTHORS   Yin,J., Hou,W., Vogel,U., Li,X., Ma,Y., Wang,C., Wang,H. and Sun,Z.
  TITLE     TP53 common variants and interaction with PPP1R13L and CD3EAP SNPs
            and lung cancer risk and smoking behavior in a Chinese population
  JOURNAL   Biomed J 45 (1), 169-178 (2022)
   PUBMED   35351459
  REMARK    GeneRIF: TP53 common variants and interaction with PPP1R13L and
            CD3EAP SNPs and lung cancer risk and smoking behavior in a Chinese
            population.
REFERENCE   6  (bases 1 to 2822)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   7  (bases 1 to 2822)
  AUTHORS   Yamamoto,K., Yamamoto,M., Hanada,K., Nogi,Y., Matsuyama,T. and
            Muramatsu,M.
  TITLE     Multiple protein-protein interactions by RNA polymerase
            I-associated factor PAF49 and role of PAF49 in rRNA transcription
  JOURNAL   Mol Cell Biol 24 (14), 6338-6349 (2004)
   PUBMED   15226435
REFERENCE   8  (bases 1 to 2822)
  AUTHORS   Bouwmeester,T., Bauch,A., Ruffner,H., Angrand,P.O., Bergamini,G.,
            Croughton,K., Cruciat,C., Eberhard,D., Gagneur,J., Ghidelli,S.,
            Hopf,C., Huhse,B., Mangano,R., Michon,A.M., Schirle,M., Schlegl,J.,
            Schwab,M., Stein,M.A., Bauer,A., Casari,G., Drewes,G., Gavin,A.C.,
            Jackson,D.B., Joberty,G., Neubauer,G., Rick,J., Kuster,B. and
            Superti-Furga,G.
  TITLE     A physical and functional map of the human TNF-alpha/NF-kappa B
            signal transduction pathway
  JOURNAL   Nat Cell Biol 6 (2), 97-105 (2004)
   PUBMED   14743216
  REMARK    Erratum:[Nat Cell Biol. 2004 May;6(5):465]
REFERENCE   9  (bases 1 to 2822)
  AUTHORS   Yamazaki,T., Hamano,Y., Tashiro,H., Itoh,K., Nakano,H., Miyatake,S.
            and Saito,T.
  TITLE     CAST, a novel CD3epsilon-binding protein transducing activation
            signal for interleukin-2 production in T cells
  JOURNAL   J Biol Chem 274 (26), 18173-18180 (1999)
   PUBMED   10373416
REFERENCE   10 (bases 1 to 2822)
  AUTHORS   Whitehead,C.M., Winkfein,R.J., Fritzler,M.J. and Rattner,J.B.
  TITLE     ASE-1: a novel protein of the fibrillar centres of the nucleolus
            and nucleolus organizer region of mitotic chromosomes
  JOURNAL   Chromosoma 106 (8), 493-502 (1997)
   PUBMED   9426281
  REMARK    GeneRIF: ASE-1 co-localises with the RNA polymerase I transcription
            initiation factor UBF/NOR-90 throughout all stages of the cell
            cycle and these two proteins associate with each other in vitro.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U86751.1.
            
            On Feb 27, 2020 this sequence version replaced NM_012099.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1. It
            encodes isoform 2, which is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038992.1, AK292183.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309424.8/ ENSP00000310966.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2822              U86751.1           436-3257
FEATURES             Location/Qualifiers
     source          1..2822
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..2822
                     /gene="POLR1G"
                     /gene_synonym="ASE-1; ASE1; CAST; CD3EAP; PAF49; RPA34"
                     /note="RNA polymerase I subunit G"
                     /db_xref="GeneID:10849"
                     /db_xref="HGNC:HGNC:24219"
                     /db_xref="MIM:107325"
     exon            1..75
                     /gene="POLR1G"
                     /gene_synonym="ASE-1; ASE1; CAST; CD3EAP; PAF49; RPA34"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1586
                     /gene="POLR1G"
                     /gene_synonym="ASE-1; ASE1; CAST; CD3EAP; PAF49; RPA34"
                     /note="isoform 2 is encoded by transcript variant 2; CD3e
                     antigen, epsilon polypeptide associated protein;
                     DNA-directed RNA polymerase I subunit RPA34; antisense to
                     ERCC-1 protein; RNA polymerase I-associated factor PAF49;
                     CD3e molecule, epsilon associated protein; CD3e molecule
                     associated protein; DNA-directed RNA polymerase I subunit
                     G"
                     /codon_start=1
                     /product="DNA-directed RNA polymerase I subunit RPA34
                     isoform 2"
                     /protein_id="NP_036231.1"
                     /db_xref="CCDS:CCDS12661.1"
                     /db_xref="GeneID:10849"
                     /db_xref="HGNC:HGNC:24219"
                     /db_xref="MIM:107325"
                     /translation="MEEPQAGDAARFSCPPNFTAKPPASESPRFSLEALTGPDTELWL
                     IQAPADFAPECFNGRHVPLSGSQIVKGKLAGKRHRYRVLSSCPQAGEATLLAPSTEAG
                     GGLTCASAPQGTLRILEGPQQSLSGSPLQPIPASPPPQIPPGLRPRFCAFGGNPPVTG
                     PRSALAPNLLTSGKKKKEMQVTEAPVTQEAVNGHGALEVDMALGSPEMDVRKKKKKKN
                     QQLKEPEAAGPVGTEPTVETLEPLGVLFPSTTKKRKKPKGKETFEPEDKTVKQEQINT
                     EPLEDTVLSPTKKRKRQKGTEGMEPEEGVTVESQPQVKVEPLEEAIPLPPTKKRKKEK
                     GQMAMMEPGTEAMEPVEPEMKPLESPGGTMAPQQPEGAKPQAQAALAAPKKKTKKEKQ
                     QDATVEPETEVVGPELPDDLEPQAAPTSTKKKKKKKERGHTVTEPIQPLEPELPGEGQ
                     PEARATPGSTKKRKKQSQESRMPETVPQEEMPGPPLNSESGEEAPTGRDKKRKQQQQQ
                     PV"
     exon            76..217
                     /gene="POLR1G"
                     /gene_synonym="ASE-1; ASE1; CAST; CD3EAP; PAF49; RPA34"
                     /inference="alignment:Splign:2.1.0"
     exon            218..2822
                     /gene="POLR1G"
                     /gene_synonym="ASE-1; ASE1; CAST; CD3EAP; PAF49; RPA34"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1846..1851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POLR1G"
                     /gene_synonym="ASE-1; ASE1; CAST; CD3EAP; PAF49; RPA34"
                     /note="hexamer: ATTAAA"
     polyA_site      1871
                     /gene="POLR1G"
                     /gene_synonym="ASE-1; ASE1; CAST; CD3EAP; PAF49; RPA34"
                     /note="major polyA site"
     regulatory      2800..2805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POLR1G"
                     /gene_synonym="ASE-1; ASE1; CAST; CD3EAP; PAF49; RPA34"
                     /note="hexamer: AATAAA"
     polyA_site      2822
                     /gene="POLR1G"
                     /gene_synonym="ASE-1; ASE1; CAST; CD3EAP; PAF49; RPA34"
                     /note="major polyA site"
ORIGIN      
        1 aacctggtgc gagcagcccg ggctacaggg ttgcctgagg tgtgggtccc aggatggagg
       61 agccccaggc cggcgatgct gctcggttct cttgtccccc caactttacc gcgaagcccc
      121 cagcctcaga gtcccctcgt ttctccttgg aggcgctgac gggtccagat acggagctgt
      181 ggcttattca ggcccctgca gactttgccc cagaatgctt caatgggcgg catgtgcctc
      241 tctctggctc ccagatcgtc aagggcaaat tggcaggcaa gcggcaccgc tatcgagtcc
      301 tcagcagctg tccccaagct ggagaagcga ccctgctggc cccctcaacg gaggcaggag
      361 gtggactcac ctgtgcctca gccccccagg gcaccctaag gatccttgag ggtccccagc
      421 aatccctgtc agggagccct ctgcagccca tcccagcaag tcccccacca cagatccctc
      481 ctggcctgag gcctcggttc tgtgcctttg ggggcaaccc accagtcaca gggcctaggt
      541 cagccttggc ccccaacctg ctcacctcag ggaagaagaa aaaggagatg caggtgacag
      601 aggccccagt cactcaggag gcagtgaatg ggcacggggc cctggaggtg gacatggctt
      661 tggggtcgcc agaaatggat gtgcggaaga agaagaagaa aaaaaatcag cagctgaaag
      721 aaccagaggc agcagggcct gtggggacag agcccacagt ggagacactg gagcctctgg
      781 gagtgctgtt cccgtccacc accaagaaga ggaagaagcc caaagggaaa gaaaccttcg
      841 agccagaaga caagacagtg aagcaggaac agattaacac tgagcctcta gaagacacag
      901 tcctgtcccc gaccaaaaag agaaagaggc aaaaggggac ggaagggatg gagccagagg
      961 agggggtgac agttgagtct cagccacagg tgaaggtgga gccactggag gaagccatcc
     1021 ctctgccccc tacgaagaag aggaaaaaag aaaagggaca gatggcaatg atggagccag
     1081 ggacggaggc gatggagcca gtggagccgg agatgaagcc tctggagtcc ccagggggga
     1141 ccatggcgcc tcaacagcca gaaggagcga agcctcaggc ccaggcagct ctggcagctc
     1201 ccaaaaagaa gacgaagaaa gaaaaacagc aagatgccac agtggagcca gagacagagg
     1261 tggtggggcc tgagctgccg gatgaccttg agcctcaggc agctcccaca tccaccaaga
     1321 agaagaagaa gaagaaagag agaggtcaca cagtgactga gccaattcag ccactagagc
     1381 ctgaactgcc aggggaggga cagcctgaag ccagggcaac tccgggatcc accaagaaga
     1441 ggaagaagca gagtcaggaa agccggatgc cagagacagt gccccaagag gagatgccag
     1501 ggccgccact gaattcagag tctggggagg aggctcccac aggccgggac aagaagcgga
     1561 agcagcagca gcagcagcct gtgtagtctg cccccgggaa actgaggaac taaagaaagc
     1621 tgaaggtgcc cacctgggcc accagaaggt gacaccccca gaatccctcc ccagagactg
     1681 caccagcgca gccagcagga gcctggcctg ggaggacgat ttattattac actgggggtt
     1741 tccttggcag ctggggtcat cagggtactt tcaagaaggg ctcgtgcagg acatcaaaca
     1801 gcctccgggc ctggatggga gggagaaaaa aatgaggaac cagtcattaa aggagctgtt
     1861 tcctgggtaa atctagagtg gggttttggt tctttatttt cccctatacc ctcaagcatt
     1921 tatccattga gttacaaaca atccagttac aatcttttta agttattatt attattatta
     1981 tttttttttt ttttgagatg gagtctcgct ctgtcgccca ggttggagtg cagtggcgca
     2041 atctcggctc actgcaagct ccgcctcccg ggttcacgcc attctcctgc ctcagcctcc
     2101 tgagtagctg ggactacagg cccctgccca gctaattttt tgtatttttt tttagtagag
     2161 atggggtttc accacgttag ccaggatggt ctcgatctcc tgacctcctg atgcgcctgc
     2221 ctcagcctcc cagtgctggg attataggtg tgagccactg cgcctggcta agttattatt
     2281 atttttttga gacagtctcc tggtgtcacc caggctggag tgcagtggtg tgatcttggc
     2341 tcactgcaac ctccgcctcc tgggttccaa cgattctcct gcctcagcct cccgagtagc
     2401 tgggcctaaa ggtgcccacc actatacccg gctaattttt gtatttttag tagagacagg
     2461 ggtttcacca tattggccag gctggtctcg aactcctgac ctcgtgatcc acctgccttg
     2521 acctcccaaa gtgctaggat aacaggtgtg agccaccgca ccctgccaag ttattttaaa
     2581 atgtaccatt attattgact atagtcacct ggttgtgtta tcaaatagta tgtcttattc
     2641 attctttctt tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tggtacccat taaccttccc
     2701 catctccctg ccagccccta actaccctcc ccagcctcca ggaactatcc atccactctt
     2761 atctccatga gttcaattgt tttgattttt agatacacaa ataaataaga acatgcaatg
     2821 tt
//
