LOCUS       NM_001002926            3893 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens RNA polymerase I subunit F (POLR1F), mRNA.
ACCESSION   NM_001002926 XM_166508 XM_379792
VERSION     NM_001002926.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3893)
  AUTHORS   Daiss,J.L., Pilsl,M., Straub,K., Bleckmann,A., Hocherl,M.,
            Heiss,F.B., Abascal-Palacios,G., Ramsay,E.P., Tluckova,K.,
            Mars,J.C., Furtges,T., Bruckmann,A., Rudack,T., Bernecky,C.,
            Lamour,V., Panov,K., Vannini,A., Moss,T. and Engel,C.
  TITLE     The human RNA polymerase I structure reveals an HMG-like docking
            domain specific to metazoans
  JOURNAL   Life Sci Alliance 5 (11), e202201568 (2022)
   PUBMED   36271492
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3893)
  AUTHORS   Zhao,D., Liu,W., Chen,K., Wu,Z., Yang,H. and Xu,Y.
  TITLE     Structure of the human RNA polymerase I elongation complex
  JOURNAL   Cell Discov 7 (1), 97 (2021)
   PUBMED   34671025
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3893)
  AUTHORS   He,M., Xu,M., Zhang,B., Liang,J., Chen,P., Lee,J.Y., Johnson,T.A.,
            Li,H., Yang,X., Dai,J., Liang,L., Gui,L., Qi,Q., Huang,J., Li,Y.,
            Adair,L.S., Aung,T., Cai,Q., Cheng,C.Y., Cho,M.C., Cho,Y.S.,
            Chu,M., Cui,B., Gao,Y.T., Go,M.J., Gu,D., Gu,W., Guo,H., Hao,Y.,
            Hong,J., Hu,Z., Hu,Y., Huang,J., Hwang,J.Y., Ikram,M.K., Jin,G.,
            Kang,D.H., Khor,C.C., Kim,B.J., Kim,H.T., Kubo,M., Lee,J., Lee,J.,
            Lee,N.R., Li,R., Li,J., Liu,J., Longe,J., Lu,W., Lu,X., Miao,X.,
            Okada,Y., Ong,R.T., Qiu,G., Seielstad,M., Sim,X., Song,H.,
            Takeuchi,F., Tanaka,T., Taylor,P.R., Wang,L., Wang,W., Wang,Y.,
            Wu,C., Wu,Y., Xiang,Y.B., Yamamoto,K., Yang,H., Liao,M., Yokota,M.,
            Young,T., Zhang,X., Kato,N., Wang,Q.K., Zheng,W., Hu,F.B., Lin,D.,
            Shen,H., Teo,Y.Y., Mo,Z., Wong,T.Y., Lin,X., Mohlke,K.L., Ning,G.,
            Tsunoda,T., Han,B.G., Shu,X.O., Tai,E.S., Wu,T. and Qi,L.
  TITLE     Meta-analysis of genome-wide association studies of adult height in
            East Asians identifies 17 novel loci
  JOURNAL   Hum Mol Genet 24 (6), 1791-1800 (2015)
   PUBMED   25429064
REFERENCE   4  (bases 1 to 3893)
  AUTHORS   Foroud,T., Lai,D., Koller,D., Van't Hof,F., Kurki,M.I.,
            Anderson,C.S., Brown,R.D. Jr., Connolly,E.S., Eriksson,J.G.,
            Flaherty,M., Fornage,M., von Und Zu Fraunberg,M., Gaal,E.I.,
            Laakso,A., Hernesniemi,J., Huston,J., Jaaskelainen,J.E.,
            Kiemeney,L.A., Kivisaari,R., Kleindorfer,D., Ko,N., Lehto,H.,
            Mackey,J., Meissner,I., Moomaw,C.J., Mosley,T.H., Moskala,M.,
            Niemela,M., Palotie,A., Pera,J., Rinkel,G., Ripke,S., Rouleau,G.,
            Ruigrok,Y., Sauerbeck,L., Slowik,A., Vermeulen,S.H., Woo,D.,
            Worrall,B.B. and Broderick,J.
  CONSRTM   Familial Intracranial Aneurysm Study Investigators
  TITLE     Genome-wide association study of intracranial aneurysm identifies a
            new association on chromosome 7
  JOURNAL   Stroke 45 (11), 3194-3199 (2014)
   PUBMED   25256182
REFERENCE   5  (bases 1 to 3893)
  AUTHORS   Goodfellow,S.J. and Zomerdijk,J.C.
  TITLE     Basic mechanisms in RNA polymerase I transcription of the ribosomal
            RNA genes
  JOURNAL   Subcell Biochem 61, 211-236 (2013)
   PUBMED   23150253
  REMARK    Review article
REFERENCE   6  (bases 1 to 3893)
  AUTHORS   Lango Allen,H., Estrada,K., Lettre,G., Berndt,S.I., Weedon,M.N.,
            Rivadeneira,F., Willer,C.J., Jackson,A.U., Vedantam,S.,
            Raychaudhuri,S., Ferreira,T., Wood,A.R., Weyant,R.J., Segre,A.V.,
            Speliotes,E.K., Wheeler,E., Soranzo,N., Park,J.H., Yang,J.,
            Gudbjartsson,D., Heard-Costa,N.L., Randall,J.C., Qi,L., Vernon
            Smith,A., Magi,R., Pastinen,T., Liang,L., Heid,I.M., Luan,J.,
            Thorleifsson,G., Winkler,T.W., Goddard,M.E., Sin Lo,K., Palmer,C.,
            Workalemahu,T., Aulchenko,Y.S., Johansson,A., Zillikens,M.C.,
            Feitosa,M.F., Esko,T., Johnson,T., Ketkar,S., Kraft,P., Mangino,M.,
            Prokopenko,I., Absher,D., Albrecht,E., Ernst,F., Glazer,N.L.,
            Hayward,C., Hottenga,J.J., Jacobs,K.B., Knowles,J.W., Kutalik,Z.,
            Monda,K.L., Polasek,O., Preuss,M., Rayner,N.W., Robertson,N.R.,
            Steinthorsdottir,V., Tyrer,J.P., Voight,B.F., Wiklund,F., Xu,J.,
            Zhao,J.H., Nyholt,D.R., Pellikka,N., Perola,M., Perry,J.R.,
            Surakka,I., Tammesoo,M.L., Altmaier,E.L., Amin,N., Aspelund,T.,
            Bhangale,T., Boucher,G., Chasman,D.I., Chen,C., Coin,L.,
            Cooper,M.N., Dixon,A.L., Gibson,Q., Grundberg,E., Hao,K., Juhani
            Junttila,M., Kaplan,L.M., Kettunen,J., Konig,I.R., Kwan,T.,
            Lawrence,R.W., Levinson,D.F., Lorentzon,M., McKnight,B.,
            Morris,A.P., Muller,M., Suh Ngwa,J., Purcell,S., Rafelt,S.,
            Salem,R.M., Salvi,E., Sanna,S., Shi,J., Sovio,U., Thompson,J.R.,
            Turchin,M.C., Vandenput,L., Verlaan,D.J., Vitart,V., White,C.C.,
            Ziegler,A., Almgren,P., Balmforth,A.J., Campbell,H., Citterio,L.,
            De Grandi,A., Dominiczak,A., Duan,J., Elliott,P., Elosua,R.,
            Eriksson,J.G., Freimer,N.B., Geus,E.J., Glorioso,N., Haiqing,S.,
            Hartikainen,A.L., Havulinna,A.S., Hicks,A.A., Hui,J., Igl,W.,
            Illig,T., Jula,A., Kajantie,E., Kilpelainen,T.O., Koiranen,M.,
            Kolcic,I., Koskinen,S., Kovacs,P., Laitinen,J., Liu,J., Lokki,M.L.,
            Marusic,A., Maschio,A., Meitinger,T., Mulas,A., Pare,G.,
            Parker,A.N., Peden,J.F., Petersmann,A., Pichler,I.,
            Pietilainen,K.H., Pouta,A., Ridderstrale,M., Rotter,J.I.,
            Sambrook,J.G., Sanders,A.R., Schmidt,C.O., Sinisalo,J., Smit,J.H.,
            Stringham,H.M., Bragi Walters,G., Widen,E., Wild,S.H.,
            Willemsen,G., Zagato,L., Zgaga,L., Zitting,P., Alavere,H.,
            Farrall,M., McArdle,W.L., Nelis,M., Peters,M.J., Ripatti,S., van
            Meurs,J.B., Aben,K.K., Ardlie,K.G., Beckmann,J.S., Beilby,J.P.,
            Bergman,R.N., Bergmann,S., Collins,F.S., Cusi,D., den Heijer,M.,
            Eiriksdottir,G., Gejman,P.V., Hall,A.S., Hamsten,A., Huikuri,H.V.,
            Iribarren,C., Kahonen,M., Kaprio,J., Kathiresan,S., Kiemeney,L.,
            Kocher,T., Launer,L.J., Lehtimaki,T., Melander,O., Mosley,T.H. Jr.,
            Musk,A.W., Nieminen,M.S., O'Donnell,C.J., Ohlsson,C., Oostra,B.,
            Palmer,L.J., Raitakari,O., Ridker,P.M., Rioux,J.D., Rissanen,A.,
            Rivolta,C., Schunkert,H., Shuldiner,A.R., Siscovick,D.S.,
            Stumvoll,M., Tonjes,A., Tuomilehto,J., van Ommen,G.J., Viikari,J.,
            Heath,A.C., Martin,N.G., Montgomery,G.W., Province,M.A., Kayser,M.,
            Arnold,A.M., Atwood,L.D., Boerwinkle,E., Chanock,S.J., Deloukas,P.,
            Gieger,C., Gronberg,H., Hall,P., Hattersley,A.T., Hengstenberg,C.,
            Hoffman,W., Lathrop,G.M., Salomaa,V., Schreiber,S., Uda,M.,
            Waterworth,D., Wright,A.F., Assimes,T.L., Barroso,I., Hofman,A.,
            Mohlke,K.L., Boomsma,D.I., Caulfield,M.J., Cupples,L.A.,
            Erdmann,J., Fox,C.S., Gudnason,V., Gyllensten,U., Harris,T.B.,
            Hayes,R.B., Jarvelin,M.R., Mooser,V., Munroe,P.B., Ouwehand,W.H.,
            Penninx,B.W., Pramstaller,P.P., Quertermous,T., Rudan,I.,
            Samani,N.J., Spector,T.D., Volzke,H., Watkins,H., Wilson,J.F.,
            Groop,L.C., Haritunians,T., Hu,F.B., Kaplan,R.C., Metspalu,A.,
            North,K.E., Schlessinger,D., Wareham,N.J., Hunter,D.J.,
            O'Connell,J.R., Strachan,D.P., Wichmann,H.E., Borecki,I.B., van
            Duijn,C.M., Schadt,E.E., Thorsteinsdottir,U., Peltonen,L.,
            Uitterlinden,A.G., Visscher,P.M., Chatterjee,N., Loos,R.J.,
            Boehnke,M., McCarthy,M.I., Ingelsson,E., Lindgren,C.M.,
            Abecasis,G.R., Stefansson,K., Frayling,T.M. and Hirschhorn,J.N.
  TITLE     Hundreds of variants clustered in genomic loci and biological
            pathways affect human height
  JOURNAL   Nature 467 (7317), 832-838 (2010)
   PUBMED   20881960
REFERENCE   7  (bases 1 to 3893)
  AUTHORS   Yuan,X., Zhao,J., Zentgraf,H., Hoffmann-Rohrer,U. and Grummt,I.
  TITLE     Multiple interactions between RNA polymerase I, TIF-IA and TAF(I)
            subunits regulate preinitiation complex assembly at the ribosomal
            gene promoter
  JOURNAL   EMBO Rep 3 (11), 1082-1087 (2002)
   PUBMED   12393749
REFERENCE   8  (bases 1 to 3893)
  AUTHORS   Kosan,C. and Kunz,J.
  TITLE     Identification and characterisation of the gene TWIST NEIGHBOR
            (TWISTNB) located in the microdeletion syndrome 7p21 region
  JOURNAL   Cytogenet Genome Res 97 (3-4), 167-170 (2002)
   PUBMED   12438708
  REMARK    GeneRIF: describe the localisation and characterisation of the
            TWIST NEIGHBOR (TWISTNB) gene
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC056267.1, AK090846.1 and AC004940.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001002926.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.167769.1,
                                           SRR1660805.17726.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2159607 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222567.6/ ENSP00000222567.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-609               BC056267.1         15-623
            610-3892            AK090846.1         1-3283
            3893-3893           AC004940.1         20528-20528
FEATURES             Location/Qualifiers
     source          1..3893
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p21.1"
     gene            1..3893
                     /gene="POLR1F"
                     /gene_synonym="A43; RPA43; TWISTNB"
                     /note="RNA polymerase I subunit F"
                     /db_xref="GeneID:221830"
                     /db_xref="HGNC:HGNC:18027"
                     /db_xref="MIM:608312"
     exon            1..275
                     /gene="POLR1F"
                     /gene_synonym="A43; RPA43; TWISTNB"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1038
                     /gene="POLR1F"
                     /gene_synonym="A43; RPA43; TWISTNB"
                     /note="twist neighbor protein; DNA-directed RNA polymerase
                     I subunit F"
                     /codon_start=1
                     /product="DNA-directed RNA polymerase I subunit RPA43"
                     /protein_id="NP_001002926.1"
                     /db_xref="CCDS:CCDS34606.1"
                     /db_xref="GeneID:221830"
                     /db_xref="HGNC:HGNC:18027"
                     /db_xref="MIM:608312"
                     /translation="MAAGCSEAPRPAAASDGSLVGQAGVLPCLELPTYAAACALVNSR
                     YSCLVAGPHQRHIALSPRYLNRKRTGIREQLDAELLRYSESLLGVPIAYDNIKVVGEL
                     GDIYDDQGHIHLNIEADFVIFCPEPGQKLMGIVNKVSSSHIGCLVHGCFNASIPKPEQ
                     LSAEQWQTMEINMGDELEFEVFRLDSDAAGVFCIRGKLNITSLQFKRSEVSEEVTENG
                     TEEAAKKPKKKKKKKDPETYEVDSGTTKLADDADDTPMEESALQNTNNANGIWEEEPK
                     KKKKKKKHQEVQDQDPVFQGSDSSGYQSDHKKKKKKRKHSEEAEFTPPLKCSPKRKGK
                     SNFL"
     exon            276..417
                     /gene="POLR1F"
                     /gene_synonym="A43; RPA43; TWISTNB"
                     /inference="alignment:Splign:2.1.0"
     exon            418..626
                     /gene="POLR1F"
                     /gene_synonym="A43; RPA43; TWISTNB"
                     /inference="alignment:Splign:2.1.0"
     exon            627..3893
                     /gene="POLR1F"
                     /gene_synonym="A43; RPA43; TWISTNB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2603..2608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POLR1F"
                     /gene_synonym="A43; RPA43; TWISTNB"
                     /note="hexamer: AATAAA"
     polyA_site      2622
                     /gene="POLR1F"
                     /gene_synonym="A43; RPA43; TWISTNB"
     regulatory      3868..3873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POLR1F"
                     /gene_synonym="A43; RPA43; TWISTNB"
                     /note="hexamer: AATAAA"
     polyA_site      3893
                     /gene="POLR1F"
                     /gene_synonym="A43; RPA43; TWISTNB"
                     /note="major polyA site"
ORIGIN      
        1 gtgggaacct tgacaagcag catggctgca ggttgctcag aggcgccgcg gccagcggcg
       61 gcttctgatg ggtctctggt agggcaggct ggcgtcctgc cttgcctaga gttgccgact
      121 tatgccgctg cttgtgcgct ggtgaacagt cgctactcat gcctggtggc cgggccgcac
      181 caaaggcaca tcgcgctgtc gccccgctac cttaacagga aacgcaccgg cattcgagaa
      241 cagcttgatg cggagctcct tcgctattct gagagccttt taggtgtccc tattgcatat
      301 gataacatca aagttgtggg agagcttgga gatatttatg atgatcaagg acacattcat
      361 cttaacattg aagccgattt tgttattttc tgccctgaac cagggcagaa gcttatgggt
      421 atagttaata aagtgtcttc tagccacatt ggctgtttag tacatgggtg tttcaatgcc
      481 tccattccta aacctgagca gttgtcagct gagcagtggc aaaccatgga gataaacatg
      541 ggtgatgaac tagaatttga agtatttcgt ttagactcag atgctgctgg agtattctgc
      601 attcggggaa aactaaatat cacaagttta caattcaagc gctctgaagt ttctgaagaa
      661 gttacagaaa atggcactga ggaagctgct aaaaaaccta aaaagaagaa aaagaagaaa
      721 gacccagaga catatgaagt ggacagtggt accacaaagc tagcagatga tgcagatgac
      781 actccaatgg aagagtcagc cctgcagaat actaataatg cgaatggcat ctgggaggag
      841 gagccaaaga aaaagaagaa gaagaaaaag caccaggaag ttcaggacca ggaccctgtt
      901 ttccaaggca gtgactccag tggttaccaa agtgaccata aaaagaaaaa aaagaaaaga
      961 aaacacagtg aagaggccga atttacccca cctttgaaat gctcaccaaa aagaaaaggg
     1021 aaaagtaatt ttctttagtg tattttaaac acgattcagt ttttaaaaga tcgatctaca
     1081 tacaatagat gaataaatgt tttcagtgat atgaaaaggt taagtatgcc agtagtttac
     1141 aaaacagaaa atacttaact aggagtagga ggctttatat gctaaaaatg ataaaactga
     1201 ctgtaaatta atttggggaa agccagtatt gttaaaatac cattttatac aaaataaaaa
     1261 gctgctctca ctgtcagctc tcatattctt ccaggttttg cactctacat aaaattattt
     1321 ctacaatgtc aagactagcc aaaggacttt ataatacaat attatattac taaagaatga
     1381 gttaagtttg agattttgat gatttgattt tgtgtgtgtt taataggctt caccttatta
     1441 catgctattt tattttgctt ttttaaaaac tcaggacatt aactaatttt aggttttcct
     1501 ttatcatggc tttctacagt atttctattg tttaacataa aatagtttgc caaagaagtt
     1561 tctgaagtct tcacagctct taaaagccag gccagtactg actgtgtggt ggtaaatgct
     1621 attcattatt ttcttttctt tcttccaagt gcatgtgtgt ccttgtcttc ttaagtctga
     1681 gaggttgctg gaaaggactg ttttcttgta cttgttcatt tgtgcctcag ccattctagt
     1741 tttgttgtgt gttggaggac agtctaatga agacaggata aatgtgattc tgactagtgg
     1801 gaaatttcag attacttttt aatgattgga atgggctata agatattgtg ctgaagagaa
     1861 aacagttgtt ctgttcactg ctttcattga gaaaatgtgg aatgtctctt gactaattga
     1921 caaagtgtaa tgaaatgaca agctggttga agctggtaat caatgcatgg ccatatttat
     1981 tcattttcca cacacttgac catctacttt gtataacaca ttctgctaag gcccagggat
     2041 acaatggcaa acaagataga tgtagttcct tcccttgtgg catgtcataa gagaaacaga
     2101 tgtgcatata cacacaataa ataagaaaat taataattgt attaagtggt atgaaaaaaa
     2161 gggggaggat tgttcactca ctgttacctg tgttagtatc tgcaaatgca tgaatggttg
     2221 aactcccatg tcagcatttt tgttgccatt tatttagtac cagacatagt gctggtctca
     2281 cagcttaata tttggtaatg aataaattct gctagtggta tatgttgatc tgaacttaca
     2341 atgatgggat atagaattgg cagagtggca gatgttcaca attgtctaca agtagatgtg
     2401 ctagacaatg gaaggatgca ggccaacctc tttgattaca attgagattc atgtgactat
     2461 tgagccctgg aaatgtagct tgtccaaatt gagatgtgct gtcagtataa aatacatacc
     2521 agattttaaa gatgtaccaa aaaatgtaaa ctatctcaat ttttatattg gtgaaatcaa
     2581 tatgtcttgg tatagtggct taaataaaac aattttagcc tttctcagtt tatttttctg
     2641 caaaaagatt aaaaattgta catgaagctc atgttaactt tcttttggtc agtgctattt
     2701 taaaggaagt atgagttgaa aaaaaattga aataaactat atcatattac taggacttaa
     2761 tatagtggca tacccaggaa atgcttagta agtgttccct tcacatttta aaatttgagt
     2821 atacaatcat gtttgacaat atagaaattt aatttttagt gaaacaattc taaacccctt
     2881 ttccatagac acaagaaaga tggcaaattt atgctattcc tggaaaaata cattgtggct
     2941 tagcaaataa gcaagttccc acgttacttt tgttttgctt caagtaatac ttctgccagt
     3001 tgtgttttat gaattaaaca gggaacggca tgctgaactt gaaactagat ttgttcctgc
     3061 ttttttcaca atgtgagtag ttttgaaaag tcagatctgg ccatttgtct ttcctagaat
     3121 agcataactt tgttcattgt tttttttgtt tgtctttctg acacagaaag actgatgatg
     3181 gtgtccacta tgtattcttc aaaacatttg gcacatgctg cactaaccta gtctatcttt
     3241 tctatcttgg aatttgctca tacaaaccct atagcctaga ctagatccct taccctctct
     3301 ccagttccta tcattcaccc atttcactgt gcaagacacc tcactagtca ccagtgatac
     3361 agaaatgact tttaagcagt ttctgctctt aagggcttac cgttttgtct ataagataca
     3421 caagtataaa tgacaagtac aaataacaat gaatgtttaa tgctttacgt ttagtgttta
     3481 agcttgttgt tggaagagca gcattttgac ccttggagaa gaaaaactag ctgtggcatt
     3541 ccaggtggag aacctgacag aggactaaga agttatctaa tgtaaaagac ctcaggcacc
     3601 accttcgcat aaactttttc cagacaaggc taaatgtgca tgcttcataa ccataattct
     3661 tatttttctt taataaatat ttttctactt gtaacactgt gcattatttc aaactgttta
     3721 cctgtttgta aagcttgtct cttaatcaaa tttgtcttga ccaaataagt ttcctgaggg
     3781 ctggaattat gccttaacta tatctatagt atttaacagt gaatcctttg tataatgaaa
     3841 gcatcaacag ataattttaa attgataaat aaaaagcaca gtttcaaatg gta
//
