LOCUS       NM_006502               8368 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens DNA polymerase eta (POLH), transcript variant 1, mRNA.
ACCESSION   NM_006502
VERSION     NM_006502.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8368)
  AUTHORS   Menck,C.F.M., Galhardo,R.S. and Quinet,A.
  TITLE     The accurate bypass of pyrimidine dimers by DNA polymerase eta
            contributes to ultraviolet-induced mutagenesis
  JOURNAL   Mutat Res 828, 111840 (2024)
   PUBMED   37984186
  REMARK    GeneRIF: The accurate bypass of pyrimidine dimers by DNA polymerase
            eta contributes to ultraviolet-induced mutagenesis.
            Review article
REFERENCE   2  (bases 1 to 8368)
  AUTHORS   Richie-Jannetta,R., Pallan,P., Kingsley,P.J., Kamdar,N., Egli,M.
            and Marnett,L.J.
  TITLE     The peroxidation-derived DNA adduct, 6-oxo-M1dG, is a strong block
            to replication by human DNA polymerase eta
  JOURNAL   J Biol Chem 299 (8), 105067 (2023)
   PUBMED   37468099
  REMARK    GeneRIF: The peroxidation-derived DNA adduct, 6-oxo-M1dG, is a
            strong block to replication by human DNA polymerase eta.
REFERENCE   3  (bases 1 to 8368)
  AUTHORS   Averill,J.R. and Jung,H.
  TITLE     Mutagenic incorporation of inosine into DNA via T:I mismatch
            formation by human DNA polymerase eta (poleta)
  JOURNAL   Biochem J 480 (9), 649-664 (2023)
   PUBMED   37129084
  REMARK    GeneRIF: Mutagenic incorporation of inosine into DNA via T:I
            mismatch formation by human DNA polymerase eta (poleta).
REFERENCE   4  (bases 1 to 8368)
  AUTHORS   Chakraborty,A., Tapryal,N., Islam,A., Sarker,A.H., Manohar,K.,
            Mitra,J., Hegde,M.L. and Hazra,T.
  TITLE     Human DNA polymerase eta promotes RNA-templated error-free repair
            of DNA double-strand breaks
  JOURNAL   J Biol Chem 299 (3), 102991 (2023)
   PUBMED   36758800
  REMARK    GeneRIF: Human DNA polymerase eta promotes RNA-templated error-free
            repair of DNA double-strand breaks.
REFERENCE   5  (bases 1 to 8368)
  AUTHORS   Chang,C., Lee Luo,C., Eleraky,S., Lin,A., Zhou,G. and Gao,Y.
  TITLE     Primer terminal ribonucleotide alters the active site dynamics of
            DNA polymerase eta and reduces DNA synthesis fidelity
  JOURNAL   J Biol Chem 299 (3), 102938 (2023)
   PUBMED   36702254
  REMARK    GeneRIF: Primer terminal ribonucleotide alters the active site
            dynamics of DNA polymerase eta and reduces DNA synthesis fidelity.
REFERENCE   6  (bases 1 to 8368)
  AUTHORS   Yamada,A., Masutani,C., Iwai,S. and Hanaoka,F.
  TITLE     Complementation of defective translesion synthesis and UV light
            sensitivity in xeroderma pigmentosum variant cells by human and
            mouse DNA polymerase eta
  JOURNAL   Nucleic Acids Res 28 (13), 2473-2480 (2000)
   PUBMED   10871396
REFERENCE   7  (bases 1 to 8368)
  AUTHORS   Masutani,C., Kusumoto,R., Iwai,S. and Hanaoka,F.
  TITLE     Mechanisms of accurate translesion synthesis by human DNA
            polymerase eta
  JOURNAL   EMBO J 19 (12), 3100-3109 (2000)
   PUBMED   10856253
REFERENCE   8  (bases 1 to 8368)
  AUTHORS   Johnson,R.E., Kondratick,C.M., Prakash,S. and Prakash,L.
  TITLE     hRAD30 mutations in the variant form of xeroderma pigmentosum
  JOURNAL   Science 285 (5425), 263-265 (1999)
   PUBMED   10398605
REFERENCE   9  (bases 1 to 8368)
  AUTHORS   Masutani,C., Kusumoto,R., Yamada,A., Dohmae,N., Yokoi,M., Yuasa,M.,
            Araki,M., Iwai,S., Takio,K. and Hanaoka,F.
  TITLE     The XPV (xeroderma pigmentosum variant) gene encodes human DNA
            polymerase eta
  JOURNAL   Nature 399 (6737), 700-704 (1999)
   PUBMED   10385124
REFERENCE   10 (bases 1 to 8368)
  AUTHORS   Kraemer,K.H., DiGiovanna,J.J. and Tamura,D.
  TITLE     Xeroderma Pigmentosum
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301571
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC416114.1, AB024313.1 and
            AL353602.10.
            
            On Aug 31, 2019 this sequence version replaced NM_006502.2.
            
            Summary: This gene encodes a member of the Y family of specialized
            DNA polymerases. It copies undamaged DNA with a lower fidelity than
            other DNA-directed polymerases. However, it accurately replicates
            UV-damaged DNA; when thymine dimers are present, this polymerase
            inserts the complementary nucleotides in the newly synthesized DNA,
            thereby bypassing the lesion and suppressing the mutagenic effect
            of UV-induced DNA damage. This polymerase is thought to be involved
            in hypermutation during immunoglobulin class switch recombination.
            Mutations in this gene result in XPV, a variant type of xeroderma
            pigmentosum. Several transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, May
            2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB024313.1, AK294430.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372236.9/ ENSP00000361310.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                DC416114.1         45-67
            24-2447             AB024313.1         1-2424
            2448-8368           AL353602.10        21524-27444
FEATURES             Location/Qualifiers
     source          1..8368
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..8368
                     /gene="POLH"
                     /gene_synonym="RAD30; RAD30A; XP-V; XPV"
                     /note="DNA polymerase eta"
                     /db_xref="GeneID:5429"
                     /db_xref="HGNC:HGNC:9181"
                     /db_xref="MIM:603968"
     exon            1..256
                     /gene="POLH"
                     /gene_synonym="RAD30; RAD30A; XP-V; XPV"
                     /inference="alignment:Splign:2.1.0"
     exon            257..397
                     /gene="POLH"
                     /gene_synonym="RAD30; RAD30A; XP-V; XPV"
                     /inference="alignment:Splign:2.1.0"
     CDS             261..2402
                     /gene="POLH"
                     /gene_synonym="RAD30; RAD30A; XP-V; XPV"
                     /EC_number="2.7.7.7"
                     /note="isoform 1 is encoded by transcript variant 1;
                     xeroderma pigmentosum variant type protein; RAD30 homolog
                     A; polymerase (DNA directed), eta; polymerase (DNA) eta;
                     DNA polymerase eta transcript"
                     /codon_start=1
                     /product="DNA polymerase eta isoform 1"
                     /protein_id="NP_006493.1"
                     /db_xref="CCDS:CCDS4902.1"
                     /db_xref="GeneID:5429"
                     /db_xref="HGNC:HGNC:9181"
                     /db_xref="MIM:603968"
                     /translation="MATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKG
                     GGIIAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVMEI
                     MSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGLPQGPTTAEET
                     VQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIERETGFQCSAGISH
                     NKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIRSLGGKLGASVIEILGIEYMG
                     ELTQFTESQLQSHFGEKNGSWLYAMCRGIEHDPVKPRQLPKTIGCSKNFPGKTALATR
                     EQVQWWLLQLAQELEERLTKDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDA
                     HKMSHDAFTVIKNCNTSGIQTEWSPPLTMLFLCATKFSASAPSSSTDITSFLSSDPSS
                     LPKVPVTSSEAKTQGSGPAVTATKKATTSLESFFQKAAERQKVKEASLSSLTAPTQAP
                     MSNSPSKPSLPFQTSQSTGTEPFFKQKSLLLKQKQLNNSSVSSPQQNPWSNCKALPNS
                     LPTEYPGCVPVCEGVSKLEESSKATPAEMDLAHNSQSMHASSASKSVLEVTQKATPNP
                     SLLAAEDQVPCEKCGSLVPVWDMPEHMDYHFALELQKSFLQPHSSNPQVVSAVSHQGK
                     RNPKSPLACTNKRPRPEGMQTLESFFKPLTH"
     exon            398..532
                     /gene="POLH"
                     /gene_synonym="RAD30; RAD30A; XP-V; XPV"
                     /inference="alignment:Splign:2.1.0"
     exon            533..750
                     /gene="POLH"
                     /gene_synonym="RAD30; RAD30A; XP-V; XPV"
                     /inference="alignment:Splign:2.1.0"
     exon            751..920
                     /gene="POLH"
                     /gene_synonym="RAD30; RAD30A; XP-V; XPV"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1024
                     /gene="POLH"
                     /gene_synonym="RAD30; RAD30A; XP-V; XPV"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1144
                     /gene="POLH"
                     /gene_synonym="RAD30; RAD30A; XP-V; XPV"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1268
                     /gene="POLH"
                     /gene_synonym="RAD30; RAD30A; XP-V; XPV"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1334
                     /gene="POLH"
                     /gene_synonym="RAD30; RAD30A; XP-V; XPV"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1504
                     /gene="POLH"
                     /gene_synonym="RAD30; RAD30A; XP-V; XPV"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..8368
                     /gene="POLH"
                     /gene_synonym="RAD30; RAD30A; XP-V; XPV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4602..4607
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POLH"
                     /gene_synonym="RAD30; RAD30A; XP-V; XPV"
                     /note="hexamer: AATAAA"
     polyA_site      4629
                     /gene="POLH"
                     /gene_synonym="RAD30; RAD30A; XP-V; XPV"
                     /note="major polyA site"
     regulatory      6923..6928
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POLH"
                     /gene_synonym="RAD30; RAD30A; XP-V; XPV"
                     /note="hexamer: AATAAA"
     polyA_site      6948
                     /gene="POLH"
                     /gene_synonym="RAD30; RAD30A; XP-V; XPV"
     regulatory      8342..8347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="POLH"
                     /gene_synonym="RAD30; RAD30A; XP-V; XPV"
                     /note="hexamer: AATAAA"
     polyA_site      8368
                     /gene="POLH"
                     /gene_synonym="RAD30; RAD30A; XP-V; XPV"
ORIGIN      
        1 agtctggcgg ctgcattgct gggcgcgccg ctctcgtctg atccctgctg gggacggttg
       61 cccgggcagg atcctttacg atcccttctc ggtttctccg tcgtcacagg gaataaatct
      121 cgctcgaaac tcactggacc gctcctagaa aggcgaaaag atattcagga gcccttccat
      181 tttccttcca gtaggcaccg aacccagcat tttcggcaac cgctgctggc agttttgcca
      241 ggtgtttgtt accttgaaaa atggctactg gacaggatcg agtggttgct ctcgtggaca
      301 tggactgttt ttttgttcaa gtggagcagc ggcaaaatcc tcatttgagg aataaacctt
      361 gtgcagttgt acagtacaaa tcatggaagg gtggtggaat aattgcagtg agttatgaag
      421 ctcgtgcatt tggagtcact agaagtatgt gggcagatga tgctaagaag ttatgtccag
      481 atcttctact ggcacaagtt cgtgagtccc gtgggaaagc taacctcacc aagtaccggg
      541 aagccagtgt tgaagtgatg gagataatgt ctcgttttgc tgtgattgaa cgtgccagca
      601 ttgatgaggc ttacgtagat ctgaccagtg ctgtacaaga gagactacaa aagctacaag
      661 gtcagcctat ctcggcagac ttgttgccaa gcacttacat tgaagggttg ccccaaggcc
      721 ctacaacggc agaagagact gttcagaaag aggggatgcg aaaacaaggc ttatttcaat
      781 ggctcgattc tcttcagatt gataacctca cctctccaga cctgcagctc accgtgggag
      841 cagtgattgt ggaggaaatg agagcagcca tagagaggga gactggtttt cagtgttcag
      901 ctggaatttc acacaataag gtcctggcaa aactggcctg tggactaaac aagcccaacc
      961 gccaaaccct ggtttcacat gggtcagtcc cacagctctt cagccaaatg cccattcgca
     1021 aaatccgtag tcttggagga aagctagggg cctctgtcat tgagatccta gggatagaat
     1081 acatgggtga actgacccag ttcactgaat cccagctcca gagtcatttt ggggagaaga
     1141 atgggtcttg gctatatgcc atgtgccgag ggattgaaca tgatccagtt aaacccaggc
     1201 aactacccaa aaccattggc tgtagtaaga acttcccagg aaaaacagct cttgctactc
     1261 gggaacaggt acaatggtgg ctgttgcaat tagcccagga actagaggag agactgacta
     1321 aagaccgaaa tgataatgac agggtagcca cccagctggt tgtgagcatt cgtgtacaag
     1381 gagacaaacg cctcagcagc ctgcgccgct gctgtgccct tacccgctat gatgctcaca
     1441 agatgagcca tgatgcattt actgtcatca agaactgtaa tacttctgga atccagacag
     1501 aatggtctcc tcctctcaca atgcttttcc tctgtgctac aaaattttct gcctctgccc
     1561 cttcatcttc tacagacatc accagcttct tgagcagtga cccaagttct ctgccaaagg
     1621 tgccagttac cagctcagaa gctaagaccc agggaagtgg cccagcggtg acagccacta
     1681 agaaagcaac cacgtctctg gaatcattct tccaaaaagc tgcagaaagg cagaaagtta
     1741 aagaagcttc gctttcatct cttactgctc ccactcaggc tcccatgagc aattcaccat
     1801 ccaagccctc attacctttt caaaccagtc aaagtacagg aactgagccc ttctttaagc
     1861 agaaaagtct gcttctaaag cagaaacagc ttaataattc ttcagtttct tccccccaac
     1921 aaaacccatg gtccaactgt aaagcattac caaactcttt accaacagag tatccagggt
     1981 gtgtccctgt ttgtgaaggg gtgtcgaagc tagaagaatc ctctaaagca actcctgcag
     2041 agatggattt ggcccacaac agccaaagca tgcacgcctc ttcagcttcc aaatctgtgc
     2101 tggaggtgac tcagaaagca accccaaatc caagtcttct agctgctgag gaccaagtgc
     2161 cctgtgagaa gtgtggctcc ctggtaccgg tatgggatat gccagaacac atggactatc
     2221 attttgcatt ggagttgcag aaatcctttt tgcagcccca ctcttcaaac ccccaggttg
     2281 tttctgccgt atctcatcaa ggcaaaagaa atcccaagag ccctttggcc tgcactaata
     2341 aacgccccag gcctgagggc atgcaaacat tggaatcatt ttttaagcca ttaacacatt
     2401 agtgctgccc tcaggcttgc ctgtaggatt taatattttt tatctttaca gatctttatc
     2461 tttaatattt tatctttaca gatttccctg agaaagggaa ttatgaaatt tttaatacaa
     2521 aaaataatcc atttaggtgc tgagttacgg tcccatctct tcacaggcat ggattctaat
     2581 cccactgctg acagagatgt aaaaattcat cctaccagag tttttaatct ttagcattta
     2641 gggaggcagt gtcataaagt aaaaagtgtg tgggccttgg agtctaagag acgtggttgc
     2701 aaacttagct ctggttattg caatgagggc cttgaacaag tcattttctt cacattctca
     2761 tctgtaaaat ggagataata ccttacagat tattgcagat taataacaat gtattcaaat
     2821 tatgtaactc ggccgggtac aatggctcac gcctgtaatc ctaacacttt gggaggccga
     2881 ggcagacaga tcacctgagg tcaggagttt gagaccagcc tggccaacat ggcaaaacca
     2941 tctctactaa aaatagaaaa attagccagg cacgttccag gcacctgtga tcccagctac
     3001 ttagaggctg aggcagaaga attgctttaa ccttggaggc ggaggttgca ttgagctgag
     3061 atcatgctag tgcgctccag cctgggcaac agagcgagac ttcatctcag aaaataaaaa
     3121 ataggggcca ggcacagtgg ctcatacctg taatgccagc actttgggag gccaaggcgg
     3181 gcagatcacg aggtcaggag tttcagacca atatggtgaa accccatctc tactaaaatt
     3241 acaaaaaaaa ttatccaggc gtggtggtgc acgcctgtaa tcccagctac tcaggaggct
     3301 aaggcaggag aatcacttga acccaggagg cagaggttgg agtgagctga gatcgcgcca
     3361 ccgcactcca gcctgggcaa cagagcgaga ctccatctca aacaaaaaca agaacaaaaa
     3421 caaacataaa gttggcacag aaaagggacc aagtttaaaa aagggtttta aatgtaatga
     3481 gacttgcata gttaaaaaaa aaaaagggat tatttttatt tttatttttt atttttgaga
     3541 cggagtctcc ctctgtcgtc aggctagaat gcagtggtgc gttctcagct caccgcaacc
     3601 tccgtctcct gggttcaagc aattctcctg cctcagcctc ccaagtagct gggactacag
     3661 gcacgtgcta ccacactcag ctaatttttg tatttttaat agagatgagg tttcaccatg
     3721 ttggccagga tggtctcgat tgcttgacct catgatccgc ctgcctcgac ctcccaaagt
     3781 tgctgggatt acagatgtta gccaccgatc ctggcccccc caaaaaaagg attttaagaa
     3841 aaacttctct tggccgggcg cagtggctca cgcctgcaat cccagcactt tgggaggccg
     3901 aggcgggcgg atcacaaggt caggagatcg agaccacggt gaaaccccgt ctctactaaa
     3961 aaatacaaaa aaaaattagc cgggtgcggt ggcaggcgcc tgtagtccca gctactcggg
     4021 aggctgaggc aggagaatgg tgtgaacccg ggaggcggag cttgcagtga gccgagagcg
     4081 cgccactgca ctccagcctg ggtgacagag cgagactccg tctcaaaaaa aaaaaaaaaa
     4141 gaaaaacttc tctttaggct gggtgcggtt cctcatgcct ataatcccag catttaggga
     4201 ggctgaggtg agtggattgc aggagctcag gagttcgaga ccagcctggg caaggtggca
     4261 aaaccccgtc tctactaaaa aaaattagct gggcttggtg gcaggcgcct gtaatcccag
     4321 gtactcggga gactgaggca ggagaattgc ttgaacctgg aaggtggagg ttgcagtgag
     4381 ttgagatcac accaatgcac tccagccagg gtgagagtga gagactgtct caaaaaaaaa
     4441 aaaaacaaaa gaaaaacttc tctctagctc tgtgacgggc agttcagata ataccttcac
     4501 cagatttacc tgttttcagc tgaagaatgt gagatgaagc cttgaaaccc taaaagtgat
     4561 atggtaacta gggcaggtct ttctgtacat aaaagtgact taataaacag tgaatttcat
     4621 acaggtaaac cctattatac cctcagttct aaccattggc ctatctcttg cgttttgttc
     4681 taatgtagaa ttagattgct acttgactag ttcaggaact ctgtttagat ctgataagtc
     4741 ataatcaaat cttgccaggc gtggtggttt atgcctgtta tcccagcact ttgggaggcc
     4801 aaggcaggtg gaccacgtga agtcaggagt tcaagacaag catggccaac atggcgaaac
     4861 cctgtatcta ctaaaaatac aaaaattagc cgggcatggt ggtgggtgcg tgtaatccca
     4921 gctagttggg aggctgaggc aggagaatca cttgaacctg ggaggcagag gttgcagtga
     4981 gccgagattt ccactgcatt ccagcctggg cgatagagta actctgtctc aaaaaaaccc
     5041 actagatcat ctctagaaca ttgctactcc caagtatgat ttgaggaaca gcagcctcag
     5101 tatcaccagg gaacttatta gaaatagtct cagcctcacc actattccca cttaattgta
     5161 atctgatatt aacaagattt cccaatgtgg gtcaggtgtg gtggctcatg cctgtaatcc
     5221 cacactttgg gaggccaagg tgggcggatc acttgaggct gggagtttga gaccaggctg
     5281 gccaacatgg ggaaaaccca tctctacaaa aaataacaaa aattaggtgt gtgtggtgac
     5341 gcatgcgtgt aatcccagct acttaggagg ctgaggcagg agaatcactt gaatctggga
     5401 ggcagaggtt gtagtgagct gagattgtgc cactgcactc cagtctgggc aacagagtga
     5461 cactgtttaa aaaaaaaaaa attcccaatg tgggccgggt gcagtggctc atgcctgtaa
     5521 tcccagcact ttgggaggct gaggtgggtg tatcacgagg tcaagagatc aaggccatcc
     5581 tggccaacat ggtgaaaccc cgtctctact gaaaatacaa ctgggcgtgg tggtgcacgc
     5641 ctgtagtccc agctacttgg gaggctgagg cagaagaatt gcttgacctg ggaggcggag
     5701 cttgcagtga gcccagatcg tgccactgca ctgcaccctg gcgacacagc aagactgtct
     5761 caaaaaaaaa aaaattccca atgtgtatct taaagtttga gaaatgctga tctaaaagat
     5821 actaatgacc aggtgtgtag aggacatttt cttaagccct taagtacaaa tttaagaggt
     5881 aagtgcttca gccattaggg ttactggctt gttcatcttt cccactgagt gtaaatattt
     5941 agcttagggt ttaaaatttg ttatgtagct ttttgcactt gtccatgttt atactactgt
     6001 attattatta tttttttttg agatggagtc tcgctgtgta gccaggctgg agtgcagtgg
     6061 tgcaatcttg gctcactgca acctccgtct ctcgggttca agcaattctc ctgcctcagc
     6121 ttcccgaata gctgagacta caagcgtgca ccaccatgcc cagctaattt ttgtattttt
     6181 agtagagaca ggttttcacc atgttggcca ggctggtctc tatctagacc tcgtgatcca
     6241 tccgcctcgg cctcccaaag tgctgggatt ataggcatga gccaccacgc ccagcctata
     6301 gtactgtatt cttattctcc actcttgtgt gtgaaaagtc agctcttttg gcttttctgt
     6361 tatggggaaa cttgaattac acagggaacc caactgaaga aaatgaactg aagtaggtgg
     6421 cgctgggtga agtgggccca gagaatggtg tacacatccc tcccatacat atacccaaac
     6481 ttctattttt ttatgtgacg gagtttctct catcgccccg gctggaatgc aatggcacga
     6541 tctcggctca ctgcaacctc cgcctcccgg gttcaagcga ttctcctgca tcagcctcct
     6601 gagtagctgg gattataggc atgcaccatc acgcctggct aatttttgta tttttagtag
     6661 agatggggtt tcgccacgtt ggccaggctg gtcttgaact cttgatctca agtgatccac
     6721 ccgccctggc ctcccaaagt gctgggatta caggcctgag ccaccaggcc agccccaact
     6781 tctacttttt attttattta taaattgggg ggggggttct atatttagtt tgaagaggtg
     6841 gggaagattt gaaaaccact agatttacca ggaaattttt ttcttcaaaa atattttctg
     6901 cttttatgat acttgaatat ctaataaaag acaatattta gccagtcacg gtggctgatg
     6961 cttgtaatcc taacactttg ggaggctgag gtgggtggac tactggagcc ctggagttca
     7021 aaaccggcct aagccacatg gcaaaacagt ctttacaaaa aatacaaaga tggtggctta
     7081 tgcctgtagt cgtacctact caggaggctg aggttgggag gatcacctga atctgggagt
     7141 ttggggctgc aataagccat gattgtgccg ctgcactcca gcctgggtga cagtctgaga
     7201 ccctgtctca aaaaaaaaaa aaaaaaaaaa aaaaaaaaag actacattca ctgtatacgt
     7261 ggccttttcc ccctaactag ctatgtagct tcttaaaggc aaagattctt catagtgctt
     7321 tgcacatgat aggtgctgat actcattgga tgaatgtata tagtgaagaa ttttagatct
     7381 gattaccaca attgggatca taaacatgta taaactcctt gggagtctgc cttatatact
     7441 ttttatcccc ctaaatgttc cattaatgtt gcagagaggc tcactagttc ctggagatgt
     7501 cttattaagt actgaaatgt gattttccaa aattttcttt acaatacagg caaaagataa
     7561 gtaaattgtg gacaaagctt tcatctctat cagcagctat agagaggaag taaacagctt
     7621 agcccctaat acaggaggaa gttgttcaac tacaggcttg ttagtagcaa gttaaaccag
     7681 ttacatttta taaaacagcc tgagtggtag ggaagctatc actttaatac tctagaggca
     7741 gaatgccaca taggactttg ggtcacatat ttcttttcca gggtctcctc aaaatgcagt
     7801 ttctatttac agttgacttt ggcccctatt tacccataaa atgtcaaaat caagtagtat
     7861 gaacatggaa acaggagcag ggactaaggt ttggtcaagt ggccctcatt gttccaagag
     7921 taatttaggc tatgtaaact tgaaaaatat gggaccagat taccttttgt ctctaaattc
     7981 tactcttctt taagtagctg gcactgtatc tctgccaggg cacagaagtg ggctccttac
     8041 tattctgacc actagcaagt ggccaactct tcaaatacag ggtagctacc tatttcacgt
     8101 gaaaggcctc agtattctgc tcacttgaac tacggaaaat aggccacaat acttggttac
     8161 aatactggaa ctctgaacct atgtggagga gagaaaaaca atggtgaacg agataccagc
     8221 tgggctcttt ccacattcag ggctcagcag tgttggggtt tcacttgtct ctaatcctga
     8281 agaggtatct agccctggaa ggaagctgag cctgtagcta acgcataagc acagtgtatt
     8341 caataaaaca tttttattct gtacaata
//
